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Dietary supplement

Less Stress, More Yes Mango Lemon Ingredients & Drug Interactions

by N by Nutrilite

Less Stress, More Yes Mango Lemon label
See full label image
Gummy Or Jelly Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Less Stress, More Yes Mango Lemon against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Less Stress, More Yes Mango Lemon is a dietary supplement by N by Nutrilite with 2 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 581 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Theanine, Lemon Balm (aerial) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Less Stress, More Yes Mango Lemon by N by Nutrilite

Ask about any prescription or over-the-counter medication and we check it for interactions with Less Stress, More Yes Mango Lemon by N by Nutrilite — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Less Stress, More Yes Mango Lemon by N by Nutrilite

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 13, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product has 2 active ingredients. L-theanine is an amino acid that may support calm focus and cognitive function.

Lemon balm aerial extract is a plant-based ingredient traditionally used for stress and mood support. The remaining ingredients — tapioca syrup, cane sugar, water, glycerin, agar, citric acid, lactic acid, natural flavors, turmeric, locust bean gum, and paprika — are inactive ingredients that give the gummy its texture, taste, and shelf stability.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: help reduce occasional stress and promote calm.
  • We looked for evidence on: Stress, Anxiety, Generalized anxiety disorder (GAD), Insomnia, Restlessness, Nervousness — and 1 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Lemon Balm is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia.
  • Also on file: Theanine is rated "Insufficient Reliable Evidence To Rate" for Generalized anxiety disorder (GAD), Insomnia, Stress.

L-theanine is possibly effective for supporting cognitive function, though the evidence for age-related cognitive decline and Alzheimer's disease is insufficient to rate. Its effectiveness for anxiety disorders, OCD, or cancer is also not well established in the data we hold.

Lemon balm extract is possibly effective for cold sores and stress, and possibly effective for mood support. The evidence for depression is listed as possibly effective as well.

The evidence, ingredient by ingredient Theanine Lemon Balm

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine is generally well tolerated for short-term use in healthy adults, but long-term safety hasn't been well studied. The most common side effects are headaches, drowsiness, and increased dream activity.

One case of facial tics was reported in a child, though it wasn't clearly linked to the ingredient. Lemon balm is generally well tolerated for short-term use, and studies show it doesn't impair reaction time or cognitive performance even when combined with alcohol.

One case of heart rhythm changes was reported with a multi-ingredient product containing lemon balm, but it's unclear if lemon balm was the cause. There's not enough safety data for either ingredient during pregnancy; the facts advise against use unless your doctor advises otherwise.

For breastfeeding, lemon balm safety information is limited — talk with your doctor or pharmacist before use.

Side effects, ingredient by ingredient Theanine Lemon Balm

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Lemon Balm, Theanine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 581 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your doctor or pharmacist if you're on thyroid hormone replacement therapy (lemon balm may interfere with it) or blood pressure medications (L-theanine may lower pressure further). Also flag any CNS depressants — sedatives, sleep aids, anxiety medications, or pain relievers that make you drowsy — since both ingredients can add to that effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you take blood pressure medications, thyroid hormone replacement, or sedating medications (sleep aids, anxiety drugs, pain relievers), talk with your doctor or pharmacist before starting this product. L-theanine and lemon balm are generally well tolerated short-term, but long-term safety data is limited.

Avoid during pregnancy unless your doctor says it's okay, and check with your pharmacist if you're breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Less Stress, More Yes Mango Lemon, straight from the product label.

Brand N by Nutrilite
Barcode (UPC) 850210008460
Net contents 60 Gummy(ies)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 246527
Product type Other Combinations
Supplement form Gummy Or Jelly
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Less Stress, More Yes Mango Lemon by N by Nutrilite, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Gummy(ies)
Maximum serving Sizes:
2 Gummy(ies)
Servings per container
30
UPC/BARCODE
850210008460
IngredientAmount% DV
Calories20 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
L-Theanine50 mg--
Added Sugars3 Gram(s)6%
Total Sugars3 Gram(s)--
Lemon Balm (aerial) extract20 mg--

Other ingredients: Tapioca Syrup, Cane Sugar, Water, Glycerin, Agar, Citric Acid, Lactic Acid, Natural Flavors, Turmeric, Locust Bean Gum, Paprika

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Feeling stressed? Try these great tasting gummies!

U got this.

Exclusively from Amway

Formulation

Free from all the nasties of artificial flavors, sweeteners, and colors.

These can help you find you Zen.

Free From: Peanuts, tree nuts, soy, eggs, high fructose corn syrup, shellfish, and crustacean. GF (Gluten free) Dairy free

V (Vegetarian)

Produced following Amway standards.

Relax

Product of Colombia.

Formula

The Good Stuff L-Theanine - a natural amino acid known to help reduce occasional stress. Lemon Balm - used traditionally as a calming botanical.

Mango lemon with other natural flavors

L-Theanine & lemon balm

Precautions

Keep out of the reach of children

If you have a medical condition, long-term stress disorder, chronic illness, are taking prescription drugs or are pregnant or nursing, please consult your healthcare professional prior to use.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Use Instructions: Adults: Take 2 gummies daily. Chew thoroughly before swallowing.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Less Stress, More Yes Mango Lemon by N by Nutrilite label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Less Stress, More Yes Mango Lemon label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Less Stress, More Yes Mango Lemon by N by Nutrilite

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Gummy(ies) Dosage formGummy Or Jelly Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
50 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Lemon Balm (aerial) extract

Interacts with
264 drugs
20 mg per serving

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Lemon Balm (aerial) extract monograph & interactions

Other (inactive) ingredients: Tapioca Syrup, Cane Sugar, Water, Glycerin, Agar, Citric Acid, Lactic Acid, Natural Flavors, Turmeric, Locust Bean Gum, Paprika. These complete the product’s ingredient list but are not active constituents.

Interaction report

Less Stress, More Yes Mango Lemon by N by Nutrilite Drug Interactions

Want to check YOUR meds against Less Stress, More Yes Mango Lemon?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
581Drugs
435 Moderate 146 Minor

Ingredients driving the most interactions

L-Theanine 565
Lemon Balm (aerial) extract 264

Individual Drug Interactions

The ingredients in Less Stress, More Yes Mango Lemon interact with 581 drugs. Click any drug to see the details.

2 of the 2 ingredients in Less Stress, More Yes Mango Lemon interact with drugs. Each result below shows which ingredient is responsible. L-Theanine Lemon Balm (aerial) extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Less Stress, More Yes Mango Lemon with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Lemon Balm (aerial) extract2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Lemon Balm (aerial) extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Less Stress, More Yes Mango Lemon, from the product label.

N by Nutrilite

See all N by Nutrilite products
Name
Amway Corp.
City
Ada
State
MI
ZipCode
49355
Phone Number
1-800-253-6500
Web Address
Amway.com
Pharmacist Counseling Corner

Less Stress, More Yes Mango Lemon by N by Nutrilite: Common Questions

Does Less Stress, More Yes Mango Lemon by N by Nutrilite interact with any medications?
Yes. Based on its ingredients, Less Stress, More Yes Mango Lemon has a known interaction with 581 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Less Stress, More Yes Mango Lemon contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
There isn't enough safety data for L-theanine during pregnancy, so it's best avoided unless your doctor advises otherwise. Lemon balm is also not recommended in pregnancy for the same reason. If you're breastfeeding, lemon balm safety information is limited — talk with your doctor or pharmacist for personalized advice before using it.
What are the side effects?
L-theanine may cause headaches, drowsiness, increased sleep time, or vivid dreams. Lemon balm may cause dizziness or sedation in theory, though studies don't show these occur more often than with placebo. Both ingredients are generally well tolerated, but long-term safety isn't well studied.
Does L-theanine actually help with focus and thinking?
L-theanine is possibly effective for cognitive function based on the data we hold. For age-related cognitive decline and Alzheimer's disease, the evidence is insufficient to rate.
Can lemon balm really help with stress and mood?
Lemon balm extract is possibly effective for stress and possibly effective for supporting mood. It's also possibly effective for cold sores if you're looking to use it for that.
Will this make me drowsy?
Both ingredients have theoretical sedating effects, so drowsiness is possible — especially if you're also taking sleep aids, anxiety medications, or other CNS depressants. If you're sensitive to sedation, check with your pharmacist first.
Is this safe to take long-term?
Both L-theanine and lemon balm are generally well tolerated for short-term use, but long-term safety hasn't been well studied. Talk with your doctor about how long you plan to use it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Less Stress, More Yes Mango Lemon label
Go deeper

The Full Monographs Behind Less Stress, More Yes Mango Lemon’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph →
Sources

Sources & How We Checked

Less Stress, More Yes Mango Lemon's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 18 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Lemon Balm 12 references
  1. Wolbling RH, Leonhardt K. Local therapy of herpes simplex with dried extract from Melissa officinalis. Phytomedicine 1994;1:25-31.
  2. Akhondzadeh S, Noroozian M, Mohammadi M, et al. Melissa officinalis extract in the treatment of patients with mild to moderate Alzheimer's disease: a double blind, randomised, placebo controlled trial. J Neurol Neurosurg Psychiatry 2003;74:863-6. PubMed
  3. Kennedy DO, Scholey AB, Tildesley NT, et al. Modulation of mood and cognitive performance following acute administration of Melissa officinalis (lemon balm). Pharmacol Biochem Behav 2002;72:953-64. PubMed
  4. Albrecht M, Berger W, Laux P, Schmidt U, et al. Psychopharmaka und Verkehrssicherheit. Der Einfluß von Euvegal® - Dragees forte auf die Fahrtüchtigkeit und Kombinationswirkungen mit Alkohol Z Allg Med 1995;71:1215-25.
  5. Herberg, KW. Nebenwirkungen pflanzlicher Beruhigungsmittel/ Leistung und Befinden nach Einnahme einer Baldrian-Hopfen-Kombination. Z.Allg Med 1996;72:234-240.
  6. Soulimani R, Fleurentin J, Mortier F, et al. Neurotropic action of the hydroalcoholic extract of Melissa officinalis in the mouse. Planta Med. 1991 Apr;57:105-9.
  7. Sourgens H, Winterhoff H, Gumbinger HG, et al. Antihormonal effects of plant extracts. TSH- and prolactin-suppressing properties of Lithospermum officinale and other plants. Planta Med. 1982 Jun;45:78-86. DOI
  8. Auf'mkolk M, Ingbar JC, Amir SM, et al. Inhibition by certain plant extracts of the binding and adenylate cyclase stimulatory effect of bovine thyrotropin in human thyroid membranes. Endocrinology. 1984 Aug;115:527-34. PubMed
  9. Santini F, Vitti P, Ceccarini G, et al. In vitro assay of thyroid disruptors affecting TSH-stimulated adenylate cyclase activity. J Endocrinol Invest. 2003 Oct;26:950-5. PubMed
  10. Alijaniha F, et al. Heart palpitation relief with Melissa officinalis leaf extract: double blind, randomized, placebo controlled trial of efficacy and safety. J Ethnopharmacol. 2015;164:378-384. doi: 10.1016/j.jep.2015.02.007. Epub 2015 Feb 11. PubMed
  11. Araj-Khodaei M, Noorbala AA, Yarani R, et al. A double-blind, randomized pilot study for comparison of Melissa officinalis L. and Lavandula angustifolia Mill. with Fluoxetine for the treatment of depression. BMC Complement Med Ther. 2020;20(1):207. PubMed
  12. Kucuk U, Pham M, Raza Raja MH, Saad Shaukat MH, Clark R. Transient complete atrioventricular block associated with herbal supplement use. S D Med 2023;76(7):311-313.

See these in context on the Lemon Balm monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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