Major interaction on record — check this product against your medications before combining. Based on 7 of 12 ingredients. Check your meds →
Dietary supplement

NITRO TECH Power French Vanilla Swirl Ingredients & Drug Interactions

by MuscleTech Performance Series

NITRO TECH Power French Vanilla Swirl label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking NITRO TECH Power French Vanilla Swirl against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

NITRO TECH Power French Vanilla Swirl is a dietary supplement by MuscleTech Performance Series with 12 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 508 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Fenugreek, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series

Ask about any prescription or over-the-counter medication and we check it for interactions with NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 10 of its 10 active ingredients.
  • “BCAA Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Muscle Growth and Recovery Complex” is a proprietary blend — the label doesn't break down how much of each component you get.
  • “Test Support Complex” is a proprietary blend — the label doesn't break down how much of each component you get.

NITRO TECH Power French Vanilla Swirl contains 10 active ingredients. Sodium and calcium are key minerals — sodium helps fluid balance and nerve signaling, while calcium supports bone health and muscle function.

Creatine monohydrate fuels muscle cells and may enhance strength and athletic performance. The product includes branched-chain amino acids (BCAAs): L-valine, L-isoleucine, and L-leucine, which are amino acids that support muscle repair and recovery.

Betaine anhydrous is an organic compound that may support muscle and athletic performance. Boron citrate is a trace mineral, and fenugreek is a plant seed used traditionally for various health purposes.

Tart cherry concentrate may help with exercise recovery. The inactive ingredients include a protein blend, natural and artificial flavors, gums, salt, silicon dioxide, sucralose, acesulfame-potassium, and soy and sunflower lecithin.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Performance protein for muscle strength and exercise.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Exercise-induced muscle soreness, Cognitive function, Memory, Muscle recovery — and 2 related terms.
  • The strongest evidence on file: Sour Cherry is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Athletic performance.
  • Also on file: Boron is rated "Possibly Ineffective" for Athletic performance.

Calcium in this product is effective for treating low blood calcium and may be likely effective for osteoporosis prevention. Creatine monohydrate is possibly effective for building muscle strength and athletic performance, and possibly effective for sarcopenia (age-related muscle loss).

Fenugreek is possibly effective for sexual function and managing diabetes. Boron is likely effective for boron deficiency, and tart cherry concentrate is possibly effective for athletic performance.

Betaine anhydrous is effective for a rare genetic condition called homocystinuria and possibly effective for high homocysteine levels, but evidence for other uses — including muscle performance — is insufficient. For most other marketed claims on this product, we hold no effectiveness data.

The evidence, ingredient by ingredient Sodium Calcium Creatine Betaine Anhydrous Sour Cherry Boron Fenugreek

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium is generally well tolerated at recommended amounts; common mild side effects are constipation, bloating, and stomach upset. Sodium should be kept within normal dietary amounts — too much raises blood pressure and strains the heart and kidneys, and high intake is linked to increased gastric cancer risk.

Creatine is generally well tolerated in healthy adults but may cause dehydration, muscle cramps, water retention, and diarrhea; those with kidney disease should be careful. Rare serious effects include kidney inflammation and rhabdomyolysis.

Safety in pregnancy has not been established; avoid creatine if pregnant or nursing. Betaine anhydrous is generally well tolerated but may cause body odor, nausea, vomiting, and digestive upset.

Boron is safe in small amounts but can be toxic at high doses; avoid supplemental boron in pregnancy or while breastfeeding. Fenugreek is generally well tolerated but may cause abdominal pain, bloating, diarrhea, nausea, and in rare cases severe allergic reactions including anaphylaxis.

Tart cherry is generally well tolerated; a small number of people reported abdominal pain and loose stools in trials.

Side effects, ingredient by ingredient Sodium Calcium Creatine Betaine Anhydrous Sour Cherry Boron Fenugreek

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 7 matched ingredients can interact with medications — Fenugreek, Calcium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium.
  • For scale: 508 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before taking this product if you use HIV integrase inhibitors (dolutegravir, elvitegravir), the antibiotic ceftriaxone, blood pressure medications, corticosteroids, lithium, the HIV drug didanosine, bowel-prep solutions, tolvaptan, the heart drug diltiazem, the thyroid medication levothyroxine, the beta-blocker sotalol, the psoriasis drug calcipotriene, the HIV drug raltegravir, blood thinners or aspirin, diabetes medications, heart medications like metoprolol, seizure medications like phenytoin, or the erectile-dysfunction drug sildenafil. The sodium and calcium content particularly need review with your medications.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a protein powder designed for muscle building and recovery, built around amino acids, creatine, and other performance-focused ingredients. If you take any blood pressure medications, lithium, HIV drugs, blood thinners, diabetes medications, seizure medications, or heart medications, you need to check your exact drugs against the interaction tool before using this product — the calcium and sodium especially matter.

Talk to your pharmacist, particularly if you have kidney disease or take medications regularly.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 10 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about NITRO TECH Power French Vanilla Swirl, straight from the product label.

Brand MuscleTech Performance Series
Barcode (UPC) 631656709506
Net contents 2 lbs; 907 Gram(s)
Market status On market
Date entered into DSLD Oct 25, 2018
DSLD ID 182909
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
47 Gram(s)
Maximum serving Sizes:
94 Gram(s)
Servings per container
19
UPC/BARCODE
631656709506
IngredientAmount% DV
Calories330 Calorie(s), 160 Calorie(s)--
Total Carbohydrates6 Gram(s), 3 Gram(s)2%, 1%
Sugar4 Gram(s), 2 Gram(s)--
Calories from Fat60 Calorie(s), 30 Calorie(s)--
Saturated Fat4 Gram(s), 2 Gram(s)20%, 10%
Sodium320 mg, 160 mg13%, 7%
Cholesterol180 mg, 90 mg60%, 30%
Calcium420 mg, 210 mg42%, 21%
Total Fat7 Gram(s), 3.5 Gram(s)11%, 5%
Creatine Monohydrate6 Gram(s), 3 Gram(s)--
Protein60 Gram(s), 30 Gram(s)120%, 60%
L-Valine3.4 Gram(s), 1.7 Gram(s)--
L-Isoleucine3.4 Gram(s), 1.7 Gram(s)--
Betaine Anhydrous2.5 Gram(s), 1.25 Gram(s)--
Boron Citrate200 mg, 100 mg--
Fenugreek200 mg, 100 mg--
BCAA Complex0 NP, 0 NP--
L-Leucine8 Gram(s), 4 Gram(s)--
Muscle Growth and Recovery Complex0 NP, 0 NP--
Tart Cherry concentrate480 mg, 240 mg--
Test Support Complex0 NP, 0 NP--

Other ingredients: Multi-Phase Protein+ Blend, Natural and Artificial flavors, Gum Blend, Salt, Silicon Dioxide, Sucralose, Acesulfame-Potassium, Soy Lecithin, Sunflower Lecithin

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

#1 name in performance protein

#1 Most award winning sports nutrition brand

20 years of excellence

No hype No exceptions

See the research for yourself!

In a double-blind, placebo-controlled study, subjects supplementing with this same dose of creatine gained 11 lbs. of mass in 12 weeks (versus 7.5 lbs. for the placebo group). Willoughby and Rosene, 2001. Medicine & Science in Sports and Exercise. 33(10):1674-81.

In a gold-standard study, subjects gained 3.75 lbs. of muscle in 6 weeks (vs. 0.66 lbs. for the placebo) – an incredible 5 times the muscle! Cholewa et al., 2013. Journal of the International Society of Sports Nutrition. 10(1):39. Hoffman et al., 2009. Journal of the International Society of Sports Nutrition. 6:7.

Increased muscle strength and amplified recovery

Ispoglou et al., 2011. International Journal of Sports Physiology and Performance. 6(1):38-50.

Connolly et al., 2006. British Journal of Sports Medicine. 40:679-683.

Enhanced ATP regeneration and free testosterone support

Buford et al., 2007. Journal of the International Society of Sports Nutrition. 4:6.

Naghii et al., 2011. Journal of Trace Elements in Medicine and Biology. 25:54-58.

New! Research & Development

Subjects built 11 lbs. of mass & increased strength by 40% Enhances muscle performance & recovery Boosts testosterone & ATP regeneration Results based on core ingredient testing. See back for study details. Natural and artificial flavors

Like us on Facebook Twitter Instagram @MuscleTech

Note: This product is sold by weight. Some settling may occur.

Not intended to treat low testosterone or sexual dysfunction.

Made in the U.S.A. from domestic and international ingredients.

Seals/Symbols

Made in the USA from domestic & international ingredients

#1 Most Clinical Studies in Science American Masters of Taste Gold Medal Superior Taste

Guaranteed Banned Substance Free cGMP Manufactured Manufactured according to cGMP standards, as is required for all dietary supplements.

Formulation

Guaranteed Banned Substance Free

No proprietary blends No underdosed key ingredients No banned substances No fillers

Brand IP Statement(s)

Superior Science. Superior Results.

NITRO-TECH Power is the latest musclebuilding innovation from MuscleTech, the brand with over 20 years of excellence. NITRO-TECH Power contains several key ingredients shown in multiple clinical studies to help you pack on more muscle than ever.

Protected by U.S. patent #6,326,513.

2017.

Formula

The ultimate muscle-amplifying Protein

Scientifically superior musclebuilding Protein To create the ultimate musclebuilding protein, MuscleTech researchers started by packing a researched dose of 6g of Creatine into every 2 scoops of NITRO-TECH Power.

NITRO-TECH Power also contains a scientifically validated 2.5g dose of Betaine (per 2 scoops), which has been shown in multiple studies to increase strength and lean muscle.

This super-engineered formula is loaded with 14.8g of BCAAs, including 8g of highly anabolic Leucine (in 2 scoops), and is sure to ignite protein synthesis and put your body in a prime anabolic state. The amount of Leucine found in just one scoop of NITRO-TECH Power has been scientifically shown to increase strength by over 40%!

What’s more, this complete formula also features the 480mg dose (per 2 scoops) of Tart Cherry Powder that has been shown in emerging research to improve recovery through the reduction of muscle soreness post-exercise.

NITRO-TECH Power delivers a potent dose of Creatine, which research has shown can help your body regenerate ATP energy stores depleted during resistance training.

MuscleTech researchers also included the scientifically studied 200mg dose of Boron Citrate (per 2 scoops), supplying a dose of boron that has been shown to decrease estradiol and increase free testosterone within the normal range in only 7 days.

NITRO-TECH Power is superior to the competition Product NITRO-TECH Power Competitor Protein 60g 40g Total BCAAs 14.8g 11.98g Leucine 8g 6.66g Product NITRO-TECH Power Competitor Creatine 6g 2g Betaine 2.5g None Tart Cherry 480mg None Boron Citrate 200mg None

6-in-1 Supercharged Whey Peptide+ Formula Ultimate muscle-amplifying protein

60g Protein 14.8g BCAAs 8g Leucine Per 2 scoops

6g Creatine 2.5g Betaine 480mg Tart Cherry

Contains milk and soy ingredients.

FDA Statement of Identity

Dietary Supplement

Precautions

Contains milk and soy ingredients. Processed in a facility that processes wheat, egg, tree nut, peanut, fish and shellfish ingredients.

Do not use if packaging has been tampered with.

Warning: Not intended for use by persons under 18.

Do not use if pregnant or nursing.

Consult a medical doctor before starting any diet or exercise program, or if you have a medical condition.

Keep out of reach of children.

Notice: Use this product as a food supplement only. Do not use for weight reduction.

Suggested/Recommended/Usage/Directions

Directions: Mix 1 serving (1 scoop) with 8 oz. of water daily. For full effects, mix 2 servings (2 scoops) with 16 oz. of water. Maintain an adequate state of hydration during use.

Shake container before use.

Storage

Store in a cool, dry place (60(0)F to 80(0)F).

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

General

13556US 0917

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

NITRO TECH Power French Vanilla Swirl label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series

These are the 12 active ingredients this product is made of. Select any to open its full monograph.

Serving size47 Gram(s) Dosage formPowder Servings per container19 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

4 Gram(s) per serving

Sodium

Interacts with
205 drugs
320 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
420 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Protein

60 Gram(s) per serving

BCAA Complex

0 NP per serving
  • › L-Valine
  • › L-Isoleucine
  • › L-Leucine

Muscle Growth and Recovery Complex

0 NP per serving

Test Support Complex

0 NP per serving

Other (inactive) ingredients: Multi-Phase Protein+ Blend, Natural and Artificial flavors, Gum Blend, Salt, Silicon Dioxide, Sucralose, Acesulfame-Potassium, Soy Lecithin, Sunflower Lecithin. These complete the product’s ingredient list but are not active constituents.

Interaction report

NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series Drug Interactions

Want to check YOUR meds against NITRO TECH Power French Vanilla Swirl?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
508Drugs
7 Major 499 Moderate 2 Minor

Ingredients driving the most interactions

Fenugreek 389
Sodium 205
Calcium 168

Individual Drug Interactions

The ingredients in NITRO TECH Power French Vanilla Swirl interact with 508 drugs. Click any drug to see the details.

3 of the 12 ingredients in NITRO TECH Power French Vanilla Swirl interact with drugs. Each result below shows which ingredient is responsible. Fenugreek Sodium Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in NITRO TECH Power French Vanilla Swirl with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Fenugreek9 drug types · 389 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, fenugreek might have additive effects when used with anticoagulant or antiplatelet drugs.
Some of the constituents in fenugreek have antiplatelet effects in animal and in vitro research. However, common fenugreek products might not contain sufficient concentrations of these constituents for clinical effects. A clinical study in patients with coronary artery disease or diabetes shows that taking fenugreek seed powder 2.5 grams twice daily for 3 months does not affect platelet aggregation, fibrinolytic activity, or fibrinogen levels .

Likelihood Unlikely Evidence B
Antidiabetes Drugs

Theoretically, fenugreek seed might have additive hypoglycemic effects when used with antidiabetes drugs.
Clinical research shows that fenugreek seed can reduce fasting blood glucose and 2-hour postprandial glucose levels in adults with type 2 diabetes.

Likelihood Probable Evidence B
Clopidogrel (Plavix)

Theoretically, fenugreek seed might alter the clinical effects of clopidogrel by inhibiting its conversion to the active form.
Animal research shows that fenugreek seed 200 mg/kg daily for 14 days increases the maximum serum concentration of clopidogrel by 21%. It is unclear how this affects the pharmacokinetics of the active metabolite of clopidogrel; however, this study found that concomitant use of fenugreek seed and clopidogrel prolonged bleeding time by an additional 11%.

Likelihood Possible Evidence D
Metoprolol (Toprol)

Theoretically, fenugreek seed might have additive hypotensive effects when used with metoprolol.
Animal research shows that fenugreek seed 300 mg/kg daily for 2 weeks decreases systolic and diastolic blood pressure by 9% and 11%, respectively, when administered alone, and by 15% and 22%, respectively, when given with metoprolol 10 mg/kg.

Likelihood Probable Evidence B
Phenytoin (Dilantin)

Theoretically, fenugreek might decrease plasma levels of phenytoin.
Animal research shows that taking fenugreek seeds for 1 week decreases maximum concentrations and the area under the curve of a single dose of phenytoin by 44% and 72%, respectively. This seems to be related to increased clearance. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Sildenafil (Viagra)

Theoretically, concurrent use of sildenafil and fenugreek might reduce levels and therapeutic effects of sildenafil.
Animal research shows that taking fenugreek seeds for 1 week reduces maximum concentrations and the area under the curve of a single dose of sildenafil by 27% and 48%, respectively. So far, this interaction has not been reported in humans.

Likelihood Possible Evidence D
Theophylline

Theoretically, fenugreek may reduce the levels and clinical effects of theophylline.
Animal research shows that fenugreek 50 grams daily for 7 days reduces the maximum serum concentration (Cmax) of theophylline by 28% and the area under the plasma drug concentration-time curve (AUC) by 22%.

Likelihood Possible Evidence D
Warfarin (Coumadin)

Theoretically, fenugreek might have additive effects with warfarin and increase the international normalized ratio (INR).
Some fenugreek constituents have antiplatelet effects, although these might not be present in concentrations that are clinically significant. In one case report, a patient taking warfarin experienced an increased INR when starting to take fenugreek in combination with boldo.

Likelihood Possible Evidence D
Antihypertensive Drugs

Fenugreek may also have an additive effect on blood pressure-lowering medications. Studies on animals have shown that fenugreek seed can decrease both systolic and diastolic blood pressure by up to 22% when combined with metoprolol. Therefore, it is essential to monitor your blood pressure regularly if you are taking fenugreek and metoprolol together or any other antihypertensive drugs.

Likelihood Possible Evidence C
Fenugreek full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for NITRO TECH Power French Vanilla Swirl, from the product label.

MuscleTech Performance Series

See all MuscleTech Performance Series products
Name
Iovate Health Sciences U.S.A. Inc.
Street Address
1105 North Market Street, Suite 1330
City
Wilmington
State
DE
ZipCode
19801
Web Address
muscletech.com
Pharmacist Counseling Corner

NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series: Common Questions

Does NITRO TECH Power French Vanilla Swirl by MuscleTech Performance Series interact with any medications?
Yes. Based on its ingredients, NITRO TECH Power French Vanilla Swirl has a known interaction with 508 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
NITRO TECH Power French Vanilla Swirl contains 12 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe if I'm pregnant?
Safety data for most ingredients in this product during pregnancy isn't established or is limited. Creatine should be avoided in pregnancy. For the others, there isn't enough information to say yes or no — talk with your doctor or pharmacist about whether this product is right for you during pregnancy.
Can I use this if I'm breastfeeding?
Safety while breastfeeding hasn't been well established for creatine, betaine, boron, or the other ingredients in this blend. Fenugreek is sometimes used to boost milk supply, but evidence is limited. Discuss with your healthcare provider before starting.
Does creatine cause kidney damage?
Creatine is generally well tolerated in healthy adults. Rare case reports have raised concerns about kidney inflammation and reduced kidney function, but research in healthy people hasn't confirmed creatine damages kidneys. If you have kidney disease or reduced kidney function, check with your doctor first.
Will this actually build muscle?
Creatine is possibly effective for muscle strength and athletic performance. The amino acids support muscle repair. But a powder alone won't build muscle — you need resistance training and adequate overall protein, calories, and recovery.
What's the sodium content, and is it a problem?
The product facts don't specify the sodium amount per serving. Sodium is essential, but excess intake raises blood pressure and can strain your heart and kidneys. If you take blood pressure medications or lithium, or you have heart or kidney disease, the added sodium from this product may matter — ask your pharmacist to check the label.
Can I take this with my blood pressure medication?
Sodium in high amounts can reduce how well blood pressure drugs work. Because this product contains sodium, your pharmacist needs to review it with your specific medication and your doctor may need to adjust your dose. Don't start without checking first.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

NITRO TECH Power French Vanilla Swirl label
Go deeper

The Full Monographs Behind NITRO TECH Power French Vanilla Swirl’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph → Herb & supplement monograph

Sour Cherry

Sour cherry (often sold as tart cherry or Montmorency cherry) is a fruit-based supplement rich in antioxidants that people use for muscle recovery, joint and gout symptoms, and sleep. Early...

Read the full Sour Cherry monograph → Herb & supplement monograph

Boron

Boron is a trace mineral found in many plant foods and sold as a supplement, mainly promoted for bone, joint, and hormone health. The human evidence for most of these uses is limited or prel...

Read the full Boron monograph → Herb & supplement monograph

Fenugreek

Interacts with 389 drugs

Fenugreek is a common kitchen spice that is also taken as a supplement, mainly for blood sugar, cholesterol, and to support breast milk production. Some early research is encouraging for blo...

Read the full Fenugreek monograph →
Sources

Sources & How We Checked

NITRO TECH Power French Vanilla Swirl's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 237 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
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  27. Graudal NA, Hubeck-Graudal T, Jurgens G. Effects of low sodium diet versus high sodium diet on blood pressure, renin, aldosterone, catecholamines, cholesterol, and triglyceride. Cochrane Database Syst Rev 2020;12(12):CD004022. PubMed
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  30. Kyozuka H, Fukusda T, Murata T, et al. Impact of preconception sodium intake on hypertensive disorders of pregnancy: The Japan Environment and Children's study. Pregnancy Hypertens 2021;23:66-72. PubMed
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  35. Wang DD, Li Y, Nguyen XT, et al. Dietary sodium and potassium intake and risk of non-fatal cardiovascular diseases: The million veteran program. Nutrients 2022;14(5):1121. PubMed
  36. Kwak JH, Park CH, Eun CS, et al. The associations of dietary intake of high sodium and low zinc with gastric cancer mortality: A prospective cohort study in Korea. Nutr Cancer 2022;74(10):3501-3508. PubMed
  37. George S, Maiti R, Mishra BR, Jena M, Mohapatra D. Effect of regulated add-on sodium chloride intake on stabilization of serum lithium concentration in bipolar disorder: A randomized controlled trial. Bipolar Disord 2023;25(1):66-75. PubMed
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See these in context on the Sodium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Creatine 86 references
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  4. Soltanifar A, Moharreri F, Bakhtiari E, Hosseinpour A. The Effect of Adding Sour Cherry Concentrate to The Usual Treatment of Attention Deficit Hyperactivity Disorder In 6 To 12 Years Old Children. J Atten Disord 2023;27(2):214-219. PubMed

See these in context on the Sour Cherry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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