Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

NattoKinase Patented Ingredients & Drug Interactions

by Symbiotics

NattoKinase Patented label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NattoKinase Patented against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

NattoKinase Patented is a dietary supplement by Symbiotics with 2 active ingredients. Its ingredients are commonly taken for heart and circulatory health, blood clot prevention, high blood pressure.Based on those ingredients, 289 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Nattokinase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NattoKinase Patented by Symbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with NattoKinase Patented by Symbiotics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of NattoKinase Patented by Symbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 1 of its 2 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (50 mg) without saying how much of each component you get.

NattoKinase Patented contains two active ingredients: nattokinase, an enzyme extracted from fermented soy, and BIO-lipid, for which we hold no detailed information. The product is packaged in gelatin capsules.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nattokinase's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: maintains normal blood pressure and circulation.
  • We looked for evidence on: Hypertension, Cardiovascular disease (CVD), Atherosclerosis, Peripheral arterial disease (PAD), Venous insufficiency, Stroke — and 3 related terms.
  • The closest evidence on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Atherosclerosis (Natural Medicines).
  • Also on file: Nattokinase is rated "Insufficient Reliable Evidence To Rate" for Cardiovascular disease (CVD), Hypertension, Peripheral arterial disease (PAD), Stroke, and more.

The evidence we hold on nattokinase does not establish that it reliably works for angina, atherosclerosis, cancer, cardiovascular disease, or chronic fatigue syndrome — all are rated insufficient reliable evidence. If you're considering this product for one of these conditions, talk it over with your doctor to weigh what we know against other options.

The evidence, ingredient by ingredient Nattokinase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nattokinase is generally well tolerated short-term, but because it thins the blood, it carries risk for anyone prone to bleeding. The facts note rare reports of bleeding, including one case of brain hemorrhage when nattokinase was combined with aspirin.

Additionally, nattokinase can trigger allergic reactions in people sensitive to fermented soy (natto), ranging from throat symptoms to anaphylaxis — reactions typically appear within 2 hours of taking it. The safety data advises against nattokinase during pregnancy and while breastfeeding because there isn't enough information to know it's safe in those states.

If you're pregnant, planning pregnancy, or nursing, talk with your doctor or pharmacist before using this product.

Side effects, ingredient by ingredient Nattokinase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nattokinase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 289 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check your medications with your pharmacist or doctor before taking this product if you use blood thinners (anticoagulants like warfarin, or antiplatelets like aspirin or clopidogrel) — nattokinase increases bleeding risk (Moderate severity). Also check if you take blood pressure medications (antihypertensives) — nattokinase may lower pressure further (Moderate severity).

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product is for adults interested in nattokinase's cardiovascular effects, but evidence for most claimed uses is insufficient. If you take blood pressure or blood clotting medications, you must check your exact drugs with your pharmacist or doctor before starting — the bleeding risk is real.

Anyone with a history of bleeding, a soy allergy, or who is pregnant or breastfeeding should avoid it.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NattoKinase Patented, straight from the product label.

Brand Symbiotics
Barcode (UPC) 647303010468
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Jan 23, 2015
DSLD ID 41323
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NattoKinase Patented by Symbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
60
UPC/BARCODE
647303010468
IngredientAmount% DV
Proprietary Blend50 mg--
Nattokinase20000 {Unit(s)}--
BIO-lipid(TM)0 NP--

Other ingredients: Gelatin Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Assists in Maintaining Normal Blood Pressure*

- Helps Maintain Circulation & Blood Flow* - Helps Reduce Excess Blood Viscosity* - Helps Arterial Flexibility*

Vitamin K removed for safety by a patented process.

Quality and Purity Guaranteed - We guarantee that this product meets the highest standards of quality, purity and freshness.

Made in U.S.A.

ITEM NO. 07UGG12NKS

EXPIRATION DATE ON BOTTOM OF CONTAINER

BIO-lipid liposomal delivery speeds and increases absorption for optimal benefit.

Seals/Symbols

QUALITY GUARANTEED High BIO Availability

Symbiotics(R)

QUALITY GUARANTEE PURITY

FDA Statement of Identity

DIETARY SUPPLEMENT

Precautions

Warnings: Not for use by persons under 18 years of age.

Pregnant or lactating women, and anyone on blood thinners or high blood pressure medications should consult a health care provider before taking this or any other dietary supplement.

Do not use if imprinted seal under bottle cap is broken or missing.

Each bottle is safety sealed with an outer neckband and inner seal. Do not use if either seal is broken or missing.

Formula

Suitable for lactose-free diets.

Suggested/Recommended/Usage/Directions

Suggested Use: Daily use - Adults: One (1) capsule in the morning and one (1) capsule prior to bedtime. Advanced use - Two (2) capsules in the morning and two (2) capsules prior to bedtime.

FDA Disclaimer Statement

THESE STATEMENTS HAVE NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE OR PREVENT ANY DISEASE.

Storage

Close tightly and store in a dry place at room temperature.

Brand IP Statement(s)

(C)2005-2010

Nattokinase(TM) is a fibrinolytic soy-based enzyme produced by Bacillus subtilsin natto during fermentation.

For enhanced reduction of inflammation and immune benefits, use with Symbiotics(R) Colostrum.

General

1046-010A-v01

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NattoKinase Patented by Symbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NattoKinase Patented label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NattoKinase Patented by Symbiotics

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

50 mg per serving

Other (inactive) ingredients: Gelatin Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

NattoKinase Patented by Symbiotics Drug Interactions

Want to check YOUR meds against NattoKinase Patented?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
289Drugs
289 Moderate

Ingredients driving the most interactions

Nattokinase 289

Individual Drug Interactions

The ingredients in NattoKinase Patented interact with 289 drugs. Click any drug to see the details.

1 of the 2 ingredients in NattoKinase Patented interact with drugs. Each result below shows which ingredient is responsible. Nattokinase

Each ingredient & the kinds of drugs it affects

For each ingredient in NattoKinase Patented with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nattokinase2 drug types · 289 drugs

Anticoagulant/Antiplatelet Drugs

Nattokinase might increase the risk of bleeding when used with anticoagulant/antiplatelet drugs.
Nattokinase has thrombolytic and anticoagulant effects. There is a case report of intracranial hemorrhage in a patient who added nattokinase to aspirin therapy.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, nattokinase might increase the risk of hypotension when used with antihypertensive drugs.
Some clinical research suggests that nattokinase may reduce systolic and diastolic blood pressure.

Likelihood Possible Evidence D
Nattokinase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NattoKinase Patented, from the product label.

Symbiotics

See all Symbiotics products
Name
Naturade a division of NNC LLC
City
Orange
State
CA
ZipCode
92868
Phone Number
1-800-421-1830
Web Address
www.naturade.com
Pharmacist Counseling Corner

NattoKinase Patented by Symbiotics: Common Questions

Does NattoKinase Patented by Symbiotics interact with any medications?
Yes. Based on its ingredients, NattoKinase Patented has a known interaction with 289 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NattoKinase Patented contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is nattokinase, and where does it come from?
Nattokinase is an enzyme extracted from natto, a traditional Japanese food made from fermented soybeans. It's the active ingredient in this product.
Can I take this if I'm allergic to soy?
No. Nattokinase comes from fermented soy and can trigger allergic reactions in people sensitive to natto, from throat swelling to severe reactions. If you have a soy allergy, avoid this product.
Is nattokinase safe during pregnancy or while breastfeeding?
The safety data advises against it — there isn't enough information during pregnancy, and safety while breastfeeding is unknown. Talk with your doctor or pharmacist before using it if you're pregnant, planning pregnancy, or nursing.
What does the research show nattokinase actually does?
The evidence we hold doesn't establish that nattokinase reliably works for heart disease, angina, cancer, atherosclerosis, or chronic fatigue — all lack sufficient reliable evidence. If you're considering it for one of these, ask your doctor what the current evidence supports.
Why is there a warning about combining this with aspirin?
Nattokinase thins the blood, and there's a documented case of brain bleeding in someone who took it while on low-dose aspirin. Combining blood-thinning substances raises the risk of serious bleeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if NattoKinase Patented is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NattoKinase Patented label
Go deeper

The Full Monographs Behind NattoKinase Patented’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nattokinase

Interacts with 289 drugs

Nattokinase is an enzyme from the fermented soybean food natto that may have mild blood-thinning and blood-flow effects. Some small studies hint at benefits for blood pressure and circulatio...

Read the full Nattokinase monograph →
Sources

Sources & How We Checked

NattoKinase Patented's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 9 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nattokinase 9 references
  1. Suzuki Y, Kondo K, Matsumoto Y, et al. Dietary supplementation of fermented soybean, natto, suppresses intimal thickening and modulates the lysis of mural thrombi after endothelial injury in rat femoral artery. Life Sci 2003;73:1289-98.. PubMed
  2. Sumi H, Hamada H, Nakanishi K, Hiratani H. Enchancement of fibrinolytic activity in plasma by oral administration of nattokinase. Acta Haematol 1990;84:139-43.
  3. Chang, Y. Y., Liu, J. S., Lai, S. L., Wu, H. S., and Lan, M. Y. Cerebellar hemorrhage provoked by combined use of nattokinase and aspirin in a patient with cerebral microbleeds. Intern Med 2008;47(5):467-469. PubMed
  4. Kim, J. Y., Gum, S. N., Paik, J. K., Lim, H. H., Kim, K. C., Ogasawara, K., Inoue, K., Park, S., Jang, Y., and Lee, J. H. Effects of nattokinase on blood pressure: a randomized, controlled trial. Hypertens.Res 2008;31(8):1583-1588. PubMed
  5. <p>Maruyama M, Sumi H (eds): Effect of natto diet on blood pressure, in Basic and Clinical Aspects of Japanese Traditional Food Natto II. Japan Technology Transfer Association (JTTAS), 1998, pp 1–3.</p>
  6. Kurosawa Y, Nirengi S, Homma T, et al. A single-dose of oral nattokinase potentiates thrombolysis and anti-coagulation profiles. Sci Rep 2015;5:11601. PubMed
  7. Ramachandran L, Aqeel A, Jafri A, Sidhu Y, Mohamed Djirdeh T. Nattokinase-associated hemoperitoneum in an elderly woman. Cureus 2021;13(12):e20074. PubMed
  8. Awatani-Yoshidome K, Hashimoto T, Satoh T. Anaphylaxis from nattokinase in a patient with fermented soybean (natto) allergy. Allergol Int 2022;71(1):153-4. PubMed
  9. Suzuki K, Nakamura M, Sato N, Futamura K, Matsunaga K, Yagami A. Nattokinase, a subtilisin family serine protease, is a novel allergen contained in the traditional Japanese fermented food natto. Allergol Int 2022.

See these in context on the Nattokinase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

Keep exploring
Supplement interaction checker › Check any supplement or product against your medications Drug–drug interactions › Check two or more of your medications against each other Browse medications A–Z › Every drug we've checked against herbs & supplements NDC & pricing lookup › Find a drug’s NDCs, packaging and costs Ask a pharmacist › Free, personal answer from our licensed team