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Dietary supplement

Micronized Glutamine Ingredients & Drug Interactions

by Bodybuilding.com Signature

Micronized Glutamine label
See full label image
Powder Category: Amino Acid/protein
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Micronized Glutamine against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Micronized Glutamine is a dietary supplement by Bodybuilding.com Signature with 1 active ingredient. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 50 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Micronized Glutamine by Bodybuilding.com Signature

Ask about any prescription or over-the-counter medication and we check it for interactions with Micronized Glutamine by Bodybuilding.com Signature — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Micronized Glutamine by Bodybuilding.com Signature

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 20, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product is pure L-glutamine, an amino acid your body makes naturally and uses for gut health, immune function, and muscle recovery. It's a single active ingredient in micronized powder form, which means the particles are finely ground for easier mixing and absorption.

There are no other active ingredients or fillers listed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Muscle recovery and post-workout performance.
  • We looked for evidence on: Exercise-induced muscle damage, Athletic performance, Postoperative recovery, Wound healing, Critical illness (trauma), Sports recovery — and 2 related terms.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Critical illness (trauma) (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Effective" for Postoperative recovery.
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.

Glutamine is effective for sickle cell disease. It's possibly effective for HIV/AIDS-related wasting, recovery after surgery, and critical illness from trauma.

The evidence we hold doesn't establish how it works for other purposes people sometimes use it for, like general muscle building or athletic performance.

The evidence, ingredient by ingredient Glutamine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults. The most common side effects from oral doses are digestive issues—belching, bloating, constipation, diarrhea, flatulence, nausea, vomiting, and stomach pain—plus headache and musculoskeletal pain.

A couple of rare cases of mood changes (mania) have been reported in people with bipolar disorder taking high doses. If you have kidney or liver disease, use glutamine only under your doctor's supervision.

Safety data in pregnancy is limited, but it's rated likely safe. There isn't enough data to know if it's safe at supplement doses while breastfeeding, so talk with your doctor or pharmacist about whether it's right for you.

Side effects, ingredient by ingredient Glutamine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Glutamine.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications.
  • For scale: 50 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Anticonvulsant medications (seizure drugs) are the main class to double-check. Glutamine may theoretically reduce how well these drugs work, though it hasn't been seen in patients yet.

Check your exact medications with the tool on this page, and clear it with your own doctor or pharmacist before you start.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Glutamine works for sickle cell disease and may help with recovery after surgery, trauma, or with certain wasting conditions. If you take seizure medication, check with your doctor or pharmacist before starting—the interaction risk is theoretical but worth confirming for your situation.

Generally well tolerated, though digestive side effects are common at higher doses. Talk it over with your own healthcare provider to see if this product makes sense for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Feb 21, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Micronized Glutamine, straight from the product label.

Brand Bodybuilding.com Signature
Barcode (UPC) 853002007603
Net contents 17.64 Ounce(s); 500 Gram(s)
Market status On market
Date entered into DSLD Feb 21, 2023
DSLD ID 282411
Product type Amino Acid/protein
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Micronized Glutamine by Bodybuilding.com Signature, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
5 Gram(s)
Maximum serving Sizes:
5 Gram(s)
Servings per container
100
UPC/BARCODE
853002007603
IngredientAmount% DV
L-Glutamine5 Gram(s)--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

We created our Signature line of products because we believe it shouldn't be a workout to get the highest quality supplements without paying the highest prices. As a trusted fitness brand, we've been delivering top-quality products to aid your fitness journey for over two decades. We don't take shortcuts and we don't make excuses, so you can trust that every Signature supplement is filler-free and formulated with effective doses of research-backed ingredients. Bottom line: We're crushing it so you can go crush your personal goals.

Suggested/Recommended/Usage/Directions

Directions for Use: Mix 1 level scoop with 4 - 6 oz. of water or combine with your favorite flavored supplements. For optimal results, take at least 1 serving post workout or prior to bed.

Precautions

Warnings: Consult your physician before using this product if you're taking any medications or are under a physician's care for a medical condition. Not for use by those under the age of 18 or by women that are pregnant, trying to get pregnant or nursing.

Not for use by those under the age of 18 or by women that are pregnant, trying to get pregnant or nursing.

Made in a facility that processes dairy, soy, egg, and tree nuts.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Formula

5 g glutamine

Formulation

Micronized for optimal absorption & post workout recovery

Gluten and soy free

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Micronized Glutamine by Bodybuilding.com Signature label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Micronized Glutamine label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Micronized Glutamine by Bodybuilding.com Signature

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size5 Gram(s) Dosage formPowder Servings per container100 Amounts shown are per serving.

L-Glutamine

Interacts with
50 drugs
5 Gram(s) per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions
Interaction report

Micronized Glutamine by Bodybuilding.com Signature Drug Interactions

Want to check YOUR meds against Micronized Glutamine?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
50Drugs
50 Moderate

Ingredients driving the most interactions

L-Glutamine 50

Individual Drug Interactions

The ingredients in Micronized Glutamine interact with 50 drugs. Click any drug to see the details.

1 of the 1 ingredient in Micronized Glutamine interact with drugs. Each result below shows which ingredient is responsible. L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in Micronized Glutamine with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Micronized Glutamine, from the product label.

Bodybuilding.com Signature

See all Bodybuilding.com Signature products
Name
Bodybuilding.com
Street Address
4900 Engineers Way, Suite 108, N.
City
Las Vegas
State
Nevada
ZipCode
89081
Web Address
Bodybuilding.com
Pharmacist Counseling Corner

Micronized Glutamine by Bodybuilding.com Signature: Common Questions

Does Micronized Glutamine by Bodybuilding.com Signature interact with any medications?
Yes. Based on its ingredients, Micronized Glutamine has a known interaction with 50 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Micronized Glutamine contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is L-glutamine and why is it in this product?
L-glutamine is an amino acid your body naturally produces. It plays a role in gut health, immune function, and muscle recovery. This supplement is used to boost glutamine levels, especially for people with sickle cell disease or recovery needs.
Is glutamine safe if I'm pregnant or breastfeeding?
Glutamine is rated likely safe in pregnancy. If you're breastfeeding, there isn't enough safety data, so talk with your doctor or pharmacist about whether supplemental glutamine is right for you.
What side effects might I notice?
Digestive issues are the most common—bloating, gas, constipation, diarrhea, nausea, and stomach pain. Headache and muscle pain have also been reported. These tend to happen more at higher doses and often improve if you lower the amount.
Who shouldn't take this without talking to their doctor first?
People with kidney or liver disease should only use it under medical supervision. If you take seizure medication (anticonvulsants), check with your doctor or pharmacist first because glutamine might interfere with how well those drugs work.
Does glutamine actually work for muscle building?
The data we hold shows glutamine is effective for sickle cell disease and possibly effective for recovery after surgery, trauma, and HIV/AIDS-related wasting. We don't have established evidence for general muscle building or athletic performance.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Micronized Glutamine is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Micronized Glutamine label
Go deeper

The Full Monographs Behind Micronized Glutamine’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph →
Sources

Sources & How We Checked

Micronized Glutamine's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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