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Dietary supplement

Nattokinase 800 mg 4000 FU Ingredients & Drug Interactions

by NusaPure

Nattokinase 800 mg 4000 FU label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nattokinase 800 mg 4000 FU against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Nattokinase 800 mg 4000 FU is a dietary supplement by NusaPure with 1 active ingredient. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nattokinase 800 mg 4000 FU by NusaPure

Ask about any prescription or over-the-counter medication and we check it for interactions with Nattokinase 800 mg 4000 FU by NusaPure — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nattokinase 800 mg 4000 FU by NusaPure

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nattokinase, an enzyme derived from fermented soybean. It's a fibrin-dissolving (thrombolytic) compound that some people use to support cardiovascular health.

The capsule also contains inactive ingredients — cellulose, silica, magnesium stearate, and rice flour — which are standard excipients that help form and stabilize the capsule.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Heart and circulatory health, blood clot prevention.
  • We looked for evidence on: Cardiovascular disease (CVD), Hypertension, Atherosclerosis, Hyperlipidemia, Peripheral arterial disease (PAD), Venous thromboembolism (VTE) — and 4 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Angina (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis, Cardiovascular disease (CVD), Hyperlipidemia, Hypertension, and more.

The evidence we hold shows insufficient reliable data to rate nattokinase for any of the conditions listed, including angina, atherosclerosis, cardiovascular disease, cancer, and chronic fatigue syndrome. That means studies haven't established whether it works for these purposes — not that it doesn't work, but that we don't have the evidence on file to say it does.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated short-term, but its blood-thinning effect means you need to be cautious if you have any bleeding risk or take blood thinners. Rare cases of serious bleeding, including brain hemorrhage, have been reported.

Additionally, hypersensitivity reactions — including anaphylaxis — can occur in people sensitive to natto or its components; symptoms typically appear within 2 hours of taking it. The safety data advises against use during pregnancy.

Safety while breastfeeding isn't established, so it's best avoided then too. If you're pregnant, planning to become pregnant, or breastfeeding, talk with your doctor or pharmacist before taking this product.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this, double-check with your doctor or pharmacist if you use blood thinners or antiplatelet drugs (warfarin, aspirin, clopidogrel, and others) — nattokinase can increase bleeding risk, and a case of serious brain bleeding has been reported with this combination. Also confirm if you take blood-pressure medications, since nattokinase may lower blood pressure further.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Nattokinase is one to check before you start if you take any blood-thinning or blood-pressure medications — the interaction risk is real and documented. If you have a history of bleeding, sensitivity to soy or natto, or are pregnant or breastfeeding, discuss this product with your doctor or pharmacist first.

The evidence for its effectiveness isn't established in our data, so clarity on why you're considering it is worth a conversation with your provider.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2021.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nattokinase 800 mg 4000 FU, straight from the product label.

Brand NusaPure
Barcode (UPC) X001O8CRY5
Net contents 200 Veg Cap(s)
Market status On market
Date entered into DSLD Apr 22, 2021
DSLD ID 246790
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nattokinase 800 mg 4000 FU by NusaPure, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Veg Capsule(s)
Maximum serving Sizes:
2 Veg Capsule(s)
Servings per container
100
UPC/BARCODE
X001O8CRY5
IngredientAmount% DV
Nattokinase800 mg--

Other ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: For adults, take one (1) to two (2) capsules daily with a meal or a glass of water.

Precautions

Warning: For adults only.

Do not use if you are pregnant or nursing, taking "blood thinning" medications (anticoagulants) (such as aspirin, warfarin, heparin), or if you have any ongoing bleeding or coagulation problems (including but not limited to: active ulcer, recent surgery/trauma, hemophilia).

Consult physician if you have a medical condition (including uncontrolled high blood pressure).

Not intended for use by persons under the age of 18.

Keep out of reach of children.

Allergen Information: Contains no artificial coloring, artificial flavor, yeast, corn starch, milk or milk derivatives, lactose, salt, sodium, sugar, gluten, egg, wheat, fish, shellfish or tree nut ingredients. Produced in a GMP facility that processes other ingredients containing these allergens. Contains Soy

Formulation

Natural color variation may occur in this product.

GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

Assembled in USA Natural 4000 FU of Activity per serving Supports cardiovascular health Promotes healthy circulation Max Strength

Allergen Information: Contains no artificial coloring, artificial flavor, yeast, corn starch, milk or milk derivatives, lactose, salt, sodium, sugar, gluten, egg, wheat, fish, shellfish or tree nut ingredients.

Storage

Store in cool dry place. Avoid excessive heat or moisture.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Seals/Symbols

Premium Quality Assembled in USA GMO Free Made with non-GMO Ingredients Gluten Free FDA Registered Facility

Manufactured in a cGMP Inspected Facility

Formula

Nattokinase 800 mg 4000 FU per serving

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nattokinase 800 mg 4000 FU by NusaPure label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nattokinase 800 mg 4000 FU label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nattokinase 800 mg 4000 FU by NusaPure

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Veg Capsule(s) Dosage formCapsule Servings per container100 Amounts shown are per serving.

Nattokinase

Interacts with
289 drugs
800 mg per serving Form: Natto Extract

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at be...

Nattokinase monograph & interactions

Other (inactive) ingredients: Cellulose, Silica, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nattokinase 800 mg 4000 FU by NusaPure Drug Interactions

Want to check YOUR meds against Nattokinase 800 mg 4000 FU?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in Nattokinase 800 mg 4000 FU interact with 289 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nattokinase 800 mg 4000 FU interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in Nattokinase 800 mg 4000 FU with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nattokinase 800 mg 4000 FU, from the product label.

NusaPure

See all NusaPure products
Name
Gmax Central LLC
Street Address
4700 Millenia Boulevard, Suite 175 PMB 92909
City
Orlando
State
FL
ZipCode
32839
Pharmacist Counseling Corner

Nattokinase 800 mg 4000 FU by NusaPure: Common Questions

Does Nattokinase 800 mg 4000 FU by NusaPure interact with any medications?
Yes. Based on its ingredients, Nattokinase 800 mg 4000 FU has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nattokinase 800 mg 4000 FU contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on aspirin?
No, not without checking with your doctor first. Nattokinase thins the blood, and a documented case reports brain bleeding when someone combined it with low-dose aspirin. Your doctor needs to weigh the risk for you personally.
What is nattokinase and where does it come from?
It's an enzyme made from fermented soybean (natto). It breaks down fibrin, a protein involved in blood clotting, which is why it has blood-thinning effects.
Does this product actually work for heart disease or angina?
We don't have reliable evidence in our data to say it does. The studies haven't established whether it helps for these conditions.
What if I'm allergic to soy — can I take this?
Be cautious. Nattokinase comes from fermented soy, and some people have had allergic reactions (including anaphylaxis) to it or related soy compounds. Symptoms can happen quickly — within 2 hours. If you have a soy allergy, talk with your doctor or pharmacist before trying it.
Is it safe to take while I'm pregnant or breastfeeding?
No. The safety data advises against use during pregnancy, and safety while breastfeeding isn't established, so it's best avoided. Discuss any questions with your doctor or pharmacist.
What are the side effects?
It's generally well tolerated, but the main risk is bleeding — nattokinase thins the blood, and rare cases of serious bleeding (including brain hemorrhage) have been reported. Allergic reactions to soy components can also occur, usually within 2 hours of taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nattokinase 800 mg 4000 FU label
Go deeper

The Full Monographs Behind Nattokinase 800 mg 4000 FU’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

Nattokinase 800 mg 4000 FU's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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