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Dietary supplement

Magnesium Breakthrough 500mg, 7 Forms of Magnesium Ingredients & Drug Interactions

by BiOptimizers

Magnesium Breakthrough 500mg, 7 Forms of Magnesium label
See full label image
Capsule Category: Mineral Supplement
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 29, 2026 · Label data verified by our pharmacy team
What is this page for?

First and foremost: checking Magnesium Breakthrough 500mg, 7 Forms of Magnesium against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Magnesium Breakthrough 500mg, 7 Forms of Magnesium is a dietary supplement by BiOptimizers with 4 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 512 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Magnesium, Vitamin B6, Manganese. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers

Ask about any prescription or over-the-counter medication and we check it for interactions with Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 29, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 4 of its 4 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Magnesium Breakthrough contains 4 active ingredients: vitamin B6, magnesium, manganese, and humic acid. Vitamin B6 supports nerve function and red blood cell formation.

Magnesium helps muscles relax, supports bone health, and aids digestion. Manganese plays a role in bone formation and metabolism.

The product also contains inactive ingredients—hypromellose, ascorbyl palmitate, microcrystalline cellulose, and goMCT—which serve as capsule material and fillers.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: restorative sleep and stress support.
  • We looked for evidence on: Insomnia, Anxiety, Migraine headache, Muscle cramps, Exercise-induced muscle soreness, Cognitive function — and 4 related terms.
  • The closest evidence on file: Magnesium is rated "Possibly Ineffective" for Muscle cramps (Natural Medicines).
  • Also on file: Vitamin B6 is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Cognitive function, Depression, Insomnia, and more.
  • Also on file: Magnesium is rated "Insufficient Reliable Evidence To Rate" for Perioperative anxiety.

Vitamin B6 is effective for sideroblastic anemia (a blood disorder) and vitamin B6 deficiency itself, likely effective for high homocysteine levels, and possibly effective for pregnancy-related nausea. Magnesium is effective for indigestion and constipation, and effective for low magnesium levels and prevention of pre-eclampsia in pregnancy.

Manganese is effective for manganese deficiency, but evidence is insufficient to rate it for hay fever, osteoporosis, COPD, weight loss, or arthritis. We hold no effectiveness data for humic acid.

The evidence, ingredient by ingredient Vitamin B6 Magnesium Manganese Humic Acid

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at doses under 100 mg daily, with mild side effects like headache, nausea, and heartburn. High doses over time can cause nerve damage (sensory neuropathy), particularly above 1,000 mg daily.

Magnesium is generally well tolerated and causes mainly mild gastrointestinal effects—diarrhea, nausea, vomiting—at normal doses. Manganese is safe in appropriate doses but high-dose supplements risk neurotoxicity resembling Parkinson's disease.

For pregnancy: vitamin B6 is likely safe but possibly unsafe (use only under doctor's guidance); magnesium is likely to possibly safe (needed in pregnancy but supplement under medical supervision); manganese safety in pregnancy is not on file. For breastfeeding: vitamin B6 is likely safe; magnesium is possibly safe (check with your doctor); manganese safety while breastfeeding is unclear.

Humic acid has limited safety data and should be avoided in pregnancy and breastfeeding.

Side effects, ingredient by ingredient Vitamin B6 Magnesium Manganese Humic Acid

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Manganese, Vitamin B6, Magnesium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; Parkinson's medications.
  • For scale: 512 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you're on levodopa/carbidopa (Major interaction with magnesium). Also confirm with your doctor or pharmacist if you take blood pressure medications, seizure drugs (phenobarbital or phenytoin), heart rhythm drugs (amiodarone), muscle relaxants, diabetes medications (sulfonylureas), water pills (potassium-sparing diuretics), acid reducers, antibiotics (quinolones, tetracyclines, or bisphosphonates), or antipsychotic drugs—all carry Moderate interactions with one or more ingredients here.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Major medication interactions have been identified, and safety information is well characterized.

This product is worth considering if you're looking for magnesium support and have no interactions with the medications you take. If you take levodopa/carbidopa for Parkinson's, blood pressure or seizure medications, muscle relaxants, diabetes drugs, or certain antibiotics, talk with your doctor or pharmacist before starting—several of these combinations need close monitoring or separation of doses.

Check your exact medications with the tool on this page, then discuss the results with your own healthcare provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 29, 2026.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Magnesium Breakthrough 500mg, 7 Forms of Magnesium, straight from the product label.

Brand BiOptimizers
Barcode (UPC) 750363800754
Net contents 60 Capsules
Market status On market
Added to our catalog Sep 29, 2026
Product type Mineral Supplement
Supplement form Capsule
Dietary claims / uses Restorative sleep support, Healthy stress response, Muscle function and recovery, Cognitive function support, Mood balance, Metabolism support
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers, compiled by our pharmacy team from the manufacturer's label.

Supplement Facts

Daily Value (DV) Target Group(s):
N/A
Minimum serving Sizes:
2 Capsule
Maximum serving Sizes:
2 Capsule
Servings per container
30
UPC/BARCODE
750363800754
IngredientAmount% DV
Vitamin B60.85 mg--
Magnesium500 mg--
Manganese1 mg--
Humic Acid1 mg--

Other ingredients: Hypromellose, Ascorbyl Palmitate, Microcrystalline Cellulose, goMCT

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested Use

Take 2 capsules daily, preferably with a meal or as directed by a healthcare professional. For sleep support, take 30–60 minutes before bed.

Storage

Store in a cool, dry place away from direct sunlight.

Warnings

Use only as directed. Keep out of reach of children. Do not use if safety seal is broken or missing. Consult your healthcare practitioner before use if pregnant, nursing, taking medication, or under medical supervision. Discontinue use if adverse reactions occur.

Keep out of reach of children. Consult a physician before beginning any new supplement, diet, training program, or if you are undergoing treatment of a medical condition. In high doses beyond our suggested serving size, magnesium supplementation can cause nausea, abdominal cramps, and diarrhea.

Marketing

Supports Restorative Sleep

Promotes a Healthy Stress Response

Supports Muscle Function & Recovery

Magnesium Breakthrough delivers 7 bioavailable forms of magnesium for comprehensive wellness, including support for restorative sleep, a healthy stress response, and muscle function and recovery.

7 Forms of Magnesium: Our formula combines 7 types of magnesium, including magnesium glycinate, malate, and citrate, to support overall wellness.

Other

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers label

The product's label imagery, on file with our pharmacy team. Tap to enlarge.

Magnesium Breakthrough 500mg, 7 Forms of Magnesium label

Label images reflect the product version on file with our pharmacy team. Always read your actual product label.

What’s inside

The Ingredients in Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
0.85 mg per serving Form: as pyridoxal-5-phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Magnesium

Interacts with
295 drugs
500 mg per serving Form: Proprietary Blend: magnesium amino acid chelate, magnesium bisglycinate, Sucrosomial magnesium (magnesium oxide), magnesium malate, magnesium orotate, magnesium taurate, magnesium citrate

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preven...

Magnesium monograph & interactions

Manganese

Interacts with
83 drugs
1 mg per serving Form: as manganese citrate

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get...

Manganese monograph & interactions

Humic Acid

No known
interactions
1 mg per serving Form: from black mineral powder

Humic acid is a natural substance formed when plant and animal matter break down in soil, peat, and coal-like deposits, and it is sold as a supplement...

Humic Acid monograph & interactions

Other (inactive) ingredients: Hypromellose, Ascorbyl Palmitate, Microcrystalline Cellulose, GoMCT. These complete the product’s ingredient list but are not active constituents.

Interaction report

Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers Drug Interactions

Want to check YOUR meds against Magnesium Breakthrough 500mg, 7 Forms of Magnesium?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
512Drugs
6 Major 398 Moderate 108 Minor

Ingredients driving the most interactions

Magnesium 295
Vitamin B6 210
Manganese 83

Individual Drug Interactions

The ingredients in Magnesium Breakthrough 500mg, 7 Forms of Magnesium interact with 512 drugs. Click any drug to see the details.

3 of the 4 ingredients in Magnesium Breakthrough 500mg, 7 Forms of Magnesium interact with drugs. Each result below shows which ingredient is responsible. Magnesium Vitamin B6 Manganese

Each ingredient & the kinds of drugs it affects

For each ingredient in Magnesium Breakthrough 500mg, 7 Forms of Magnesium with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Magnesium15 drug types · 295 drugs

Levodopa/Carbidopa (Sinemet)

Magnesium can reduce the bioavailability of levodopa/carbidopa.
Clinical research in healthy volunteers shows that taking magnesium oxide 1000 mg with levodopa 100 mg/carbidopa 10 mg reduces the area under the curve (AUC) of levodopa by 35% and of carbidopa by 81%. In vitro and animal research shows that magnesium produces an alkaline environment in the digestive tract, which might lead to degradation and reduced bioavailability of levodopa/carbidopa.

Likelihood Probable Evidence B
Aminoglycoside Antibiotics

Concomitant use of aminoglycoside antibiotics and magnesium can increase the risk for neuromuscular weakness.
Both aminoglycosides and magnesium reduce presynaptic acetylcholine release, which can lead to neuromuscular blockade and possible paralysis. This is most likely to occur with high doses of magnesium given intravenously.

Likelihood Possible Evidence D
Antacids

Use of acid reducers may reduce the laxative effect of magnesium oxide.
A retrospective analysis shows that, in the presence of H2 receptor antagonists (H2RAs) or proton pump inhibitors (PPIs), a higher dose of magnesium oxide is needed for a laxative effect. This may also occur with antacids. Under acidic conditions, magnesium oxide is converted to magnesium chloride and then to magnesium bicarbonate, which has an osmotic laxative effect. By reducing acidity, antacids may reduce the conversion of magnesium oxide to the active bicarbonate salt.

Likelihood Possible Evidence D
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Magnesium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after magnesium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Magnesium can decrease absorption of bisphosphonates.
Cations, including magnesium, can decrease bisphosphonate absorption. Advise patients to separate doses of magnesium and these drugs by at least 2 hours.

Likelihood Probable Evidence B
Calcium Channel Blockers

Magnesium can have additive effects with calcium channel blockers, although evidence is conflicting.
Magnesium inhibits calcium entry into smooth muscle cells and may therefore have additive effects with calcium channel blockers. Severe hypotension and neuromuscular blockades may occur when nifedipine is used with intravenous magnesium, although some contradictory evidence suggests that concurrent use of magnesium with nifedipine does not increase the risk of neuromuscular weakness. High doses of magnesium could theoretically have additive effects with other calcium channel blockers.

Likelihood Possible Evidence D
Digoxin

Magnesium salts may reduce absorption of digoxin.
Clinical evidence suggests that treatment with oral magnesium hydroxide or magnesium trisilicate reduces absorption of digoxin from the intestines. This may reduce the blood levels of digoxin and decrease its therapeutic effects.

Likelihood Possible Evidence B
Potassium-Sparing Diuretics

Potassium-sparing diuretics decrease excretion of magnesium, possibly increasing magnesium levels.
Potassium-sparing diuretics also have magnesium-sparing properties, which can counteract the magnesium losses associated with loop and thiazide diuretics. Theoretically, increased magnesium levels could result from concomitant use of potassium-sparing diuretics and magnesium supplements.

Likelihood Probable Evidence D
Quinolone Antibiotics

Magnesium decreases absorption of quinolones.
Magnesium can form insoluble complexes with quinolones and decrease their absorption. Advise patients to take these drugs at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Probable Evidence D
Skeletal Muscle Relaxants

Parenteral magnesium alters the pharmacokinetics of skeletal muscle relaxants, increasing their effects and accelerating the onset of effect.
Parenteral magnesium shortens the time to onset of skeletal muscle relaxants by about 1 minute and prolongs the duration of action by about 2 minutes. Magnesium potentiates the effects of skeletal muscle relaxants by decreasing calcium-mediated release of acetylcholine from presynaptic nerve terminals, reducing postsynaptic sensitivity to acetylcholine, and having a direct effect on the membrane potential of myocytes. Magnesium also has vasodilatory actions and increases cardiac output, allowing a greater amount of muscle relaxant to reach the motor end plate. A clinical study found that low-dose rocuronium (0.45 mg/kg), when given after administration of magnesium 30 mg/kg over 10 minutes, has an accelerated onset of effect, which matches the onset of effect seen with a full-dose rocuronium regimen (0.6 mg/kg). In another clinical study, onset times for rocuronium doses of 0.3, 0.6, and 1.2 mg/kg were 86, 76, and 50 seconds, respectively, when given alone, but were reduced to 66, 44, and 38 seconds, respectively, when the doses were given after a 15-minute infusion of magnesium sulfate 60 mg/kg. Giving intraoperative intravenous magnesium sulfate, 50 mg/kg loading dose followed by 15 mg/kg/hour, reduces the onset time of rocuronium, enhances its clinical effects, reduces the dose of intraoperative opiates, and prolongs the spontaneous recovery time. It does not affect the activity of subsequently administered neostigmine.

Likelihood Probable Evidence A
Sulfonylureas

Magnesium increases the systemic absorption of sulfonylureas, increasing their effects and side effects.
Clinical research shows that administration of magnesium hydroxide with glyburide increases glyburide absorption, increases maximal insulin response by 35-fold, and increases the risk of hypoglycemia, when compared with glyburide alone. A similar interaction occurs between magnesium hydroxide and glipizide. The mechanism of this effect appears to be related to the elevation of gastrointestinal pH by magnesium-based antacids, increasing solubility and enhancing absorption of sulfonylureas.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Magnesium decreases absorption of tetracyclines.
Magnesium can form insoluble complexes with tetracyclines in the gut and decrease their absorption and antibacterial activity. Advise patients to take these drugs 1 hour before or 2 hours after magnesium supplements.

Likelihood Probable Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, magnesium may have antiplatelet effects, but the evidence is conflicting.
In vitro evidence shows that magnesium sulfate inhibits platelet aggregation, even at low concentrations. Some preliminary clinical evidence shows that infusion of magnesium sulfate increases bleeding time by 48% and reduces platelet activity. However, other clinical research shows that magnesium does not affect platelet aggregation, although inhibition of platelet-dependent thrombosis can occur.

Likelihood Unlikely Evidence B
Gabapentin (Neurontin)

Gabapentin absorption can be decreased by magnesium.
Clinical research shows that giving magnesium oxide orally along with gabapentin decreases the maximum plasma concentration of gabapentin by 33%, time to maximum concentration by 36%, and area under the curve by 43%. Advise patients to take gabapentin at least 2 hours before, or 4 to 6 hours after, magnesium supplements.

Likelihood Unlikely Evidence B
Sevelamer (Renagel, Renvela)

Sevelamer may increase serum magnesium levels.
In patients on hemodialysis, sevelamer use was associated with a 0.28 mg/dL increase in serum magnesium. The mechanism of this interaction remains unclear.

Likelihood Possible Evidence B
Magnesium full monograph & interactions

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Manganese3 drug types · 83 drugs

Antipsychotic Drugs

Theoretically, the risk for manganese toxicity might increase when taken with antipsychotic drugs.
Hallucinations and behavioral changes have been reported in a patient with liver disease who was taking haloperidol and manganese. Researchers speculate that taking manganese along with haloperidol, phenothiazine-derivatives, or other antipsychotic medications might increase the risk of manganese toxicity in some patients.

Likelihood Possible Evidence D
Quinolone Antibiotics

Theoretically, manganese might reduce the absorption of quinolone antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced quinolone absorption have been reported between quinolones and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, manganese might reduce the absorption of tetracycline antibiotics.
Manganese is a multivalent cation. Interactions resulting in reduced tetracycline absorption have been reported between tetracyclines and other multivalent cations, such as calcium and iron.

Likelihood Probable Evidence D
Manganese full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Magnesium Breakthrough 500mg, 7 Forms of Magnesium, from the product label.

BiOptimizers

See all BiOptimizers products
Pharmacist Counseling Corner

Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers: Common Questions

Does Magnesium Breakthrough 500mg, 7 Forms of Magnesium by BiOptimizers interact with any medications?
Yes. Based on its ingredients, Magnesium Breakthrough 500mg, 7 Forms of Magnesium has a known interaction with 512 medications, including 6 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Magnesium Breakthrough 500mg, 7 Forms of Magnesium contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant?
Magnesium is needed in pregnancy and rated likely to possibly safe, but you should use a supplement only under your doctor's guidance. Vitamin B6 is likely safe but possibly unsafe in pregnancy, so check with your doctor before taking this product. Manganese safety data in pregnancy aren't on file. Talk with your OB or pharmacist about whether this blend is right for you.
Is this safe to breastfeed while taking?
Vitamin B6 is likely safe while breastfeeding, and magnesium is possibly safe, but you should confirm with your doctor or pharmacist first. Manganese safety while breastfeeding is unclear, and humic acid should be avoided. Get personalized guidance from your healthcare provider before using this supplement.
What is humic acid and does it work?
Humic acid is one of the four active ingredients in this product. We hold no effectiveness data for it, and safety information is limited. Because product purity varies and human safety data are sparse, use it cautiously and avoid it if you're pregnant or breastfeeding.
Can high doses of this product cause side effects?
Yes. Vitamin B6 above 100 mg daily can cause nerve damage with long-term use, especially above 1,000 mg daily. Manganese at high doses risks Parkinson-like symptoms. Magnesium at high doses can cause severe gastrointestinal upset. Stick to the recommended dose on the label and discuss any concerns with your pharmacist.
Will this help with constipation?
Magnesium is effective for constipation, so yes—it may help. However, the product's effectiveness depends on the dose and form of magnesium included, which aren't broken out in the ingredient list. Talk with your pharmacist about whether this particular product is a good fit for that use.
Does this product have fillers?
Yes. Besides the four active ingredients, it contains hypromellose, ascorbyl palmitate, microcrystalline cellulose, and goMCT as inactive ingredients—these are capsule material and fillers that help deliver the product.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Magnesium Breakthrough 500mg, 7 Forms of Magnesium label
Go deeper

The Full Monographs Behind Magnesium Breakthrough 500mg, 7 Forms of Magnesium’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Magnesium

Interacts with 295 drugs

Magnesium is an essential mineral your body needs for muscles, nerves, blood pressure, and many other functions, and supplements are useful for preventing or correcting deficiency. Some othe...

Read the full Magnesium monograph → Herb & supplement monograph

Manganese

Interacts with 83 drugs

Manganese is an essential trace mineral your body needs in small amounts for bone formation, metabolism, and antioxidant defense, and most people get enough from a normal diet. Supplements m...

Read the full Manganese monograph → Herb & supplement monograph

Humic Acid

Humic acid is a natural substance formed when plant and animal matter break down in soil, peat, and coal-like deposits, and it is sold as a supplement marketed for immune, gut, and 'detox' s...

Read the full Humic Acid monograph →
Sources

Sources & How We Checked

Magnesium Breakthrough 500mg, 7 Forms of Magnesium's label data was compiled by the HelloPharmacist pharmacy team from the manufacturer's product label; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 138 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
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Magnesium 82 references
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See these in context on the Magnesium monograph →

Manganese 21 references
  1. Hansten PD, Horn JR. Hansten and Horn's Drug Interactions Analysis and Management. Vancouver, CAN:Appl Therapeut, 1999.
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  4. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
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  17. Li D, Ge X, Liu Z, et al. Association between long-term occupational manganese exposure and bone quality among retired workers. Environ Sci Pollut Res Int 2020;27(1):482-9. PubMed
  18. Martin KV, Sucharew H, Dietrich KN, et al. Co-exposure to manganese and lead and pediatric neurocognition in East Liverpool, Ohio. Environ Res 2021;202:111644. PubMed
  19. Racette BA, Nelson G, Dlamini WW, et al. Depression and anxiety in a manganese-exposed community. Neurotoxicology 2021;85:222-33. PubMed
  20. Ruiz-Azcona L, Fernández-Olmo I, Expósito A, et al. Impact of environmental airborne manganese exposure on cognitive and motor functions in adults: a systematic review and meta-analysis. Int J Environ Res Public Health 2021;18(8):4075. PubMed
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See these in context on the Manganese monograph →

Humic Acid 3 references
  1. Dietary Supplements: What You Need to Know — NIH Office of Dietary Supplements Source
  2. Using Dietary Supplements Wisely — NIH NCCIH Source
  3. Dietary Supplements — MedlinePlus Source

See these in context on the Humic Acid monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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