Liposomal Magnesium Ingredients & Drug Interactions
by Codeage
What is this page for?
First and foremost: checking Liposomal Magnesium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Liposomal Magnesium is a dietary supplement by Codeage with 3 active ingredients. Its ingredients are commonly taken for preventing or treating magnesium deficiency, constipation, muscle cramps.Based on those ingredients, 373 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium, Sunflower Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Liposomal Magnesium by Codeage
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AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Liposomal Magnesium by Codeage
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This capsule contains three active ingredients. The main one is magnesium (supplied as Magtein), which supports digestive comfort, bowel regularity, and helps prevent low magnesium in the blood.
The other two — Sunflower Lecithin and Sunflower Oil — are part of the liposomal delivery system, designed to help your body absorb the magnesium more effectively. One inactive ingredient, methylcellulose, acts as a capsule binder.
Does it work?
Strong evidence
Magnesium in this product is rated Effective for indigestion (dyspepsia), constipation, and preventing or treating low magnesium levels. It's also Effective for pre-eclampsia (high blood pressure in pregnancy) when used under medical supervision.
Sunflower Lecithin's effectiveness is not established in our data — the evidence for cognitive decline, anxiety, and several other conditions is insufficient or the ingredient is rated likely ineffective for them. Sunflower Oil is rated Possibly Effective for high cholesterol and heart disease prevention.
How safe is it?
Well-documented data
Magnesium is generally well tolerated at recommended doses. The most common side effects taken by mouth are diarrhea, nausea, vomiting, and stomach irritation — which is why some people use it as a laxative.
Sunflower Lecithin is generally considered safe in food and supplement amounts, though it may cause stomach pain, diarrhea, bloating, or nausea in some people. If you have an egg or soy allergy, lecithin (which can be derived from either) may trigger an allergic skin reaction.
Sunflower Oil is safe in normal food amounts; if you're allergic to ragweed or related plants (like chrysanthemums or daisies), there's a small theoretical risk of reaction, though actual cases are rare. During pregnancy, the safety of magnesium supplements varies — it's likely safe in normal dietary amounts and is actually needed, but the rating for higher supplement doses is less certain.
Talk with your doctor before taking magnesium supplements while pregnant or breastfeeding. Sunflower Lecithin and Sunflower Oil are both rated Likely Safe in pregnancy and lactation.
Meds to double-check
Major interaction found
Before starting, double-check if you take levodopa/carbidopa (Sinemet) — magnesium can significantly reduce how much of this drug your body absorbs. Also flag any skeletal muscle relaxants, calcium channel blockers (blood pressure drugs), potassium-sparing diuretics, diabetes medications (both older sulfonylureas and newer antidiabetes drugs), quinolone antibiotics, bisphosphonates, or acid-reducing medications.
Magnesium can affect the timing, dose, or effectiveness of all these.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're looking to support digestive comfort or regular bowel function and your doctor confirms you need extra magnesium. If you take levodopa/carbidopa for Parkinson's, any muscle relaxant, blood pressure medication, diabetes drugs, certain antibiotics, or bone-health drugs, you'll need to check your specific medications first — spacing and dose adjustments may be needed.
Talk with your pharmacist before adding this to your routine.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Liposomal Magnesium, straight from the product label.
| Brand | Codeage |
|---|---|
| Barcode (UPC) | 850049609258 |
| Net contents | 90 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jun 25, 2025 |
| DSLD ID | 333424 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | Nutrient, All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Liposomal Magnesium by Codeage, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Magnesium | 144 mg | 34% |
| Sunflower Lecithin | 0 NP | -- |
| Sunflower Oil | 0 NP | -- |
| Phospholipid Complex | 100 mg | -- |
| Magtein | 2000 mg | -- |
Other ingredients: Methylcellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Essential Mineral Essential Phospholipids
Magnesium L-Threonate Magtein
Formulation
Vegan
Non-GMO Soy-Free Dairy-Free Gluten-Free
cGMP Certified Manufacturing
Enhanced Absorption Bioavailable
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Suggested use: Adults take 3 capsules daily, or as recommended your by healthcare practitioner, with 8 ounces of water or your favorite beverage. May be taken with or without food.
Brand IP Statement(s)
Copyright Codeage LLC. All rights reserved.
Magtein is protected under a family of US patents, pending patents, and is protected worldwide. Magtein is a trademark of Magceutics, Inc. and is distributed exclusively by AIDP, Inc.
Precautions
Caution: Do not exceed recommended dose. Discontinue use two weeks prior to surgery.
Pregnant or nursing mothers and individuals with a known medical condition should consult a physician before using this or any dietary supplement.
Please use caution if you have any allergies or sensitivities to any of the listed ingredients.
Do not use if product has been opened or tampered with in any way.
Keep out of reach of children and pets.
General Statements
Please recycle Bottle & Cap Please take off the label Questions? Codeage.com Scan for info
Feel Different.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
Storage
Store in a cool, dry place.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Liposomal Magnesium by Codeage label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Liposomal Magnesium by Codeage
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size3 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Magnesium
Interacts with295 drugs
Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...
Magnesium monograph & interactions- › Magtein
Phospholipid Complex
Other (inactive) ingredients: Methylcellulose. These complete the product’s ingredient list but are not active constituents.
Liposomal Magnesium by Codeage Drug Interactions
HelloPharmacist Interaction Report
Codeage's Liposomal Magnesium contains three active ingredients, and the magnesium component (Magtein) has documented interactions with a number of medications.
The most serious is with levodopa/carbidopa (Sinemet), used for Parkinson's disease — magnesium can cut the drug's blood levels by up to 35%, reducing how well it works.
Read the full breakdown — every affected drug type, severity by severity
Magnesium also interacts with skeletal muscle relaxants (drugs like cyclobenzaprine that ease muscle tightness), calcium channel blockers (blood pressure medications), potassium-sparing diuretics (water pills that preserve potassium), sulfonylureas (older diabetes drugs), quinolone antibiotics, and bisphosphonates (bone-strengthening drugs). All of these are Moderate severity — meaning magnesium either reduces their effectiveness or increases their effects and side effects.
Magnesium may also affect how your body handles antidiabetes drugs more broadly, and it can reduce the laxative effect of magnesium oxide if you're taking acid-reducing medications.
Sunflower Lecithin has no documented interactions. Sunflower Oil carries one Moderate interaction with antidiabetes drugs — it may theoretically lower their effectiveness and could raise your fasting blood sugar if you have type 2 diabetes.
Altogether, these interactions span 370 individual medications. If you take any prescription medication, please check your exact drugs with the search tool on this page before starting.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Liposomal Magnesium?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Liposomal Magnesium interact with 373 drugs. Click any drug to see the details.
2 of the 3 ingredients in Liposomal Magnesium interact with drugs. Each result below shows which ingredient is responsible. Magnesium Sunflower Oil
RetapamulinAltabax, Altargo
How Retapamulin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinQuinolone Antibiotics, Tetracycline Antibiotics +1 Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magtein + Retapamulin interactionRisedronateActonel DR
How Risedronate interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magtein + Risedronate interactionRisedronate SodiumActonel, Actonel Once a Week
How Risedronate Sodium interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magtein + Risedronate Sodium interactionRocuroniumZemuron
How Rocuronium interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magtein + Rocuronium interactionRosiglitazone MaleateAvandia
How Rosiglitazone Maleate interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Rosiglitazone Maleate interactionSacubitril, ValsartanEntresto
How Sacubitril, Valsartan interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinPotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magtein + Sacubitril, Valsartan interactionSaxagliptinOnglyza
How Saxagliptin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Saxagliptin interactionSaxagliptin, Metformin XrKombiglyze
How Saxagliptin, Metformin Xr interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Saxagliptin, Metformin Xr interactionSemaglutideOzempic, Rybelsus, Wegovy
How Semaglutide interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Semaglutide interactionSimvastatin, SitagliptinJuvisync
How Simvastatin, Sitagliptin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Simvastatin, Sitagliptin interactionSitagliptinJanuvia, Zituvio
How Sitagliptin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Sitagliptin interactionSitagliptin, MetforminZituvimet
How Sitagliptin, Metformin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Sitagliptin, Metformin interactionSodium Bicarbonate (otc Drug)Sodium Bicarbonate
How Sodium Bicarbonate (otc Drug) interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinAntacids Moderate
Interaction Summary
Use of acid reducers may reduce the laxative effect of magnesium oxide.
Read the full Magtein + Sodium Bicarbonate (otc Drug) interactionSotagliflozinInpefa
How Sotagliflozin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Sotagliflozin interactionSparfloxacinZagam
How Sparfloxacin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinQuinolone Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magtein + Sparfloxacin interactionSpironolactoneAldactone, Carospir, Spiroton
How Spironolactone interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinPotassium-sparing Diuretics Moderate
Interaction Summary
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Read the full Magtein + Spironolactone interactionStreptomycinStreptomycin
How Streptomycin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinAminoglycoside Antibiotics Moderate
Interaction Summary
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Read the full Magtein + Streptomycin interactionSuccinylcholineAnectine, Quelicin
How Succinylcholine interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magtein + Succinylcholine interactionTelmisartan, AmlodipineTwynsta
How Telmisartan, Amlodipine interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinCalcium Channel Blockers Moderate
Interaction Summary
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Read the full Magtein + Telmisartan, Amlodipine interactionTenofovir Disoproxil FumarateViread
How Tenofovir Disoproxil Fumarate interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Read the full Magtein + Tenofovir Disoproxil Fumarate interactionTenofovir, Emtricitabine, EfavirenzAtripla
How Tenofovir, Emtricitabine, Efavirenz interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinBictegravir/emtricitabine/tenofovir Alafenamide (biktarvy) Moderate
Interaction Summary
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Read the full Magtein + Tenofovir, Emtricitabine, Efavirenz interactionTetracyclineAchromycin, Achromycin V, Nor-Tet, Robitet, Sumycin, Sumycin 250 +6 more
How Tetracycline interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinTetracycline Antibiotics Moderate
Interaction Summary
Magnesium decreases absorption of tetracyclines.
Read the full Magtein + Tetracycline interactionTigecyclineTygacil
How Tigecycline interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinQuinolone Antibiotics, Tetracycline Antibiotics +1 Moderate
Interaction Summary
Magnesium decreases absorption of quinolones.
Read the full Magtein + Tigecycline interactionTiludronate DisodiumSkelid
How Tiludronate Disodium interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinBisphosphonates Moderate
Interaction Summary
Magnesium can decrease absorption of bisphosphonates.
Read the full Magtein + Tiludronate Disodium interactionTirzepatideMounjaro, Zepbound
How Tirzepatide interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Tirzepatide interactionTizanidineOntralfy, Zanaflex
How Tizanidine interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinSkeletal Muscle Relaxants Moderate
Interaction Summary
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Read the full Magtein + Tizanidine interactionTobramycinBethkis, Kitabis PAK, Nebcin, Tobi Podhaler
How Tobramycin interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
MagteinAminoglycoside Antibiotics Moderate
Interaction Summary
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Read the full Magtein + Tobramycin interactionTobutamideMobenol
How Tobutamide interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Tobutamide interactionTolazamideTolinase
How Tolazamide interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Tolazamide interactionTolbutamideOrinase
How Tolbutamide interacts with Liposomal Magnesium — through 1 ingredient. Tap an ingredient for the detail:
Sunflower OilAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
Read the full Sunflower Oil + Tolbutamide interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Liposomal Magnesium with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Magnesium
Levodopa/Carbidopa (Sinemet)
Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.
Aminoglycoside Antibiotics
Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.
Antacids
Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)
Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.
Bisphosphonates
Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.
Calcium Channel Blockers
Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.
Digoxin
Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.
Potassium-Sparing Diuretics
Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.
Quinolone Antibiotics
Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Skeletal Muscle Relaxants
Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.
Sulfonylureas
Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.
Tetracycline Antibiotics
Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.
Anticoagulant/Antiplatelet Drugs
Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.
Gabapentin (Neurontin)
Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.
Sevelamer (Renagel, Renvela)
Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.
Sunflower Oil
Antidiabetes Drugs
Theoretically, sunflower oil might decrease the effectiveness of antidiabetes medications.
A diet using sunflower oil as a fat source can cause increased fasting blood glucose levels in patients with type 2 diabetes. Dose adjustments to diabetes medications might be necessary.
Brand information
Manufacturer and brand details for Liposomal Magnesium, from the product label.
Codeage
See all Codeage products- Name
- Codeage LLC
- Street Address
- 5628 Washington Blvd
- City
- Los Angeles
- State
- CA
- ZipCode
- 90016
- Web Address
- www.codeage.com
Liposomal Magnesium by Codeage: Common Questions
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Will this help my constipation?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Liposomal Magnesium is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Liposomal Magnesium’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Magnesium
Interacts with 295 drugsMagnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...
Read the full Magnesium monograph → Herb & supplement monographLecithin
Lecithin is a natural fatty substance found in foods and made by the body that is widely used as a supplement and food emulsifier. Evidence supporting most of its health claims is limited, t...
Read the full Lecithin monograph → Herb & supplement monographSunflower Oil
Interacts with 86 drugsSunflower oil is a common edible vegetable oil rich in unsaturated fats and vitamin E that most people can use safely as part of a normal diet. As a food it is generally regarded as safe, an...
Read the full Sunflower Oil monograph →Sources & How We Checked
Liposomal Magnesium's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 93 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Magnesium 82 references
- Rodin SM, Johnson BF. Pharmacokinetic interactions with digoxin. Clin Pharmacokinet 1988;15:227-44.
- Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
- Dahle LO, Berg G, Hammar M, et al. The effect of oral magnesium substitution on pregnancy-induced leg cramps. Am J Obstet Gynecol 1995;173:175-80. PubMed
- Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
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