Major interaction on record — check this product against your medications before combining. Based on 4 of 6 ingredients. Check your meds →
Dietary supplement

Mass Amino Acid Ingredients & Drug Interactions

by Beverly International

Mass Amino Acid label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Mass Amino Acid against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Mass Amino Acid is a dietary supplement by Beverly International with 6 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 259 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Sodium, Whey Protein, Lysine Hydrochloride. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Mass Amino Acid by Beverly International

Ask about any prescription or over-the-counter medication and we check it for interactions with Mass Amino Acid by Beverly International — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Mass Amino Acid by Beverly International

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 1 of its 5 active ingredients.
  • “Mass Amino Acid Hydrolysate Blend” is a proprietary blend — the label gives one combined amount (5,000 mg) without saying how much of each component you get.

Mass Amino Acid contains five active ingredients: sodium, whey protein, lysine hydrochloride, a hydrolysate amino acid blend, and casein protein. These are meant to support muscle amino acid intake and protein intake overall.

The tablet also contains inactive ingredients — microcrystalline cellulose, croscarmellose sodium, silicon dioxide, magnesium stearate, stearic acid, and a few film-coating agents — which are standard binding and coating materials.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: support building and preservation of lean muscle mass.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Muscle strength, Sarcopenia, muscle hypertrophy — and 2 related terms.
  • The strongest evidence on file: Whey Protein is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Lysine is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Muscle strength.
  • Also on file: Whey Protein is rated "Insufficient Reliable Evidence To Rate" for Sarcopenia, Exercise-induced muscle damage.

Sodium is likely effective for cystic fibrosis and possibly effective for amphotericin B–related kidney damage, though you wouldn't be supplementing sodium for those reasons without medical guidance. Whey protein is possibly effective for athletic performance but possibly ineffective for osteoporosis.

Lysine is possibly effective for cold sores. Evidence for casein in athletic performance, bone health, lung disease, and blood sugar control is not yet established in our data.

Effectiveness for growth and wound healing across the amino acids is insufficient to rate.

The evidence, ingredient by ingredient Sodium Whey Protein Lysine Casein Protein

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 4 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 4 of 4.
  • General safety write-ups exist for 4 of 4.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is generally well tolerated at normal dietary amounts, but excess intake is linked to high blood pressure and heart strain — avoid sodium supplements or very high intake without your doctor's advice. Rare serious effects from too much sodium include worsened heart disease, high blood pressure, and kidney disease.

Whey protein is generally well tolerated by healthy adults, though it's been reported to trigger or worsen acne in some users, and common dose-related side effects include bloating, cramps, diarrhea, nausea, and reflux. Lysine is generally well tolerated at typical doses but may cause stomach upset, diarrhea, and abdominal pain, especially at high amounts; one rare case of kidney inflammation linked to high-dose lysine has been reported.

Casein protein is well tolerated but rarely can cause allergic reaction (skin reactions, breathing trouble, stomach distress, or anaphylaxis); it may also cause constipation or delayed digestion. We hold no pregnancy or breastfeeding data for whey protein, lysine, or casein in this context; sodium's data shows it is likely safe in pregnancy but possibly unsafe while breastfeeding — talk with your doctor or pharmacist.

Side effects, ingredient by ingredient Sodium Whey Protein Lysine Casein Protein

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 4 matched ingredients can interact with medications — Lysine, Whey Protein, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: lithium; Parkinson's medications.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before starting if you take levodopa for Parkinson's disease (Major interaction with whey protein). Also double-check if you take antihypertensive (blood pressure) drugs, corticosteroids, lithium, quinolone or tetracycline antibiotics, bisphosphonates, or any sodium-containing or sodium-regulating medications — all are affected by sodium or whey protein in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is an amino acid supplement aimed at muscle support. If you take blood pressure pills, lithium, certain antibiotics, bone medications, or Parkinson's drugs, you need to check your specific medications before starting — several have Moderate to Major interactions with ingredients here.

Talk to your pharmacist or doctor first, especially if you have high blood pressure, heart disease, kidney disease, or a milk allergy.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 25, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Mass Amino Acid, straight from the product label.

Brand Beverly International
Barcode (UPC) 857254000603
Net contents 500 Tablet(s)
Market status On market
Date entered into DSLD Jun 25, 2025
DSLD ID 332835
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Seniors/Mature (>50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Mass Amino Acid by Beverly International, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
125
UPC/BARCODE
857254000603
IngredientAmount% DV
Protein4 Gram(s)8%
Sodium70 mg3%
Whey Protein0 NP--
Lysine Hydrochloride0 NP--
Calories20 Calorie(s)--
Mass Amino Acid Hydrolysate Blend5000 mg--
Casein0 NP--
Milk Protein, Hydrolysate0 NP--

Other ingredients: Croscarmellose Sodium, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate, Stearic Acid, Hydroxypropyl Methylcellulose, Gum Acacia, Hydroxypropyl Cellulose, micronized Wax, Talc

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Mass Amino Acids is an advanced amino acid nitrogen technology used by natural physique athletes to support the building and preservation of lean muscle mass.

Advanced amino acid Nitrogen Technology w/ peptide-bonded amino acids

Formulation

Distinguishing features: Perfect for hard gainers, natural physique athletes, the 40+ (40 years and over), and anyone else committed to doing whatever it takes to make their muscles bigger, fuller, harder and stronger, naturally. Reduces loss of muscle mass and strength during fat-loss or cutting diets and layoff from training, and helps you "regain" muscle faster afterwards.

100% money-back guarantee If you are not 100% satisfied after using this product for 60 days, then we will refund your money. No questions asked.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

Use: Take 4 tablets daily with a meal. For maximum results: Take 1 tablet per 10 lbs of bodyweight per day. Divide your daily allotment of tablets into smaller doses. Take each dose with meals and while working out. Example: A 180-lb athlete would take 18 tablets per day. This allotment might be divided into 4 tablets with each of 3 meals (12 tablets total) plus 6 tablets while working out.

General Statements

"The Stack of the Century": For years, Beverly customers have been telling us that the combination of Mass Amino Acids and Ultra 40 is the most effective stack they've ever used. Try it for even more dramatic gains.

Brand IP Statement(s)

Beverly International 1967

FDA Statement of Identity

Dietary Supplement

Precautions

Contains milk.

Warning: Consult your physician prior to using this product if you are: under 18 years of age; pregnant; nursing; trying to become pregnant; taking medication; or have a medical condition.

Warning: Consult your physician prior to using this product if you are: under 18 years of age; pregnant; nursing; trying to become pregnant; taking medication; or have a medical condition. Keep out of reach of children.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Mass Amino Acid by Beverly International label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Mass Amino Acid label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Mass Amino Acid by Beverly International

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container125 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

4 Gram(s) per serving

Sodium

Interacts with
205 drugs
70 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Mass Amino Acid Hydrolysate Blend

5000 mg per serving

Other (inactive) ingredients: Croscarmellose Sodium, Microcrystalline Cellulose, Silicon Dioxide, Magnesium Stearate, Stearic Acid, Hydroxypropyl Methylcellulose, Gum Acacia, Hydroxypropyl Cellulose, Micronized Wax, Talc. These complete the product’s ingredient list but are not active constituents.

Interaction report

Mass Amino Acid by Beverly International Drug Interactions

Want to check YOUR meds against Mass Amino Acid?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
5 Major 253 Moderate 1 Minor

Ingredients driving the most interactions

Sodium 205
Whey Protein 53
Lysine Hydrochloride 1

Individual Drug Interactions

The ingredients in Mass Amino Acid interact with 259 drugs. Click any drug to see the details.

3 of the 6 ingredients in Mass Amino Acid interact with drugs. Each result below shows which ingredient is responsible. Sodium Whey Protein Lysine Hydrochloride

Each ingredient & the kinds of drugs it affects

For each ingredient in Mass Amino Acid with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Whey Protein4 drug types · 53 drugs

Levodopa

Theoretically, whey protein might decrease levodopa absorption.
Small clinical studies show that concomitant ingestion of protein or high doses of leucine or isoleucine (100 mg/kg) and levodopa can exacerbate tremor, rigidity, and the "on-off" syndrome in patients with Parkinson disease.

Likelihood Probable Evidence D
Bisphosphonates

Theoretically, whey protein might reduce the absorption of bisphosphonates.
Whey protein contains minerals such as calcium that bind bisphosphonates in the gut. Advise patients to take bisphosphonates at least 30 minutes before whey protein, but preferably at a different time of day.

Likelihood Probable Evidence D
Quinolone Antibiotics

Theoretically, whey protein might decrease quinolone absorption.
Whey protein contains minerals, such as calcium, that can bind to quinolones in the gut. To avoid this interaction, advise patients to take oral quinolones at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Tetracycline Antibiotics

Theoretically, whey protein might decrease tetracycline absorption.
Whey protein contains minerals, such as calcium, that bind to tetracyclines in the gut. To avoid this interaction, advise patients to take oral tetracyclines at least 2 hours before or 4-6 hours after whey protein.

Likelihood Probable Evidence D
Whey Protein full monograph & interactions

Lysine Hydrochloride1 drug type · 1 drug

5-Ht4 Agonists

Theoretically, lysine may reduce the effects of 5-HT4 agonists.
Animal research suggests that L-lysine is a partial serotonin receptor 4 (5-HT4) antagonist and inhibits diarrhea induced by the 5-HT4 agonist, 5-hydroxytryptophane.

Likelihood Unlikely Evidence D
Lysine Hydrochloride full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Mass Amino Acid, from the product label.

Beverly International

See all Beverly International products
Name
Beverly International Nutrition, Inc
City
Cold Spring
State
KY
ZipCode
41076
Phone Number
(800) 781-3475
Web Address
www.BeverlyInternational.com
Pharmacist Counseling Corner

Mass Amino Acid by Beverly International: Common Questions

Does Mass Amino Acid by Beverly International interact with any medications?
Yes. Based on its ingredients, Mass Amino Acid has a known interaction with 259 medications, including 5 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Mass Amino Acid contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I have high blood pressure?
The sodium in this product can interfere with how well blood pressure medications work and may raise your blood pressure further. Talk with your doctor before taking it.
Will this help me build muscle or improve my athletic performance?
Whey protein is possibly effective for athletic performance. Lysine is not established for that purpose in our data. Whether this supplement adds real benefit beyond protein you get from food depends on your goals — your doctor or a sports nutritionist can advise.
What are the most common side effects?
Whey protein can cause bloating, cramps, diarrhea, nausea, and reflux, especially at higher doses. Lysine may cause stomach upset and diarrhea. Most of these are dose-related and improve if you lower the dose or stop.
Is this safe during pregnancy or breastfeeding?
Sodium is likely safe in pregnancy but possibly unsafe while breastfeeding. We don't have pregnancy or breastfeeding data on file for whey protein, lysine, or casein in supplement form — talk with your doctor or pharmacist for personalized advice.
What is lysine used for?
Lysine is possibly effective for cold sores. It's also included as an amino acid to support overall muscle amino acid intake, though evidence for growth, wound healing, and other uses is not yet established.
I'm allergic to milk. Can I take this?
This product contains whey protein, casein, and milk protein hydrolysate — all milk-derived. If you have a milk allergy, do not take this; it can trigger allergic reaction.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Mass Amino Acid is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Mass Amino Acid label
Go deeper

The Full Monographs Behind Mass Amino Acid’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Whey Protein

Interacts with 53 drugs

Whey protein is a high-quality, complete protein made from cow's milk that can help people meet protein needs and support muscle growth when combined with exercise. It is generally safe for...

Read the full Whey Protein monograph → Herb & supplement monograph

Lysine

Interacts with 1 drug

Lysine is an essential amino acid your body cannot make on its own, so it must come from food or supplements. People most often take extra lysine to try to prevent or shorten cold sores, but...

Read the full Lysine monograph → Herb & supplement monograph

Casein Protein

Casein is a slow-digesting protein from milk that supplies all the essential amino acids and is popular for muscle recovery, especially overnight. It is generally safe for most people who to...

Read the full Casein Protein monograph →
Sources

Sources & How We Checked

Mass Amino Acid's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 131 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
  7. Boudville N, Ward S, Benaroia M, House AA. Increased sodium intake correlates with greater use of antihypertensive agents by subjects with chronic kidney disease. Am J Hypertens 2005;18(10):1300-5. PubMed
  8. Bennett WM. Drug interactions and consequences of sodium restriction. Am J Clin Nutr 1997;65(2 Suppl):678S-681S. PubMed
  9. Okusa MD, Crystal LJ. Clinical manifestations and management of acute lithium intoxication. Am J Med 1994;97(4):383-9. PubMed
  10. Food and Nutrition Board, Institute of Medicine. Dietary reference intakes for water, potassium, sodium, chloride, and sulfate. Washington, DC: National Academy Press, 2005. Available at: http://www.nap.edu/openbook.php?record_id=10925. DOI
  11. D'Elia L, Rossi G, Ippolito R, Cappuccio FP, Strazzullo P. Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr 2012;31(4):489-98. PubMed
  12. Goldsmith SR. Hyponatremia in heart failure: time for a trial. J Card Fail 2013;19(6):398-400. PubMed
  13. Willocks L, Brettle R, Keen J, Valentine C, Pinching AJ. Formulations of didanosine (ddI) and salt overload. Lancet 1992;339(8786):190.
  14. Chen L, Zhang Z, Chen W, Whelton PK, Appel LJ. Lower Sodium Intake and Risk of Headaches: Results From the Trial of Nonpharmacologic Interventions in the Elderly. Am J Public Health. 2016;106(7):1270-5. PubMed
  15. Cook NR, Appel LJ, Whelton PK. Lower levels of sodium intake and reduced cardiovascular risk. Circulation. 2014;129(9):981-9. PubMed
  16. Cook NR, Appel LJ, Whelton PK. Sodium Intake and All-Cause Mortality Over 20 Years in the Trials of Hypertension Prevention. J Am Coll Cardiol. 2016;68(15):1609-1617. PubMed
  17. Mente A, O'Donnell M, Rangarajan S, et al. Associations of urinary sodium excretion with cardiovascular events in individuals with and without hypertension: a pooled analysis of data from four studies. Lancet. 2016;388(10043):465-75. PubMed
  18. Moosavian SP, Haghighatdoost F, Surkan PJ, Azadbakht L. Salt and obesity: a systematic review and meta-analysis of observational studies. Int J Food Sci Nutr. 2017;68(3):265-277. PubMed
  19. O'Donnell M, Mente A, Rangarajan S, et al. Urinary sodium and potassium excretion, mortality, and cardiovascular events. N Engl J Med. 2014;371(7):612-23. DOI
  20. Poggio R, Gutierrez L, Matta MG, Elorriaga N, Irazola V, Rubinstein A. Daily sodium consumption and CVD mortality in the general population: systematic review and meta-analysis of prospective studies. Public Health Nutr. 2015;18(4):695-704. PubMed
  21. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad
  22. Mahtani KR, Heneghan C, Onakpoya I, et al. Reduced Salt Intake for Heart Failure: A Systematic Review. JAMA Intern Med. 2018 Dec 1;178(12):1693-1700. PubMed
  23. Yancy CW. Sodium Restriction in Heart Failure: Too Much Uncertainty-Do the Trials. JAMA Intern Med. 2018 Dec 1;178(12):1700-1701. PubMed
  24. He FJ, Campbell NRC, Ma Y, MacGregor GA, Cogswell ME, Cook NR. Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health. Int J Epidemiol. 2018;47(6):1784-1795. PubMed
  25. Murthy K, Ondrey GJ, Malkani N, et al. THE EFFECTS OF HYPONATREMIA ON BONE DENSITY AND FRACTURES: A SYSTEMATIC REVIEW AND META-ANALYSIS. Endocr Pract. 2019;25(4):366-378. PubMed
  26. Messerli FH, Hofstetter L, Syrogiannouli L, et al. Sodium intake, life expectancy, and all-cause mortality. Eur Heart J 2021;42(21):2103-2112. PubMed
  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
  28. Giatti S, Santos RB, Aielo AN, et al. Association of sodium with obstructive sleep apnea. The ELSA-Brasil study. Ann Am Thorac Soc 2021;18(3):502-510. PubMed
  29. Nan X, Lu H, Wu J, et al. The interactive association between sodium intake, alcohol consumption and hypertension among elderly in northern China: a cross-sectional study. BMC Geriatr 2021;21(1):135. PubMed
  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
  31. Zhao L, Ogden CL, Yang Q, et al. Association of usual sodium intake with obesity among US children and adolescents, NHANES 2009-2016. Obesity (Silver Spring) 2021;29(3):587-594. PubMed
  32. Ma Y, He FJ, Sun Q, et al. 24-Hour urinary sodium and potassium excretion and cardiovascular risk. N Engl J Med 2022;386(3):252-263. PubMed
  33. Liu J, Yang X, Zhang P, et al. Association of urinary sodium excretion and left ventricular hypertrophy in people with type 2 diabetes mellitus: A cross-sectional study. Front Endocrinol (Lausanne) 2021;12:728493. PubMed
  34. Filippini T, Malavolti M, Whelton PK, Vinceti M. Sodium intake and risk of hypertension: A systematic review and dose-response meta-analysis of observational cohort studies. Curr Hypertens Rep 2022;24(5):133-144. PubMed
  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
  38. Zhou TL, Schütten MTJ, Kroon AA, et al. Urinary Sodium Excretion and Salt Intake Are Not Associated With Blood Pressure Variability in a White General Population. J Am Heart Assoc 2023;12(1):e026578. PubMed

See these in context on the Sodium monograph →

Whey Protein 25 references
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  14. Zhu, K., Meng, X., Kerr, D. A., Devine, A., Solah, V., Binns, C. W., and Prince, R. L. The effects of a two-year randomized, controlled trial of whey protein supplementation on bone structure, IGF-1, and urinary calcium excretion in older postmenopausal
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See these in context on the Whey Protein monograph →

Lysine 7 references
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See these in context on the Lysine monograph →

Casein Protein 61 references
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  10. Cuevas, A. M., Irribarra, V. L., Castillo, O. A., Yanez, M. D., and Germain, A. M. Isolated soy protein improves endothelial function in postmenopausal hypercholesterolemic women. Eur.J Clin.Nutr. 2003;57(8):889-894. PubMed
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  15. Gooderham, M. H., Adlercreutz, H., Ojala, S. T., Wahala, K., and Holub, B. J. A soy protein isolate rich in genistein and daidzein and its effects on plasma isoflavone concentrations, platelet aggregation, blood lipids and fatty acid composition of plasm
  16. Baum, J. A., Teng, H., Erdman, J. W., Jr., Weigel, R. M., Klein, B. P., Persky, V. W., Freels, S., Surya, P., Bakhit, R. M., Ramos, E., Shay, N. F., and Potter, S. M. Long-term intake of soy protein improves blood lipid profiles and increases mononuclear
  17. Willoughby, D. S., Stout, J. R., and Wilborn, C. D. Effects of resistance training and protein plus amino acid supplementation on muscle anabolism, mass, and strength. Amino.Acids 2007;32(4):467-477. PubMed
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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