Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Mane Brain Ingredients & Drug Interactions

by Magnum Nutraceuticals

Mane Brain label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mane Brain against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Mane Brain is a dietary supplement by Magnum Nutraceuticals with 6 active ingredients. Its ingredients are commonly taken for anxiety and stress, relaxation and calm, sleep support.Based on those ingredients, 1,424 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacopa monnieri 30:1 extract, L-Theanine, organic Lion's Mane 10:1 extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mane Brain by Magnum Nutraceuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Mane Brain by Magnum Nutraceuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mane Brain by Magnum Nutraceuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Mane Brain contains 6 active ingredients: L-theanine, N-acetyl L-tyrosine, alpha-GPC, a 10:1 lion's mane mushroom extract, a 30:1 bacopa extract, and a 30:1 huperzine A extract. Each is included at a dose meant to support cognitive function and mental clarity.

The capsules also contain inactive ingredients—magnesium stearate, silicon dioxide, microcrystalline cellulose, and gelatin—to hold and deliver the formula.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Memory and brain health support.
  • We looked for evidence on: Age-related cognitive decline, Alzheimer disease, Anxiety, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Cognitive impairment — and 4 related terms.
  • The strongest evidence on file: Huperzine A is rated "Possibly Effective" for Alzheimer disease (Natural Medicines).
  • Also on file: Theanine is rated "Possibly Effective" for Cognitive function.
  • Also on file: Alpha-gpc is rated "Possibly Effective" for Alzheimer disease.

Evidence for these ingredients is mixed and often limited. Huperzine A shows possibly effective evidence for Alzheimer disease; alpha-GPC is possibly effective for Alzheimer disease as well.

L-theanine is possibly effective for cognitive function generally, but the data on whether it helps with age-related cognitive decline, Alzheimer disease, anxiety, or obsessive-compulsive disorder is insufficient to rate. For bacopa and lion's mane, the evidence on cognitive function, cognitive impairment, Alzheimer disease, and related conditions is also insufficient to rate.

In short, while some ingredients have preliminary support, we don't yet have strong evidence that this combination improves memory or brain function in healthy people.

The evidence, ingredient by ingredient Theanine Alpha-gpc Lion's Mane Mushroom Bacopa Huperzine A

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-theanine, alpha-GPC, bacopa, and lion's mane are generally well tolerated for short-term use in healthy adults, though long-term safety isn't well studied. Huperzine A is a pharmacologically active compound and requires medical guidance.

Common side effects include headache, nausea, gastrointestinal discomfort, diarrhea, and dizziness. Bacopa use for at least 2 months has been rarely associated with an elevated stroke risk compared with non-users.

Huperzine A can cause dose-dependent cholinergic effects (blurred vision, constipation, dry mouth, insomnia, sweating, vomiting) and may slow heart rate. Not enough safety data exists for pregnancy or breastfeeding—the safety data advises against all five ingredients during pregnancy and while breastfeeding.

N-acetyl L-tyrosine safety information is not on file.

Side effects, ingredient by ingredient Theanine Alpha-gpc Lion's Mane Mushroom Bacopa Huperzine A

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Bacopa, Huperzine A, Theanine, Alpha-gpc, Lion's Mane Mushroom.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,425 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications before taking Mane Brain if you take any of the following: blood thinners or antiplatelet drugs (moderate risk of increased bleeding from lion's mane); blood pressure medication (moderate risk of excessive lowering from L-theanine); diabetes drugs (moderate risk of additive blood-sugar lowering from lion's mane); drugs metabolized by CYP1A2, CYP2C19, CYP2C9, or CYP3A4 enzymes in your liver (moderate risk of increased drug levels from bacopa); cholinergic drugs or anticholinergic drugs (moderate risk of altered effectiveness from bacopa and huperzine A); sedatives or central nervous system depressants (minor risk of additive sedation from L-theanine); motion-sickness patches like scopolamine (minor risk from alpha-GPC); or thyroid hormone (minor risk from bacopa). Talk with your doctor or pharmacist before combining this product with any prescription or over-the-counter medication.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Mane Brain is marketed for brain health and cognitive support, but evidence for its ingredients is still emerging and often insufficient to confirm they work. If you take blood pressure medication, blood thinners, diabetes drugs, or medications your liver breaks down, you'll need to check with your doctor or pharmacist first—the interaction risk is real.

Pregnant or breastfeeding women should avoid it. For anyone else considering it, talk it over with your own healthcare provider to see if it fits your health picture.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2020.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mane Brain, straight from the product label.

Brand Magnum Nutraceuticals
Barcode (UPC) 821008001055
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Sep 25, 2020
DSLD ID 236736
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mane Brain by Magnum Nutraceuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
821008001055
IngredientAmount% DV
L-Theanine200 mg--
N-Acetyl L-Tyrosine350 mg--
Alpha-GPC300 mg--
organic Lion's Mane 10:1 extract500 mg--
Bacopa monnieri 30:1 extract300 mg--
Huperzine serrata 30:1 extract200 mcg--

Other ingredients: Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose, certified Halal and Kosher Gelatin Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution: Consult a healthcare practitioner prior to use if you are pregnant or breastfeeding, or have liver disease, kidney disease, migraines or psychiatric or neurologic disorder such as, but not limited to depression, schizophrenia, seizure disorders, epilepsy, affective disorder, or Parkinson's disease.

May cause digestive disturbances. Hypersensitivity has been known to occur; in which case, discontinue use. Sealed for your protection.

Keep out of reach of children.

Storage

Store in a cool, dry place.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

Gluten free

Made in Canada

General Statements

Site Licensed

New science King of Nootropics

Better ingredients, better results.

Seals/Symbols

Certified cGMP Current Good Manufacturing Practices

Formula

825mg per capsule

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Recommended Dose (Adults): Take 2 capsules daily. Avoid taking at bedtime.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mane Brain by Magnum Nutraceuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mane Brain label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mane Brain by Magnum Nutraceuticals

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Theanine

Interacts with
565 drugs
200 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

N-Acetyl L-Tyrosine

350 mg per serving

Alpha-GPC

Interacts with
16 drugs
300 mg per serving

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition...

Alpha-GPC monograph & interactions

Organic Lion's Mane 10:1 extract

Interacts with
327 drugs
500 mg per serving Form: Beta-Glucan, Polysaccharides

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and...

Organic Lion's Mane 10:1 extract monograph & interactions

Bacopa monnieri 30:1 extract

Interacts with
930 drugs
300 mg per serving Form: Bacosides A & B

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for s...

Bacopa monnieri 30:1 extract monograph & interactions

Huperzine serrata 30:1 extract

Interacts with
219 drugs
200 mcg per serving Form: Huperzine A

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription A...

Huperzine serrata 30:1 extract monograph & interactions

Other (inactive) ingredients: Magnesium Stearate, Silicon Dioxide, Microcrystalline Cellulose, Certified Halal and Kosher Gelatin Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mane Brain by Magnum Nutraceuticals Drug Interactions

Want to check YOUR meds against Mane Brain?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,424Drugs
1,267 Moderate 157 Minor

Ingredients driving the most interactions

Bacopa monnieri 30:1 extract 930
L-Theanine 565
organic Lion's Mane 10:1 extract 327
Huperzine serrata 30:1 extract 219
Alpha-GPC 16

Individual Drug Interactions

The ingredients in Mane Brain interact with 1,424 drugs. Click any drug to see the details.

5 of the 6 ingredients in Mane Brain interact with drugs. Each result below shows which ingredient is responsible. Bacopa monnieri 30:1 extract L-Theanine organic Lion's Mane 10:1 extract Huperzine serrata 30:1 extract Alpha-GPC

Each ingredient & the kinds of drugs it affects

For each ingredient in Mane Brain with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacopa monnieri 30:1 extract8 drug types · 930 drugs

Anticholinergic Drugs

Theoretically, concurrent use might decrease the effectiveness of both agents.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels, which could counteract the effects of anticholinergic drugs. Similarly, anticholinergic drugs might counteract the cholinergic effects of bacopa.

Likelihood Possible Evidence D
Cevimeline (Evoxac)

Theoretically, bacopa might increase the effects and adverse effects of cevimeline.
In one case, a 58-year-old female taking cevimeline long-term for Sjogren syndrome experienced hyperhidrosis, malaise, nausea, and tachycardia shortly after taking a single dose of bacopa. Symptoms resolved after two days. Cevimeline is metabolized by cytochrome P450 (CYP) 2D6 and CYP3A4, and researchers theorize that bacopa may have inhibited these isoenzymes. However, it is unclear if bacopa causes clinically significant inhibition of either CYP2D6 or CYP3A4.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of bacopa with other cholinergic drugs might have additive effects.
Bacopa seems to inhibit acetylcholinesterase and might increase acetylcholine levels. Theoretically, this could result in additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP1A2 substrates.
Research on the effects of bacopa extracts on CYP1A2 enzymes is conflicting. Some in vitro evidence shows that bacopa extract can moderately and non-competitively inhibit CYP1A2, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C19 substrates.
In vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C19 enzymes. It is not known whether this is clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP2C9 substrates.
Research on the effect of bacopa extracts on CYP2C9 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and non-competitively inhibit CYP2C9, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, bacopa might increase the levels and adverse effects of CYP3A4 substrates.
Research on the effects of bacopa extracts on CYP3A4 enzymes is conflicting. Some in vitro evidence suggests that bacopa extract can moderately and competitively inhibit CYP3A4, while other in vitro evidence suggests that any effect is unlikely to be clinically significant.

Likelihood Possible Evidence D
Thyroid Hormone

Theoretically, bacopa might have additive effects when used with thyroid hormone.
Animal research suggests that bacopa increases thyroxine (T4) levels in mice by about 40%.

Likelihood Possible Evidence D
Bacopa monnieri 30:1 extract full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

organic Lion's Mane 10:1 extract3 drug types · 327 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, lion's mane mushroom may increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
In vitro research suggests that lion's mane mushroom extracts can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, lion's mane mushroom may have additive effects when used with antidiabetes drugs.
Animal research suggests that an aqueous extract of lion's mane mushroom can reduce serum glucose and increase serum insulin.

Likelihood Possible Evidence D
Immunosuppressants

Theoretically, concurrent use of lion's mane mushroom might interfere with immunosuppressive therapy.
In animal and in vitro research, lion's mane mushroom polysaccharides stimulate the immune system.

Likelihood Possible Evidence D
organic Lion's Mane 10:1 extract full monograph & interactions

Huperzine serrata 30:1 extract2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, huperzine A might decrease the effects of anticholinergic drugs.
Huperzine A has acetylcholinesterase (AChE) inhibiting effects. In animal models, huperzine A reversed cognitive deficits induced by scopolamine, an anticholinergic drug.

Likelihood Possible Evidence D
Cholinergic Drugs

Theoretically, concurrent use of huperzine A with cholinergic drugs might increase the effects and side effects of these medications.
Huperzine A can inhibit acetylcholinesterase (AChE) and might cause cumulative effects if used with cholinergic drugs.

Likelihood Possible Evidence B
Huperzine serrata 30:1 extract full monograph & interactions

Alpha-GPC1 drug type · 16 drugs

Scopolamine (Transderm Scop)

Theoretically, alpha-GPC might decrease the effects of scopolamine.
A small clinical study shows that alpha-GPC can partially counteract the attention and memory impairment effects caused by scopolamine given intramuscularly. Whether alpha-GPC can decrease the beneficial anti-motion sickness effects of the scopolamine patch (Transderm Scop) is unclear.

Likelihood Possible Evidence B
Alpha-GPC full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mane Brain, from the product label.

Magnum Nutraceuticals

See all Magnum Nutraceuticals products
Name
Magnum Nutraceuticals Inc.
Street Address
19278 25th Ave
City
Surrey
State
BC
ZipCode
V3Z 3X1
Phone Number
1.888.662.4686
Web Address
www.Magnumsupps.com
Pharmacist Counseling Corner

Mane Brain by Magnum Nutraceuticals: Common Questions

Does Mane Brain by Magnum Nutraceuticals interact with any medications?
Yes. Based on its ingredients, Mane Brain has a known interaction with 1,424 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mane Brain contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Mane Brain if I'm pregnant or breastfeeding?
The safety data advises against it. Not enough information exists for L-theanine, alpha-GPC, bacopa, lion's mane, or huperzine A during pregnancy or while breastfeeding. Talk with your doctor or pharmacist for personalized guidance.
What is huperzine A, and why is it in here?
Huperzine A is an alkaloid extracted from Huperzia serrata, a plant used in traditional medicine. It works by inhibiting an enzyme that breaks down acetylcholine, a brain chemical involved in memory and learning. The data shows it's possibly effective for Alzheimer disease, though evidence for healthy people is insufficient.
What are the most common side effects?
Headache, nausea, gastrointestinal discomfort, diarrhea, and dizziness are the most frequently reported. Huperzine A can also cause blurred vision, constipation, dry mouth, insomnia, and sweating at higher doses. If you experience any of these, stop and talk with your pharmacist.
Does Mane Brain actually improve memory or focus?
The evidence is limited. Huperzine A and alpha-GPC are possibly effective for Alzheimer disease, and L-theanine is possibly effective for cognitive function overall, but the data on whether these ingredients improve memory or focus in healthy people is insufficient to rate.
Is this safe for long-term use?
Long-term safety is not well studied for any of these ingredients. The data we have covers short-term use in healthy adults. If you plan to take it regularly, talk with your doctor or pharmacist about what's safe for you.
What's the difference between the extracts listed—like the '10:1' and '30:1'?
A 10:1 extract means 10 pounds of raw material were concentrated into 1 pound of extract, making it more potent per dose. A 30:1 extract is even more concentrated. These ratios tell you how much the herb was concentrated, but they don't tell you the exact amount of active compounds in each capsule.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mane Brain label
Go deeper

The Full Monographs Behind Mane Brain’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Alpha-gpc

Interacts with 16 drugs

Alpha-GPC is a choline-containing compound used mainly for memory, brain health, and as a choline source. There is some evidence it may help cognition in people with dementia, but evidence i...

Read the full Alpha-gpc monograph → Herb & supplement monograph

Lion's Mane Mushroom

Interacts with 327 drugs

Lion's mane is an edible mushroom that is popular as a 'nootropic' for memory, focus, and nerve health, but solid human evidence is still limited and early. It is generally well tolerated as...

Read the full Lion's Mane Mushroom monograph → Herb & supplement monograph

Bacopa

Interacts with 930 drugs

Bacopa is an Ayurvedic herb most often used for memory and thinking. Some small studies suggest it may modestly help memory when taken regularly for several weeks, but the evidence is limite...

Read the full Bacopa monograph → Herb & supplement monograph

Huperzine A

Interacts with 219 drugs

Huperzine A is a purified compound from a Chinese clubmoss that acts like a mild cholinesterase inhibitor, similar in mechanism to some prescription Alzheimer's drugs. Some small studies sug...

Read the full Huperzine A monograph →
Sources

Sources & How We Checked

Mane Brain's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 41 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Theanine 6 references
  1. Yokogoshi H, Kobayashi M. Hypotensive effect of gamma-glutamylethylamide in spontaneously hypertensive rats. Life Sci 1998;62:1065-8.
  2. Haskell, C. F., Kennedy, D. O., Milne, A. L., Wesnes, K. A., and Scholey, A. B. The effects of L-theanine, caffeine and their combination on cognition and mood. Biol.Psychol. 2008;77(2):113-122. PubMed
  3. Yokogoshi, H., Kato, Y., Sagesaka, Y. M., Takihara-Matsuura, T., Kakuda, T., and Takeuchi, N. Reduction effect of theanine on blood pressure and brain 5-hydroxyindoles in spontaneously hypertensive rats. Biosci.Biotechnol.Biochem. 1995;59(4):615-618. PubMed
  4. Lyon MR, Kapoor MP, Juneja LR. The effects of L-theanine (Suntheanine®) on objective sleep quality in boys with attention deficit hyperactivity disorder (ADHD): a randomized, double-blind, placebo-controlled clinical trial. Altern Med Rev. 2011;16(4):348-
  5. Hidese S, Ota M, Wakabayashi C, et al. Effects of chronic l-theanine administration in patients with major depressive disorder: an open-label study. Acta Neuropsychiatr 2017;29(2):72-9.
  6. Tsuchiya T, Honda H, Oikawa M, et al. Oral administration of the amino acids cystine and theanine attenuates the adverse events of S-1 adjuvant chemotherapy in gastrointestinal cancer patients. Int J Clin Oncol 2016;21(6):1085-90. PubMed

See these in context on the Theanine monograph →

Alpha-gpc 4 references
  1. Di Perri R, Coppola G, Ambrosio LA, et al. A multicentre trial to the evaluate the efficacy and tolerability of alpha-glycerylphosphorylcholine versus cytosine diphosphocholine in patients with vascular dementia. J Int Med Res 1991;19:330-41.
  2. Barbagallo Sangiorgi G, Barbagallo M, Giordano M, et al. Alpha-glycerophosphocholine in the mental recovery of cerebral ischemic attacks: An Italian multicenter clinical trial. Ann N Y Acad Sci 1994;717:253-69. PubMed
  3. Canal N, Franceschi M, Alberoni M, et al. Effect of L-alpha-glyceryl-phosphorylcholine on amnesia caused by scopolamine. Int J Clin Pharmacol Ther Toxicol 1991;29:103-7.
  4. Lee G, Choi S, Chang J, et al. Association of L-a glycerylphosphorylcholine with subsequent stroke risk after 10 Years. JAMA Netw Open 2021;4(11):e2136008.

See these in context on the Alpha-gpc monograph →

Lion's Mane Mushroom 6 references
  1. Product information for <em>Niaspan</em>. Abbott Laboratories. North Chicago, IL 60064. April 2015.
  2. Liang B, Guo Z, Xie F, Zhao A. Antihyperglycemic and antihyperlipidemic activities of aqueous extract of Hericium erinaceus in experimental diabetic rats. BMC Complement Altern Med. 2013;13:253. PubMed
  3. Mori K, Inatomi S, Ouchi K, Azumi Y, Tuchida T. Improving effects of the mushroom Yamabushitake (Hericium erinaceus) on mild cognitive impairment: a double-blind placebo-controlled clinical trial. Phytother Res. 2009;23(3):367-72.
  4. Mori K, Kikuchi H, Obara Y, et al. Inhibitory effect of hericenone B from Hericium erinaceus on collagen-induced platelet aggregation. Phytomedicine. 2010;17(14):1082-5. PubMed
  5. Li IC, Chang HH, Lin CH, et al. Prevention of early Alzheimer's disease by erinacine A-enriched Hericium erinaceus mycelia pilot double-blind placebo-controlled study. Front Aging Neurosci 2020 Jun 3;12:155. doi: 10.3389/fnagi.2020.00155. PubMed
  6. Tian B, Liu R, Xu T, et al. Modulating effects of Hericium erinaceus polysaccharides on the immune response by regulating gut microbiota in cyclophosphamide-treated mice. J Sci Food Agric 2023;103(6):3050-3064.

See these in context on the Lion's Mane Mushroom monograph →

Bacopa 12 references
  1. Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology 2001;156:481-4..
  2. Yadav SK, Jain AK, Tripathi SN, Gupta JP. Irritable bowel syndrome: therapeutic evaluation of indigenous drugs. Indian J Med Res 1989;90:496-503..
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See these in context on the Bacopa monograph →

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See these in context on the Huperzine A monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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