Interactions on record — worth a quick check against your medications. Based on 8 of 16 ingredients. Check your meds →
Dietary supplement

Candida Balance with Colostrum Plus Ingredients & Drug Interactions

by Symbiotics

Candida Balance with Colostrum Plus label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Candida Balance with Colostrum Plus against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Candida Balance with Colostrum Plus is a dietary supplement by Symbiotics with 16 active ingredients. Its ingredients are commonly taken for digestive health and regularity, infant colic and gut support, diarrhea (including antibiotic-related).Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bifidobacterium breve, Lactobacillus acidophilus, Bifidobacterium longum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Candida Balance with Colostrum Plus by Symbiotics

Ask about any prescription or over-the-counter medication and we check it for interactions with Candida Balance with Colostrum Plus by Symbiotics — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Candida Balance with Colostrum Plus by Symbiotics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 4 of its 18 active ingredients.
  • “Proprietary Blend” is a proprietary blend — the label gives one combined amount (295 mg) without saying how much of each component you get.
  • “Bovine Colostrum” is listed as a grouped ingredient — the label gives one combined amount (692 mg) without saying how much of each component you get.

This product contains 18 ingredients, including multiple probiotic bacterial strains (Lactobacillus and Bifidobacterium species), lactoferrin (an iron-binding protein), and bovine colostrum components like immunoglobulins and proline-rich polypeptides. The inactive ingredients are rice flour, medium chain triglycerides, sunflower lecithin, and HPMC (a capsule material).

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: maintain normal candida albicans balance.
  • We looked for evidence on: Diarrhea, Antibiotic-associated diarrhea, Constipation, Abdominal pain, Colic, Clostridioides difficile infection — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactoferrin is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Radiation-induced diarrhea, Rotaviral diarrhea, Travelers' diarrhea, and more.

Evidence for the probiotics and colostrum components in this product varies widely. Lactobacillus acidophilus is possibly effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is possibly effective for irritable bowel syndrome and respiratory tract infections. For many other uses—such as allergic rhinitis, anxiety, asthma, and age-related cognitive decline—the evidence we hold is insufficient to rate these ingredients.

Lactoferrin is possibly effective for sepsis and pregnancy-related iron deficiency, but likely ineffective for reducing fetal and premature infant mortality and necrotizing enterocolitis. For most of the other probiotic strains and colostrum components, effectiveness data are not established in our records.

The evidence, ingredient by ingredient Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Streptococcus Thermophilus Lactobacillus Delbrueckii Bovine Colostrum Lactoferrin

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactoferrin is generally well tolerated at typical doses, but higher doses of 7.2 grams daily increase the risk of side effects including diarrhea, constipation, anorexia, fatigue, and chills. The probiotics in this product are generally well tolerated in healthy people, though gastrointestinal effects like bloating, flatulence, and mild abdominal discomfort have been reported rarely.

Rare cases of bacteremia (bacteria in the bloodstream) have occurred with some Bifidobacterium strains in critically ill or immunocompromised patients, but these are uncommon in otherwise healthy individuals. Long-term safety data for lactoferrin are limited.

Lactoferrin safety in pregnancy is not fully established, so use only under medical supervision; lactoferrin occurs naturally in breast milk, but supplement safety while breastfeeding is not well studied. Pregnancy and breastfeeding safety data for most of the probiotic strains are not on file; Bifidobacterium longum is rated possibly safe in pregnancy.

For all probiotics, check with your healthcare provider before use, especially if you're very ill or have a weakened immune system.

Side effects, ingredient by ingredient Bifidobacterium Breve Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Streptococcus Thermophilus Lactobacillus Delbrueckii Bovine Colostrum Lactoferrin

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 7 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Breve, Bifidobacterium Bifidum, Bifidobacterium Longum, Lactobacillus Delbrueckii.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, check with your pharmacist about timing—these probiotics work best when separated from antibiotics by several hours. Altogether, these interactions span 182 individual medications.

We could not check several probiotic strains for interactions, but the ones we evaluated only interact with antibiotics at Moderate severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help with certain digestive and immune concerns, but evidence is strongest for Lactobacillus acidophilus and Bifidobacterium bifidum in specific conditions like IBS and respiratory infections. If you take antibiotics, separate them from this product by a few hours to keep the probiotics viable.

Talk to your pharmacist or doctor before starting, especially if you're pregnant, breastfeeding, or have a weakened immune system.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 18 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Mar 22, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Candida Balance with Colostrum Plus, straight from the product label.

Brand Symbiotics
Barcode (UPC) 647303040021
Net contents 120 Veg Capsule(s)
Market status On market
Date entered into DSLD Mar 22, 2023
DSLD ID 275844
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Candida Balance with Colostrum Plus by Symbiotics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
647303040021
IngredientAmount% DV
Calories7 Calorie(s)--
Proprietary Blend295 mg--
Lactoferrin7 mg--
Lactobacillus salivarius0 NP--
Lactobacillus plantarum0 NP--
Lactobacillus paracasei0 NP--
Bifidobacterium breve0 NP--
Lactobacillus acidophilus0 NP--
Lactobacillus rhamnosus0 NP--
Bifidobacterium animalis lactis0 NP--
Bifidobacterium longum0 NP--
Lactobacillus casei0 NP--
Bifidobacterium bifidum0 NP--
Streptococcus thermophilus0 NP--
Lactobacillus bulgaricus0 NP--
Lactococcus lactis0 NP--
Immunoglobulins135 mg--
Proline-rich Polypeptides33 mg--
Lactobacillus brevis0 NP--
Bovine Colostrum692 mg--
Lactoferrin24 mg--

Other ingredients: Rice Flour, Medium Chain Triglycerides, Sunflower Lecithin, HPMC

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Immune Factors

Helps maintain normal levels of Candida albicans bacteria! It's normal to have Candida albicans in the body, but it's critical to keep it in balance.

Qualtiy and purity assured. Symbiotics Colostrum is exclusively from USDA Grade A dairies. Only from first milking.

Laboratory tested and verified free from pesticides, antibiotics and rBHT hormones.

Supports healthy immune response Helps maintain healthy intestinal flora

Gluten free

Made in the U.S.A. with U.S.A. Colostrum and imported ingredients

Formula

Symbiotics Candida Balance works through 3 different mechanisms of action. Lactoferrin robs Candida of iron needed for growth. "Friendly" bacteria promote GI tract health and feed on Candida. Colostrum Plus includes IgG and PRPs to promote overall immune health.

With Immulox 10% and probiotics

Precautions

Each bottle is double sealed for quality and safety. If either seal is broken or missing, do not use and call 1-800-421-1830.

Warning: If you have a physician-diagnosed health condition, consult your doctor before taking this product. Discontinue use if you experience adverse reactions and consult your doctor.

Contains: Milk.

Storage

Close tightly and store in cool, dry place (below 75 degrees F), away from heat.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Brand IP Statement(s)

Symbiotics and Colostrum Plus are registered trademarks of Prevention, LLC. Nature's First Immune Defense is a trademark of Prevention, LLC. Immulox is a registered trademark of APS Biogroup.

Nature's First Immune Defense

Copyright 2016 Prevention, LLC.

General Statements

New veg caps

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take 2 capsules, twice daily, with water or your drink of choice, on empty stomach. Triple this amount in times of environmental or physical stress.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Candida Balance with Colostrum Plus by Symbiotics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Candida Balance with Colostrum Plus label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Candida Balance with Colostrum Plus by Symbiotics

These are the 16 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend

295 mg per serving

Bovine Colostrum

No known
interactions
692 mg per serving Form: Milk

Bovine colostrum is the nutrient-rich first milk from cows, packed with antibodies, growth factors, and protein. Early research suggests it may help w...

Bovine Colostrum monograph & interactions
  • › Lactoferrin
  • › Immunoglobulins
  • › Proline-rich Polypeptides

Lactoferrin

No known
interactions
24 mg per serving

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is...

Lactoferrin monograph & interactions

Other (inactive) ingredients: Rice Flour, Medium Chain Triglycerides, Sunflower Lecithin, HPMC. These complete the product’s ingredient list but are not active constituents.

Interaction report

Candida Balance with Colostrum Plus by Symbiotics Drug Interactions

Want to check YOUR meds against Candida Balance with Colostrum Plus?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bifidobacterium breve 182
Lactobacillus acidophilus 182
Bifidobacterium longum 182
Bifidobacterium bifidum 182
Lactobacillus bulgaricus 182

Individual Drug Interactions

The ingredients in Candida Balance with Colostrum Plus interact with 182 drugs. Click any drug to see the details.

5 of the 16 ingredients in Candida Balance with Colostrum Plus interact with drugs. Each result below shows which ingredient is responsible. Bifidobacterium breve Lactobacillus acidophilus Bifidobacterium longum Bifidobacterium bifidum Lactobacillus bulgaricus

Each ingredient & the kinds of drugs it affects

For each ingredient in Candida Balance with Colostrum Plus with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bifidobacterium breve1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium breve with antibiotic drugs might decrease the effectiveness of B. breve.
Since B. breve preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. breve preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium breve full monograph & interactions

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions

Lactobacillus bulgaricus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus delbrueckii with antibiotic drugs might decrease the effectiveness of L. delbrueckii.
Lactobacillus delbrueckii preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. delbrueckii preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus bulgaricus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Candida Balance with Colostrum Plus, from the product label.

Symbiotics

See all Symbiotics products
Name
Naturade a division of Prevention, LLC
City
Irvine
State
CA
ZipCode
92614
Phone Number
1-800-421-1830
Web Address
www.symbiotics.com
Pharmacist Counseling Corner

Candida Balance with Colostrum Plus by Symbiotics: Common Questions

Does Candida Balance with Colostrum Plus by Symbiotics interact with any medications?
Yes. Based on its ingredients, Candida Balance with Colostrum Plus has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Candida Balance with Colostrum Plus contains 16 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are probiotics, and why are they in this product?
Probiotics are live beneficial bacteria and fungi that support digestive and immune health. This product contains multiple Lactobacillus and Bifidobacterium strains, which research suggests may help with conditions like irritable bowel syndrome, antibiotic-associated diarrhea, and certain infections.
What is lactoferrin and what does it do?
Lactoferrin is a protein that binds iron and occurs naturally in breast milk and other body fluids. In this product it's included for its possible role in sepsis and pregnancy-related iron deficiency, though it's likely not effective for reducing fetal mortality or necrotizing enterocolitis.
Can I take this if I'm on antibiotics?
Yes, but timing matters. The antibiotics in this product's live organisms can kill the beneficial bacteria, so separate antibiotic doses from this product by a few hours to preserve the probiotics' effectiveness. Ask your pharmacist for specific guidance.
What side effects should I watch for?
Most people tolerate this well. Mild gastrointestinal effects like bloating, flatulence, and abdominal discomfort are uncommon but possible. Lactoferrin at higher doses can cause constipation, diarrhea, nausea, or fatigue; typical doses are much gentler.
Is it safe to take while pregnant or breastfeeding?
Safety data for most ingredients are limited or not established. Lactoferrin safety in pregnancy is not fully studied, so use only under medical supervision. For the probiotics, Bifidobacterium longum is rated possibly safe in pregnancy, but check with your doctor or pharmacist before starting any of these, especially if you're pregnant or nursing.
How long does it take to work?
The product facts don't specify a timeline. Probiotics often need several weeks of consistent use to show effects, but talk to your pharmacist about what to expect for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Candida Balance with Colostrum Plus is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Candida Balance with Colostrum Plus label
Go deeper

The Full Monographs Behind Candida Balance with Colostrum Plus’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bifidobacterium Breve

Interacts with 182 drugs

Bifidobacterium breve is a 'friendly' gut bacterium taken as a probiotic, most often to support digestion and balance the gut microbiome. Some studies suggest possible benefits for certain d...

Read the full Bifidobacterium Breve monograph → Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph → Herb & supplement monograph

Lactobacillus Delbrueckii

Interacts with 182 drugs

Lactobacillus delbrueckii is a 'friendly' bacterium used in food fermentation and sold as a probiotic, often as part of multi-strain products. It is generally considered safe for healthy peo...

Read the full Lactobacillus Delbrueckii monograph → Herb & supplement monograph

Bovine Colostrum

Bovine colostrum is the nutrient-rich first milk from cows, packed with antibodies, growth factors, and protein. Early research suggests it may help with gut health, certain types of diarrhe...

Read the full Bovine Colostrum monograph → Herb & supplement monograph

Lactoferrin

Lactoferrin is an iron-binding protein found naturally in milk and other body fluids, and supplements are usually made from cow's milk or rice. It is being studied for immune support, iron l...

Read the full Lactoferrin monograph →
Sources

Sources & How We Checked

Candida Balance with Colostrum Plus's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 96 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactoferrin 6 references
  1. Food and Drug Administration, CFSAN/Office of Food Additive Safety. Agency Response Letter GRAS Notice No. GRN 000130. 2003. Available at: http://www.cfsan.fda.gov/~rdb/opa-g130.html (Accessed 29 June 2005).
  2. Okada S, Tanaka K, Sato T, et al. Dose-response trial of lactoferrin in patients with chronic hepatitis C. Jpn J Cancer Res 2002;93:1063-9. PubMed
  3. Abu Hashim H, Foda O, Ghayaty E. Lactoferrin or ferrous salts for iron deficiency anemia in pregnancy: A meta-analysis of randomized trials. Eur J Obstet Gynecol Reprod Biol. 2017;219:45-52. PubMed
  4. Tarnow-Mordi WO, Abdel-Latif ME, Martin A, et al. The effect of lactoferrin supplementation on death or major morbidity in very low birthweight infants (LIFT): a multicentre, double-blind, randomised controlled trial. Lancet Child Adolesc Health. 2020 Jun PubMed
  5. ELFIN trial investigators group. Enteral lactoferrin supplementation for very preterm infants: a randomised placebo-controlled trial. Lancet. 2019 Feb 2;393(10170):423-433. doi: 10.1016/S0140-6736(18)32221-9.
  6. Lepanto MS, Rosa L, Cutone A, Conte MP, Paesano R, Valenti P. Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: An interventional study. Front Immunol. 2018 Sep 21;9:2123. PubMed

See these in context on the Lactoferrin monograph →

Bifidobacterium Breve 9 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  3. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  4. Ohishi A, Takahashi S, Ito Y, et al. Bifidobacterium septicemia associated with postoperative probiotic therapy in a neonate with omphalocele. J Pediatr. 2010;156(4):679-81. PubMed
  5. Sakurai Y, Watanabe T, Miura Y, et al. Clinical and bacteriologic characteristics of six cases of Bifidobacterium breve bacteremia due to probiotic administration in the neonatal intensive care unit. Pediatr Infect Dis J 2022;41(1):62-65. PubMed
  6. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  7. Wakabayashi Y, Nakayama S, Yamamoto A, et al. First case of necrotizing fasciitis and bacteremia caused by Bifidobacteriumbreve. Anaerobe 2022;76:102613.
  8. Takeda Y, Ota K, Kondo A, et al. A case of necrotizing fasciitis caused by Bifidobacterium breve. IDCases 2022;31:e01667. PubMed
  9. Suwantarat N, Romagnoli M, Wakefield T, Carroll KC. Ventriculoperitoneal shunt infection caused by Bifidobacterium breve. Anaerobe 2014;28:1-3. PubMed

See these in context on the Bifidobacterium Breve monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
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See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
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Bifidobacterium Bifidum 7 references
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  6. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  7. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed

See these in context on the Bifidobacterium Bifidum monograph →

Streptococcus Thermophilus 21 references
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  12. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
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See these in context on the Streptococcus Thermophilus monograph →

Lactobacillus Delbrueckii 9 references
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  2. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  3. Ranchal P, Gupta R, Goldberg R, A Lobo S, Pascual A, El Khoury MY. Penicillin-sensitive Lactobacillus jensenii bacteremia. Am J Ther 2021;28(2):e250-e252. PubMed
  4. Grazioli-Gauthier L, Rigamonti E, Leo LA, Martinetti Lucchini G, Lo Priore E, Bernasconi E. Lactobacillus jensenii mitral valve endocarditis: Case report, literature review and new perspectives. IDCases 2022;27:e01401. PubMed
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See these in context on the Lactobacillus Delbrueckii monograph →

Bovine Colostrum 8 references
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  2. Greenberg PD, Cello JP. Treatment of severe diarrhea caused by Cryptosporidium parvum with oral bovine immunoglobulin concentrate in patients with AIDS. J Acquir Immune Defic Syndr Hum Retrovirol 1996;13:348-54. PubMed
  3. Duff WR, Chilibeck PD, Rooke JJ, Kaviani M, Krentz JR, Haines DM. The effect of bovine colostrum supplementation in older adults during resistance training. Int J Sport Nutr Exerc Metab. 2014 Jun;24(3):276-85. PubMed
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  8. Simonsen MB, Kappel SS, Aunsholt L, Möller S, Sangild PT, Zachariassen G. Mineral supplementation for very preterm infants fed fortified human milk. J Pediatr Gastroenterol Nutr 2024;78(6):1389-1397. PubMed

See these in context on the Bovine Colostrum monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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