Interactions on record — worth a quick check against your medications. Based on 3 of 5 ingredients. Check your meds →
Dietary supplement

Methyl B Complete Ingredients & Drug Interactions

by Pure TheraPro Rx

Methyl B Complete label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Methyl B Complete against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Methyl B Complete is a dietary supplement by Pure TheraPro Rx with 5 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 250 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, Riboflavin, Vitamin B12. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Methyl B Complete by Pure TheraPro Rx

Ask about any prescription or over-the-counter medication and we check it for interactions with Methyl B Complete by Pure TheraPro Rx — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Methyl B Complete by Pure TheraPro Rx

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 6 of its 6 active ingredients.
  • “Folate” is listed as a grouped ingredient — the label gives one combined amount (3,400 mcg DFE) without saying how much of each component you get.
  • “Vitamin B12” is listed as a grouped ingredient — the label gives one combined amount (1,000 mcg) without saying how much of each component you get.

Methyl B Complete contains 6 active ingredients: vitamin B6, folate, riboflavin, adenosylcobalamin (a form of vitamin B12), vitamin B12 (which is a container for component ingredients listed separately), trimethylglycine, and mecobalactive (another B12 form). Together they support energy metabolism, nerve function, and red blood cell formation.

The product also contains inactive ingredients—a capsule material (DRcaps) and tricalcium phosphate as a filler.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Homocysteine metabolism and B vitamin support.
  • We looked for evidence on: Hyperhomocysteinemia, Fatigue, Peripheral neuropathy, Chemotherapy-induced peripheral neuropathy, Isoniazid-induced neuropathy, Premenstrual syndrome (PMS) — and 4 related terms.
  • The strongest evidence on file: Vitamin B6 is rated "Likely Effective" for Hyperhomocysteinemia (Natural Medicines).
  • Also on file: Vitamin B12 is rated "Possibly Effective" for Hyperhomocysteinemia.
  • Also on file: Vitamin B6 is rated "Possibly Effective" for Pregnancy-induced nausea and vomiting, Premenstrual syndrome (PMS).

Vitamin B6 is effective for sideroblastic anemia and B6 deficiency, likely effective for high homocysteine (a heart risk marker), and possibly effective for pregnancy-related nausea. The B12 forms (adenosylcobalamin and mecobalactive) are effective for B12 deficiency and a rare absorption disorder (Imerslund-Grasbeck disease), likely effective for cyanide poisoning, and possibly effective for canker sores and nerve pain after shingles.

Riboflavin and folate have no established effectiveness ratings in our data. Trimethylglycine and quatrefolic also have no effectiveness data on file.

The evidence, ingredient by ingredient Vitamin B6 Riboflavin Vitamin B12

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is well tolerated at doses under 100 mg daily, though doses above that over time can damage nerves (sensory neuropathy). Doses over 1,000 mg daily or cumulative totals of 1,000 grams or more carry the highest risk, but neuropathy can happen at lower doses too.

Common side effects include abdominal pain, headache, heartburn, nausea, and drowsiness. Riboflavin is very safe; excess leaves your body in urine.

You may notice bright yellow urine or mild nausea at higher doses. B12 (adenosylcobalamin and mecobalactive) is very safe with no upper limit; excess is excreted.

Rarely, B12 can cause allergic reactions like rash or itching. For pregnancy: vitamin B6 is likely safe, though one rating notes possibly unsafe—talk with your doctor about dosing.

Riboflavin and B12 are likely safe in pregnancy and lactation at recommended amounts.

Side effects, ingredient by ingredient Vitamin B6 Riboflavin Vitamin B12

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 3 matched ingredients can interact with medications — Vitamin B12, Vitamin B6, Riboflavin.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 250 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your doctor or pharmacist before starting if you take seizure medications (phenobarbital or phenytoin), blood pressure-lowering drugs, the heart rhythm medication amiodarone, tetracycline antibiotics, or metformin for diabetes. These have Moderate or Minor interactions documented with the B vitamins in this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This is a B-vitamin complex useful if you're deficient in B6 or B12 or managing high homocysteine. Be careful if you take seizure medications (phenobarbital or phenytoin), blood pressure drugs, amiodarone, or metformin—check each one with your own pharmacist or doctor before starting.

Avoid high doses of B6 long-term to protect your nerves. Have the conversation with your doctor or pharmacist before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 4 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Methyl B Complete, straight from the product label.

Brand Pure TheraPro Rx
Barcode (UPC) X000S6O43B
Net contents 60 Acid-Resistant Capsule(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 305958
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Methyl B Complete by Pure TheraPro Rx, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
X000S6O43B
IngredientAmount% DV
Vitamin B615 mg882%
Folate3400 mcg DFE850%
Riboflavin25 mg1923%
Adenosylcobalamin500 mcg--
Vitamin B121000 mcg41667%
Trimethylglycine650 mg--
Mecobalactive500 mcg--
Quatrefolic4 mg--

Other ingredients: DRcaps, Tricalcium Phosphate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Take one (1) capsule one to two times daily, or as directed by a healthcare practitioner.

Precautions

Individuals taking medications, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Do not use if tamper seal is damaged.

Keep out of reach of children.

Individuals taking medications, children and pregnant or lactating women should consult their healthcare practitioner prior to use.

Formulation

Please note: Natural color variations from light yellow to bright orange may occur between lots.

Formulated to exclude: Fillers, gluten, wheat, soy, corn, yeast, animal or dairy products, shellfish, fish, peanuts, tree nuts, egg, ingredients derived from genetically modified organisms (GMO's), artificial preservatives, sweeteners or colors.

Vegan

Helps energize, supports methylation & detoxification

Formulated, tested & packaged in the USA

Formula

Methyl B Complete is a vegan formula that contains five key nutrients which are involved in homocysteine metabolism: Folate as Quatrefolic for increased bioactivity; Trimethylglycine; and Vitamins B12, B6, and B2 (riboflavin). This unique complex intends to support optimal methylation and help sustain healthy homocysteine levels already within normal range.

Storage

Storage: Keep tightly closed in a cool, dry place. For optimal freshness, do not discard desiccant.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

GMP Certified Good Manufacturing Practice

FDA Statement of Identity

Professional Dietary Supplement

Brand IP Statement(s)

Quatrefolic Quatrefolic is a registered trademark of Gnosis SPA Corp. Produced under US Patent 7,947,662.

DRcaps Hypromellose capsules DRcaps & logo are trademarks of Lonza or its affiliates. Mecobalactive The active form of B12 Mecobalactive is a trademark of healthtech bio actives, S.L.U.

Copyright 2022 Pure Therapro Rx

Pure TheraPro Rx Purity is priority

General Statements

Please recycle

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Methyl B Complete by Pure TheraPro Rx label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Methyl B Complete label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Methyl B Complete by Pure TheraPro Rx

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Vitamin B6

Interacts with
210 drugs
15 mg per serving Form: Pyridoxal 5-Phosphate

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Folate

3400 mcg DFE per serving
  • › Quatrefolic

Riboflavin

Interacts with
20 drugs
25 mg per serving Form: Riboflavin 5-Phosphate Sodium

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally...

Riboflavin monograph & interactions

Vitamin B12

Interacts with
20 drugs
1000 mcg per serving

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very h...

Vitamin B12 monograph & interactions

Trimethylglycine

650 mg per serving

Other (inactive) ingredients: DRcaps, Tricalcium Phosphate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Methyl B Complete by Pure TheraPro Rx Drug Interactions

Want to check YOUR meds against Methyl B Complete?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
250Drugs
225 Moderate 25 Minor

Ingredients driving the most interactions

Vitamin B6 210
Riboflavin 20
Vitamin B12 20

Individual Drug Interactions

The ingredients in Methyl B Complete interact with 250 drugs. Click any drug to see the details.

3 of the 5 ingredients in Methyl B Complete interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 Riboflavin Vitamin B12

Each ingredient & the kinds of drugs it affects

For each ingredient in Methyl B Complete with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

Riboflavin1 drug type · 20 drugs

Tetracycline Antibiotics

Theoretically, taking riboflavin with tetracycline antibiotics may decrease the potency of these antibiotics.
In vitro research suggests that riboflavin may inhibit the potency of tetracycline antibiotics. It is not clear if this effect is clinically significant, as this interaction has not been reported in humans.

Likelihood Possible Evidence D
Riboflavin full monograph & interactions

Vitamin B121 drug type · 20 drugs

Metformin (Glucophage)

Metformin, a common medication used to manage type 2 diabetes, has been associated with lower vitamin B12 levels in some individuals. Prolonged use of metformin can interfere with the absorption of B12 in the digestive system, potentially leading to a deficiency in this essential vitamin.

Likelihood Possible Evidence A
Vitamin B12 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Methyl B Complete, from the product label.

Pure TheraPro Rx

See all Pure TheraPro Rx products
Name
Pure TheraPro Rx
Street Address
8781 Sheridan Blvd #6080
City
Westminster
State
CO
ZipCode
80003
Phone Number
888-655-4648
Web Address
Purethera.com
Pharmacist Counseling Corner

Methyl B Complete by Pure TheraPro Rx: Common Questions

Does Methyl B Complete by Pure TheraPro Rx interact with any medications?
Yes. Based on its ingredients, Methyl B Complete has a known interaction with 250 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Methyl B Complete contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
Vitamin B6 has mixed ratings—one says likely safe, another says possibly unsafe in pregnancy—so you need to talk with your doctor about dosing and whether it's right for you. Riboflavin and B12 are likely safe at recommended amounts in pregnancy. Always check with your own provider before starting any supplement while pregnant.
Can I take this if I'm breastfeeding?
Vitamin B6, riboflavin, and B12 are all considered safe at recommended amounts while breastfeeding. If you're thinking about higher doses, clear that with your doctor or pharmacist first.
What does vitamin B6 actually do?
B6 supports nerve function, helps your body use amino acids, and is needed for red blood cell formation and immune health. It's effective for treating B6 deficiency and sideroblastic anemia, and may help with nausea in pregnancy.
Why are there two B12 ingredients (adenosylcobalamin and mecobalactive)?
The product contains two different forms of vitamin B12 to support different metabolic pathways. Both are effective for B12 deficiency and work similarly in your body.
Can high doses of B6 cause nerve damage?
Yes. Doses over 1,000 mg daily or long-term use at high levels can damage nerves (sensory neuropathy). Even lower doses can cause it with extended use. This product should be used as directed on the label.
Will this turn my urine yellow?
Riboflavin at higher doses can cause bright yellow urine—that's normal and harmless. Excess B vitamins are water-soluble and leave your body in urine.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Methyl B Complete is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Methyl B Complete label
Go deeper

The Full Monographs Behind Methyl B Complete’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph → Herb & supplement monograph

Riboflavin

Interacts with 20 drugs

Riboflavin (vitamin B2) is an essential nutrient your body needs to turn food into energy and to keep skin, eyes, and nerves healthy. It is generally very safe at typical doses, and the stro...

Read the full Riboflavin monograph → Herb & supplement monograph

Vitamin B12

Interacts with 20 drugs

Vitamin B12 (cobalamin) is an essential nutrient your body needs to make red blood cells, keep nerves healthy, and support DNA. Supplements are very helpful for people who are deficient — su...

Read the full Vitamin B12 monograph →
Sources

Sources & How We Checked

Methyl B Complete's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 67 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Riboflavin 5 references
  1. Schoenen J, Jacquy J, Lenaerts M. Effectiveness of high-dose riboflavin in migraine prophylaxis. A randomized controlled trial. Neurology 1998;50:466-70. PubMed
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Leeson LJ, Weidenheimer JF. Stability of tetracycline and riboflavin. J Pharm Sci. 1969;58(3):355-7. PubMed
  4. MacLennan, S. C., Wade, F. M., Forrest, K. M., Ratanayake, P. D., Fagan, E., and Antony, J. High-dose riboflavin for migraine prophylaxis in children: a double-blind, randomized, placebo-controlled trial. J Child Neurol. 2008;23(11):1300-1304.
  5. Dietary reference intakes (DRIs): estimated average requirements. Food and Nutrition Board, Institute of Medicine, National Academics. https://www.nal.usda.gov/sites/default/files/fnic_uploads//recommended_intakes_individuals.pdf Accessed July 24, 2017.

See these in context on the Riboflavin monograph →

Vitamin B12 30 references
  1. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  2. Hartman TJ, Woodson K, Stolzenberg-Solomon R, et al. Association of the B-vitamins pyridoxal 5'-phosphate (B6), B12, and folate with lung cancer risk in older men. Am J Epidemiol 2001;153:688-94.. DOI
  3. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  4. Lange H, Suryapranata H, De Luca G, et al. Folate therapy and in-stent restenosis after coronary stenting. N Engl J Med 2004;350:2673-81. PubMed
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See these in context on the Vitamin B12 monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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