NiaCel 400 Ingredients & Drug Interactions
by Thorne
What is this page for?
First and foremost: checking NiaCel 400 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
NiaCel 400 is a dietary supplement by Thorne with 2 active ingredients. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside Hydrogen Malate. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against NiaCel 400 by Thorne
Ask about any prescription or over-the-counter medication and we check it for interactions with NiaCel 400 by Thorne — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of NiaCel 400 by Thorne
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
NiaCel 400 contains two active ingredients: nicotinamide riboside hydrogen malate and betaine anhydrous. Nicotinamide riboside is a form of vitamin B3 that your cells convert into NAD, a molecule involved in energy production and cellular repair.
Betaine is an amino acid compound that supports methylation reactions in your body — processes that affect everything from heart health to liver function. The capsule also contains inactive ingredients (hypromellose, calcium laurate, microcrystalline cellulose, and silicon dioxide) that help deliver the actives.
Does it work?
Strong evidence
The evidence for nicotinamide riboside in this product is still developing. We don't have reliable data to rate it for age-related macular degeneration, Alzheimer's disease, athletic performance, nonalcoholic fatty liver disease, or heart failure.
Betaine anhydrous is effective for homocystinuria (a rare genetic disorder affecting amino acid metabolism) and possibly effective for high homocysteine levels. For other uses like nonalcoholic fatty liver disease, depression, or acid reflux, the evidence is insufficient to rate.
How safe is it?
Well-documented data
Nicotinamide riboside is generally well tolerated in short-term studies, but we don't know its long-term safety profile yet. The most common side effects are bloating, muscle pain, nausea, itching, sweating, and changes in bowel habits.
One patient reported leg cramps. The data advises against use in pregnancy and while breastfeeding.
Betaine anhydrous is generally well tolerated at studied doses, though it can cause body odor, diarrhea, nausea, vomiting, and gastrointestinal upset. A rare serious effect (cerebral swelling) has been reported.
There's no safety data on file for pregnancy or lactation, so talk with your doctor or pharmacist before taking it during either.
Meds to double-check
Minor interactions only
If you take blood pressure medications (antihypertensives), double-check this product with your pharmacist or doctor first — nicotinamide riboside may add to their effect and lower your blood pressure further. No other medication interactions are documented for the ingredients we could check.
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Only minor medication interactions are documented, and safety information is well characterized.
NiaCel 400 is best suited for people interested in NAD support and methylation health who don't take blood pressure medication. If you're on antihypertensives, check with us first — nicotinamide riboside may enhance their effect.
Neither ingredient is recommended during pregnancy or breastfeeding without a doctor's OK. Talk to your pharmacist before starting, especially if you're taking any medications.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 23, 2025.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about NiaCel 400, straight from the product label.
| Brand | Thorne |
|---|---|
| Barcode (UPC) | 693749012085 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Jan 23, 2025 |
| DSLD ID | 323125 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for NiaCel 400 by Thorne, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Nicotinamide Riboside Hydrogen Malate | 415 mg | -- |
| Betaine Anhydrous | 85 mg | -- |
Other ingredients: Hypromellose, Calcium Laurate, Microcrystalline Cellulose, Silicon Dioxide
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Brain/Nerves Healthy Aging Metabolism
Gluten free
Suggested/Recommended/Usage/Directions
Suggested use: Take 1 capsule daily or as recommended by your health-care practitioner.
Precautions
Tamper Evident: Use only if bottle is sealed.
If pregnant, consult your health-care practitioner before using this product.
Storage
Store tightly sealed in a cool, dry place.
Seals/Symbols
NSF Certified Sport
General Statements
T Exclusive
Formula
Nicotinamide Riboside
FDA Statement of Identity
Dietary Supplement
FDA Disclaimer Statement
This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
NiaCel 400 by Thorne label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in NiaCel 400 by Thorne
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Nicotinamide Riboside Hydrogen Malate
Interacts with172 drugs
Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...
Nicotinamide Riboside Hydrogen Malate monograph & interactionsBetaine Anhydrous
No knowninteractions
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...
Betaine Anhydrous monograph & interactionsOther (inactive) ingredients: Hypromellose, Calcium Laurate, Microcrystalline Cellulose, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.
NiaCel 400 by Thorne Drug Interactions
HelloPharmacist Interaction Report
NiaCel 400 by Thorne contains nicotinamide riboside and betaine anhydrous.
Nicotinamide riboside may interact with blood pressure medications (antihypertensives). Theory suggests it could add to their effect and lower your blood pressure further, though the evidence is mixed — one small study showed a modest drop in blood pressure, but other research did not.
This is rated a Minor interaction.
Read the full breakdown — every affected drug type, severity by severity
Betaine anhydrous has no known interactions documented in our data.
Although we've checked both active ingredients, we hold interaction data for only one medication type. Altogether, these interactions span 170 individual medications.
If you take blood pressure medication, run your exact drug names through the checker below before you start this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against NiaCel 400?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in NiaCel 400 interact with 172 drugs. Click any drug to see the details.
1 of the 2 ingredients in NiaCel 400 interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide Riboside Hydrogen Malate
Bumetanide (iv)Bumex
How Bumetanide (iv) interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Bumetanide (iv) interactionBumetanide (oral)Bumex
How Bumetanide (oral) interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Bumetanide (oral) interactionCandesartan CilexetilAmias, Atacand
How Candesartan Cilexetil interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Candesartan Cilexetil interactionCandesartan Cilexetil, HydrochlorothiazideAtacand HCT
How Candesartan Cilexetil, Hydrochlorothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Candesartan Cilexetil, Hydrochlorothiazide interactionCaptoprilAcepril, Capoten
How Captopril interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Captopril interactionCaptopril, HydrochlorothiazideAcezide, Capozide
How Captopril, Hydrochlorothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Captopril, Hydrochlorothiazide interactionCarteololCartrol, Ocupress
How Carteolol interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Carteolol interactionCarvedilolCoreg, Coreg CR
How Carvedilol interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Carvedilol interactionCeliprololCelicard
How Celiprolol interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Celiprolol interactionChlorothiazideDiuril
How Chlorothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Chlorothiazide interactionChlorothiazide, MethyldopaAldochlor, Aldoclor 150, Aldoclor 250
How Chlorothiazide, Methyldopa interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Chlorothiazide, Methyldopa interactionChlorothiazide, ReserpineDiupres
How Chlorothiazide, Reserpine interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Chlorothiazide, Reserpine interactionChlorthalidoneHygroton, Thalitone
How Chlorthalidone interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Chlorthalidone interactionChlorthalidone, ClonidineClorpres, Combipres
How Chlorthalidone, Clonidine interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Chlorthalidone, Clonidine interactionCilazaprilInhibace
How Cilazapril interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Cilazapril interactionClevidipineCleviprex
How Clevidipine interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Clevidipine interactionClonidineCatapres
How Clonidine interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Clonidine interactionCryptenamine, MethyclothiazideDiutensen
How Cryptenamine, Methyclothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Cryptenamine, Methyclothiazide interactionCyclothiazideAnhydron, Fluidil
How Cyclothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Cyclothiazide interactionDeserpidineHarmonyl
How Deserpidine interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Deserpidine interactionDeserpidine, HydrochlorothiazideOreticyl, Oreticyl Forte
How Deserpidine, Hydrochlorothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Deserpidine, Hydrochlorothiazide interactionDeserpidine, MethyclothiazideEnduronyl, Enduronyl Forte
How Deserpidine, Methyclothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Deserpidine, Methyclothiazide interactionDiltiazemAdizem-SR, Adizem-XL, Angitil SR, Angitil XL, Calcicard CR, Cardizem +23 more
How Diltiazem interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Diltiazem interactionDiltiazem, EnalaprilTeczem
How Diltiazem, Enalapril interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Diltiazem, Enalapril interactionDoxazosin MesylateCardura
How Doxazosin Mesylate interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Doxazosin Mesylate interactionEnalapril MaleateEpaned, Vasotec
How Enalapril Maleate interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Enalapril Maleate interactionEnalapril Maleate, FelodipineLexxel
How Enalapril Maleate, Felodipine interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Enalapril Maleate, Felodipine interactionEnalapril Maleate, HydrochlorothiazideVaseretic
How Enalapril Maleate, Hydrochlorothiazide interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Enalapril Maleate, Hydrochlorothiazide interactionEplerenoneInspra
How Eplerenone interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Eplerenone interactionEpoprostenolFlolan
How Epoprostenol interacts with NiaCel 400 — through 1 ingredient. Tap an ingredient for the detail:
Nicotinamide Riboside Hydrogen MalateAntihypertensive Drugs Minor
Interaction Summary
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
Read the full Nicotinamide Riboside Hydrogen Malate + Epoprostenol interactionEach ingredient & the kinds of drugs it affects
For each ingredient in NiaCel 400 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Nicotinamide Riboside Hydrogen Malate
Antihypertensive Drugs
Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.
Brand information
Manufacturer and brand details for NiaCel 400, from the product label.
NiaCel 400 by Thorne: Common Questions
Does NiaCel 400 by Thorne interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take NiaCel 400 if I'm pregnant or breastfeeding?
What side effects might I experience?
Is this safe for long-term use?
What is nicotinamide riboside used for in this product?
What does betaine do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if NiaCel 400 is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind NiaCel 400’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Nicotinamide Riboside
Interacts with 172 drugsNicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...
Read the full Nicotinamide Riboside monograph → Herb & supplement monographBetaine Anhydrous
Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...
Read the full Betaine Anhydrous monograph →Sources & How We Checked
NiaCel 400's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 18 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Nicotinamide Riboside 7 references
- Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
- Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
- Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
- Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
- Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
- Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
- EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.
See these in context on the Nicotinamide Riboside monograph →
Betaine Anhydrous 11 references
- Cystadane (betaine anhydrous for oral solution) Package insert. Orphan Medical, Inc. Minnetonka, MN. November 2005.
- Abdelmalek MF, Angulo P, Jorgensen RA, et al. Betaine, a promising new agent for patients with nonalcoholic steatohepatitis: results of a pilot study. Am J Gastroenterol 2001;96:2711-7.. PubMed
- Schwab U, Torronen A, Toppinen L, et al. Betaine supplementation decreases plasma homocysteine concentrations but does not affect body weight, body composition, or resting energy expenditure in human subjects. Am J Clin Nutr 2002;76:961-7. PubMed
- McGregor DO, Dellow WJ, Robson RA, et al. Betaine supplementation decreases post-methionine hyperhomocysteinemia in chronic renal failure. Kidney Int 2002;61:1040-6. PubMed
- Olthof MR, van Vliet T, Verhoef P, et al. Effect of homocysteine-lowering nutrients on blood lipids: results from four randomised, placebo-controlled studies in healthy humans. PloS Med 2005;2:e135. PubMed
- Knopman, D. and Patterson, M. An open-label, 24-week pilot study of the methyl donor betaine in Alzheimer disease patients. Alzheimer Dis.Assoc.Disord. 2001;15(3):162-165. PubMed
- Moat, S. J., Madhavan, A., Taylor, S. Y., Payne, N., Allen, R. H., Stabler, S. P., Goodfellow, J., McDowell, I. F., Lewis, M. J., and Lang, D. High- but not low-dose folic acid improves endothelial function in coronary artery disease. Eur J Clin Invest 2 PubMed
- Abdelmalek, M. F., Sanderson, S. O., Angulo, P., Soldevila-Pico, C., Liu, C., Peter, J., Keach, J., Cave, M., Chen, T., McClain, C. J., and Lindor, K. D. Betaine for nonalcoholic fatty liver disease: results of a randomized placebo-controlled trial. Hepa PubMed
- Ashtary-Larky D, Bagheri R, Ghanavati M, et al. Effects of betaine supplementation on cardiovascular markers: a systematic review and meta-analysis. Crit Rev Food Sci Nutr. 2021 Mar 25:1-18. PubMed
- Zawieja EE, Zawieja B, Chmurzynska A. Betaine supplementation moderately increases total cholesterol levels: a systematic review and meta-analysis. J Diet Suppl. 2021;18(1):105-117. PubMed
- Imbard A, Toumazi A, Magréault S, et al. Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial. Orphanet J Rare Dis 2022;17(1):417. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC