Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Methyl B Complete Ingredients & Drug Interactions

by Pure TheraPro Rx

Methyl B Complete label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Methyl B Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Methyl B Complete is a dietary supplement by Pure TheraPro Rx with 5 active ingredients. Its ingredients are commonly taken for treating or preventing b12 deficiency, pernicious anemia, low energy and fatigue.Based on those ingredients, 250 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Vitamin B12, Riboflavin. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Methyl B Complete by Pure TheraPro Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Methyl B Complete by Pure TheraPro Rx — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Methyl B Complete by Pure TheraPro Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Vitamin B12” is listed as a grouped ingredient — the label gives one combined amount (1,000 mcg) without saying how much of each component you get.

Methyl B Complete contains 6 active ingredients: three forms of B vitamins—vitamin B6, riboflavin, and two forms of vitamin B12 (adenosylcobalamin and mecobalactive)—plus trimethylglycine and folate. The B vitamins help your body use food for energy and support nerve and red blood cell function.

Trimethylglycine and folate play roles in metabolism and cell function. The capsule also contains two inactive ingredients: DRcaps (the capsule material) and tricalcium phosphate (a filler).

All the B vitamins are water-soluble, so your body removes excess amounts through urine.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: MTHFR support and B vitamin nutrient.
  • We looked for evidence on: Fatigue, Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Diabetic neuropathy, Isoniazid-induced neuropathy, Hyperhomocysteinemia — and 4 related terms.
  • The strongest evidence on file: Vitamin B6 is rated "Likely Effective" for Hyperhomocysteinemia (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B6 is rated "Possibly Effective" for Pregnancy-induced nausea and vomiting, Premenstrual syndrome (PMS).

Vitamin B6 is established as effective for sideroblastic anemia (a type of blood disorder) and vitamin B6 deficiency itself, and likely effective for high homocysteine levels (a blood marker). It's possibly effective for pregnancy-related nausea and vomiting, though it should only be used under a doctor's guidance if you're pregnant.

Vitamin B12 (both forms) is effective for vitamin B12 deficiency and a rare absorption disorder called Imerslund-Grasbeck disease, and likely effective for cyanide poisoning. It's possibly effective for canker sores and nerve pain after shingles.

We hold no effectiveness data for riboflavin, trimethylglycine, or folate in this product.

The evidence, ingredient by ingredient Vitamin B12 Vitamin B6 Riboflavin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated at doses under 100 mg daily. Common mild effects at any dose include headache, nausea, heartburn, and loss of appetite.

High doses or long-term use can damage nerves (sensory neuropathy)—the risk rises significantly above 1,000 mg daily or cumulative doses of 1,000 grams or more, though nerve damage can occur at lower doses too. Riboflavin is very safe; any excess leaves in your urine.

At high doses you may notice bright yellow urine or mild nausea. Vitamin B12 is generally very safe with no upper limit; it's well tolerated and any excess is removed in your urine.

Rare allergic reactions (rash, itching) have been reported, and there's a theoretical concern that correcting severe B12 deficiency could trigger a dangerous drop in potassium—talk with your doctor if you have severe deficiency. Pregnancy and lactation safety data show vitamin B6 is likely safe in pregnancy (though one rating notes possibly unsafe—follow your doctor's advice), and riboflavin and B12 are likely safe during both pregnancy and breastfeeding at recommended amounts.

Side effects, ingredient by ingredient Vitamin B12 Vitamin B6 Riboflavin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin B12, Vitamin B6, Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 250 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, check with your own doctor or pharmacist if you're on antihypertensive drugs (blood pressure medications), seizure medications (phenobarbital or phenytoin), amiodarone, tetracycline antibiotics, or metformin. These have documented interactions with the B vitamins in this formula—especially at higher doses of B6, which can lower blood pressure and seizure medication levels.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Methyl B Complete is a multiB vitamin supplement useful if you're deficient in B6 or B12 or need these vitamins for a specific condition like sideroblastic anemia. If you take blood pressure medications, seizure medications, amiodarone, tetracycline antibiotics, or metformin for diabetes, check with your own doctor or pharmacist before starting—this product may interact.

Vitamin B6 at high doses can harm nerves over time, so stick to the label dose and talk with your healthcare provider about whether it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Methyl B Complete, straight from the product label.

Brand Pure TheraPro Rx
Barcode (UPC) X000S6O43B
Net contents 120 Acid-Resistant Capsule(s)
Market status On market
Date entered into DSLD Jan 24, 2024
DSLD ID 305957
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Methyl B Complete by Pure TheraPro Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
120
UPC/BARCODE
X000S6O43B
IngredientAmount% DV
Vitamin B121000 mcg41667%
Vitamin B615 mg882%
Riboflavin25 mg1923%
Adenosylcobalamin500 mcg--
Trimethylglycine650 mg--
Mecobalactive500 mcg--
Folate3400 mcg DFE850%

Other ingredients: DRcaps, Tricalcium Phosphate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: take one (1) capsule one to two times daily, or as directed by a healthcare practitioner.

Precautions

Warning: individuals taking medication, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Warning: individuals taking medication, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Do not use if tamper seal is damaged.

Keep out of reach of children.

Formulation

Please note: natural color variations from light yellow to bright orange may occur between lots.

Formulated to exclude: fillers, gluten, wheat, soy, corn, yeast, animal or dairy products, shellfish, fish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMO's), artificial preservatives, sweeteners or colors.

Vegan

Supports energy production, methylation & detoxification

Formulated, tested & packaged in the USA

Formula

Methyl B complete is a cutting-edge formula compromised of 5 key nutrients: quatrefolic folate for maximum MTHFR support, trimethylglycine, a super-bioactive blend of vitamin B12 (including patented mecobalactive methylcobalamin), as well as vitamin B6 in its coenzyme form and the highest-quality vitamin B2 (riboflavin). This synergistic formula is responsible for supporting healthy homocysteine levels, vibrant energy production, optimal detoxification, a robust metabolism, and peak cognitive function.

Storage

Storage: keep tightly closed in a cool, dry place.

For optimal freshness, do not discard desiccant.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Good Manufacturing Practice GMP Certified

FDA Statement of Identity

Professional Dietary Supplement

Brand IP Statement(s)

Quatrefolic produced under US Patent 7,947,662. MecobalActive The active form of B12 Mecobalacative is a trademark of Healthtech Bio Actives, S.L.U. DRcaps hypromellose capsules Quatrefolic is a registered trademark of Gnosis SPA Corp. DRcaps & logo are trademarks of Lonza or its affiliates. Copyright 2022 Pure TheraPro RX.

Pure TheraPro Rx Purity is priority

General Statements

Please recycle

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Methyl B Complete by Pure TheraPro Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Methyl B Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Methyl B Complete by Pure TheraPro Rx

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container120 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Vitamin B6

Interacts with
210 drugs
15 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Riboflavin

Interacts with
20 drugs
25 mg per serving Form: Riboflavin 5-Phosphate Sodium

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Trimethylglycine

650 mg per serving

Folate

3400 mcg DFE per serving Form: Quatrefolic

Other (inactive) ingredients: DRcaps, Tricalcium Phosphate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Methyl B Complete by Pure TheraPro Rx Drug Interactions

Want to check YOUR meds against Methyl B Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
250Drugs
225 Moderate 25 Minor

Ingredients driving the most interactions

Vitamin B6 210
Vitamin B12 20
Riboflavin 20

Individual Drug Interactions

The ingredients in Methyl B Complete interact with 250 drugs. Click any drug to see the details.

3 of the 5 ingredients in Methyl B Complete interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Vitamin B12 Riboflavin

Each ingredient & the kinds of drugs it affects

For each ingredient in Methyl B Complete with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Methyl B Complete, from the product label.

Pure TheraPro Rx

See all Pure TheraPro Rx products
Name
Pure TheraPro Rx
Street Address
8781 Sheridan Blvd #6080
City
Westminster
State
CO
ZipCode
80003
Phone Number
888-655-4648
Web Address
Purethera.com
Pharmacist Counseling Corner

Methyl B Complete by Pure TheraPro Rx: Common Questions

Does Methyl B Complete by Pure TheraPro Rx interact with any medications?
Yes. Based on its ingredients, Methyl B Complete has a known interaction with 250 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Methyl B Complete contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this while I'm pregnant?
The safety data shows vitamin B6 is likely safe at normal amounts but one source notes it's possibly unsafe—you need personalized advice from your doctor. Riboflavin and vitamin B12 are both likely safe during pregnancy at recommended doses. Talk with your healthcare provider before starting any supplement in pregnancy.
Can high doses of B6 in this product damage my nerves?
Yes, high doses of vitamin B6 over time can cause sensory nerve damage (paresthesia or neuropathy). The risk rises sharply above 1,000 mg daily, but nerve damage can happen at lower doses too with long-term use. Stick to the label dose and avoid going beyond what's recommended.
What's the difference between the two B12 forms in this product?
This product contains adenosylcobalamin and mecobalactive—both are forms of vitamin B12 (cobalamin). They work the same way in your body to treat B12 deficiency and support nerve and blood cell health. The product facts don't explain why both forms are included.
Will this help my vitamin B deficiency?
Vitamin B6 is effective for B6 deficiency, and both B12 forms are effective for B12 deficiency. If that's what you're taking it for, the evidence supports it. Ask your doctor to confirm which B vitamins you're actually low in so you know whether this formula fits your needs.
What are the most common side effects?
At normal doses, the most common effects are mild: headache, nausea, heartburn, loss of appetite, and abdominal pain. Riboflavin can also cause bright yellow urine and dose-related nausea. These usually aren't serious, but tell your pharmacist if they bother you.
I'm taking metformin for diabetes—is this product okay?
The B12 forms in this product have a Minor interaction with metformin: metformin can lower B12 levels over time, so taking a B12 supplement may actually help. Still, check with your own doctor or pharmacist to make sure the timing and dose work for your situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Methyl B Complete is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Methyl B Complete label
Go deeper

The Full Monographs Behind Methyl B Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph →
Sources

Sources & How We Checked

Methyl B Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
  5. Collin, S. M., Metcalfe, C., Refsum, H., Lewis, S. J., Zuccolo, L., Smith, G. D., Chen, L., Harris, R., Davis, M., Marsden, G., Johnston, C., Lane, J. A., Ebbing, M., Bonaa, K. H., Nygard, O., Ueland, P. M., Grau, M. V., Baron, J. A., Donovan, J. L., Nea
  6. Geissbuhler, P., Mermillod, B., and Rapin, C. H. Elevated serum vitamin B12 levels associated with CRP as a predictive factor of mortality in palliative care cancer patients: a prospective study over five years. J.Pain Symptom.Manage. 2000;20(2):93-103. PubMed
  7. Salles, N., Herrmann, F., Sakbani, K., Rapin, C. H., and Sieber, C. High vitamin B12 level: a strong predictor of mortality in elderly inpatients. J Am Geriatr.Soc 2005;53(5):917-918.
  8. Looker, H. C., Fagot-Campagna, A., Gunter, E. W., Pfeiffer, C. M., Sievers, M. L., Bennett, P. H., Nelson, R. G., Hanson, R. L., and Knowler, W. C. Homocysteine and vitamin B(12) concentrations and mortality rates in type 2 diabetes. Diabetes Metab Res R
  9. Uhl, W., Nolting, A., Golor, G., Rost, K. L., and Kovar, A. Safety of hydroxocobalamin in healthy volunteers in a randomized, placebo-controlled study. Clin Toxicol (Phila) 2006;44 Suppl 1:17-28. PubMed
  10. Borron, S. W., Baud, F. J., Barriot, P., Imbert, M., and Bismuth, C. Prospective study of hydroxocobalamin for acute cyanide poisoning in smoke inhalation. Ann Emerg.Med 2007;49(6):794-801, 801. PubMed
  11. Borron, S. W., Baud, F. J., Megarbane, B., and Bismuth, C. Hydroxocobalamin for severe acute cyanide poisoning by ingestion or inhalation. Am J Emerg.Med 2007;25(5):551-558. PubMed
  12. Lewis, J. G. Gout, Steatorrhoea, and Megaloblastic Anaemia. Ann Rheum.Dis 1962;21(3):284-286. PubMed
  13. Tal, S., Shavit, Y., Stern, F., and Malnick, S. Association between vitamin B12 levels and mortality in hospitalized older adults. J Am Geriatr.Soc 2010;58(3):523-526. PubMed
  14. Baztan, J. J., Gavidia, J. J., Gomez-Pavon, J., Esteve, A., and Ruiperez, I. High vitamin B12 levels and in-hospital mortality. J Am Geriatr.Soc 2010;58(11):2237-2238. PubMed
  15. Omboni, E., Checchini, M., and Longoni, F. [Hypopotassemia and megaloblastic anemia. Presentation of a case]. Minerva Med 8-31-1987;78(16):1255-1257.
  16. Aalfs As, Scholvinck LH, Horvath B. Acneiform eruption in a 5-year old due to vitamin B12 supplementation. Eur J Dermatol 2013;23(5):726-7. PubMed
  17. Balta I, Ozuguz P. Vitamin B12-induced acneiform eruption. Cutan Ocul Toxicol 2014;33(2):94-5. PubMed
  18. Carman KB, Belgemen T, Yis U. Involuntary movements misdiagnosed as seizure during vitamin B12 treatment. Pediatr Emerg Care 2013;29(11):1223-4. PubMed
  19. Djuric V, Bogic M, Popadic AP, et al. Anaphylactic reaction to hydroxycobalamin with tolerance to cyanocobalamin. Ann Allergy Asthma Immunol 2012;108(3):207-8. PubMed
  20. Kartel O, Gulec M, Demirel F, et al. Vitamin B12 allergy and successful desensitization with cyanocobalamin: A case report. Allergol Immunopath (Madr) 2012;40(5):324-5.
  21. Patiroglu T, Unal E, Yildirim S. Infantile tremor syndrome associated with cobalamin therapy: A case report. Clin Neurol Neurosurg 2013;115(9):1903-5. PubMed
  22. Schulte S, Barkema LW, Kardaun SH. Long-lasting atypical acneiform eruption with prominent comedones induced by hydroxocobalamin (vitamin B12). J Dtsch Dermatol Ges 2014;12(6):502-3.
  23. Zanus C, Alberini E, Costa P, et al. Involuntary movements after correction of vitamin B12 deficiency: A video-case report. Epileptic Disord 2012;14(2):174-80. PubMed
  24. Fanidi A, Carreras-Torres R, Larose TL, et al. Is high vitamin B12 status a cause of lung cancer? Int J Cancer. 2019 Sep 15;145(6):1499-1503. PubMed
  25. Fujita Y, Mizukami T, Maya Y, et al. Vitamin B12 allergy manifesting as lymphomatoid contact dermatitis. Eur J Dermatol. 2020;30(3):304-305. PubMed
  26. Dépret F, Hoffmann C, Daoud L, et al. Association between hydroxocobalamin administration and acute kidney injury after smoke inhalation: a multicenter retrospective study. Crit Care. 2019;23(1):421. PubMed
  27. Khairan P, Sobue T, Eshak ES, et al. Association of dietary intakes of vitamin B12, vitamin B6, folate, and methionine with the risk of esophageal cancer: the Japan Public Health Center-based (JPHC) prospective study. BMC Cancer 2021;21(1):982. PubMed
  28. Evans J, Pandya A, Ding Y, Qunibi WY. Hydroxocobalamin-Induced Oxalate Nephropathy in a Patient With Smoke Inhalation. Kidney Int Rep 2021;6(8):2228-2231. PubMed
  29. Lacombe V, Chabrun F, Lacout C, et al. Persistent elevation of plasma vitamin B12 is strongly associated with solid cancer. Sci Rep 2021;11(1):13361. PubMed
  30. Pegalajar-García MD, Cebolla-Verdugo M, Prados-Carmona Á, Llamas-Segura C, Navarro-Triviño FJ. Systemic allergic dermatitis to cobalt present in cyanocobalamin supplementation. Contact Dermatitis 2023;89(3):203-205. PubMed

See these in context on the Vitamin B12 monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
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See these in context on the Vitamin B6 monograph →

Riboflavin 5 references
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See these in context on the Riboflavin monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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