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Dietary supplement

Phenbuterol Ingredients & Drug Interactions

by MuscleMeds

Phenbuterol label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Phenbuterol against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Phenbuterol is a dietary supplement by MuscleMeds with 1 active ingredient.Based on those ingredients, 1,345 medications have a known interaction with it, the most serious rated major. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Phenbuterol by MuscleMeds

Ask about any prescription or over-the-counter medication and we check it for interactions with Phenbuterol by MuscleMeds — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Phenbuterol by MuscleMeds

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Phenbuterol” is listed as a grouped ingredient — the label gives one combined amount (595 mg) without saying how much of each component you get.
  • “UCP-1 Fat Burning Catalyst” is listed as a grouped ingredient — the label doesn't break down how much of each component you get.

Phenbuterol contains five active ingredients. Caffeine anhydrous is a stimulant that increases alertness and energy.

Yerba mate leaf extract is a plant source that also contains caffeine. Bitter orange (Advantra Z) contains synephrine and other compounds with stimulant properties.

Indian snakeroot extract (Rauwolfia serpentina) contains alkaloids like reserpine and yohimbine that affect heart rate and blood pressure. Grains of Paradise seed extract is included as a thermogenic agent.

The product has no inactive ingredients listed.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: fat burning and brown adipose tissue activation.
  • We looked for evidence on: Obesity, Athletic performance, Thermogenesis, Metabolic rate.
  • The strongest evidence on file: Caffeine is rated "Likely Effective" for Athletic performance (Natural Medicines).
  • Also on file: Caffeine is rated "Possibly Effective" for Obesity.
  • Also on file: Yerba Mate is rated "Insufficient Reliable Evidence To Rate" for Athletic performance, Obesity.

The evidence for this product's active ingredients is mixed. Caffeine has established effectiveness for neonatal apnea and postoperative headache, is likely effective for mental alertness and athletic performance, and is possibly effective for bronchopulmonary dysplasia — but those clinical uses don't reflect what a healthy adult takes this product for.

For yerba mate, the data we hold shows insufficient evidence to rate it for athletic performance, arrhythmia, osteoporosis, chronic fatigue, headache, or cognitive function. Bitter orange, Indian snakeroot, and Grains of Paradise all show insufficient evidence to rate for their claimed uses.

The product's overall muscle-building and fat-burning claims are not covered in our effectiveness data.

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 4 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Caffeine in moderate doses is generally well tolerated, though high amounts carry serious risks. Common side effects include anxiety, insomnia, tremors, nausea, restlessness, and headache.

Rarely, stroke has been reported. Yerba mate has similar caffeine-related risks and can cause tachycardia and nervousness; long-term heavy use raises additional concerns.

Bitter orange can raise blood pressure and heart rate, especially in combination with caffeine, and may cause hypertension and tachycardia as common effects. Indian snakeroot is potentially unsafe at higher doses and frequently causes sedation, low blood pressure, slow heart rate, weight gain, and nightmares; serious adverse effects (rare) include heart attack, atrial fibrillation, and depression.

Grains of Paradise safety is not well studied in supplement amounts. Pregnancy: Caffeine is possibly unsafe at high doses; yerba mate and bitter orange are possibly unsafe; Indian snakeroot should be avoided.

Breastfeeding: Small amounts of caffeine pass into milk and are usually acceptable with moderation; yerba mate is possibly unsafe; bitter orange and Indian snakeroot should be avoided.

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 4 of the 5 matched ingredients can interact with medications — Indian Snakeroot, Yerba Mate, Bitter Orange, Caffeine.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; heart-rhythm medications; lithium; Parkinson's medications.
  • For scale: 1,346 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check with your pharmacist or doctor immediately if you take ephedrine (Major risk of life-threatening stimulant effects), MAOIs (Major hypertensive crisis risk), midazolam or other sedatives, beta-blockers, digoxin, levodopa, antipsychotics, blood thinners, blood pressure medications, fluoroquinolone antibiotics, seizure drugs like phenobarbital or carbamazepine, clozapine, cimetidine, dipyridamole, dextromethorphan, blood sugar medications, or any CYP3A4 substrate (a large group including many statins and blood pressure drugs). No interactions are documented for Grains of Paradise.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with clinical evidence supporting its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This is a high-stimulant, multi-ingredient product with serious interactions — especially if you take heart medications, blood pressure drugs, seizure medicines, antipsychotics, antidepressants, or any sedative. Because Indian snakeroot can cause depression and significant blood pressure changes, it's not suitable for routine supplementation without medical oversight.

Talk to your pharmacist or doctor before starting, and bring a list of all your medications to check against our interaction database.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 22, 2019.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phenbuterol, straight from the product label.

Brand MuscleMeds
Net contents 30 Capsule(s)
Market status On market
Date entered into DSLD Dec 22, 2019
DSLD ID 210057
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phenbuterol by MuscleMeds, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
30
IngredientAmount% DV
Caffeine Anhydrous0 NP--
Ilex paraguariensis leaf extract0 NP--
Phenbuterol595 mg--
UCP-1 Fat Burning Catalyst0 NP--
Advantra Z0 NP--
Grains of Paradise (Aframomum melegueta) seed extract0 NP--
Rauwolfia serpentina extract0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

(UCP-1 Activator 595 mg)

Formulation

Maximum strength fat burning catalyst

Upregulates UCP-1 Activates brown adipose tissue ATP sparing thermogenesis

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Phenbuterol by MuscleMeds label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Phenbuterol label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Phenbuterol by MuscleMeds

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Phenbuterol

595 mg per serving
  • › UCP-1 Fat Burning Catalyst
Interaction report

Phenbuterol by MuscleMeds Drug Interactions

Want to check YOUR meds against Phenbuterol?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,345Drugs
101 Major 1,223 Moderate 21 Minor

Ingredients driving the most interactions

Individual Drug Interactions

The ingredients in Phenbuterol interact with 1,345 drugs. Click any drug to see the details.

0 of the 1 ingredient in Phenbuterol interact with drugs. Each result below shows which ingredient is responsible.

Each ingredient & the kinds of drugs it affects

For each ingredient in Phenbuterol with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

The maker

Brand information

Manufacturer and brand details for Phenbuterol, from the product label.

MuscleMeds

See all MuscleMeds products
Name
MuscleMeds
Pharmacist Counseling Corner

Phenbuterol by MuscleMeds: Common Questions

Does Phenbuterol by MuscleMeds interact with any medications?
Yes. Based on its ingredients, Phenbuterol has a known interaction with 1,345 medications, including 101 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phenbuterol contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does this product really build muscle?
The effectiveness data we hold doesn't cover muscle-building claims for this product or most of its ingredients. Caffeine is proven effective for mental alertness and athletic performance, but that's a far cry from building muscle. Talk to your doctor or a trainer about whether this product is right for your goals.
What's the biggest risk I should know about?
If you take ephedrine (in any diet pill or decongestant) or an MAOI antidepressant, this product poses a Major interaction risk — potentially life-threatening. Indian snakeroot can also cause serious heart and mood effects on its own. Even if you don't take those drugs, the combination of stimulants here can spike your blood pressure and heart rate dangerously.
Can I take this while pregnant?
The caffeine is possibly unsafe at high doses, and both yerba mate and bitter orange are rated possibly unsafe in pregnancy. Indian snakeroot should be avoided entirely. Talk to your doctor about safer options.
Will this give me the jitters or affect my sleep?
Yes. Caffeine and yerba mate commonly cause anxiety, tremors, insomnia, and restlessness, especially at the doses likely in a product like this. Indian snakeroot can cause sedation and nightmares, which may conflict with the stimulant effects of the caffeine.
Is Indian snakeroot safe to take regularly?
No. The facts show it contains potent alkaloids that frequently cause sedation, low blood pressure, slow heart rate, and weight gain. Long-term use also raises the risk of depression. It should only be used under medical supervision, not as a routine supplement.
What is Grains of Paradise supposed to do?
It's included in the product as a thermogenic (fat-burning) ingredient. However, we have no effectiveness data to rate how well it works for that purpose, and its safety in supplement amounts is not well studied.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phenbuterol is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phenbuterol label
Sources

Sources & How We Checked

Phenbuterol's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 451 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Caffeine 236 references
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See these in context on the Caffeine monograph →

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Grains Of Paradise 2 references
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