Interactions on record — worth a quick check against your medications. Based on 5 of 6 ingredients. Check your meds →
Dietary supplement

Max TribuStak Ingredients & Drug Interactions

by MM Sports Nutrition

Max TribuStak label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Max TribuStak against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Max TribuStak is a dietary supplement by MM Sports Nutrition with 6 active ingredients. Its ingredients are commonly taken for anti-aging and low dhea levels, mood and depression, vaginal dryness and sexual health.Based on those ingredients, 1,096 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Epimedium sagittatum, Dehydroepiandrosterone, Tribulus Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Max TribuStak by MM Sports Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Max TribuStak by MM Sports Nutrition — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Max TribuStak by MM Sports Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 3 of its 8 active ingredients.
  • “Tribulus Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.
  • “Tribulus terrestris” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.
  • “TribuStak Blend” is a proprietary blend — the label gives one combined amount (500 mg) without saying how much of each component you get.

Max TribuStak contains 8 active ingredients. The primary ones are DHEA (a hormone naturally produced by your adrenal glands), Avena sativa (oats), a Tribulus Blend, Eurycoma longifolia (also called tongkat ali or Malaysian ginseng), Tribulus terrestris (a plant extract), Protodioscin (a compound from tribulus), Saponins/Sapogenins (plant compounds), and Epimedium sagittatum (horny goat weed).

The product also contains inactive ingredients — rice powder, magnesium stearate, and gelatin capsule material — that help deliver the actives. Vitex agnus castus (chasteberry) is listed as part of a blend; however, we hold no interaction data for it.

Oats are generally well tolerated as a food or supplement, while the other herbal extracts have limited long-term safety data in concentrated supplement form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: testosterone production and male sexual health.
  • We looked for evidence on: Age-related testosterone deficiency, Erectile dysfunction (ED), Male infertility, Partial androgen deficiency, Low libido, Sexual performance.
  • The strongest evidence on file: Dhea is rated "Possibly Effective" for Infertility (Natural Medicines).
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Male infertility.
  • Also on file: Dhea is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Partial androgen deficiency.

According to the evidence we have, DHEA is likely effective for vaginal atrophy and possibly effective for infertility, aging skin, and depression. Oats are likely effective for managing cholesterol levels (dyslipidemia) and heart disease risk.

Eurycoma longifolia is possibly effective for sexual desire but appears possibly ineffective for athletic performance; evidence for back pain, osteoporosis, and diabetes is insufficient. Tribulus terrestris is possibly effective for sexual dysfunction but possibly ineffective for athletic performance; evidence for benign prostatic hyperplasia is insufficient.

Horny goat weed shows insufficient evidence to rate it for bronchitis, sexual dysfunction, osteoporosis, or heart disease. We hold no effectiveness ratings for Protodioscin, Saponins/Sapogenins, or Vitex agnus castus.

The evidence, ingredient by ingredient Dhea Tribulus Oats Eurycoma Longifolia Horny Goat Weed

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

DHEA is generally well tolerated short-term at typical doses, but long-term oral use carries theoretical concern for increased cancer risk. Common side effects include acne (especially in women), headache, insomnia, mood changes, and nausea; in women, masculinization symptoms like voice deepening and irregular periods can occur.

Mood-related effects such as anxiety, irritability, and mania have been reported. Because DHEA is a hormone, it requires medical oversight.

Oats are well tolerated and commonly cause only mild gastrointestinal effects like bloating, gas, or an unpleasant taste if doses are increased too quickly. Eurycoma longifolia is generally tolerated short-term but long-term safety is uncertain, and theoretically could trigger testosterone-related side effects (acne, insulin resistance, liver issues) if testosterone rises above normal.

Tribulus is often well tolerated short-term but carries rare reports of liver and kidney injury, seizures, and painful erection. Horny goat weed is generally tolerated short-term with mild side effects like dizziness, dry mouth, and nosebleed; one case report linked it to heart rhythm problems, though causality was unclear.

All ingredients except oats should be avoided in pregnancy and breastfeeding due to insufficient safety data or hormonal effects.

Side effects, ingredient by ingredient Dhea Tribulus Oats Eurycoma Longifolia Horny Goat Weed

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Tribulus, Dhea, Horny Goat Weed, Oats, Eurycoma Longifolia.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 1,097 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Max TribuStak, check with your doctor or pharmacist if you take antidepressants (DHEA risk of mood changes including mania), blood thinners or antiplatelet drugs (increased bleeding risk from DHEA and horny goat weed), diabetes medications or insulin (oats and tribulus may lower blood sugar), blood pressure medications (tribulus and horny goat weed may increase the effect), triazolam or other sleep aids, cancer medications like tamoxifen or aromatase inhibitors, propranolol, lithium, estrogen therapy, or drugs metabolized by liver enzymes. These are the medication types with documented interactions we can confirm.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a multi-ingredient hormonal and herbal supplement designed to support sexual function and athletic performance. Because it contains DHEA and several herbal extracts that affect hormones, blood pressure, blood sugar, and liver metabolism, it's not appropriate for everyone — especially if you take antidepressants, blood thinners, diabetes or blood pressure medications, or cancer medications.

Before starting Max TribuStak, talk with your doctor or pharmacist about your current medications and whether this product is right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Max TribuStak, straight from the product label.

Brand MM Sports Nutrition
Barcode (UPC) 691381509000
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 37354
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Max TribuStak by MM Sports Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
45
UPC/BARCODE
691381509000
IngredientAmount% DV
Dehydroepiandrosterone50 mg, 25 mg--
Avena sativa0 NP, 0 NP--
Tribulus Blend1000 mg, 500 mg--
Eurycoma longifolia0 NP, 0 NP--
Tribulus terrestris0 NP, 0 NP--
Tribulus terrestris0 NP, 0 NP--
Protodioscin200 mg, 100 mg--
Saponins/Sapogenins200 mg, 100 mg--
TribuStak Blend500 mg, 250 mg--
Vitex agnus castus0 NP, 0 NP--
Epimedium sagittatum0 NP, 0 NP--

Other ingredients: Rice powder, Magnesium Stearate, Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

If you are looking for one of the most potent Tribulus formulas available then TribuStak is for you.

Protodioscin is thought to be the active ingredient in Tribulus and the scientists at MMSN went out and found the strongest Tribulus available. Most Tribulus formulas contain no Protodioscin at all or maybe some small insignificant amount, but there's nothing tiny about TribuStak.

To cap it all off the TribuStak Proprietary Blend combines four herbs known for their ability to support male hormones. Simple and strong, that's what TribuStak is all about. Try it for a month. We know you'll notice the difference in the gym, the mirror and the bedroom. Kick your testosterone and your workouts into high gear with Max Muscle TribuStak!

- Libido and Sex Drive

Formula

MMSN bring you an amazing Tribulus terrestris formula containing 500mg of Tribulus that delivers 100mg of Portodioscin and 100mg of Saponins/Sapogenins.

Then we added in DHEA, the precursor to testosterone production. TribuStak supports your natural testosterone production with Protodioscin from Tribulus and provides the raw material to make the testosterone with DHEA.

Male Hormone Support

- Maximum Protodioscin Formula - Highest Potency Tribulus

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General

70-05-113 32512

Seals/Symbols

MM SPORTS NUTRITION(R)

QIG QUALITY INGREDIENTS GUARANTEED

MADE IN THE USA

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement take two (2) capsules one (1) to two (2) times daily with eight (8) ounces of water. May be taken with or without food.

Precautions

ALLERGY INFORMATION: Manufactured in a facility that processes milk, egg, fish, Crustacean shellfish, tree nuts, wheat and soybeans.

KEEP OUT OF THE REACH OF CHILDREN.

Storage

STORE IN A COOL, DRY PLACE AWAY FROM MOISTURE, SUNLIGHT AND EXCESS HEAT. ALWAYS KEEP TIGHTLY SEALED.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Max TribuStak by MM Sports Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Max TribuStak label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Max TribuStak by MM Sports Nutrition

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container45 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dehydroepiandrosterone

Interacts with
776 drugs
50 mg per serving

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed...

Dehydroepiandrosterone monograph & interactions

Tribulus Blend

Interacts with
259 drugs
1000 mg per serving

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Tribulus Blend monograph & interactions

TribuStak Blend

500 mg per serving

Other (inactive) ingredients: Rice powder, Magnesium Stearate, Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Max TribuStak by MM Sports Nutrition Drug Interactions

Want to check YOUR meds against Max TribuStak?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,096Drugs
1,074 Moderate 22 Minor

Ingredients driving the most interactions

Epimedium sagittatum 963
Dehydroepiandrosterone 776
Tribulus Blend 259
Eurycoma longifolia 248
Avena sativa 86

Individual Drug Interactions

The ingredients in Max TribuStak interact with 1,096 drugs. Click any drug to see the details.

5 of the 6 ingredients in Max TribuStak interact with drugs. Each result below shows which ingredient is responsible. Epimedium sagittatum Dehydroepiandrosterone Tribulus Blend Eurycoma longifolia Avena sativa

Each ingredient & the kinds of drugs it affects

For each ingredient in Max TribuStak with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Epimedium sagittatum6 drug types · 963 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, horny goat weed might increase the risk of bleeding.
In vitro research and animal research shows that horny goat weed can inhibit platelet aggregation and thrombus formation. This effect has not been reported in humans.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, horny goat weed might increase the risk of hypotension.
Laboratory research suggests that horny goat weed might have hypotensive effects. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP1A2 substrates.
In vitro, horny goat weed leaf extract inhibits CYP1A2. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2B6 (Cyp2B6) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP2B6 substrates.
In vitro, horny goat weed leaf extract inhibits CYP2B6. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, horny goat weed might increase the effects and side effects of CYP3A4 substrates.
In vitro, horny goat weed extract inhibits CYP3A4 and suppresses CYP3A4 mRNA expression. This effect has not been reported in humans.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of horny goat weed with estrogens might increase their therapeutic and adverse effects.
In vitro evidence suggests that horny goat weed has estrogenic activity. In clinical research, horny goat weed has been shown to increase blood levels of estrogen in some females.

Likelihood Possible Evidence D
Epimedium sagittatum full monograph & interactions

Dehydroepiandrosterone10 drug types · 776 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, DHEA might increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
Human and laboratory research show that DHEA and DHEA-S can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidepressant Drugs

Theoretically, DHEA might increase the risk of psychiatric adverse events when used with antidepressants.
In a human case report, the use of a selective serotonin reuptake inhibitor (SSRI) with DHEA caused a manic episode. Concern for this interaction may be greater in younger individuals with higher baseline DHEA levels.

Likelihood Possible Evidence D
Aromatase Inhibitors

Theoretically, DHEA might interfere with the clinical effects of aromatase inhibitors.
DHEA is a potent estrogen agonist, which may antagonize the anti-estrogen activity of aromatase inhibitors.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, DHEA might increase the levels of drugs metabolized by CYP3A4.
Some preliminary evidence shows that DHEA may inhibit CYP3A4; however, the clinical significance of this potential interaction is not known.

Likelihood Possible Evidence D
Fulvestrant (Faslodex)

Theoretically, DHEA might interfere with the anti-estrogen effects of fulvestrant.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist action of fulvestrant in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Tamoxifen (Nolvadex)

Theoretically, DHEA might interfere with the anti-estrogen effects of tamoxifen.
DHEA is a potent estrogen agonist. Some research shows that it can overcome the estrogen receptor antagonist activity of tamoxifen in estrogen-receptor positive cancer cells.

Likelihood Possible Evidence D
Triazolam (Halcion)

DHEA can increase blood levels of triazolam.
Administration of DHEA 200 mg daily for two weeks was shown to inhibit the cytochrome P450 3A4 (CYP3A4) metabolism of triazolam. This inhibition appears to be due to DHEA-S, rather than DHEA.

Likelihood Probable Evidence D
Tuberculosis Vaccine

DHEA might reduce the effectiveness of the tuberculosis vaccine.
Animal research shows that high doses of DHEA can reduce the efficacy of the Bacillus Calmette-Guérin (BCG) tuberculosis vaccine.

Likelihood Possible Evidence D
Estrogens

Theoretically, DHEA might increase the effects and adverse effects of estrogen therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. Also, in clinical research, estrogen-progestin oral contraceptives and conjugated estrogens reduce blood levels of DHEA and DHEA-S. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Testosterone

Theoretically, DHEA might increase the effects and side effects of testosterone therapy.
DHEA is a precursor to estrogen and androgen and is metabolized into those substances. In clinical research, DHEA supplements increase the levels of these hormones. The clinical significance of these findings is unclear.

Likelihood Possible Evidence D
Dehydroepiandrosterone full monograph & interactions

Tribulus Blend3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Tribulus Blend full monograph & interactions

Eurycoma longifolia5 drug types · 248 drugs

Propranolol (Inderal)

Eurycoma longifolia can reduce the levels and clinical effects of propranolol.
A small clinical study in healthy persons shows that taking a single dose of a water-based Eurycoma longifolia extract 200 mg, in combination with a single dose of propranolol 80 mg, reduces the propranolol area under the curve (AUC) by 29%, reduces the peak concentration by 42%, and increases time to peak concentration by 86% when compared with control. Since the elimination half-life of propranolol did not change, it seems that Eurycoma longifolia alters the kinetics of propranolol by decreasing its absorption in the gut, and not by altering its metabolism. It is not known if separating administration will prevent this interaction.

Likelihood Probable Evidence A
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, Eurycoma longifolia might increase levels CYP1A2 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP1A2 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2A6 (Cyp2A6) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2A6 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2A6 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Cytochrome P450 2C19 (Cyp2C19) Substrates

Theoretically, Eurycoma longifolia might increase levels of CYP2C19 substrates.
In vitro research suggests that methanolic Eurycoma longifolia root extract weakly inhibits CYP2C19 enzymes. This effect has not been reported in humans.

Likelihood Possible Evidence D
Testosterone

Theoretically, Eurycoma longifolia may further increase levels of testosterone.
A clinical study in aging males with testosterone levels below 300 ng/dL shows that taking a specific water extract of Eurycoma longifolia roots (Physta; Biotropics Malaysia) 100-200 mg daily with breakfast for 12 weeks increases total testosterone levels by 8% to 11% when compared with placebo. It is unclear whether this increase would occur in individuals with normal testosterone levels.

Likelihood Possible Evidence D
Eurycoma longifolia full monograph & interactions

Avena sativa2 drug types · 86 drugs

Antidiabetes Drugs

Theoretically, oats may have additive effects with antidiabetic agents and might increase the risk of hypoglycemia.
Consuming oats can decrease blood glucose in patients with diabetes. In those who require insulin, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence D
Insulin

Concomitant use of oats and insulin might increase the risk of hypoglycemia.
In patients with insulin-dependent type 2 diabetes, taking oats 100 grams daily for 2 days reduces the insulin dose required to achieve metabolic control.

Likelihood Possible Evidence B
Avena sativa full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Max TribuStak, from the product label.

MM Sports Nutrition

See all MM Sports Nutrition products
Name
Max Muscle Sports Nutrition
Street Address
210 W. Taft Ave.
City
Orange
State
CA
ZipCode
92865
Web Address
www.maxmuscle.com
Pharmacist Counseling Corner

Max TribuStak by MM Sports Nutrition: Common Questions

Does Max TribuStak by MM Sports Nutrition interact with any medications?
Yes. Based on its ingredients, Max TribuStak has a known interaction with 1,096 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Max TribuStak contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on an antidepressant?
Not without talking to your doctor first. DHEA in this product interacts with antidepressants and in one case report caused a manic episode when combined with an SSRI. Your doctor or pharmacist needs to weigh the risks for you personally.
Is this safe during pregnancy or breastfeeding?
No. DHEA, Eurycoma longifolia, tribulus, and horny goat weed should all be avoided in pregnancy and breastfeeding. Oats as a food are generally considered safe in pregnancy and breastfeeding, but concentrated oat supplements haven't been well studied in those settings. Talk with your doctor or pharmacist before using this product if you're pregnant or nursing.
What are the most common side effects?
The most frequently reported side effect is acne, especially in women. Other common ones include headache, insomnia, mood changes, nausea, and gastrointestinal effects like bloating or gas. In women, some hormonal side effects like voice changes or irregular periods are possible with long-term use.
Does this work for sexual performance?
DHEA is possibly effective for sexual function in some contexts. Eurycoma longifolia is possibly effective for sexual desire, but horny goat weed shows insufficient evidence. Tribulus terrestris is possibly effective for sexual dysfunction. Results vary by person, and this is a multi-ingredient blend, so it's hard to know which ingredient, if any, would help you.
Can I take this if I have diabetes?
Oats, tribulus, and possibly other ingredients in this product can lower blood sugar. If you take diabetes medication or insulin, combining this supplement could increase your risk of low blood sugar. Check with your doctor or pharmacist before taking it.
What if I take a blood thinner like warfarin?
Don't take this product without talking to your doctor. DHEA and horny goat weed both theoretically increase bleeding risk when combined with blood thinners, and your dose might need adjustment. Your pharmacist or doctor should review this with you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Max TribuStak label
Go deeper

The Full Monographs Behind Max TribuStak’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Dhea

Interacts with 776 drugs

DHEA is a natural hormone that the body makes and that declines with age, and it is sold as a supplement claiming many benefits. The evidence is mixed and limited for most uses, and because...

Read the full Dhea monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph → Herb & supplement monograph

Oats

Interacts with 86 drugs

Oats are a well-studied whole grain whose soluble fiber (beta-glucan) can help lower cholesterol and support heart health when eaten regularly. As a food, oats are safe for most people, and...

Read the full Oats monograph → Herb & supplement monograph

Eurycoma Longifolia

Interacts with 248 drugs

Eurycoma longifolia (tongkat ali) is a Southeast Asian herb most popular for supporting testosterone, libido, and male fertility, with some small human studies suggesting possible benefits....

Read the full Eurycoma Longifolia monograph → Herb & supplement monograph

Horny Goat Weed

Interacts with 963 drugs

Horny goat weed (Epimedium) is a traditional Chinese herb most often marketed for low libido and erectile problems, but solid human evidence for these uses is lacking. While short-term use s...

Read the full Horny Goat Weed monograph →
Sources

Sources & How We Checked

Max TribuStak's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 136 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Dhea 98 references
  1. Frye RF, Kroboth PD, Folan MM, et al. Effect of DHEA on CYP3A-mediated metabolism of triazolam. Clin Pharmacol Ther 2000;67:109 (abstract PI-82).
  2. Kuritzky L. DHEA: Science or wishful thinking? Hosp Pract 1998;33:85-6. PubMed
  3. Van Vollenhoven RF, Morabito LM, Engleman EG, et al. Treatment of systemic lupus erythematosus with dehydroepiandrosterone: 50 patients treated up to 12 months. J Rheumatol 1998;25:285-9.
  4. Van Vollenhoven RF, Engleman EG, McGurie JL. Dehydroepiandrosterone in Systemic Lupus Erythematosus. Arth Rheum 1995;38:1826-31. DOI
  5. Ebeling P, Koivisto VA. Physiological importance of dehydroepiandrosterone. Lancet 1994;343:1479-81. PubMed
  6. Yen SS, Morales AJ, Khorram O. Replacement of DHEA in aging men and women. Potential remedial effects. Ann N Y Acad Sci 1995;774:128-42. PubMed
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Eurycoma Longifolia 4 references
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See these in context on the Eurycoma Longifolia monograph →

Horny Goat Weed 11 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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