Interactions on record — worth a quick check against your medications. Based on 8 of 20 ingredients. Check your meds →
Dietary supplement

Performance Probiotic Digestive Support Ingredients & Drug Interactions

by Nutra Sport

Performance Probiotic Digestive Support label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Performance Probiotic Digestive Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Performance Probiotic Digestive Support is a dietary supplement by Nutra Sport with 20 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium bifidum. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Performance Probiotic Digestive Support by Nutra Sport

Ask about any prescription or over-the-counter medication and we check it for interactions with Performance Probiotic Digestive Support by Nutra Sport — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Performance Probiotic Digestive Support by Nutra Sport

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 20 active ingredients.
  • “20 Billion x 10 Strain Pre- and Pro-Blend” is a proprietary blend — the label gives one combined amount (445 mg) without saying how much of each component you get.
  • “BioCore Optimum Complete Digestion Support” is listed as a grouped ingredient — the label gives one combined amount (220 mg) without saying how much of each component you get.

This product contains 20 active ingredients: digestive enzymes (Amylase, Protease, Lipase, Lactase, Peptidase, Invertase, Glucoamylase, Alpha-Galactosidase, and Acid Maltase) plus ten probiotic bacteria strains (Lactobacillus acidophilus, Bifidobacterium longum, Bifidobacterium bifidum, Streptococcus thermophilus, Lactobacillus bulgaricus, Lactobacillus casei, Bifidobacterium animalis lactis, Lactobacillus brevis, Lactobacillus rhamnosus, and Lactococcus lactis), along with Fructooligosaccharides (a prebiotic fiber that feeds beneficial bacteria). The enzymes break down different food components — fats, proteins, carbohydrates, and sugars — to help digestion, while the probiotics add beneficial live organisms to your gut.

The inactive ingredients are Gelatin, Cellulose, Silica, Magnesium Stearate, and Stearic Acid.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: digestive health and gut balance support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Diarrhea, Dyspepsia, Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The strongest evidence on file: Lactase is rated "Effective" for Lactose intolerance (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea, Irritable bowel syndrome (IBS).
  • Also on file: Bifidobacterium Bifidum is rated "Possibly Effective" for Irritable bowel syndrome (IBS).

The evidence for most ingredients in this product is limited. Lactobacillus acidophilus is rated Possibly Effective for irritable bowel syndrome, Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

Bifidobacterium bifidum is rated Possibly Effective for irritable bowel syndrome and respiratory tract infections. Lactase is rated Effective for lactose intolerance — that one has solid backing.

For the other probiotics and enzymes — Bifidobacterium longum, Fructooligosaccharides, Streptococcus thermophilus, Protease, Lipase — the evidence we hold is Insufficient Reliable Evidence, meaning we don't yet know if they work for the conditions they're marketed for. We have no effectiveness data on file for Amylase, Peptidase, Invertase, Glucoamylase, Alpha-Galactosidase, Lactobacillus bulgaricus, Lactobacillus casei, Bifidobacterium animalis lactis, Lactobacillus brevis, Lactobacillus rhamnosus, Acid Maltase, or Lactococcus lactis.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Fructo-oligosaccharides (fos) Streptococcus Thermophilus Proteolytic Enzymes (proteases) Lipase Lactase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 8 of the 8 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 8 of 8.
  • General safety write-ups exist for 8 of 8.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated in healthy adults. Protease may cause digestive upset or allergic reactions in rare cases; occupational exposure to airborne protease can cause allergic reactions in sensitive workers.

Lactase has been associated with contact dermatitis and allergic rhinitis (nasal and eye allergy) in workers exposed to powdered form, but this is uncommon. The probiotic bacteria are normally safe for healthy people but carry a rare theoretical risk of infection in critically ill or severely immune-compromised patients.

Fructooligosaccharides commonly cause gas, bloating, and abdominal discomfort, especially at higher doses, though these effects are generally mild under 10 grams daily. For pregnancy: Lactase is Likely Safe during pregnancy.

Lactobacillus acidophilus, Bifidobacterium longum, and Bifidobacterium bifidum have limited or no specific safety data during pregnancy — check with your doctor before use. Protease should be avoided during pregnancy unless prescribed.

For breastfeeding: Lactase is acceptable but ask your provider first. Protease and Lipase have little safety data during breastfeeding, so use is not recommended without medical advice.

The other probiotics have limited or no safety data while breastfeeding — consult your healthcare provider.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum Bifidobacterium Bifidum Fructo-oligosaccharides (fos) Streptococcus Thermophilus Proteolytic Enzymes (proteases) Lipase Lactase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 3 of the 8 matched ingredients can interact with medications — Lactobacillus Acidophilus, Bifidobacterium Bifidum, Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotic drugs (Moderate severity) are the main concern: Lactobacillus acidophilus, Bifidobacterium longum, and Bifidobacterium bifidum can lose effectiveness if taken together with antibiotics because the antibiotic kills the live beneficial organisms. Separate your doses by a few hours.

Several ingredients in this formula we could not check against medications, so make sure to search your specific prescriptions in the tool below.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

If you're taking antibiotics, space out the doses — don't take this at the same time. It's generally well tolerated in healthy adults, though some people may experience gas or bloating.

If you have a weakened immune system or are critically ill, talk to your pharmacist before starting. Run your exact medications through our checker on this page before you begin.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 8 of 20 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Performance Probiotic Digestive Support, straight from the product label.

Brand Nutra Sport
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2024
DSLD ID 319229
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Performance Probiotic Digestive Support by Nutra Sport, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
IngredientAmount% DV
Amylase0 NP--
Protease0 NP--
Lipase0 NP--
Lactase0 NP--
Peptidase0 NP--
Invertase0 NP--
Lactobacillus acidophilus0 NP--
Bifidobacterium longum0 NP--
Bifidobacterium bifidum0 NP--
Fructooligosaccharides0 NP--
Glucoamylase0 NP--
Alpha-Galactosidase0 NP--
Lactobacillus bulgaricus0 NP--
Lactobacillus casei0 NP--
Bifidobacterium animalis lactis0 NP--
Streptococcus thermophilus0 NP--
Lactobacillus brevis0 NP--
Lactobacillus rhamnosus0 NP--
Acid Maltase0 NP--
Lactococcus lactis0 NP--
20 Billion x 10 Strain Pre- and Pro-Blend445 mg--
BioCore Optimum Complete Digestion Support220 mg--

Other ingredients: Gelatin, Cellulose, Silica, Magnesium Stearate, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested Use: Take two capsules daily with liquid.

Formula

Prebiotics, probiotics, and enzymes to support a healthy digestive system Our Performance Probiotic Digestive Support features a high count blend of 10 probiotic strains to promote balance, along with the functional prebiotic to feed these beneficial bacteria. Nutrient absorption and digestion are further supported by a broad spectrum of enzymes to help promote normal digestive function.

20 Billion per 2 capsules C.f.u. at time of manufacture. 10 strains with prebiotic and enzymes

Formulation

Contains no artificial colors, flavors or preservatives; no wheat, gluten, eggs, peanuts, tree nuts, soy, crustacean shellfish or fish.

We guarantee our supplements for potency and purity

Double Verified GF Gluten free Copyright No GMO Ingredients Copyright SGS verified the process for manufacturing this product with no GMO ingredients. www.sgs.com/no-gmo

Intestinal health with digestive support

Brand IP Statement(s)

BioCore is a registered trademark of the National Enzyme Company

Storage

Store in a cool, dry place if not refrigerated.

Precautions

To report a serious adverse event, call 1-888-710-0006

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

Double Verified GF Gluten free Copyright No GMO Ingredients Copyright SGS verified the process for manufacturing this product with no GMO ingredients. www.sgs.com/no-gmo

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Performance Probiotic Digestive Support by Nutra Sport label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Performance Probiotic Digestive Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Performance Probiotic Digestive Support by Nutra Sport

These are the 20 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

20 Billion x 10 Strain Pre- and Pro-Blend

445 mg per serving

BioCore Optimum Complete Digestion Support

220 mg per serving
  • › Amylase
  • › Protease
  • › Lipase
  • › Lactase
  • › Peptidase
  • › Invertase
  • › Glucoamylase
  • › Alpha-Galactosidase
  • › Acid Maltase

Other (inactive) ingredients: Gelatin, Cellulose, Silica, Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Performance Probiotic Digestive Support by Nutra Sport Drug Interactions

Want to check YOUR meds against Performance Probiotic Digestive Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus 182
Bifidobacterium longum 182
Bifidobacterium bifidum 182

Individual Drug Interactions

The ingredients in Performance Probiotic Digestive Support interact with 182 drugs. Click any drug to see the details.

3 of the 20 ingredients in Performance Probiotic Digestive Support interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus Bifidobacterium longum Bifidobacterium bifidum

Each ingredient & the kinds of drugs it affects

For each ingredient in Performance Probiotic Digestive Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus full monograph & interactions

Bifidobacterium longum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium longum with antibiotic drugs might decrease the effectiveness of B. longum.
Since B. longum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. longum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium longum full monograph & interactions

Bifidobacterium bifidum1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bifidobacterium. bifidum with antibiotic drugs might decrease the effectiveness of B. bifidum.
Since B. bifidum preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. bifidum preparations by at least 2 hours.

Likelihood Probable Evidence D
Bifidobacterium bifidum full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Performance Probiotic Digestive Support, from the product label.

Nutra Sport

See all Nutra Sport products
Name
E-NutritionStore.com
City
Elkridge
State
MD
ZipCode
21075
Phone Number
443-483-3340
Web Address
E-NutritionStore.com
Pharmacist Counseling Corner

Performance Probiotic Digestive Support by Nutra Sport: Common Questions

Does Performance Probiotic Digestive Support by Nutra Sport interact with any medications?
Yes. Based on its ingredients, Performance Probiotic Digestive Support has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Performance Probiotic Digestive Support contains 20 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this hurt if I'm taking antibiotics?
Taking the probiotic bacteria in this product at the same time as antibiotics may reduce how well the probiotics work, because antibiotics kill the live organisms. Separate your doses by a few hours — take the antibiotic at one time of day and the probiotic at another — and let your pharmacist or doctor know you're using both.
What do the enzymes in this do?
The enzymes break down different parts of food: some break down fats (Lipase), some break down proteins (Protease), and some break down carbohydrates and sugars (Amylase, Lactase, Glucoamylase, Alpha-Galactosidase). The idea is to help your body digest food more completely.
Is it safe to take while pregnant?
Lactase has been rated Likely Safe in pregnancy. Most of the other ingredients either have limited safety data or are best avoided — Protease should be avoided unless prescribed. Talk with your doctor or pharmacist before using this product during pregnancy, since individual ingredients vary in their safety profile.
Can this give me gas or bloating?
Yes, the Fructooligosaccharides (prebiotic fiber) can cause gas, bloating, and abdominal discomfort, especially if you're not used to them. These effects are usually mild at lower doses and tend to improve as your gut adjusts. The probiotic bacteria may also cause mild gas or bloating in some people when first taken.
Does lactase actually work if I'm lactose intolerant?
Lactase is rated Effective for lactose intolerance — that's the one ingredient in this product with solid evidence behind it. Lactase breaks down lactose (the sugar in milk), so it can help you digest dairy products more comfortably.
What about the other probiotics — do they actually help my digestion?
Lactobacillus acidophilus and Bifidobacterium bifidum are rated Possibly Effective for irritable bowel syndrome and a couple of other conditions, but for most of the other probiotic strains in here, the evidence is still too limited for us to say whether they work or not. Talk to your pharmacist about which strain might be right for your specific concern.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Performance Probiotic Digestive Support is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Performance Probiotic Digestive Support label
Go deeper

The Full Monographs Behind Performance Probiotic Digestive Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph → Herb & supplement monograph

Bifidobacterium Longum

Interacts with 182 drugs

Bifidobacterium longum is a 'friendly' bacterium found naturally in the human gut and used as a probiotic. It is generally well tolerated and is most studied for digestive issues, though evi...

Read the full Bifidobacterium Longum monograph → Herb & supplement monograph

Bifidobacterium Bifidum

Interacts with 182 drugs

Bifidobacterium bifidum is a 'friendly' bacteria (probiotic) that naturally lives in the human gut and is taken to support digestion and gut balance. Some evidence suggests probiotics may he...

Read the full Bifidobacterium Bifidum monograph → Herb & supplement monograph

Fructo-oligosaccharides (fos)

Fructo-oligosaccharides (FOS) are a type of soluble fiber that acts as a prebiotic, meaning they feed the helpful bacteria in your gut. They are generally considered safe for most people in...

Read the full Fructo-oligosaccharides (fos) monograph → Herb & supplement monograph

Streptococcus Thermophilus

Streptococcus thermophilus is a friendly bacterium used as a probiotic, often combined with other strains in yogurt and supplements. It is generally well tolerated in healthy people and may...

Read the full Streptococcus Thermophilus monograph → Herb & supplement monograph

Proteolytic Enzymes (proteases)

Proteolytic enzymes are proteins that help break down other proteins, and common examples include bromelain (from pineapple), papain (from papaya), trypsin, chymotrypsin, and pancreatin. Peo...

Read the full Proteolytic Enzymes (proteases) monograph → Herb & supplement monograph

Lipase

Lipase is a digestive enzyme that helps your body break down dietary fats. It is well established as part of prescription pancreatic enzyme therapy for people who cannot make enough of their...

Read the full Lipase monograph → Herb & supplement monograph

Lactase

Lactase is a digestive enzyme supplement that helps people who lack enough natural lactase break down lactose, the sugar in milk and dairy. It can reduce gas, bloating, cramping, and diarrhe...

Read the full Lactase monograph →
Sources

Sources & How We Checked

Performance Probiotic Digestive Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 75 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Proteolytic Enzymes (proteases) 3 references
  1. Weeks JA, Harper RA, Simon RA, Burdick JD. Assessment of sensitization risk of a laundry pre-spotter containing protease. Cutan Ocul Toxicol. 2011;30(4):272-9. PubMed
  2. Marquès LI, Lara S, Abós T, Bartolomé B. Occupational rhinitis due to pepsin. J Investig Allergol Clin Immunol. 2006;16(2):136-7. DOI
  3. Cartier A, Malo JL, Pineau L, Dolovich J. Occupational asthma due to pepsin. J Allergy Clin Immunol. 1984;73(5 Pt 1):574-7. PubMed

See these in context on the Proteolytic Enzymes (proteases) monograph →

Lipase 1 reference
  1. Casper C, Hascoet JM, Ertl T, et al. Recombinant bile salt-stimulated lipase in preterm infant feeding: A randomized phase 3 study. PLoS One. 2016;11(5):e0156071. PubMed

See these in context on the Lipase monograph →

Lactase 1 reference
  1. Laukkanen A, Ruoppi P, Remes S, Koistinen T, Mäkinen-Kiljunen S. Lactase-induced occupational protein contact dermatitis and allergic rhinoconjunctivitis. Contact Dermatitis. 2007;57(2):89-93. PubMed

See these in context on the Lactase monograph →

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
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See these in context on the Bifidobacterium Bifidum monograph →

Fructo-oligosaccharides (fos) 6 references
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Streptococcus Thermophilus 21 references
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See these in context on the Streptococcus Thermophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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