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Dietary supplement

Lion's Mane 600 mg Ingredients & Drug Interactions

by ALLMAX ESSENTIALS

Lion's Mane 600 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lion's Mane 600 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lion's Mane 600 mg is a dietary supplement by ALLMAX ESSENTIALS with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, nerve health, mood and anxiety.Based on those ingredients, 327 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lion's Mane Fruiting Body Extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lion's Mane 600 mg by ALLMAX ESSENTIALS

Ask about any prescription or over-the-counter medication and we check it for interactions with Lion's Mane 600 mg by ALLMAX ESSENTIALS — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lion's Mane 600 mg by ALLMAX ESSENTIALS

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: lion's mane fruiting body extract at 600 mg per capsule. Lion's mane is a medicinal mushroom traditionally used to support brain and nerve function.

The capsule itself is made from hypromellose (a plant-based polymer), microcrystalline cellulose, silicon dioxide, and magnesium stearate — all inactive ingredients that help form and preserve the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lion's Mane Mushroom's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: support mental focus clarity and mood.
  • We looked for evidence on: Anxiety, Cognitive function, Cognitive impairment, Depression, Memory, brain health — and 3 related terms.
  • The closest evidence on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Anxiety (Natural Medicines).
  • Also on file: Lion's Mane Mushroom is rated "Insufficient Reliable Evidence To Rate" for Cognitive function, Cognitive impairment, Depression, Memory.

The evidence for lion's mane is still developing. Our data shows insufficient reliable evidence to rate it for Alzheimer disease, anxiety, athletic performance, cancer, cognitive function, or cognitive impairment.

That doesn't mean it doesn't work — it means well-designed human trials are lacking or results so far have been mixed. If you're considering this supplement for any of those purposes, talk to your pharmacist or doctor about what the current science actually shows and whether it's right for your situation.

The evidence, ingredient by ingredient Lion's Mane Mushroom

How safe is it?

Some data gaps
Safety Information · database check
Some gaps

Safety data exists for these ingredients, but with some important gaps.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 0 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lion's mane is generally well tolerated as a food, but long-term safety in supplement form hasn't been thoroughly studied. The most common side effects reported are gastrointestinal discomfort, nausea, and skin rash.

If you're pregnant or breastfeeding, there isn't enough safety data — your doctor or pharmacist can help you decide whether to use it.

Side effects, ingredient by ingredient Lion's Mane Mushroom

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 327 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check any blood thinners or antiplatelet drugs you're on (Moderate interaction risk). Also flag any diabetes medications and any drugs that suppress your immune system — lion's mane may amplify or interfere with how they work.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and some safety-information gaps remain.

Lion's mane is a single-ingredient supplement that's generally well tolerated in the short term, but it does interact with blood thinners, diabetes medications, and immune-suppressing drugs. If you take any of those, check with us before you start.

The evidence for what it does is still incomplete — talk through your expectations with your pharmacist.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 24, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lion's Mane 600 mg, straight from the product label.

Brand ALLMAX ESSENTIALS
Barcode (UPC) 665553229249
Net contents 60 Veggie Cap(s)
Market status On market
Date entered into DSLD Apr 24, 2025
DSLD ID 325956
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lion's Mane 600 mg by ALLMAX ESSENTIALS, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
665553229249
IngredientAmount% DV
Lion's Mane Fruiting Body Extract600 mg--

Other ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Professional grade supplements Fuel your brain with the power of ALLMAX ESSENTIALS LION'S MANE. ALLMAX ESSENTIALS LION'S MANE delivers the whole fruiting body to support mental focus, clarity and mood.

Vegan

Non-GMO No proprietary blends

Brain fuel Made in the USA with domestic and imported ingredients

Fuel brain health & power Mental focus & clarity Immunity support

Formula

Each serving contains 600 mg of organic Lion's Mane harvested from organic mushrooms. Lion's Mane also contains fungal polysaccharides which have been shown to have immunomodulating properties.

Seals/Symbols

Lab Tested Every Lot cGMP Registered Facility

Quality Guarantee Potency & purity tested

Precautions

Prop 65

Warnings: For adult use only. Keep out of reach of children.

Consult a healthcare practitioner prior to use if you are pregnant, breastfeeding or have a known medical condition.

Stop use if hypersensitivity/allergy occurs.

Do not use if inner seal is broken.

California warning: Lead is known to the State of California to cause birth defects or reproductive harm. Consuming this product can expose you to more than 0.0000005 g of lead. For more information go to www.P65Warnings.ca.gov.

Allergen warning: Produced in a facility that also handles milk, soy, wheat, egg, peanut, tree nuts, fish, crustacean and shellfish products.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Storage

Store in a cool dry place.

Brand IP Statement(s)

Copyright 2022 ALLMAX Nutrition Inc. All rights reserved. Trademarks are property of their respective owners.

ALLMAX Science Innovation Quality Results

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lion's Mane 600 mg by ALLMAX ESSENTIALS label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lion's Mane 600 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lion's Mane 600 mg by ALLMAX ESSENTIALS

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Lion's Mane Fruiting Body Extract

Interacts with
327 drugs
600 mg per serving Form: Polysaccharides

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Lion's Mane Fruiting Body Extract monograph & interactions

Other (inactive) ingredients: Hypromellose, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lion's Mane 600 mg by ALLMAX ESSENTIALS Drug Interactions

Want to check YOUR meds against Lion's Mane 600 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
327Drugs
327 Moderate

Ingredients driving the most interactions

Lion's Mane Fruiting Body Extract 327

Individual Drug Interactions

The ingredients in Lion's Mane 600 mg interact with 327 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lion's Mane 600 mg interact with drugs. Each result below shows which ingredient is responsible. Lion's Mane Fruiting Body Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Lion's Mane 600 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lion's Mane Fruiting Body Extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
Lion's Mane Fruiting Body Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lion's Mane 600 mg, from the product label.

ALLMAX ESSENTIALS

See all ALLMAX ESSENTIALS products
Name
HBS International Corp.
Street Address
14 Edgewood Drive
City
Carmel
State
NY
ZipCode
10512
Web Address
ALLMAXNUTRITION.COM
Pharmacist Counseling Corner

Lion's Mane 600 mg by ALLMAX ESSENTIALS: Common Questions

Does Lion's Mane 600 mg by ALLMAX ESSENTIALS interact with any medications?
Yes. Based on its ingredients, Lion's Mane 600 mg has a known interaction with 327 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lion's Mane 600 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is lion's mane mushroom used for?
Lion's mane has traditionally been used to support brain and nerve function, and some research suggests it may help with cognition and memory. However, current evidence is insufficient to reliably prove it works for Alzheimer disease, anxiety, cognitive impairment, or other specific conditions — talk with your pharmacist about whether it's the right choice for what you're aiming for.
Can I take lion's mane if I'm on a blood thinner like warfarin?
Not without checking with us first. Lion's mane may slow blood clotting, which could increase your bleeding risk on top of what your blood thinner already does. This is a Moderate severity interaction — your pharmacist can review your specific medication and tell you whether it's safe.
What are the side effects?
The most common are gastrointestinal discomfort, nausea, and skin rash. Lion's mane is generally well tolerated, but long-term safety in supplement form hasn't been well studied yet.
Is it safe to take lion's mane while pregnant or breastfeeding?
There isn't enough safety data to know either way. It's best to avoid it during pregnancy and breastfeeding — talk with your doctor or pharmacist about whether it's right for you.
How much lion's mane is in each capsule?
Each capsule contains 600 mg of lion's mane fruiting body extract.
Can lion's mane affect my blood sugar?
Animal research suggests it may lower blood glucose, so if you take diabetes medications, there's a risk of low blood sugar from the combined effect. Check with your pharmacist before starting.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lion's Mane 600 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lion's Mane 600 mg label
Go deeper

The Full Monographs Behind Lion's Mane 600 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph →
Sources

Sources & How We Checked

Lion's Mane 600 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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