Interactions on record — worth a quick check against your medications. Based on 2 of 7 ingredients. Check your meds →
Dietary supplement

N'Gage Glacier Punch Ingredients & Drug Interactions

by Axis Labs

N'Gage Glacier Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking N'Gage Glacier Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

N'Gage Glacier Punch is a dietary supplement by Axis Labs with 7 active ingredients. Its ingredients are commonly taken for muscle recovery and sports performance, gut health and 'leaky gut', recovery from severe illness or injury.Based on those ingredients, 249 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6, L-Glutamine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against N'Gage Glacier Punch by Axis Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with N'Gage Glacier Punch by Axis Labs — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of N'Gage Glacier Punch by Axis Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • “2:1:1 AjiPure Instantized BCAAs” is listed as a grouped ingredient — the label gives one combined amount (5,000 mg) without saying how much of each component you get.

N'Gage Glacier Punch contains 5 active ingredients: L-glutamine and three branched-chain amino acids (L-leucine, L-isoleucine, and L-valine), plus vitamin B6 and a proprietary blend called 2:1:1 AjiPure Instantized BCAAs. These are amino acids your body uses to build and repair muscle tissue.

The product also contains inactive ingredients—natural and artificial flavors, sucralose (an artificial sweetener), and lecithin (an emulsifier).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle recovery and sports performance.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Postoperative recovery, Wound healing, muscle protein synthesis, amino acid metabolism.
  • The strongest evidence on file: Glutamine is rated "Possibly Effective" for Postoperative recovery (Natural Medicines).
  • Also on file: Glutamine is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Glutamine is rated "Insufficient Reliable Evidence To Rate" for Wound healing, Exercise-induced muscle damage.

L-glutamine is effective for sickle cell disease and possibly effective for HIV/AIDS-related wasting, recovery after surgery, and critical illness from trauma. Vitamin B6 is effective for sideroblastic anemia (a blood disorder), vitamin B6 deficiency itself, and a rare condition called pyridoxine-dependent epilepsy.

It's likely effective for high homocysteine levels and possibly effective for pregnancy-related nausea and vomiting. We hold no effectiveness data for the branched-chain amino acids in this product.

The evidence, ingredient by ingredient Glutamine Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

L-glutamine is generally well tolerated in healthy adults but requires medical supervision if you have kidney or liver disease. There isn't enough safety data to recommend supplemental doses unless your doctor advises it, and while it's rated Likely Safe in pregnancy, there isn't enough information to recommend it while breastfeeding without a clinician's input.

The most common side effects are digestive—belching, bloating, constipation, diarrhea, flatulence, nausea, and vomiting—along with headache and muscle pain. Two people with bipolar disorder taking 4 grams daily experienced mania or hypomania.

Vitamin B6 is well tolerated at doses under 100 mg daily but can damage nerves (sensory neuropathy) at high doses, especially 1000 mg daily or more or cumulative doses of 1,000 grams or more. Common side effects include headache, heartburn, nausea, and stomach pain.

It's Likely Safe in pregnancy at recommended levels (often used for morning sickness under a doctor's guidance) and Likely Safe while breastfeeding, though one piece of evidence flagged a possible increased cancer risk at higher intakes—talk with your doctor about what's right for you. We hold no safety information on file for L-leucine, L-isoleucine, or L-valine.

Side effects, ingredient by ingredient Glutamine Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Glutamine, Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: seizure medications; Parkinson's medications.
  • For scale: 249 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your own doctor or pharmacist if you take anticonvulsant medications (phenytoin, phenobarbital, or others), blood pressure medications, amiodarone, or levodopa. Vitamin B6 at high doses can reduce how well some of these drugs work or make their side effects worse.

No interactions are documented in our data for L-leucine, L-isoleucine, or L-valine.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is meant for muscle recovery and support, and its amino acids are well studied for that purpose. If you take any prescription medication—especially anticonvulsants, blood pressure drugs, amiodarone, or levodopa—you need to check with your own doctor or pharmacist before adding this supplement, because vitamin B6 and possibly L-glutamine can interfere with how those drugs work.

People with kidney or liver disease should also get medical clearance first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 26, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about N'Gage Glacier Punch, straight from the product label.

Brand Axis Labs
Barcode (UPC) 689076955102
Net contents 304.85 g
Market status On market
Date entered into DSLD Oct 26, 2011
DSLD ID 713
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for N'Gage Glacier Punch by Axis Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
8.71 Gram(s)
Maximum serving Sizes:
8.71 Gram(s)
Servings per container
35
UPC/BARCODE
689076955102
IngredientAmount% DV
Calories10 {Calories}--
Total Carbohydrates0 g--
L-Glutamine2500 mg--
Sugar0 g--
Calories from Fat0 NP--
Total Fat0 g--
Vitamin B610 mg500%
Protein0 g--
Saturated Fat0 g--
L-Leucine2500 mg--
L-Isoleucine1250 mg--
L-Valine1250 mg--
2:1:1 AjiPure Instantized BCAAs5000 mg--

Other ingredients: Natural and Artificial flavors, Sucralose, Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

int: 303-221-2110

+5 SERVINGS FREE

100% Instantized AjiPure(R)Aminos*

AJI PURE(R) AMINO ACIDS

iBCAA, GLUTAMINE AND VITAMIN B6

Introducing Axis Labs(R) N’GAGE(TM), The Recovery/Anabolic/Anti-Catabolic Solution. N’GAGE(TM) is loaded with the highest quality amino acids including Branch Chained Amino Acids (BCAAs) and Glutamine. N’GAGE(TM) is designed to be the perfect mid-day and post workout drink and to help you protect your hard earned muscle gains while providing you the anabolic platform to keep building muscle throughout the day.

Manufactured at a GMP GOOD MANUFACTURING FACILITY Approved Facility

Manufactured with Pride in the USA

Recover Faster from Workouts*

RECOVERY | ANABOLIC | ANTI-CATABOLIC

REFRESHING GLACIER PUNCH FLAVORING

Set Your Anabolic Platform*

Stack N’GAGE with Creatine Ethyl Ester for Explosive Results.

Visit www.axislabs.com for more information on our entire line of nutritional supplements.

What’s in your BCAA? Think twice before buying the cheapest BCAA you can find. Many companies cut costs by sourcing their BCAAs from sources such as Bird Feathers and Human Hair. That’s right, Human Hair. Pretty disgusting. N’GAGE(TM) is manufactured with only the highest quality BCAAs from AjiPure(R), derived from botanical sources. Demand More from Your Supplements! Demand Axis Labs(R) N’GAGE(TM)!*

Zero Sugar, Carbs, Stims or Dyes*

35 Servings

Brand IP Statement(s)

PERFORMANCE DRIVEN NUTRITION(R)

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

WARNING: KEEP OUT OF REACH OF CHILDREN. Do not use if you have any allergies to soy, pregnant or nursing. Consult your physician before using this or any dietary supplement.

Seals/Symbols

Potency and Purity GUARANTEED

Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, mix 1 scoop of N’GAGE(TM) with 8-10 oz of water. Consume 1 serving within 30 minutes following your workout. N’GAGE can also be consumed as a mid-day anabolic boost.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

N'Gage Glacier Punch by Axis Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

N'Gage Glacier Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in N'Gage Glacier Punch by Axis Labs

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size8.71 Gram(s) Dosage formPowder Servings per container35 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

L-Glutamine

Interacts with
50 drugs
2500 mg per serving

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle c...

L-Glutamine monograph & interactions

Sugar

0 g per serving

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Protein

0 g per serving

2:1:1 AjiPure Instantized BCAAs

5000 mg per serving
  • › L-Leucine
  • › L-Isoleucine
  • › L-Valine

Other (inactive) ingredients: Natural and Artificial flavors, Sucralose, Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

N'Gage Glacier Punch by Axis Labs Drug Interactions

Want to check YOUR meds against N'Gage Glacier Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
249Drugs
244 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210
L-Glutamine 50

Individual Drug Interactions

The ingredients in N'Gage Glacier Punch interact with 249 drugs. Click any drug to see the details.

2 of the 7 ingredients in N'Gage Glacier Punch interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6 L-Glutamine

Each ingredient & the kinds of drugs it affects

For each ingredient in N'Gage Glacier Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions

L-Glutamine1 drug type · 50 drugs

Anticonvulsants

Theoretically, glutamine might antagonize the effects of anticonvulsant medications.
Glutamine is metabolized to the excitatory neurotransmitter glutamate. Glutamate might have antagonistic effects with anticonvulsant drugs. However, this interaction has not yet been reported in humans.

Likelihood Possible Evidence D
L-Glutamine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for N'Gage Glacier Punch, from the product label.

Axis Labs

See all Axis Labs products
Name
Axis Labs
City
Centennial
State
CO
ZipCode
80112
Phone Number
1-877-294-7522
Web Address
www.AxisLabs.net
Pharmacist Counseling Corner

N'Gage Glacier Punch by Axis Labs: Common Questions

Does N'Gage Glacier Punch by Axis Labs interact with any medications?
Yes. Based on its ingredients, N'Gage Glacier Punch has a known interaction with 249 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
N'Gage Glacier Punch contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while I'm pregnant?
L-glutamine is rated Likely Safe in pregnancy. Vitamin B6 is also Likely Safe at recommended doses and is often used for morning sickness under a doctor's supervision. That said, there isn't enough safety data on the branched-chain amino acids. Talk with your doctor or midwife about whether this product is right for you during pregnancy, since it's an individual decision.
Can I take this while breastfeeding?
L-glutamine doesn't have enough safety data to recommend supplemental doses while breastfeeding without advice from a clinician, even though it's rated Likely Safe in pregnancy itself. Vitamin B6 is Likely Safe while breastfeeding at normal amounts. Check with your own doctor or pharmacist before starting, especially since we hold no safety information for the branched-chain amino acids.
What are BCAAs and why are they in here?
BCAAs (branched-chain amino acids) are three amino acids—leucine, isoleucine, and valine—that your body uses to build and repair muscle tissue. This product includes them as part of a muscle-support formula, along with L-glutamine and vitamin B6.
What are the common side effects?
L-glutamine may cause digestive upset—bloating, constipation, diarrhea, nausea, or vomiting—along with headache and muscle pain. Vitamin B6 at normal doses can cause headache, heartburn, nausea, and stomach pain. At very high doses, vitamin B6 can damage nerves over time.
Does it really work for muscle recovery?
We hold no effectiveness data in our files for branched-chain amino acids or for L-glutamine specifically used for muscle recovery. L-glutamine is effective for sickle cell disease and possibly effective for recovery after surgery and critical illness, but that's different from general muscle support claims.
Can I take this if I have kidney or liver disease?
L-glutamine requires medical supervision if you have kidney or liver disease. Talk with your own doctor before taking this product—they know your kidney and liver function and can advise you safely.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if N'Gage Glacier Punch is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

N'Gage Glacier Punch label
Go deeper

The Full Monographs Behind N'Gage Glacier Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Glutamine

Interacts with 50 drugs

Glutamine is the most abundant amino acid in the body and is usually made in your muscles. A prescription form is FDA-approved to help reduce sickle cell disease complications, but for most...

Read the full Glutamine monograph → Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

N'Gage Glacier Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 43 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Glutamine 11 references
  1. Miller AL. Therapeutic considerations of L-glutamine: a review of the literature. Altern Med Rev 1999;4:239-48..
  2. Bozzetti F, Biganzoli L, Gavazzi C, et al. Glutamine supplementation in cancer patients receiving chemotherapy: a double-blind randomized study. Nutrition 1997;13:748-51.. PubMed
  3. Mebane AH. L-Glutamine and mania. Am J Psychiatry 984;141:1302-3.
  4. Meldrum BS. Glutamate as a neurotransmitter in the brain: review of physiology and pathology. J Nutr 2000;130:1007S-15S.. PubMed
  5. Garlick PJ. Assessment of the safety of glutamine and other amino acids. J Nutr 2001;131:2556S-61S.. PubMed
  6. Chapman AG. Glutamate and epilepsy. J Nutr 2000;130:1043S-5S.. PubMed
  7. Ziegler TR. Glutamine supplementation in cancer patients receiving bone marrow transplantation and high dose chemotherapy. J Nutr 2001;131:2578S-84S.. PubMed
  8. Laviano A, Molfino A, Lacaria MT, Canelli A, De Leo S, Preziosa I, Rossi Fanelli F. Glutamine supplementation favors weight loss in nondieting obese female patients. A pilot study. Eur J Clin Nutr. 2014 Nov;68(11):1264-6. PubMed
  9. Endari (l-glutamine) [package insert]. Torrance, CA: Emmaus Medical,Inc; 2017.
  10. Niihara Y, Miller ST, Kanter J, et al. A Phase 3 Trial of l-Glutamine in Sickle Cell Disease. N Engl J Med 2018;379(3):226-35. doi: 10.1056/NEJMoa1715971.
  11. Ogden HB, Child RB, Fallowfield JL, et al. Gastrointestinal Tolerance of Low, Medium and High Dose Acute Oral l-Glutamine Supplementation in Healthy Adults: A Pilot Study. Nutrients. 2020;12(10):2953. PubMed

See these in context on the Glutamine monograph →

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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