Interactions on record — worth a quick check against your medications. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

Peak Maximum Endurance Ingredients & Drug Interactions

by Peak Pure & Natural

Peak Maximum Endurance label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Peak Maximum Endurance against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Peak Maximum Endurance is a dietary supplement by Peak Pure & Natural with 3 active ingredients. Its ingredients are commonly taken for estrogen/hormone balance, acne and hormonal skin issues, prostate health support.Based on those ingredients, 269 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Diindolylmethane. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Peak Maximum Endurance by Peak Pure & Natural

Ask about any prescription or over-the-counter medication and we check it for interactions with Peak Maximum Endurance by Peak Pure & Natural — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Peak Maximum Endurance by Peak Pure & Natural

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Peak Maximum Endurance has three active ingredients. Diindolylmethane is a compound found in cruciferous vegetables; N, N-Dimethylglycine Hydrochloride is an amino acid derivative; and Nitrosigine is a patented amino acid complex.

The product also contains inactive ingredients — a vegetable capsule shell and two flow agents (Nu-Flow and Nu-Mag) — to help with manufacture and absorption.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

We hold no graded evidence for this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: energy, stamina and performance.
  • We looked for evidence on: athletic endurance, exercise capacity, physical stamina.
  • Our graded evidence for these ingredients doesn't cover that particular purpose.

The data we hold shows insufficient reliable evidence to rate diindolylmethane for the conditions it is marketed to support, which include benign prostate enlargement, breast and colorectal cancers, cervical cell changes, and breast pain. That means the evidence is too limited or unclear right now to say whether it works.

We have no effectiveness data on file for the other two active ingredients.

The evidence, ingredient by ingredient Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Diindolylmethane is generally well tolerated in short-term studies, but long-term safety isn't well established. The most common side effects are diarrhea, gas, headache, nausea, rash, and vomiting.

A rare serious effect called DRESS (a drug rash with systemic symptoms) has been reported. One case of stroke was reported in a person taking diindolylmethane alongside other supplements, but that person had multiple stroke risk factors, so it's unclear if this ingredient played a role.

For pregnancy, the data says diindolylmethane is likely safe. For breastfeeding, there isn't enough safety data, so it's best avoided.

We have no safety data on file for N, N-Dimethylglycine Hydrochloride or Nitrosigine.

Side effects, ingredient by ingredient Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Diindolylmethane.
  • The most serious interaction on file is rated Moderate.
  • For scale: 269 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist before using this product if you take estrogens (birth control or hormone replacement therapy), diuretic drugs (water pills that lower sodium), or any medication metabolized by the liver enzyme CYP1A2. These are the documented interaction risks with diindolylmethane, the main active ingredient we could fully assess.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Peak Maximum Endurance is generally well tolerated for short-term use, but the evidence that it works for its stated purposes isn't established yet. If you take estrogen (birth control or hormone therapy), any water pills, or medications metabolized by your liver, talk to your pharmacist before starting — the interactions are worth reviewing.

The long-term safety picture is still unclear.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated May 21, 2025.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Peak Maximum Endurance, straight from the product label.

Brand Peak Pure & Natural
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD May 21, 2025
DSLD ID 333614
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Peak Maximum Endurance by Peak Pure & Natural, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Diindolylmethane100 mg--
N, N-Dimethylglycine Hydrochloride250 mg--
Nitrosigine500 mg--

Other ingredients: Vegetable Capsule, Nu-Flow, Nu-Mag

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: Adults take two (2) capsules daily with water, preferably with a meal, as a dietary supplement, or as directed by your healthcare practitioner.

Suggested use: Adults take two (2) capsules daily with water, preferably with a meal, as a dietary supplement, or as directed by a healthcare practitioner.

Precautions

Warnings: Keep out of reach of children.

Do not exceed recommended dose. Do not use if clear neck seal is broken or missing.

If you are nursing, pregnant, taking medication or have a medical condition, consult your physician before taking this product.

Storage

Store at room temperature, in a dry place.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formulation

For optimum energy, stamina & performance

Clean label

V

Non GMO Gluten free

FDA Statement of Identity

Dietary Supplement

Brand IP Statement(s)

Nu-Flow is a registered trademark of Ribus, Inc. Nitrosigine is a registered trademark of Nutrition 21, and is patented.

Formula

Nu-Flow is a registered trademark of Ribus, Inc. Nitrosigine

Seals/Symbols

V Manufactured in U.S.A. with quality ingredients from around the world

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Peak Maximum Endurance by Peak Pure & Natural label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Peak Maximum Endurance label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Peak Maximum Endurance by Peak Pure & Natural

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Diindolylmethane

Interacts with
269 drugs
100 mg per serving

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

Diindolylmethane monograph & interactions

N, N-Dimethylglycine Hydrochloride

250 mg per serving

Nitrosigine

500 mg per serving Form: Arginine Silicate Inositol

Other (inactive) ingredients: Vegetable Capsule, Nu-Flow, Nu-Mag. These complete the product’s ingredient list but are not active constituents.

Interaction report

Peak Maximum Endurance by Peak Pure & Natural Drug Interactions

Want to check YOUR meds against Peak Maximum Endurance?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
269Drugs
116 Moderate 153 Minor

Ingredients driving the most interactions

Diindolylmethane 269

Individual Drug Interactions

The ingredients in Peak Maximum Endurance interact with 269 drugs. Click any drug to see the details.

1 of the 3 ingredients in Peak Maximum Endurance interact with drugs. Each result below shows which ingredient is responsible. Diindolylmethane

Each ingredient & the kinds of drugs it affects

For each ingredient in Peak Maximum Endurance with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Diindolylmethane3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
Diindolylmethane full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Peak Maximum Endurance, from the product label.

Peak Pure & Natural

See all Peak Pure & Natural products
Name
Peak Pure & Natural
Street Address
P.O. Box 24638
City
West Palm Beach
State
FL
ZipCode
33416
Phone Number
1-866-773-6899
Web Address
www.PeakNatural.com
Pharmacist Counseling Corner

Peak Maximum Endurance by Peak Pure & Natural: Common Questions

Does Peak Maximum Endurance by Peak Pure & Natural interact with any medications?
Yes. Based on its ingredients, Peak Maximum Endurance has a known interaction with 269 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Peak Maximum Endurance contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this while pregnant?
The safety data rates diindolylmethane as likely safe in pregnancy. However, the other two active ingredients don't have pregnancy safety data on file, so it's smart to check with your doctor or pharmacist before taking this product during pregnancy to make sure it's right for your situation.
Can I take this while breastfeeding?
There isn't enough safety data for diindolylmethane during breastfeeding, so it's best to avoid it. The other two active ingredients also lack breastfeeding safety information. Talk with your pharmacist or doctor about whether this is the right choice for you right now.
What are the most common side effects?
The most common side effects of diindolylmethane are diarrhea, gas, headache, nausea, rash, and vomiting. Most people don't experience serious problems, but if you notice a rash that spreads or worsens, stop and call your doctor.
Does this product actually work?
The data we hold shows insufficient reliable evidence to say whether diindolylmethane works for the conditions this product markets it for — prostate health, cancer prevention, and breast pain. The evidence is too limited right now to make that call.
Why can't you check two of the ingredients for drug interactions?
We hold no interaction data for N, N-Dimethylglycine Hydrochloride or Nitrosigine, so we can't tell you whether they interact with medications. That doesn't mean they're interaction-free — it just means the information isn't available to us. Your pharmacist can help you look into those separately.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Peak Maximum Endurance label
Go deeper

The Full Monographs Behind Peak Maximum Endurance’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

Peak Maximum Endurance's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 14 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Diindolylmethane 14 references
  1. Natl Inst Health, Natl Inst Environmental Health Sci. Indole-3-carbinol. Available at: http://ntp-server.niehs.nih.gov.
  2. Balk JL. Indole-3-carbinol for cancer prevention. Altern Med Alert 2000; 3:105-7.
  3. Riby JE, Chang GHF, Firestone GL, Bjeldanes LF. Ligand-independent activation of estrogen receptor function by 3,3'-diindolylmethane in human breast cancer cells. Biochem Pharmacol 2000;60:167-77. PubMed
  4. Lake BG, Tredger JM, Renwick AB, et al. 3'3-diindolylmethane induces CYP1A2 in cultured precision-cut human liver slices. Xenobiotica 1998;28:803-11. PubMed
  5. Dalessandri, K. M., Firestone, G. L., Fitch, M. D., Bradlow, H. L., and Bjeldanes, L. F. Pilot study: effect of 3,3'-diindolylmethane supplements on urinary hormone metabolites in postmenopausal women with a history of early-stage breast cancer. Nutr Canc PubMed
  6. Reed, G. A., Arneson, D. W., Putnam, W. C., Smith, H. J., Gray, J. C., Sullivan, D. K., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose and multiple-dose administration of indole-3-carbinol to women: pharmacokinetics based on 3,3'-diindolylmetha
  7. Reed, G. A., Sunega, J. M., Sullivan, D. K., Gray, J. C., Mayo, M. S., Crowell, J. A., and Hurwitz, A. Single-dose pharmacokinetics and tolerability of absorption-enhanced 3,3'-diindolylmethane in healthy subjects. Cancer Epidemiol.Biomarkers Prev. 2008; PubMed
  8. Del Priore G., Gudipudi, D. K., Montemarano, N., Restivo, A. M., Malanowska-Stega, J., and Arslan, A. A. Oral diindolylmethane (DIM): pilot evaluation of a nonsurgical treatment for cervical dysplasia. Gynecol.Oncol. 2010;116(3):464-467. PubMed
  9. Heath, E. I., Heilbrun, L. K., Li, J., Vaishampayan, U., Harper, F., Pemberton, P., and Sarkar, F. H. A phase I dose-escalation study of oral BR-DIM (BioResponse 3,3'- Diindolylmethane) in castrate-resistant, non-metastatic prostate cancer. Am.J.Transl.R
  10. Jellinck, P. H., Forkert, P. G., Riddick, D. S., Okey, A. B., Michnovicz, J. J., and Bradlow, H. L. Ah receptor binding properties of indole carbinols and induction of hepatic estradiol hydroxylation. Biochem.Pharmacol. 3-9-1993;45(5):1129-1136. PubMed
  11. Bui PV, Moualla M, Upson DJ. A Possible Association of Diindolylmethane with Pulmonary Embolism and Deep Venous Thrombosis. Case Rep Med. 2016;2016:7527098. PubMed
  12. Castañon A, Tristram A, Mesher D, Powell N, Beer H, Ashman S, Rieck G, Fielder H, Fiander A, Sasieni P. Effect of diindolylmethane supplementation on low-grade cervical cytological abnormalities: double-blind, randomised, controlled trial. Br J Cancer. 20 PubMed
  13. Le TM, Sanders CJ, van de Corput L, van Erpecum KJ, Röckmann H. Drug rash with eosinophilia and systemic symptoms caused by the dietary supplement diindolylmethane. J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):175-6. PubMed
  14. Pence ST, Mehta K, Crum-Bailey J. The Serious Side of Supplements: An Ischemic Stroke in a Healthy 38-year-old Female. Mil Med 2022. PubMed

See these in context on the Diindolylmethane monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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