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Dietary supplement

Pau D'Arco Ingredients & Drug Interactions

by Eclectic Herb

Pau D'Arco label
See full label image
Liquid Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pau D'Arco against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pau D'Arco is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for infections (bacterial, fungal, yeast), inflammation, immune support.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pau d'Arco Inner Bark Extract, Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pau D'Arco by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Pau D'Arco by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pau D'Arco by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 1 active ingredient.

This product contains one active ingredient: pau d'arco inner bark extract, dried. Pau d'arco is a tropical tree bark traditionally used for various purposes, though modern evidence for most of those uses is limited.

The liquid is made with alcohol and filtered water as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Immune support.
  • We looked for evidence on: infection, inflammation, antifungal.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The evidence doesn't support pau d'arco for cancer, peptic ulcers, wound healing, or dysmenorrhea (menstrual pain). In all four cases, the data we hold rates effectiveness as insufficient—meaning either no solid studies exist, the studies are too small or poorly designed, or results don't consistently show a benefit.

If you're considering pau d'arco for any of these conditions, talk to your doctor or pharmacist about what the science actually backs.

The evidence, ingredient by ingredient Pau D'arco

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pau d'arco is generally well tolerated at typical doses, but human safety data is limited and side effects can occur at higher doses. If you take more than 1.5 grams daily of its main active ingredient (lapachol), you may experience anemia (low red blood cells), increased bleeding risk, severe nausea, vomiting, or diarrhea.

The safety data advises against using pau d'arco during pregnancy due to possible harm to the developing baby, and there isn't enough information to know whether it's safe while breastfeeding—talk with your doctor or pharmacist for personalized advice if either applies to you.

Side effects, ingredient by ingredient Pau D'arco

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pau D'arco.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using pau d'arco if you take any blood thinner or antiplatelet medication (warfarin, aspirin, clopidogrel, or similar drugs). The interaction is rated Moderate and relates to increased bleeding risk, especially at higher doses.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pau d'arco may be worth exploring if you're interested in traditional herbal use, but evidence for its effectiveness is thin. If you take blood thinners or antiplatelet drugs, you'll want to check this with your pharmacist before starting.

Skip it during pregnancy, and get personalized advice on breastfeeding from your doctor.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pau D'Arco, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363111183
Net contents 2 Fluid Ounce(s); 60 mL
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 316857
Product type Botanical
Supplement form Liquid
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Kosher
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pau D'Arco by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Full Dropper(s)
Maximum serving Sizes:
1 Full Dropper(s)
UPC/BARCODE
023363111183
IngredientAmount% DV
Pau d'Arco Inner Bark Extract, Dried0 NP--

Other ingredients: Alcohol, Water, Filtered

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Immune support Herbal extract

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested use: Shake well; Mix 1 full dropper in water; take 3 times daily.

Storage

Store upright.

Precautions

Keep out of reach of children. Consult your health care advisor regarding the use of herbs during pregnancy, with infants or prescription drugs.

Discontinue if unusual symptoms occur.

Consult your health care advisor regarding the use of herbs during pregnancy, with infants or prescription drugs.

Formula

100% Kosher

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent diseases.

General Statements

@eclecticherb

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pau D'Arco by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pau D'Arco label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pau D'Arco by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Full Dropper(s) Dosage formLiquid Amounts shown are per serving.

Pau d'Arco Inner Bark Extract, Dried

Interacts with
122 drugs
0 NP per serving Form: Tabebuia impetiginosa Inner Bark Extract, Dried

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activit...

Pau d'Arco Inner Bark Extract, Dried monograph & interactions

Other (inactive) ingredients: Alcohol, Water, Filtered. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pau D'Arco by Eclectic Herb Drug Interactions

Want to check YOUR meds against Pau D'Arco?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Pau d'Arco Inner Bark Extract, Dried 122

Individual Drug Interactions

The ingredients in Pau D'Arco interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pau D'Arco interact with drugs. Each result below shows which ingredient is responsible. Pau d'Arco Inner Bark Extract, Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Pau D'Arco with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pau d'Arco Inner Bark Extract, Dried1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, pau d'arco might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that pau d'arco reduces platelet aggregation and may interfere with vitamin K. One clinical study shows that taking the lapachol constituent of pau d'arco in doses above 1.5 grams daily increases the risk of bleeding. The effects of whole pau d'arco or pau d'arco extract in humans are unclear.

Likelihood Possible Evidence D
Pau d'Arco Inner Bark Extract, Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pau D'Arco, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Pau D'Arco by Eclectic Herb: Common Questions

Does Pau D'Arco by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Pau D'Arco has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pau D'Arco contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pau d'arco while pregnant?
No. The safety data advises against pau d'arco during pregnancy due to possible harm to the developing baby and a lack of safety information. Talk with your doctor about safe alternatives.
Can I take pau d'arco while breastfeeding?
There isn't enough safety information available to know whether it's safe while breastfeeding. Talk with your doctor or pharmacist for personalized advice.
Does pau d'arco really work for cancer?
The evidence we have rates it as insufficient to say. There's no solid scientific support for pau d'arco as a cancer treatment, so don't rely on it as your main approach. Talk with your oncologist about proven options.
What are the side effects at higher doses?
If you take more than 1.5 grams daily of lapachol (pau d'arco's main active ingredient), you may experience anemia, increased bleeding, severe nausea, vomiting, or diarrhea. Human safety data at these doses is limited, so be cautious.
Does this liquid contain alcohol?
Yes, alcohol and filtered water are the inactive ingredients in this extract.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pau D'Arco is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pau D'Arco label
Go deeper

The Full Monographs Behind Pau D'Arco’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pau D'arco

Interacts with 122 drugs

Pau d'arco is a South American tree bark traditionally used for infections and inflammation, and it contains compounds like lapachol that show activity in lab studies. However, strong human...

Read the full Pau D'arco monograph →
Sources

Sources & How We Checked

Pau D'Arco's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pau D'arco 6 references
  1. Gómez Castellanos JR, Prieto JM, Heinrich M. Red Lapacho (Tabebuia impetiginosa)--a global ethnopharmacological commodity? J Ethnopharmacol 2009;121:1-13. PubMed
  2. Guerra, Mde O., Mazoni, A. S., Brandao, M. A., and Peters, V. M. Toxicology of Lapachol in rats: embryolethality. Braz.J Biol. 2001;61(1):171-174. PubMed
  3. Felicio, A. C., Chang, C. V., Brandao, M. A., Peters, V. M., and Guerra, Mde O. Fetal growth in rats treated with lapachol. Contraception 2002;66(4):289-293. PubMed
  4. Son, D. J., Lim, Y., Park, Y. H., Chang, S. K., Yun, Y. P., Hong, J. T., Takeoka, G. R., Lee, K. G., Lee, S. E., Kim, M. R., Kim, J. H., and Park, B. S. Inhibitory effects of Tabebuia impetiginosa inner bark extract on platelet aggregation and vascular s
  5. Block JB, Serpick AA, Miller W, Wiernik PH. Early clinical studies with lapachol (NSC-11905). Cancer Chemother Rep 2. 1974;4(4):27-8.
  6. Algranti E, Mendonça EM, Ali SA, Kokron CM, Raile V. Occupational asthma caused by Ipe (Tabebuia spp) dust. J Investig Allergol Clin Immunol 2005;15(1):81-3.

See these in context on the Pau D'arco monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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