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Dietary supplement

Nicotinamide Riboside (NR) Ingredients & Drug Interactions

by GenuinePurity

Nicotinamide Riboside (NR) label
See full label image
Capsule Category: Vitamin
Most serious interaction: Minor
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Nicotinamide Riboside (NR) against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Minor

Nicotinamide Riboside (NR) is a dietary supplement by GenuinePurity with 1 active ingredient. Its ingredients are commonly taken for healthy aging, boosting cellular energy, supporting metabolism.Based on those ingredients, 172 medications have a known interaction with it, the most serious rated minor. The ingredients most likely to interact are Nicotinamide Riboside. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Nicotinamide Riboside (NR) by GenuinePurity

Ask about any prescription or over-the-counter medication and we check it for interactions with Nicotinamide Riboside (NR) by GenuinePurity — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Nicotinamide Riboside (NR) by GenuinePurity

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: nicotinamide riboside (also known as NR). It's a compound related to niacin (vitamin B3) that your body uses to support cellular energy and other functions.

The capsule also contains inactive ingredients — cellulose, microcrystalline cellulose, maltodextrin, a phospholipid complex, silicon dioxide, and stearate — that help hold the supplement together and make it easier to swallow.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Nicotinamide Riboside's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: Healthy aging and cellular energy support.
  • We looked for evidence on: Athletic performance, Physical performance, Heart failure, Hypertension, Hyperlipidemia, Diabetes — and 4 related terms.
  • The closest evidence on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Nicotinamide Riboside is rated "Insufficient Reliable Evidence To Rate" for Nonalcoholic fatty liver disease (NAFLD), Heart failure, Diabetes, Hyperlipidemia, and more.

The evidence for nicotinamide riboside isn't established yet for the conditions we've reviewed. We hold insufficient reliable evidence to rate it for age-related macular degeneration, Alzheimer disease, athletic performance, nonalcoholic fatty liver disease, or heart failure.

If you're considering this supplement for one of those reasons, talk with your doctor about what the current science actually shows and whether it makes sense for you.

The evidence, ingredient by ingredient Nicotinamide Riboside

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Nicotinamide riboside appears generally well tolerated in short-term studies, though long-term safety data is limited. The most common side effects reported in clinical trials were bloating, muscle pain, nausea, itching, sweating, and changes in bowel movements — usually mild and temporary.

One person in a trial reported leg cramps. The safety data advises against use during pregnancy and while breastfeeding, since there isn't enough information to know whether it's safe in those situations.

Side effects, ingredient by ingredient Nicotinamide Riboside

Meds to double-check

Minor interactions only
Known Interaction Concern · database check
Minor only

Only Minor-severity interactions are documented for these ingredients.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Nicotinamide Riboside.
  • The most serious interaction on file is rated Minor.
  • For scale: 172 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take any blood pressure medication (antihypertensive drugs), check it with the search tool before taking nicotinamide riboside. The interaction is rated Minor, but it's the only documented medication concern with this ingredient.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Only minor medication interactions are documented, and safety information is well characterized.

Nicotinamide Riboside by GenuinePurity is a single-ingredient supplement that appears to cause few side effects in the short term. If you take blood pressure medication, check your specific drugs with the tool on this page before starting — and tell your pharmacist you're considering it.

Pregnant or nursing? Skip it until you've talked with your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Aug 22, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Nicotinamide Riboside (NR), straight from the product label.

Brand GenuinePurity
Barcode (UPC) 628043001480
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 22, 2025
DSLD ID 336121
Product type Vitamin
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Nicotinamide Riboside (NR) by GenuinePurity, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 VCapsule(s)
Maximum serving Sizes:
2 VCapsule(s)
Servings per container
30
UPC/BARCODE
628043001480
IngredientAmount% DV
Nicotinamide Riboside300 mg--

Other ingredients: Cellulose, Microcrystalline Cellulose, Maltodextrin, Phospholipid Complex, Silicon Dioxide, Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: 2 capsules daily preferably with meals or as directed by a healthcare professional.

Precautions

Caution: Do not exceed recommended dose.

This product is not intended for pregnant or nursing mothers, children under the age of 18, or persons with a known medical condition including any cardiovascular disorder, hypotension (low blood pressure) and Parkinson's disease.

This product is not intended for pregnant or nursing mothers, children under the age of 18, or persons with a known medical condition including any cardiovascular disorder, hypotension (low blood pressure) and Parkinson's disease. Keep out of reach of children.

This product is manufactured and packaged in a facility which may also process milk, soy, wheat, egg, peanuts, tree nuts, fish, and crustacean shellfish.

Do not purchase if seal is broken.

Storage

Protect from heat, light and moisture. Store at 15 degrees C - 30 degrees C (59-86 degrees F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Please recycle

Seals/Symbols

Made in USA GMP Sourced from a GMP Certified Facility

Formulation

Promotes cellular regeneration, mitochondrial function & DNA Health

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Nicotinamide Riboside (NR) by GenuinePurity label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Nicotinamide Riboside (NR) label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Nicotinamide Riboside (NR) by GenuinePurity

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 VCapsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Nicotinamide Riboside

Interacts with
172 drugs
300 mg per serving

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human st...

Nicotinamide Riboside monograph & interactions

Other (inactive) ingredients: Cellulose, Microcrystalline Cellulose, Maltodextrin, Phospholipid Complex, Silicon Dioxide, Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Nicotinamide Riboside (NR) by GenuinePurity Drug Interactions

Want to check YOUR meds against Nicotinamide Riboside (NR)?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
172Drugs
172 Minor

Ingredients driving the most interactions

Nicotinamide Riboside 172

Individual Drug Interactions

The ingredients in Nicotinamide Riboside (NR) interact with 172 drugs. Click any drug to see the details.

1 of the 1 ingredient in Nicotinamide Riboside (NR) interact with drugs. Each result below shows which ingredient is responsible. Nicotinamide Riboside

Each ingredient & the kinds of drugs it affects

For each ingredient in Nicotinamide Riboside (NR) with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Nicotinamide Riboside1 drug type · 172 drugs

Antihypertensive Drugs

Theoretically, nicotinamide riboside may have additive effects with antihypertensive drugs, potentially increasing the risk for hypotension.
One small clinical study suggests that nicotinamide riboside can modestly reduce blood pressure in hypertensive patients. However, other clinical research did not find a reduction in blood pressure when compared with control.

Likelihood Possible Evidence D
Nicotinamide Riboside full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Nicotinamide Riboside (NR), from the product label.

GenuinePurity

See all GenuinePurity products
Name
Genuine Purity
Street Address
100 Fidelitone Way
City
Elizabethton
State
TN
ZipCode
37643
Web Address
www.GenuinePurity.com
Pharmacist Counseling Corner

Nicotinamide Riboside (NR) by GenuinePurity: Common Questions

Does Nicotinamide Riboside (NR) by GenuinePurity interact with any medications?
Yes. Based on its ingredients, Nicotinamide Riboside (NR) has a known interaction with 172 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Nicotinamide Riboside (NR) contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is nicotinamide riboside and what does it do?
Nicotinamide riboside (NR) is a compound related to niacin, a B vitamin. Your body uses it to support cellular energy and other functions. It's been studied for various age-related and metabolic conditions, but the evidence isn't firm enough to recommend it for any of them yet.
Can I take this if I'm pregnant or breastfeeding?
No, the safety data advises against it. There isn't enough information to know whether it's safe during pregnancy or while breastfeeding, so it's best to avoid it during those times and talk with your doctor if you're thinking about it.
What side effects should I watch for?
The most common ones reported in trials were mild and temporary: bloating, muscle pain, nausea, itching, sweating, and changes in bowel movements. One person reported leg cramps. Most people tolerate it well in the short term, but long-term safety data is still limited.
Does nicotinamide riboside actually work for age-related problems like macular degeneration or Alzheimer disease?
The evidence isn't established yet. We hold insufficient reliable evidence to rate it for age-related macular degeneration, Alzheimer disease, athletic performance, fatty liver disease, or heart failure. Talk with your doctor about what research actually supports before starting it.
Will this lower my blood pressure?
One small study suggested nicotinamide riboside can modestly lower blood pressure, but other research didn't find that effect. If you take blood pressure medication, there's a Minor risk that nicotinamide riboside could add to its effect, so check with your pharmacist first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Nicotinamide Riboside (NR) is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Nicotinamide Riboside (NR) label
Go deeper

The Full Monographs Behind Nicotinamide Riboside (NR)’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Nicotinamide Riboside

Interacts with 172 drugs

Nicotinamide riboside (NR) is a form of vitamin B3 that the body converts into NAD+, a molecule involved in cellular energy and repair. Early human studies show it can reliably raise NAD+ le...

Read the full Nicotinamide Riboside monograph →
Sources

Sources & How We Checked

Nicotinamide Riboside (NR)'s label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 7 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Nicotinamide Riboside 7 references
  1. Martens CR, Denman BA, Mazzo MR, et al. Chronic nicotinamide riboside supplementation is well-tolerated and elevates NAD+ in healthy middle-aged and older adults. Nat Commun 2018;9(1):1286. PubMed
  2. Dollerup OL, Christensen B, Svart M, et al. A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects. Am J Clin Nutr 2018;108(2):343-53. PubMed
  3. Dellinger RW, Santos SR, Morris M, et al. Repeat dose NRPT (nicotinamide riboside and pterostilbene) increases NAD+ levels in humans safety and sustainably: a randomized, double-blind, placebo-controlled study. NPJ J Aging Mech Dis 2017;3:17.
  4. Conze D, Brenner C, Kruger CL. Safety and metabolism of long-term administration of NIAGEN (nicotinamide riboside chloride) in a randomized, double-blind, placebo-controlled clinical trial of healthy overweight adults. Sci Rep 2019;9(1):9772. PubMed
  5. Remie CME, Roumans KHM, Moonen MPB, et al. Nicotinamide riboside supplementation alters body composition and skeletal muscle acetylcarnitine concentrations in healthy obese humans. Am J Clin Nutr. 2020;112(2):413-426. PubMed
  6. Turck D, Castenmiller J, de Henauw S, et al. Safety of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283 and bioavailability of nicotinamide from this source, in the context of Directive 2002/46/EC. EFSA J. 2019;17(8):e0
  7. EFSA Panel on Nutrition, Novel Foods and Food Allergens (NDA), Turck D, et al. Extension of use of nicotinamide riboside chloride as a novel food pursuant to Regulation (EU) 2015/2283. EFSA J 2021;19(11):e06843.

See these in context on the Nicotinamide Riboside monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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