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Dietary supplement

Bilberry 400 mg Ingredients & Drug Interactions

by Eclectic Herb

Bilberry 400 mg label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 9, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Bilberry 400 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Bilberry 400 mg is a dietary supplement by Eclectic Herb with 1 active ingredient. Its ingredients are commonly taken for eye and vision health, antioxidant support, diarrhea and digestive upset.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bilberry, Freeze-Dried. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Bilberry 400 mg by Eclectic Herb

Ask about any prescription or over-the-counter medication and we check it for interactions with Bilberry 400 mg by Eclectic Herb — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Bilberry 400 mg by Eclectic Herb

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 16, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains one active ingredient: bilberry, freeze-dried and concentrated to 400 mg per capsule. Bilberry is a small, dark purple berry rich in anthocyanidins — pigments thought to have antioxidant properties.

The only other ingredient listed is hypromellose, the capsule material itself.

Does it work?

No specific claim
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
General wellness

This Bilberry product is marketed for general wellness, not a specific health condition, so there's no single claim to grade — see Bilberry's own graded uses on its monograph.

Why this rating?
  • The label markets general wellness (“antioxidant support”), not a specific health condition, so there is no single claim to grade against clinical-evidence data.

The evidence for bilberry's effectiveness is mixed and limited. For night vision, current data rates it as possibly ineffective — it hasn't shown the benefit many people expect.

For age-related cognitive decline, age-related macular degeneration, atherosclerosis, high cholesterol, and chronic venous insufficiency, there simply isn't enough reliable evidence to know whether it works. If you're considering this for a specific health goal, talk it over with your doctor or pharmacist to see whether the evidence supports it for your situation.

The evidence, ingredient by ingredient Bilberry

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bilberry fruit eaten as food is generally well tolerated, but the safety of concentrated supplement doses hasn't been studied enough to be confident. The most common side effects are gastrointestinal — dark-colored or dark-green stools, flatulence, and belly discomfort.

In studies, these were mild and temporary; one trial reported them in about 13% to 33% of people, though some had existing digestive conditions. You may also notice temporary discoloration of your tongue, teeth, or stool — bilberry's pigments can stain.

Pregnancy and lactation are rated likely safe, but supplement evidence is limited overall, so discussing this with your own doctor or pharmacist beforehand is wise.

Side effects, ingredient by ingredient Bilberry

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bilberry.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications.
  • For scale: 275 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check it with your doctor or pharmacist if you take blood thinners or antiplatelet drugs like warfarin or aspirin (Moderate risk of increased bleeding), diabetes medications (Moderate risk of low blood sugar), or erlotinib for cancer (Moderate risk the drug may not work as well). Bilberry may also affect other drugs your liver processes through the CYP2E1 enzyme.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula marketed for general wellness rather than one specific gradeable purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Bilberry may interest you if you're exploring traditional herbal options, but be aware the evidence for most claimed benefits isn't solid, and it does interact with blood thinners, diabetes drugs, and certain cancer medications. If you take any prescription medication — especially anticoagulants, blood thinners, diabetes drugs, or erlotinib — check with your doctor or pharmacist before starting this supplement.

Expect possible dark stools or mild belly discomfort.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 18, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Bilberry 400 mg, straight from the product label.

Brand Eclectic Herb
Barcode (UPC) 023363301683
Net contents 120 Veg Cap(s)
Market status On market
Date entered into DSLD Jul 18, 2023
DSLD ID 294655
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Kosher, Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Bilberry 400 mg by Eclectic Herb, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Capsule(s)
Maximum serving Sizes:
3 Capsule(s)
Servings per container
40
UPC/BARCODE
023363301683
IngredientAmount% DV
Bilberry, Freeze-Dried1200 mg--

Other ingredients: Hypromellose

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Antioxidant Raw Naturally concentrated US grown

Vegan

Gluten free Non GMO Nothing artificial - no fillers or additives.

Freeze dried fresh for peak plant power Freeze-drying is the best method of preservation as it naturally concentrates the nutrients in the plant by removing only the water.

Concentrated 7 1/2 X through freeze-drying

Formula

Whole herbs Our aronia berries are locally grown and fresh freeze-dried in-house in small batches.

100% kosher.

FDA Disclaimer Statement

This statement has not been evaluated by the FDA. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

@eclecticherb

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Take 3 capsules 2 times per day.

Precautions

Keep out of reach of children.

Discontinue use if unusual symptoms occur.

Consult your health care advisor regarding herbs with pregnancy, infants or prescription drugs.

Consult your health care advisor regarding herbs with pregnancy, infants or prescription drugs.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Bilberry 400 mg by Eclectic Herb label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Bilberry 400 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Bilberry 400 mg by Eclectic Herb

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size3 Capsule(s) Dosage formCapsule Servings per container40 Amounts shown are per serving.

Bilberry, Freeze-Dried

Interacts with
275 drugs
1200 mg per serving

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye healt...

Bilberry, Freeze-Dried monograph & interactions

Other (inactive) ingredients: Hypromellose. These complete the product’s ingredient list but are not active constituents.

Interaction report

Bilberry 400 mg by Eclectic Herb Drug Interactions

Want to check YOUR meds against Bilberry 400 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
275Drugs
275 Moderate

Ingredients driving the most interactions

Bilberry, Freeze-Dried 275

Individual Drug Interactions

The ingredients in Bilberry 400 mg interact with 275 drugs. Click any drug to see the details.

1 of the 1 ingredient in Bilberry 400 mg interact with drugs. Each result below shows which ingredient is responsible. Bilberry, Freeze-Dried

Each ingredient & the kinds of drugs it affects

For each ingredient in Bilberry 400 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Bilberry, Freeze-Dried4 drug types · 275 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, bilberry fruit extract might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro, animal, and clinical research suggest that anthocyanidin extracts from bilberry can inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, bilberry leaf or fruit extract may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that bilberry leaf extract might have blood glucose-lowering activity. Also, one small clinical trial in patients with type 2 diabetes shows that taking bilberry fruit extract 470 mg as a single dose prior to an oral glucose tolerance test lowers plasma glucose levels when compared with placebo.

Likelihood Possible Evidence D
Cytochrome P450 2E1 (Cyp2E1) Substrates

Theoretically, bilberry fruit extract might decrease levels of drugs metabolized by CYP2E1.
Animal research shows that exposure to small concentrations of bilberry extract in drinking water for around one month increased CYP2E1 activity by 31%. However, exposure over a 2-month period did not increase CYP2E1 activity. This effect has not been reported in humans.

Likelihood Possible Evidence D
Erlotinib (Tarceva)

Theoretically, bilberry fruit extract might reduce the efficacy of erlotinib.
In vitro research suggests that bilberry fruit extract and its constituents, delphinidin and delphinidin-3-O-glucoside, inhibit the activity of erlotinib. This interaction has not been reported in humans.

Likelihood Possible Evidence D
Bilberry, Freeze-Dried full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Bilberry 400 mg, from the product label.

Eclectic Herb

See all Eclectic Herb products
Name
Eclectic Herb
Street Address
755 NE 6th St.
City
Gresham
State
Oregon
ZipCode
97030
Phone Number
503.668.4120
Web Address
www.eclecticherb.com
Pharmacist Counseling Corner

Bilberry 400 mg by Eclectic Herb: Common Questions

Does Bilberry 400 mg by Eclectic Herb interact with any medications?
Yes. Based on its ingredients, Bilberry 400 mg has a known interaction with 275 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Bilberry 400 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does bilberry really help with night vision?
The current evidence rates bilberry as possibly ineffective for night vision — it hasn't shown the benefit that's often claimed for it. If better vision is your goal, talk with your eye doctor about what actually works.
What are the most common side effects?
Dark-colored or dark-green stools and mild flatulence or belly discomfort are the most common effects, and they tend to be temporary. You may also notice your tongue or stool turning a dark blue-black color from bilberry's pigments — it looks alarming but isn't harmful.
Is bilberry safe during pregnancy or while breastfeeding?
Bilberry is rated likely safe in pregnancy and lactation, but safety data on concentrated supplements is limited. Talk with your doctor or midwife before taking it to make sure it's the right call for your situation.
Can I take this if I'm on diabetes medication?
That's a conversation to have with your doctor or pharmacist first. Bilberry may lower blood sugar on its own, so combining it with your diabetes drug could push your glucose too low. They can advise whether it's safe for you.
Will this work if I'm on a blood thinner?
No — you should not take this product with blood thinners or antiplatelet drugs like warfarin or aspirin without checking with your doctor first. Bilberry can slow blood clotting, and combining it with these drugs raises the risk of bleeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Bilberry 400 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Bilberry 400 mg label
Go deeper

The Full Monographs Behind Bilberry 400 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bilberry

Interacts with 275 drugs

Bilberry is a blueberry-like fruit rich in antioxidant plant compounds called anthocyanins, and it has a long history of traditional use for eye health, circulation, and mild diarrhea. While...

Read the full Bilberry monograph →
Sources

Sources & How We Checked

Bilberry 400 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bilberry 14 references
  1. Cignarella A, Nastasi M, Cavalli E, Puglisi L. Novel lipid-lowering properties of Vaccinium myrtillus L. leaves, a traditional antidiabetic treatment, in several models of rat dyslipidaemia: a comparison with ciprofibrate. Thromb Res 1996;84:311-22. PubMed
  2. Morazzoni P, Magistretti MJ. Activity of Myrtocyan, an anthosyanoside complex from Vaccinium myrtillus (VMA), on platelet aggregation and adhesiveness. Fitoterapia 1990;61:13-21.
  3. Erlund, I., Koli, R., Alfthan, G., Marniemi, J., Puukka, P., Mustonen, P., Mattila, P., and Jula, A. Favorable effects of berry consumption on platelet function, blood pressure, and HDL cholesterol. Am J Clin Nutr 2008;87(2):323-331. PubMed
  4. Hawrelak, J. A. and Myers, S. P. Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study. J Altern Complement Med 2010;16(10):1065-1071. PubMed
  5. Morazzoni P and Magistretti MJ. Effects of Vaccinium myrtillus anthocyanosides on prostacyclin-like activity in rat arterial issue. Fitoterapia 1986;57:11-14.
  6. Pulliero G, Montin S, Bettini V, and et al. Ex vivo study of the inhibitory effects of Vaccinium myrtillus anthocyanosides on human platelet aggregation. Fitoterapia 1989;60:69-75.
  7. Bottecchia D. Preliminary report on the inhibitory effect of vaccinium myrtillus anthocyanosides on platelet aggregation and clot retraction. Fitoterapia 1987;48:3-8.
  8. Fdez, M., Zaragoza, F., and Alvarez, P. In vitro platelet aggregation effects of anthocyanosides of vaccinium myrtilus L. Anales de la Real Academia de Farmacia 1983;49:79-90.
  9. Biedermann L, Mwinyi J, Scharl M, Frei P, Zeitz J, Kullak-Ublick GA, et al. Bilberry ingestion improves disease activity in mild to moderate ulcerative colitis-an open pilot study. 2013 May;7(4):271-9. PubMed
  10. Hoggard N, Cruickshank M, Moar KM, Bestwick C, Holst J, Russell W, et al. A single supplement of a standardized bilberry (Vaccinium myrtillus L.) extract (36% wet weight anthocyanins) modifies glycaemic response in individuals with type 2 diabetes control
  11. Aichinger G, Pahlke G, Nagel LJ, Berger W, Marko D. Bilberry extract, its major phenolic compounds, and soy isoflavone genistein antagonize the cytostatic drug erlotinib in human epithelial cells. Food Funct 2016;7(8):3628-36.
  12. Prokop J, Lněničková K, Cibicek N, et al. Effect of bilberry extract (Vaccinium myrtillus L.) on drug-metabolizing enzymes in rats. Food Chem Toxicol 2019;129:382-90. PubMed
  13. Chan SW, Chu TTW, Choi SW, Benzie IFF, Tomlinson B. Impact of short-term bilberry supplementation on glycemic control, cardiovascular disease risk factors, and antioxidant status in Chinese patients with type 2 diabetes. Phytother Res 2021. Online ahead o PubMed
  14. Bøhn SK, Myhrstad MCW, Thoresen M, et al. Bilberry/red grape juice decreases plasma biomarkers of inflammation and tissue damage in aged men with subjective memory impairment -a randomized clinical trial. BMC Nutr 2021;7(1):75. PubMed

See these in context on the Bilberry monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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