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Dietary supplement

Lycopene 15 mg Ingredients & Drug Interactions

by GNC

Lycopene 15 mg label
See full label image
Softgel Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Lycopene 15 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Lycopene 15 mg is a dietary supplement by GNC with 1 active ingredient. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lyc-O-Mato Lycopene. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Lycopene 15 mg by GNC

Ask about any prescription or over-the-counter medication and we check it for interactions with Lycopene 15 mg by GNC — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Lycopene 15 mg by GNC

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: lycopene, a red carotenoid pigment found in tomatoes and certain other fruits. Lycopene is what gives those foods their color and is thought to have antioxidant effects.

The softgel also includes soybean oil, gelatin, glycerin, and beta-carotene as inactive ingredients to hold and deliver the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Lycopene's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Antioxidant support for cardiovascular health.
  • We looked for evidence on: Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, Coronary artery disease, Endothelial function — and 1 related terms.
  • The closest evidence on file: Lycopene is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Lycopene is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hyperlipidemia, Hypertension.

The evidence for lycopene is mixed depending on what you're taking it for. For prostate cancer, the data suggests it's possibly effective—though more research would help nail that down.

For bladder cancer, diabetes, and high cholesterol (hyperlipidemia), the evidence either shows it's probably not helpful or isn't solid enough yet to say. For Lou Gehrig's disease (ALS) and exercise-triggered asthma, we simply don't have reliable evidence one way or the other.

The evidence, ingredient by ingredient Lycopene

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lycopene from food is considered safe, and supplement doses are generally well tolerated. The most common side effects from supplements are gastrointestinal—diarrhea, gas, bloating, nausea, vomiting, indigestion, and loss of appetite.

One case of chest pain was reported in a pregnant patient taking a lycopene product, though it's unclear whether lycopene caused it. For pregnancy, the safety data is rated Likely Safe, but supplements haven't been well studied in this setting—food amounts are fine, and if you're pregnant or planning to be, talk with your doctor before taking a supplement.

The same goes for breastfeeding: food amounts are considered okay, but supplement safety data is limited.

Side effects, ingredient by ingredient Lycopene

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lycopene.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you start this product, check with your doctor or pharmacist if you take any blood thinners or antiplatelet drugs—such as warfarin, clopidogrel, aspirin, or heparin. Lycopene may theoretically increase bleeding risk with these medications.

No other interactions are documented in our data for this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Lycopene 15 mg by GNC is a single-ingredient supplement possibly useful for prostate cancer support, though evidence for other conditions is weak or absent. The main concern is combining it with blood thinners or antiplatelet medications, which could raise bleeding risk—so check with your doctor or pharmacist before starting if you're on any of those drugs.

If you're not on blood thinners and want to try it, expect to tolerate it well, though some people experience mild digestive upset.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Lycopene 15 mg, straight from the product label.

Brand GNC
Barcode (UPC) 048107181581
Net contents 60 Softgel Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 182358
Product type Non-nutrient/non-botanical
Supplement form Softgel Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Lycopene 15 mg by GNC, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Softgel Capsule(s)
Maximum serving Sizes:
2 Softgel Capsule(s)
UPC/BARCODE
048107181581
IngredientAmount% DV
Lyc-O-Mato Lycopene15 mg--

Other ingredients: Soybean Oil, Gelatin, Glycerin, Beta-Carotene

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Keep out of reach of children.

Storage

Store in a cool, dry place.

Formula

From tomatoes

Lyc-O-Mato features a natural combination of lycopene, phytoene, phytofluene, beta-carotene and phytosterols. This all-natural extract is derived from red, ripe tomatoes.

General Statements

Provides antioxidant support for cardiovascular health

FDA Statement of Identity

Dietary Supplement

General

CODE 739012 FSG

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one or two softgel capsules daily.

Formulation

No sugar, no starch, no artificial flavors, sodium free, no wheat, gluten free, no corn, no dairy.

Brand IP Statement(s)

Lyc-O-Mato Tomato Nutrient Complex

Lyc-O-Mato is a registered trademark of Lycored.

FDA Disclaimer Statement

This statement have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Lycopene 15 mg by GNC label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Lycopene 15 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Lycopene 15 mg by GNC

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Softgel Capsule(s) Dosage formSoftgel Capsule Amounts shown are per serving.

Lyc-O-Mato Lycopene

Interacts with
122 drugs
15 mg per serving

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lyc-O-Mato Lycopene monograph & interactions

Other (inactive) ingredients: Soybean Oil, Gelatin, Glycerin, Beta-Carotene. These complete the product’s ingredient list but are not active constituents.

Interaction report

Lycopene 15 mg by GNC Drug Interactions

Want to check YOUR meds against Lycopene 15 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Lyc-O-Mato Lycopene 122

Individual Drug Interactions

The ingredients in Lycopene 15 mg interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Lycopene 15 mg interact with drugs. Each result below shows which ingredient is responsible. Lyc-O-Mato Lycopene

Each ingredient & the kinds of drugs it affects

For each ingredient in Lycopene 15 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lyc-O-Mato Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lyc-O-Mato Lycopene full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Lycopene 15 mg, from the product label.

GNC

See all GNC products
Name
General Nutrition Corporation
City
Pittsburgh
State
PA
ZipCode
15222
Phone Number
1-888-462-2548
Web Address
gnc.com
Pharmacist Counseling Corner

Lycopene 15 mg by GNC: Common Questions

Does Lycopene 15 mg by GNC interact with any medications?
Yes. Based on its ingredients, Lycopene 15 mg has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Lycopene 15 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
The safety data is rated Likely Safe, but lycopene supplements haven't been well studied in pregnancy. Food amounts are fine, but if you're pregnant or planning to be, talk with your doctor before taking this supplement to get personalized advice.
What side effects might I notice?
The most common ones are digestive: diarrhea, gas, bloating, nausea, vomiting, indigestion, or loss of appetite. These are generally mild and not everyone gets them.
Is this actually effective for prostate health?
The evidence says it's possibly effective for prostate cancer, but the research isn't conclusive yet. For other conditions listed—diabetes, high cholesterol, or bladder cancer—the evidence is much weaker or shows it probably doesn't help.
Why is there a warning about blood thinners?
Lab studies show lycopene can affect how blood clots. If you're already on a blood thinner like warfarin or aspirin, adding lycopene might raise your bleeding risk, so you need to check with your doctor first.
Can I take this while breastfeeding?
The safety data is rated Likely Safe, but supplements haven't been studied much in breastfeeding. Food amounts are considered fine, but talk with your doctor or pharmacist before taking a supplement to decide what's best for you and your baby.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Lycopene 15 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Lycopene 15 mg label
Go deeper

The Full Monographs Behind Lycopene 15 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph →
Sources

Sources & How We Checked

Lycopene 15 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
  2. Hsiao, G., Wang, Y., Tzu, N. H., Fong, T. H., Shen, M. Y., Lin, K. H., Chou, D. S., and Sheu, J. R. Inhibitory effects of lycopene on in vitro platelet activation and in vivo prevention of thrombus formation. J Lab Clin Med 2005;146(4):216-226. PubMed
  3. Clark, P. E., Hall, M. C., Borden, L. S., Jr., Miller, A. A., Hu, J. J., Lee, W. R., Stindt, D., D'Agostino, R., Jr., Lovato, J., Harmon, M., and Torti, F. M. Phase I-II prospective dose-escalating trial of lycopene in patients with biochemical relapse o
  4. O'Kennedy, N., Crosbie, L., Whelan, S., Luther, V., Horgan, G., Broom, J. I., Webb, D. J., and Duttaroy, A. K. Effects of tomato extract on platelet function: a double-blinded crossover study in healthy humans. Am.J.Clin.Nutr. 2006;84(3):561-569. PubMed
  5. Jatoi, A., Burch, P., Hillman, D., Vanyo, J. M., Dakhil, S., Nikcevich, D., Rowland, K., Morton, R., Flynn, P. J., Young, C., and Tan, W. A tomato-based, lycopene-containing intervention for androgen-independent prostate cancer: results of a Phase II stu
  6. Schwenke, C., Ubrig, B., Thurmann, P., Eggersmann, C., and Roth, S. Lycopene for advanced hormone refractory prostate cancer: a prospective, open phase II pilot study. J.Urol. 2009;181(3):1098-1103. PubMed
  7. Banerjee, S., Jeyaseelan, S., and Guleria, R. Trial of lycopene to prevent pre-eclampsia in healthy primigravidas: results show some adverse effects. J.Obstet.Gynaecol.Res. 2009;35(3):477-482. PubMed
  8. Haseen, F., Cantwell, M. M., O'Sullivan, J. M., and Murray, L. J. Is there a benefit from lycopene supplementation in men with prostate cancer? A systematic review. Prostate Cancer Prostatic.Dis. 2009;12(4):325-332. PubMed
  9. Ilic, D., Forbes, K. M., and Hassed, C. Lycopene for the prevention of prostate cancer. Cochrane.Database.Syst.Rev. 2011;(11):CD008007. PubMed
  10. Sawardekar SB, Patel TC, Uchil D. Comparative evaluation of antiplatelet effect of lycopene with aspirin and the effect of their combination on platelet aggregation: an in vitro study. Indian J Pharmacol 2016;48:26-31. PubMed

See these in context on the Lycopene monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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