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Dietary supplement

Organic Borage Oil Ingredients & Drug Interactions

by Zongle Therapeutics

Organic Borage Oil label
See full label image
Liquid Category: Fat/fatty Acid
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 30, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Organic Borage Oil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Organic Borage Oil is a dietary supplement by Zongle Therapeutics with 1 active ingredient. Its ingredients are commonly taken for eczema and dry skin, rheumatoid arthritis, inflammation.Based on those ingredients, 226 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Borage. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Organic Borage Oil by Zongle Therapeutics

Ask about any prescription or over-the-counter medication and we check it for interactions with Organic Borage Oil by Zongle Therapeutics — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Organic Borage Oil by Zongle Therapeutics

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Aug 27, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Zongle Therapeutics Organic Borage Oil is a single-ingredient supplement: borage seed oil, cold-pressed. Borage seed oil is pressed from the seeds of the borage plant and contains gamma-linolenic acid (GLA), an omega-6 fatty acid your body can convert into compounds that may help reduce inflammation.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Borage's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: skin health, joint support, inflammation relief.
  • We looked for evidence on: Atopic dermatitis (eczema), Neurodermatitis, Rheumatoid arthritis (RA), Premenstrual syndrome (PMS), Stress, Fatigue — and 3 related terms.
  • The closest evidence on file: Borage is rated "Possibly Ineffective" for Atopic dermatitis (eczema) (Natural Medicines).
  • Also on file: Borage is rated "Insufficient Reliable Evidence To Rate" for Acute respiratory distress syndrome (ARDS), Seborrheic dermatitis, Premenstrual syndrome (PMS), Rheumatoid arthritis (RA), and more.

The evidence on borage oil is mixed and incomplete. For atopic dermatitis (eczema), the data we hold suggests it's possibly ineffective.

For attention deficit-hyperactivity disorder (ADHD), acute respiratory distress syndrome (ARDS), and alcoholism, there isn't enough reliable evidence to rate whether it works.

The evidence, ingredient by ingredient Borage

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, borage seed oil is generally well tolerated, with the most common side effects being mild digestive issues: belching, bloating, diarrhea, and soft stools. However, borage plant parts that contain liver-toxic alkaloids (pyrrolizidine alkaloids, or PAs) should be avoided — while borage seed oil itself contains little to no PAs, contamination is a concern.

The safety data advises against using borage oil during pregnancy because of possible liver-toxic alkaloids and a theoretical risk to the uterus. Not enough safety data exists for breastfeeding, so it's best avoided.

If you use this product long-term, look for seed oil certified to be free of pyrrolizidine alkaloids.

Side effects, ingredient by ingredient Borage

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Borage.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 227 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this borage oil, double-check with your doctor or pharmacist if you take blood thinners or antiplatelet drugs — borage may increase bleeding risk. Also flag it if you're on antipsychotics (phenothiazines) or drugs that induce CYP3A4 liver enzymes, both Moderate interaction risks.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Zongle Therapeutics Organic Borage Oil is a single-ingredient supplement with mixed evidence for the conditions it's marketed for. If you take blood thinners, antipsychotics, or medications that speed up liver processing, you'll want to check with your doctor or pharmacist before starting this product — the interaction risk is real.

If you're pregnant, breastfeeding, or have liver concerns, talk it over with your healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Organic Borage Oil, straight from the product label.

Brand Zongle Therapeutics
Barcode (UPC) 856426006641
Net contents 4 Fluid Ounce(s); 118 mL
Market status On market
Date entered into DSLD Oct 24, 2022
DSLD ID 276617
Product type Fat/fatty Acid
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Organic, Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Organic Borage Oil by Zongle Therapeutics, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Drop(s)
Maximum serving Sizes:
1 Drop(s)
Servings per container
2000
UPC/BARCODE
856426006641
IngredientAmount% DV
Borage60 mg--

Other ingredients: Borage Oil, Cold-Pressed

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

For topical or internal use.

Formulation

USDA certified organic

Helps relieve premenstrual discomfort Promotes alertness Helps with dermatitis, eczema and other skin problems Helps reduce inflammation Helps relieve fatigue Promotes healthy joint support

Certified Organic USDA Organic

Therapeutic grade

GMO free Artificial ingredients free Paraben free Pesticide free Preservatives free Gluten free Cruelty free

Vegan

Origin: China Bottled in USA

Certified organic by GCIAOCP

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Caution: Possible skin sensitivity.

Keep out of reach of children.

If you are pregnant, nursing, or under a doctor's care, consult your physician.

Avoid contact with eyes, inner ears, and sensitive areas.

Formula

Borago officinalis

FDA Statement of Identity

Carrier Oil Supplement

Seals/Symbols

USDA Organic

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Organic Borage Oil by Zongle Therapeutics label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Organic Borage Oil label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Organic Borage Oil by Zongle Therapeutics

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Drop(s) Dosage formLiquid Servings per container2000 Amounts shown are per serving.

Borage

Interacts with
226 drugs
60 mg per serving

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arth...

Borage monograph & interactions

Other (inactive) ingredients: Borage Oil, Cold-Pressed. These complete the product’s ingredient list but are not active constituents.

Interaction report

Organic Borage Oil by Zongle Therapeutics Drug Interactions

Want to check YOUR meds against Organic Borage Oil?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
226Drugs
226 Moderate

Ingredients driving the most interactions

Borage 226

Individual Drug Interactions

The ingredients in Organic Borage Oil interact with 226 drugs. Click any drug to see the details.

1 of the 1 ingredient in Organic Borage Oil interact with drugs. Each result below shows which ingredient is responsible. Borage

Each ingredient & the kinds of drugs it affects

For each ingredient in Organic Borage Oil with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Borage3 drug types · 226 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, borage seed oil may increase the risk of bleeding if used with anticoagulant or antiplatelet drugs.
In healthy individuals, borage seed oil supplementation does not seem to affect platelet aggregation. However, gamma-linolenic acid, a constituent of borage seed oil, seems to decrease platelet aggregation by 45% and increase the risk of bleeding by 40% in animal and clinical research.

Likelihood Possible Evidence B
Cytochrome P450 3A4 (Cyp3A4) Inducers

Theoretically, taking borage with drugs that induce CYP3A4 might increase levels of pyrrolizidine alkaloid (PA) toxic metabolites.
Although borage seed oil contains little to no PAs, some borage plant parts, such as the leaf, flower, and seed, can contain hepatotoxic PAs. Hepatotoxic PAs are substrates of CYP3A4, which converts these chemicals into toxic metabolites. Tell patients to avoid borage preparations that are not certified and labeled as hepatotoxic PA-free.

Likelihood Possible Evidence D
Phenothiazines

Theoretically, taking borage sed oil with phenothiazines might increase the risk of seizures.
Borage seed oil contains gamma-linolenic acid (GLA). There is concern that taking supplements containing GLA might cause seizures, or lower the seizure threshold, when taken with phenothiazines. This is based on limited data from two reports published in the 1980s. In one report, three patients with schizophrenia who had received phenothiazines developed EEG changes suggestive of temporal lobe epilepsy after starting treatment with evening primrose, another source of GLA. However, none experienced an actual seizure. In the other report, two patients with schizophrenia who were stabilized on phenothiazines developed seizures when evening primrose 4 grams daily was added. One of these patients had a prior history of seizures. It is unclear whether evening primrose had any additive epileptogenic effects with the phenothiazines, but there is no evidence that taking GLA-containing supplements alone can cause seizures.

Likelihood Possible Evidence D
Borage full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Organic Borage Oil, from the product label.

Zongle Therapeutics

See all Zongle Therapeutics products
Name
Zongle Therapeutics LLC
City
Norcross
State
GA
ZipCode
30093
Web Address
www.zongletherapeutics.com
Pharmacist Counseling Corner

Organic Borage Oil by Zongle Therapeutics: Common Questions

Does Organic Borage Oil by Zongle Therapeutics interact with any medications?
Yes. Based on its ingredients, Organic Borage Oil has a known interaction with 226 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Organic Borage Oil contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take while pregnant?
No. The safety data advises against borage oil during pregnancy because of possible liver-toxic alkaloids and a theoretical risk to the uterus. Talk with your doctor or pharmacist before taking it if you are pregnant or planning to become pregnant.
Is this safe while breastfeeding?
There isn't enough safety data to know either way. It's best avoided until you've talked it over with your doctor or pharmacist.
What are the most common side effects?
The most common side effects are mild and digestive: belching, bloating, diarrhea, and soft stools. Serious side effects are rare with seed oil, but borage plant parts containing liver-toxic alkaloids should be avoided.
Does borage oil actually work for eczema?
The evidence we hold suggests it's possibly ineffective for atopic dermatitis (eczema). For other conditions like ADHD or acute respiratory distress syndrome, there isn't enough reliable evidence to say whether it works.
Why should I choose certified pyrrolizidine alkaloid (PA)-free seed oil?
Pyrrolizidine alkaloids are liver-toxic compounds found in some borage plant parts. While borage seed oil contains little to no PAs, contamination from other plant parts can occur during processing. Certified PA-free seed oil is generally better tolerated.
Can I take this if I'm on a blood thinner?
Borage oil may increase the risk of bleeding with blood thinners and antiplatelet drugs. Check with your doctor or pharmacist before starting — they'll know your full medication picture and can help you decide whether it's right for you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Organic Borage Oil label
Go deeper

The Full Monographs Behind Organic Borage Oil’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Borage

Interacts with 226 drugs

Borage is a Mediterranean herb whose seed oil is rich in gamma-linolenic acid (GLA), an omega-6 fatty acid studied mostly for skin conditions and arthritis with mixed results. The plant's le...

Read the full Borage monograph →
Sources

Sources & How We Checked

Organic Borage Oil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 11 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Borage 11 references
  1. Guivernau M, Meza N, Barja P, Roman O. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Prostaglandins Leukot Essent Fatty A PubMed
  2. WHO working group. Pyrrolizidine alkaloids. Environmental Health Criteria, 80. WHO: Geneva, 1988.
  3. Fan YY, Chapkin RS. Importance of dietary gamma-linolenic acid in human health and nutrition. J Nutr 1998;128:1411-4.
  4. Takwale A, Tan E, Agarwal S, et al. Efficacy and tolerability of borage oil in adults and children with atopic eczema: randomised, double blind, placebo controlled, parallel group trial. BMJ 2003;327:1385. PubMed
  5. Chojkier M. Hepatic sinusoidal-obstruction syndrome: toxicity of pyrrolizidine alkaloids. J Hepatol 2003;39:437-46. PubMed
  6. Roeder E. Medicinal plants in Europe containing pyrrolizidine alkaloids. Pharmazie 1995;50:83-98.
  7. Wang YP, Yan J, Fu PP, Chou MW. Human liver microsomal reduction of pyrrolizidine alkaloid N-oxides to form the corresponding carcinogenic parent alkaloid. Toxicol Lett 2005;155:411-20. PubMed
  8. Holman CP and Bell AF. A trial of evening primrose oil in the treatment of chronic schizophrenia. J Orhtomolecular Psych 1983;12:302-304.
  9. Vaddadi KS. The use of gamma-linolenic acid and linoleic acid to differentiate between temporal lobe epilepsy and schizophrenia. Prostaglandins Med 1981;6(4):375-379. PubMed
  10. Bard, J. M., Luc, G., Jude, B., Bordet, J. C., Lacroix, B., Bonte, J. P., Parra, H. J., and Duriez, P. A therapeutic dosage (3 g/day) of borage oil supplementation has no effect on platelet aggregation in healthy volunteers. Fundam.Clin.Pharmacol. 1997;1
  11. Puri BK. The safety of evening primrose oil in epilepsy. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. PubMed

See these in context on the Borage monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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