Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

CBD 500 Peppermint Ingredients & Drug Interactions

by Axis Labs

CBD 500 Peppermint label
See full label image
Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking CBD 500 Peppermint against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

CBD 500 Peppermint is a dietary supplement by Axis Labs with 2 active ingredients. Its ingredients are commonly taken for plant-based protein source, heart health support, skin and hair health.Based on those ingredients, 938 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Hemp Oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against CBD 500 Peppermint by Axis Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with CBD 500 Peppermint by Axis Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of CBD 500 Peppermint by Axis Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (1 mL) without saying how much of each component you get.

This product contains 2 active ingredients: a proprietary blend and hemp oil. Hemp oil is derived from hemp seed and is the ingredient with documented effects in our database.

The product also contains inactive ingredients—stevia leaf extract and natural flavor—which are excipients added for sweetness and taste.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Hemp product and its label doesn't state a use — see Hemp's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we hold for hemp doesn't establish its effectiveness. We have insufficient reliable evidence to rate it for constipation, atopic dermatitis (eczema), or familial hypercholesterolemia (a condition affecting cholesterol levels).

If you're considering this product for a specific health goal, talk with your doctor or pharmacist about what the broader research shows.

The evidence, ingredient by ingredient Hemp

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Hemp seed foods are generally well tolerated in normal dietary amounts, but concentrated extracts and supplements like this one are less studied, so caution is advised. In larger doses, hemp seed oil appears to be well tolerated overall.

Rare serious side effects including allergic reactions (anaphylaxis), facial swelling, and heart rhythm problems (long QT syndrome and syncope) have been reported. There are also uncommon case reports of hemp seed allergy with symptoms like hives, swelling, and breathing difficulty.

At very high doses in children, elevated liver enzymes and hepatitis have been reported in one case.

Side effects, ingredient by ingredient Hemp

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Hemp.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 939 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take estrogen therapy (Moderate interaction), blood thinners, blood pressure medications, or ACE inhibitors for hypertension (all Minor). Also flag any medications that rely heavily on your liver's CYP1A2 or CYP3A4 enzymes to break down, as hemp may speed up their clearance and reduce their effect.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in hemp oil, but the evidence for what it does isn't established yet. If you take hormone therapy, blood thinners, blood pressure medications, or drugs your liver breaks down significantly, check with your doctor or pharmacist before starting—the interactions are mostly theoretical, but they're real enough to warrant a conversation.

Anyone with a known hemp or cannabis allergy should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about CBD 500 Peppermint, straight from the product label.

Brand Axis Labs
Barcode (UPC) 735548391029
Net contents 2 fl. Oz.
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 182498
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses Nutrient, All Other
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for CBD 500 Peppermint by Axis Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 mL
Maximum serving Sizes:
2 mL
Servings per container
60
UPC/BARCODE
735548391029
IngredientAmount% DV
Proprietary Blend1 mL--
Hemp Oil0 NP--
Medium Chain Triglycerides oil0 NP--

Other ingredients: Stevia leaf extract, Natural flavor

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: As a dietary supplement, take one (1) to two (2) servings once or twice daily, or as directed by a healthcare professional.

Storage

Keep away from heat and light as not to affect potency.

Precautions

Warning: Keep out of reach of children.

Do not use if you are pregnant or nursing.

Consult your health care professional before using this or any type of dietary supplements. If the user is subject to cannabinoid testing, consult with the requiring entity before taking this or any other dietary supplement.

General

CBD04 LBL0229

Seals/Symbols

Potency & Purity Guaranteed Manufactured at a GMP Good Manufacturing Practices Compliant Facility Made in the USA

Colorado CO USA Company

Vegan V Non GMO

Formula

500 mg CBD per bottle

Hemp derived oil

8.3 mg CBD per serving Full spectrum hemp oil

1/2 Dropper = 8.3 mg CBD

General Statements

Performance Driven Nutrition

Extra strength

Naturally flavored

Delicious peppermint taste

Non-psychoactive

FDA Statement of Identity

Dietary Supplement

Formulation

Non GMO

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

CBD 500 Peppermint by Axis Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

CBD 500 Peppermint label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in CBD 500 Peppermint by Axis Labs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

1 mL per serving
  • › Hemp Oil
  • › Medium Chain Triglycerides oil

Other (inactive) ingredients: Stevia leaf extract, Natural flavor. These complete the product’s ingredient list but are not active constituents.

Interaction report

CBD 500 Peppermint by Axis Labs Drug Interactions

Want to check YOUR meds against CBD 500 Peppermint?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
938Drugs
41 Moderate 897 Minor

Ingredients driving the most interactions

Hemp Oil 938

Individual Drug Interactions

The ingredients in CBD 500 Peppermint interact with 938 drugs. Click any drug to see the details.

1 of the 2 ingredients in CBD 500 Peppermint interact with drugs. Each result below shows which ingredient is responsible. Hemp Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in CBD 500 Peppermint with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Hemp Oil6 drug types · 938 drugs

Estrogens

Theoretically, hemp might interfere with hormone therapy due to its estrogenic effects.
In an ovariectomized animal model, a diet containing hemp seed 1%, 2%, or 10% resulted in normalized plasma levels of 17-beta-estradiol. The mechanism of action for this effect is unclear.

Likelihood Possible Evidence D
Ace Inhibitors (Aceis)

Theoretically, consuming hemp seed protein isolate with ACE inhibitors might have additive effects and increase the risk of hypotension.
Hemp seed protein hydrolysate has shown ACE inhibitor-like effects in a hypertensive animal model. However, hempseed oil consumption does not seem to reduce blood pressure in humans. Until more is known, monitor blood pressure and potassium levels.

Likelihood Unlikely Evidence D
Anticoagulant/Antiplatelet Drugs

Theoretically, hemp seed might increase the risk of bleeding when used concomitantly with anticoagulant/antiplatelet drugs.
In animal research, hemp seed at 5% of the diet inhibits platelet aggregation in vitro. However, in human research, taking hemp seed oil 2 grams daily for 12 weeks does not inhibit the aggregation of platelets in vitro.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, hemp seed protein may have additive effects with antihypertensive drugs.
In a hypertensive animal model, hemp seed protein hydrolysate reduced systolic blood pressure by a mechanism possibly involving the inhibition of renin and angiotensin converting enzyme (ACE) activities. However, there was no effect of hemp seed protein on blood pressure in normotensive animals. Furthermore, hempseed oil consumption does not seem to reduce blood pressure in humans.

Likelihood Unlikely Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that hemp induces CYP1A2 enzymes.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hemp might decrease the levels and clinical effects of CYP3A4 substrates.
In vitro research shows that hemp induces CYP3A4 enzymes.

Likelihood Possible Evidence D
Hemp Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for CBD 500 Peppermint, from the product label.

Axis Labs

See all Axis Labs products
Name
Axis Labs
City
Englewood
State
CO
ZipCode
80112
Phone Number
+1-303-221-2110
Web Address
www.axislabs.com
Pharmacist Counseling Corner

CBD 500 Peppermint by Axis Labs: Common Questions

Does CBD 500 Peppermint by Axis Labs interact with any medications?
Yes. Based on its ingredients, CBD 500 Peppermint has a known interaction with 938 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
CBD 500 Peppermint contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is hemp oil the same as CBD?
Not quite. This product contains hemp oil, which comes from hemp seed and is different from CBD (cannabidiol), another compound found in hemp. The facts here cover hemp oil specifically, so I can't speak to CBD's properties directly.
Can I take this if I'm on hormone therapy?
That's a conversation you need to have with your doctor or pharmacist first. Hemp oil may interfere with how your body processes estrogen, and the effect isn't fully understood. Your prescriber can weigh whether it's safe for your specific situation.
Are there any side effects I should watch for?
Hemp seed oil is generally well tolerated in larger amounts. Rare serious side effects include allergic reactions like anaphylaxis, facial swelling, and heart rhythm problems. Allergy to hemp seed itself is uncommon but has been reported. If you have a known hemp or cannabis allergy, skip this product.
Does this product actually work for anything?
The evidence we hold doesn't establish effectiveness for any specific condition. We have insufficient reliable evidence to rate it for constipation, eczema, or cholesterol issues. Talk with your doctor about what research exists for your particular health goal.
Is this safe to take long-term?
Hemp seed foods are generally well tolerated, but concentrated extracts and supplements like this one are less studied, so caution is advised. If you're considering long-term use, check in with your doctor or pharmacist, especially if you take other medications.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if CBD 500 Peppermint is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

CBD 500 Peppermint label
Go deeper

The Full Monographs Behind CBD 500 Peppermint’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Hemp

Interacts with 938 drugs

Hemp seeds and hemp seed oil are nutritious foods rich in protein, fiber, and healthy omega-3 and omega-6 fatty acids, and they are generally safe for most people as part of the diet. While...

Read the full Hemp monograph →
Sources

Sources & How We Checked

CBD 500 Peppermint's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Hemp 12 references
  1. Kaul N, Kreml R, Austria JA, et al. A comparison of fish oil, flaxseed oil and hempseed oil supplementation on selected parameters of cardiovascular health in healthy volunteers. J Am Coll Nutr 2008;27:51-8. PubMed
  2. Saberivand A, Karimi I, Becker LA, et al. The effects of Cannabis sativa L. seed (hempseed) in the ovariectomized rat model of menopause. Methods Find Exp Clin Pharmacol. 2010;32(7):467-73. PubMed
  3. Girgih AT, Alashi A, He R, Malomo S, Aluko RE. Preventive and treatment effects of a hemp seed (Cannabis sativa L.) meal protein hydrolysate against high blood pressure in spontaneously hypertensive rats. Eur J Nutr. 2014;53(5):1237-46. PubMed
  4. Richard MN, Ganguly R, Steigerwald SN, Al-Khalifa A, Pierce GN. Dietary hempseed reduces platelet aggregation. J Thromb Haemost. 2007;5(2):424-5. PubMed
  5. Stadtmauer G, Beyer K, Bardina L, Sicherer SH. Anaphylaxis to ingestion of hempseed (Cannabis sativa). J Allergy Clin Immunol. 2003;112(1):216-7. PubMed
  6. Del Bo' C, Deon V, Abello F, et al. Eight-week hempseed oil intervention improves the fatty acid composition of erythrocyte phospholipids and the omega-3 index, but does not affect the lipid profile in children and adolescents with primary hyperlipidemia. PubMed
  7. Alkhammash S, Tsui H, Thomson DMP. Cannabis and hemp seed allergy. J Allergy Clin Immunol Pract. 2019;7(7):2429-2430.e1. PubMed
  8. Stokes JR, Hartel R, Ford LB, Casale TB. Cannabis (hemp) positive skin tests and respiratory symptoms. Ann Allergy Asthma Immunol. 2000;85(3):238-40. PubMed
  9. Déléaval M, Burri H, Bakelants E. Harmless herbs? A case report of acquired long QT syndrome and torsades de pointes in a patient taking herbal supplements. HeartRhythm Case Rep 2022;8(5):309-12. PubMed
  10. Singh M, Sehgal M, Yacoub M, et al. Severe liver dysfunction in a toddler receiving nonprescription phytocannabinoid. J Am Pharm Assoc (2003) 2022;62(4):1438-1440. PubMed
  11. Clark E, Nilsson U, Samaran Q, Raison-Peyron N. Allergic contact dermatitis from Cannabis sativa (hemp) seed oil. Contact Dermatitis 2022;87(3):292-293.
  12. Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed

See these in context on the Hemp monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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