Lymph Gland Cleanse-HY Ingredients & Drug Interactions
What is this page for?
First and foremost: checking Lymph Gland Cleanse-HY against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Lymph Gland Cleanse-HY is a dietary supplement by Nature's Sunshine with 4 active ingredients. Its ingredients are commonly taken for nerve pain (neuropathy), muscle and joint pain (arthritis), back pain.Based on those ingredients, 1,101 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Boswellia gum extract, Capsicum, Yarrow. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Lymph Gland Cleanse-HY by Nature's Sunshine
Ask about any prescription or over-the-counter medication and we check it for interactions with Lymph Gland Cleanse-HY by Nature's Sunshine — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Lymph Gland Cleanse-HY by Nature's Sunshine
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Lymph Gland Cleanse-HY contains four active ingredients: capsicum (hot pepper extract), yarrow, boswellia gum extract (frankincense resin), and parthenium. The product also includes inactive ingredients — cellulose and a capsule shell — to hold everything together.
Capsicum is the active compound in chili peppers and is used topically or taken by mouth for nerve pain and other conditions. Yarrow is a traditional herb.
Boswellia gum extract comes from the resin of the boswellia tree and is studied for joint and inflammatory conditions. Parthenium is included but we hold no interaction data for it.
Does it work?
Couldn't assess
The evidence for these ingredients is mixed. Capsicum is rated likely effective for nerve pain after shingles (postherpetic neuralgia) and diabetic nerve damage, and possibly effective for cluster headaches, back pain, and nausea after surgery.
Boswellia gum extract is rated possibly effective for osteoarthritis, but the evidence for yarrow and parthenium isn't established in our data — they're listed with insufficient reliable evidence for the conditions they're traditionally used for.
How safe is it?
Well-documented data
Capsicum is generally well tolerated in food amounts or supplement doses up to 200 mg daily, though it commonly causes burning and irritation of your mouth and digestive tract — belching, bloating, heartburn, nausea, diarrhea, and anal burning are common. Boswellia extract is also generally well tolerated short-term, with the most common side effects being abdominal pain, diarrhea, nausea, and headache.
Yarrow is often used short-term but has limited safety data and can cause allergic skin reactions. Yarrow is not recommended in pregnancy because of traditional concerns about effects on the uterus, and safety data during breastfeeding are insufficient — avoid it while nursing.
Boswellia has limited pregnancy data and is best avoided during pregnancy and breastfeeding. Capsicum in pregnancy is rated likely safe or possibly safe, and likely safe during breastfeeding in food amounts, though concentrated supplements haven't been well studied.
Meds to double-check
Moderate interaction found
Before taking this product, check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs (including aspirin or warfarin), diabetes medications, lithium, theophylline, ACE inhibitors, ciprofloxacin, or any medication processed through your liver's cytochrome P450 enzymes — including many antidepressants, statins, beta-blockers, and immunosuppressants. The interaction data for these drug families are documented, and some carry moderate severity.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is used for lymphatic support and contains herbs with some documented benefit for nerve pain and joint inflammation, but it carries moderate-severity interactions with blood thinners, diabetes medications, and several drug-metabolizing enzymes in your liver. If you take lithium, any anticoagulant or antiplatelet drug, diabetes medication, theophylline, or any medication processed through your liver, you'll want to check your exact prescriptions with the tool below and talk with your doctor or pharmacist before starting.
Yarrow should be avoided in pregnancy and breastfeeding.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Lymph Gland Cleanse-HY, straight from the product label.
| Brand | Nature's Sunshine |
|---|---|
| Barcode (UPC) | 099904009202 |
| Net contents | 100 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2022 |
| DSLD ID | 278164 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Kosher |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Lymph Gland Cleanse-HY by Nature's Sunshine, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Proprietary Blend | 850 mg | -- |
| Capsicum | 0 NP | -- |
| Yarrow | 0 NP | -- |
| Boswellia gum extract | 0 NP | -- |
| Parthenium | 0 NP | -- |
Other ingredients: Capsule, Cellulose
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
General Statements
Bottle made from 100% post consumer recycled material. We are committed to you and our planet. Scan to learn more.
We source the world's purest ingredients, no matter where they are grown, to ensure the active nutrients are delivered just as nature intended.
New look! Same great product
Formulation
Contains herbs traditionally used to support the glandular system.
Traditional lymph gland support Natural source of trace minerals
Guaranteed pure
Seals/Symbols
Ko Pareve (Kosher)
Formula
Ko Pareve (Kosher)
Precautions
Do not use if inner seal is missing or damaged.
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
Natures Sunshine Herbal experts since 1972
Suggested/Recommended/Usage/Directions
Recommended Use: Take 2 capsules with a meal daily.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Lymph Gland Cleanse-HY by Nature's Sunshine label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Lymph Gland Cleanse-HY by Nature's Sunshine
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsule(s) Dosage formCapsule Servings per container50 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Proprietary Blend
- › Capsicum
- › Yarrow
- › Boswellia gum extract
- › Parthenium
Other (inactive) ingredients: Capsule, Cellulose. These complete the product’s ingredient list but are not active constituents.
Lymph Gland Cleanse-HY by Nature's Sunshine Drug Interactions
HelloPharmacist Interaction Report
Lymph Gland Cleanse-HY by Nature's Sunshine does interact with medications, primarily through its capsicum, yarrow, and boswellia gum extract content.
The most serious documented interaction is moderate-severity: capsicum may increase bleeding risk with blood thinners (anticoagulants) and antiplatelet drugs like warfarin or aspirin.
Read the full breakdown — every affected drug type, severity by severity
Capsicum also carries moderate-severity interactions with diabetes drugs (which may lower blood sugar further), theophylline (a breathing medication that may build up in your system), and aspirin (which capsicum may reduce the effectiveness of). There's also a minor risk with ACE inhibitors (blood pressure drugs) and ciprofloxacin (an antibiotic).
Yarrow adds a moderate-severity interaction with lithium, a psychiatric medication — yarrow's diuretic effect may increase lithium levels and side effects. Boswellia gum extract presents moderate-severity interactions with a large family of medications processed through your liver's cytochrome P450 enzymes (CYP2D6, CYP2C19, CYP1A2, CYP2C9, and CYP3A4 substrates), plus immunosuppressant drugs.
We could not check parthenium for interactions.
Altogehter, these interactions span 1,102 individual medications. Use the search tool below to check your exact prescriptions before starting this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Lymph Gland Cleanse-HY?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Lymph Gland Cleanse-HY interact with 1,101 drugs. Click any drug to see the details.
3 of the 4 ingredients in Lymph Gland Cleanse-HY interact with drugs. Each result below shows which ingredient is responsible. Boswellia gum extract Capsicum Yarrow
6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractImmunosuppressants Moderate
Interaction Summary
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Read the full Boswellia Gum Extract + 6-mercaptopurine interactionAdo-trastuzumab EmtansineKadcyla
How Ado-trastuzumab Emtansine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Ado-trastuzumab Emtansine interactionAbciximabReoPro
How Abciximab interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
CapsicumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsicum + Abciximab interactionAbemaciclibVerzenio
How Abemaciclib interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Abemaciclib interactionAbiraterone
How Abiraterone interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Abiraterone interactionAbiraterone AcetateYonsa, Zytiga
How Abiraterone Acetate interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Abiraterone Acetate interactionAbrocitinibCibinqo
How Abrocitinib interacts with Lymph Gland Cleanse-HY — through 2 ingredients. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 2c9 (cyp2c9) Substrates, Immunosuppressants +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
Read the full Boswellia Gum Extract + Abrocitinib interactionCapsicumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsicum + Abrocitinib interactionAcalabrutinibCalquence
How Acalabrutinib interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Acalabrutinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
CapsicumAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Read the full Capsicum + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
CapsicumAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsicum + Acenocoumarol interactionAcetaminophenChildren's Tylenol, Children's Tylenol Meltaways, Tylenol, Tylenol Ex Strength
How Acetaminophen interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Lymph Gland Cleanse-HY — through 2 ingredients. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Aspirin interactionCapsicumAspirin, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Read the full Capsicum + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Lymph Gland Cleanse-HY — through 2 ingredients. Tap an ingredient for the detail:
CapsicumAnticoagulant/antiplatelet Drugs, Aspirin Moderate
Interaction Summary
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Read the full Capsicum + Acetaminophen, Aspirin, Caffeine interactionBoswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, ButalbitalAxocet, Bancap, Bucet, Butex Forte, Esgic CF, Orbivan CF +5 more
How Acetaminophen, Butalbital interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Butalbital interactionAcetaminophen, Butalbital, CaffeineEsgic, Esgic Plus, Fiogesic, Fioricet, Repan, Tecnal +1 more
How Acetaminophen, Butalbital, Caffeine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Butalbital, Caffeine interactionAcetaminophen, Butalbital, Caffeine, CodeineEsgic with Codeine, Fioricet w/ Codeine
How Acetaminophen, Butalbital, Caffeine, Codeine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Butalbital, Caffeine, Codeine interactionAcetaminophen, Butalbital, CodeineBancap w/ Codeine
How Acetaminophen, Butalbital, Codeine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Butalbital, Codeine interactionAcetaminophen, Butalbital, Codeine PhosphatePhrenilin #3
How Acetaminophen, Butalbital, Codeine Phosphate interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Butalbital, Codeine Phosphate interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Caffeine, CodeineGesic C15, Gesic C30, Gesic C8, Lenoltec 1, Lenoltec 2, Lenoltec 3 +1 more
How Acetaminophen, Caffeine, Codeine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Caffeine, Codeine interactionAcetaminophen, Caffeine, Codeine, SalicylamideCodalan No.1, Codalan No.2, Codalan No.3
How Acetaminophen, Caffeine, Codeine, Salicylamide interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Caffeine, Codeine, Salicylamide interactionAcetaminophen, Caffeine, DihydrocodeineDHC Plus, Panlor DC, Panlor SS
How Acetaminophen, Caffeine, Dihydrocodeine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Caffeine, Dihydrocodeine interactionAcetaminophen, Caffeine, IsomethepteneMigralam
How Acetaminophen, Caffeine, Isometheptene interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Caffeine, Isometheptene interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 2d6 (cyp2d6) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 1a2 (cyp1a2) Substrates, Cytochrome P450 3a4 (cyp3a4) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 3a4 (cyp3a4) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Lymph Gland Cleanse-HY — through 1 ingredient. Tap an ingredient for the detail:
Boswellia Gum ExtractCytochrome P450 2d6 (cyp2d6) Substrates, Cytochrome P450 1a2 (cyp1a2) Substrates +1 Moderate
Interaction Summary
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
Read the full Boswellia Gum Extract + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Lymph Gland Cleanse-HY with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Boswellia gum extract
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP1A2 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP1A2 enzymes.
Cytochrome P450 2C19 (Cyp2C19) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C19 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C19 enzymes.
Cytochrome P450 2C9 (Cyp2C9) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2C9 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2C9 enzymes.
Cytochrome P450 2D6 (Cyp2D6) Substrates
Theoretically, Boswellia serrata might increase the levels of CYP2D6 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP2D6 enzymes.
Cytochrome P450 3A4 (Cyp3A4) Substrates
Theoretically, Boswellia serrata might increase or decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that Boswellia serrata gum resin inhibits CYP3A4 enzymes. Other in vitro research shows that Boswellia serrata extract inhibits CYP3A4 enzymes at most concentrations, although it may modestly induce enzyme activity at low concentrations.
Immunosuppressants
Theoretically, Boswellia serrata might alter the effects of immunosuppressive drugs.
Some in vitro research suggests that Boswellia serrata extracts might inhibit mediators of autoimmune disorders such as leukotrienes and reduce production of antibodies and cell-mediated immunity. However, other in vitro research suggests that, when coupled with calcium ions, boswellic acids containing the keto group have immunostimulant properties within specific cell signaling pathways.
Capsicum
Anticoagulant/Antiplatelet Drugs
Theoretically, capsicum may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In vitro research shows that capsicum might increase the effects of antiplatelet drugs. Also, population research shows that capsicum is associated with an increased risk of self-reported bleeding in patients taking warfarin. However, clinical research shows that taking a single dose of capsaicin (Asian Herbex Ltd.), the active ingredient in capsicum, 400-800 mcg orally in combination with aspirin 500 mg does not decrease platelet aggregation when compared with taking aspirin 500 mg alone. Also, there was no notable effect on measures of platelet aggregation with capsaicin. It is unclear whether capsaicin must be used in more than a single dose to affect platelet aggregation.
Antidiabetes Drugs
Theoretically, taking capsicum with antidiabetes drugs might increase the risk of hypoglycemia.
Preliminary clinical research shows that consuming capsicum 5 grams along with a glucose drink attenuates the rise in plasma glucose after 30 minutes by 21%, decreases the 2-hour postprandial area under the curve of plasma glucose by 11%, and increases the 2-hour postprandial area under the curve of plasma insulin by 58% in healthy individuals when compared with placebo. Other clinical research shows that taking capsicum 5 mg daily for 28 days significantly reduces postprandial blood glucose and insulin levels, but not fasting blood glucose and insulin levels, in patients with gestational diabetes.
Aspirin
Theoretically, taking capsicum with aspirin might reduce the bioavailability of aspirin.
Animal research shows that acute or chronic intake of capsicum pepper reduces oral aspirin bioavailability. This has not been shown in humans.
Theophylline
Theoretically, taking capsicum with theophylline might increase the levels and adverse effects of theophylline.
In animal research, oral administration of capsicum reduced excretion of theophylline. However, capsicum does not seem to affect the pharmacokinetics of theophylline when administered intravenously.
Ace Inhibitors (Aceis)
Theoretically, using topical capsaicin may increase the risk of ACE inhibitor-induced cough.
There is one case report of a topically applied capsaicin cream contributing to the cough reflex in a patient using an ACEI. However, it is unclear if this interaction is clinically significant.
Ciprofloxacin (Cipro)
Theoretically, taking capsicum with ciprofloxacin might increase levels and adverse effects of ciprofloxacin.
Animal research shows that concomitant use of capsaicin, the active constituent of capsicum, and ciprofloxacin increases the bioavailability of ciprofloxacin by up to 70%.
Yarrow
Lithium
Theoretically, taking yarrow with lithium might increase the levels and adverse effects of lithium.
Animal research shows that yarrow has diuretic activity. Theoretically, due to these potential diuretic effects, yarrow might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for Lymph Gland Cleanse-HY, from the product label.
Nature's Sunshine
See all Nature's Sunshine products- Name
- Nature's Sunshine Products, Inc.
- City
- Spanish Fork
- State
- Utah
- ZipCode
- 84660
- Phone Number
- 1-800-223-8225
- Web Address
- www.naturessunshine.com
Lymph Gland Cleanse-HY by Nature's Sunshine: Common Questions
Does Lymph Gland Cleanse-HY by Nature's Sunshine interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is this safe to take while I'm pregnant?
Can I take this while breastfeeding?
What are the most common side effects?
Does capsicum actually work for pain?
What does boswellia do?
Is yarrow proven to work?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Lymph Gland Cleanse-HY is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Lymph Gland Cleanse-HY’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Capsicum
Interacts with 239 drugsCapsicum (chili pepper) contains capsaicin, which is best known and best studied as a topical treatment for certain types of pain. Topical capsaicin products are supported by reasonable evid...
Read the full Capsicum monograph → Herb & supplement monographYarrow
Interacts with 1 drugYarrow is a traditional herb long used for wounds, digestive complaints, and colds, but high-quality human studies are very limited, so its benefits are not well proven. It is generally used...
Read the full Yarrow monograph → Herb & supplement monographBoswellia Serrata
Interacts with 952 drugsBoswellia serrata is a tree resin used in traditional medicine, mainly for joint pain and inflammation. Some studies suggest it may help with osteoarthritis symptoms, but the overall evidenc...
Read the full Boswellia Serrata monograph →Sources & How We Checked
Lymph Gland Cleanse-HY's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 113 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Capsicum 89 references
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- Locock RA. Capsicum. Can Pharm J 1985;118:517-9.
- Mason L, Moore RA, Derry S, et al. Systematic review of topical capsaicin for the treatment of chronic pain. BMJ 2004;328:991. PubMed
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- Hogaboam CM, Wallace JL. Inhibition of platelet aggregation by capsaicin. An effect unrelated to actions on sensory afferent neurons. Eur J Pharmacol 1991;202:129-31. PubMed
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- Rodriguez-Stanley, S., Collings, K. L., Robinson, M., Owen, W., and Miner, P. B., Jr. The effects of capsaicin on reflux, gastric emptying and dyspepsia. Aliment.Pharmacol.Ther. 2000;14(1):129-134. PubMed
- Brown, L., Takeuchi, D., and Challoner, K. Corneal abrasions associated with pepper spray exposure. Am.J.Emerg.Med. 2000;18(3):271-272. PubMed
- Vesaluoma, M., Muller, L., Gallar, J., Lambiase, A., Moilanen, J., Hack, T., Belmonte, C., and Tervo, T. Effects of oleoresin capsicum pepper spray on human corneal morphology and sensitivity. Invest Ophthalmol.Vis.Sci. 2000;41(8):2138-2147.
- Stam, C., Bonnet, M. S., and van Haselen, R. A. The efficacy and safety of a homeopathic gel in the treatment of acute low back pain: a multi-centre, randomised, double-blind comparative clinical trial. Br Homeopath J 2001;90(1):21-28. PubMed
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- Fett, D. D. Botanical briefs: Capsicum peppers. Cutis 2003;72(1):21-23.
- McCarthy, G. M. and McCarty, D. J. Effect of topical capsaicin in the therapy of painful osteoarthritis of the hands. J.Rheumatol. 1992;19(4):604-607.
- Chaiyata, P., Puttadechakum, S., and Komindr, S. Effect of chili pepper (Capsicum frutescens) ingestion on plasma glucose response and metabolic rate in Thai women. J.Med.Assoc.Thai. 2003;86(9):854-860.
- Petruzzi, M., Lauritano, D., De Benedittis, M., Baldoni, M., and Serpico, R. Systemic capsaicin for burning mouth syndrome: short-term results of a pilot study. J.Oral Pathol.Med. 2004;33(2):111-114. PubMed
- Misra, M. N., Pullani, A. J., and Mohamed, Z. U. Prevention of PONV by acustimulation with capsicum plaster is comparable to ondansetron after middle ear surgery: [La prevention des NVPO par acustimulation avec un emplatre de Capsicum est comparable a ce PubMed
- Milke, P., Diaz, A., Valdovinos, M. A., and Moran, S. Gastroesophageal reflux in healthy subjects induced by two different species of chilli (Capsicum annum). Dig.Dis. 2006;24(1-2):184-188.
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- Final report on the safety assessment of capsicum annuum extract, capsicum annuum fruit extract, capsicum annuum resin, capsicum annuum fruit powder, capsicum frutescens fruit, capsicum frutescens fruit extract, capsicum frutescens resin, and capsaicin.
- Tandan, R., Lewis, G. A., Krusinski, P. B., Badger, G. B., and Fries, T. J. Topical capsaicin in painful diabetic neuropathy. Controlled study with long-term follow-up. Diabetes Care 1992;15(1):8-14. PubMed
- Gupta, P. J. Red hot chilli consumption is harmful in patients operated for anal fissure - a randomized, double-blind, controlled study. Dig.Surg. 2007;24(5):354-357. PubMed
- Patane, S., Marte, F., Di Bella, G., Cerrito, M., and Coglitore, S. Capsaicin, arterial hypertensive crisis and acute myocardial infarction associated with high levels of thyroid stimulating hormone. Int.J Cardiol. 5-1-2009;134(1):130-132. PubMed
- Gupta, P. J. Consumption of red-hot chili pepper increases symptoms in patients with acute anal fissures. A prospective, randomized, placebo-controlled, double blind, crossover trial. Arq Gastroenterol. 2008;45(2):124-127. PubMed
- Gupta, P. J. Consumption of red-hot chili pepper increases symptoms in patients with acute anal fissures. Ann.Ital.Chir 2008;79(5):347-351.
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- Chaiyasit, K., Khovidhunkit, W., and Wittayalertpanya, S. Pharmacokinetic and the effect of capsaicin in Capsicum frutescens on decreasing plasma glucose level. J Med.Assoc.Thai. 2009;92(1):108-113.
- Blanc, P., Liu, D., Juarez, C., and Boushey, H. A. Cough in hot pepper workers. Chest 1991;99(1):27-32. PubMed
- Akcay, A. B., Ozcan, T., Seyis, S., and Acele, A. Coronary vasospasm and acute myocardial infarction induced by a topical capsaicin patch. Turk.Kardiyol.Dern.Ars 2009;37(7):497-500.
- van Boxel, O. S., ter Linde, J. J., Siersema, P. D., and Smout, A. J. Role of chemical stimulation of the duodenum in dyspeptic symptom generation. Am J Gastroenterol. 2010;105(4):803-811. PubMed
- Niemcunowicz-Janica, A., Ptaszynska-Sarosiek, I., and Wardaszka, Z. [Sudden death caused by an oleoresin capsicum spray]. Arch.Med.Sadowej.Kryminol. 2009;59(3):252-254.
- Reuter, J., Merfort, I., and Schempp, C. M. Botanicals in dermatology: an evidence-based review. Am J Clin Dermatol 2010;11(4):247-267. PubMed
- McCormack, P. L. Capsaicin dermal patch: in non-diabetic peripheral neuropathic pain. Drugs 10-1-2010;70(14):1831-1842. PubMed
- Bortolotti, M. and Porta, S. Effect of red pepper on symptoms of irritable bowel syndrome: preliminary study. Dig.Dis.Sci 2011;56(11):3288-3295. PubMed
- Webster, L. R., Peppin, J. F., Murphy, F. T., Lu, B., Tobias, J. K., and Vanhove, G. F. Efficacy, safety, and tolerability of NGX-4010, capsaicin 8% patch, in an open-label study of patients with peripheral neuropathic pain. Diabetes Res Clin Pract. 2011 PubMed
- Gerber, S., Frueh, B. E., and Tappeiner, C. Conjunctival proliferation after a mild pepper spray injury in a young child. Cornea 2011;30(9):1042-1044. PubMed
- Lim, L. G., Tay, H., and Ho, K. Y. Curry induces acid reflux and symptoms in gastroesophageal reflux disease. Dig.Dis.Sci 2011;56(12):3546-3550. PubMed
- Ludy, M. J., Moore, G. E., and Mattes, R. D. The effects of capsaicin and capsiate on energy balance: critical review and meta-analyses of studies in humans. Chem Senses 2012;37(2):103-121. PubMed
- Sayin, M. R., Karabag, T., Dogan, S. M., Akpinar, I., and Aydin, M. A case of acute myocardial infarction due to the use of cayenne pepper pills. Wien.Klin.Wochenschr. 2012;124(7-8):285-287. PubMed
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- Derry, S. and Moore, R. A. Topical capsaicin (low concentration) for chronic neuropathic pain in adults. Cochrane.Database.Syst.Rev. 2012;9:CD010111. PubMed
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- Knight, T. E. and Hayashi, T. Solar (brachioradial) pruritus--response to capsaicin cream. Int.J.Dermatol. 1994;33(3):206-209. DOI
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- Sausenthaler, S., Koletzko, S., Schaaf, B., Lehmann, I., Borte, M., Herbarth, O., von Berg, A., Wichmann, H. E., and Heinrich, J. Maternal diet during pregnancy in relation to eczema and allergic sensitization in the offspring at 2 y of age. Am J Clin Nu PubMed
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- Kim DH, Yoon KB, Park S, et al. Comparison of NSAID patch given as monotherapy and NSAID patch in combination with transcutaneous electric nerve stimulation, a heating pad, or topical capsaicin in the treatment of patients with myofascial pain syndrome o
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- Pabalan N, Jarjanazi H, Ozcelik H. The impact of capsaicin intake on risk of developing gastric cancers: a meta-analysis. J Gastrointest Cancer. 2014;45(3):334-41. PubMed
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- Van Nooten F, Treur M, Pantiri K, Stoker M, Charokopou M. Capsaicin 8% patch versus oral neuropathic pain medications for the treatment of painful diabetic peripheral neuropathy: a systematic literature review and network meta-analysis. Clin Ther. 2017 Ap PubMed
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- Lassen CL, Meyer K, Bredthauer A, Klier TW. Facial and oral cross-contamination of a 3-year-old child with high concentration capsaicin: A case report. A A Pract. 2020;14(9):e01258. PubMed
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- Umigai N, Kozai Y, Saito T, Takara T. Effects of paprika carotenoid supplementation on bone turnover in postmenopausal women: a randomized, double-blind, placebo-controlled, parallel-group comparison study. Food Nutr Res. 2020;64. PubMed
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Yarrow 8 references
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Boswellia Serrata 16 references
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Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC