Phosphatidylserine DMAE Complex Ingredients & Drug Interactions
by NaturesPlus
What is this page for?
First and foremost: checking Phosphatidylserine DMAE Complex against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Phosphatidylserine DMAE Complex is a dietary supplement by NaturesPlus with 6 active ingredients. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dimethylaminoethanol Bitartrate, Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Phosphatidylserine DMAE Complex by NaturesPlus
Ask about any prescription or over-the-counter medication and we check it for interactions with Phosphatidylserine DMAE Complex by NaturesPlus — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Phosphatidylserine DMAE Complex by NaturesPlus
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
This product contains 6 active ingredients designed to support brain health and cell function. Phosphatidylserine and phosphatidylcholine are phospholipids — fatty compounds found in cell membranes that play a role in nerve communication.
Dimethylaminoethanol bitartrate (DMAE) is thought to increase levels of acetylcholine, a neurotransmitter. The formula also includes cephalin and phosphoinositides, which are related phospholipid compounds, plus activated soy phosphatides as a plant-derived phospholipid blend.
The inactive ingredients are cellulose, microcrystalline cellulose, magnesium stearate, silica, and purified water — standard capsule materials and binders.
Does it work?
Moderate evidence
Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer disease. Phosphatidylcholine is rated possibly effective for ulcerative colitis, though the evidence for Alzheimer disease, NAFLD, alcohol-related liver disease, and anxiety is insufficient.
For DMAE, the evidence is less encouraging — it's rated likely ineffective for Alzheimer disease and tardive dyskinesia (a movement disorder), and evidence is insufficient for ADHD, athletic performance, and aging skin. For the other ingredients in this blend — cephalin, phosphoinositides, and glycosphingolipids — no effectiveness ratings are on file in our data.
How safe is it?
Well-documented data
Phosphatidylserine and phosphatidylcholine are generally well tolerated when taken by mouth, though high doses can cause digestive upset. Common side effects reported with phosphatidylserine include flatulence, nausea, headache, and insomnia — especially at higher doses.
Phosphatidylcholine may cause altered taste, bloating, diarrhea, nausea, and vomiting. DMAE is generally tolerated but may cause abdominal cramps, diarrhea, drowsiness, nausea, or vomiting; higher doses (over 1,000 mg daily) have been linked to mood changes in people with psychiatric conditions.
For pregnancy: there isn't enough data to know whether phosphatidylserine or DMAE are safe; discuss this with your doctor. For breastfeeding: safety data on all three is insufficient — talk with your healthcare provider first.
Choline (from phosphatidylcholine) is needed during pregnancy, but supplement safety beyond food sources isn't well studied.
Meds to double-check
Moderate interaction found
Before you take this product, double-check with your doctor or pharmacist if you take anticholinergic drugs (used for bladder control, motion sickness, or certain digestive issues) — phosphatidylserine poses a Moderate risk of reducing their effectiveness. Also mention any cholinergic drugs (which boost acetylcholine); phosphatidylserine carries a Moderate risk of adding to their effects, and DMAE a Minor one.
No other interaction categories are documented in our data for the ingredients we could check.
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product may be worth considering if you're interested in supporting cognitive function and you don't take anticholinergic or cholinergic medications. Because of the Moderate interaction risk with those drug classes, check your medications carefully before starting — your doctor or pharmacist can confirm whether this supplement is appropriate for you.
If you're pregnant or breastfeeding, discuss it with your healthcare provider first, since safety data is limited.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Phosphatidylserine DMAE Complex, straight from the product label.
| Brand | NaturesPlus |
|---|---|
| Barcode (UPC) | 097467051805 |
| Net contents | 60 Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Oct 24, 2023 |
| DSLD ID | 298569 |
| Product type | Other Combinations |
| Supplement form | Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Phosphatidylserine DMAE Complex by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Phosphatidylcholine | 0 NP | -- |
| Dimethylaminoethanol Bitartrate | 100 mg | -- |
| Phosphatidylserine | 100 mg | -- |
| Cephalin | 0 NP | -- |
| Phosphoinositides | 0 NP | -- |
| Activated Soy Phosphatides | 550 mg | -- |
| Glycosphingolipids | 0 NP | -- |
Other ingredients: Cellulose, Magnesium Stearate, Microcrystalline Cellulose, Silica, Water, Purified
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula
Phosphatidylserine/DMAE Complex is a fast-acting blend of the very best brain health-supporting nutrients available. Providing a diversified, highly specialized combination of phosphatidylserine, DMAE and activated soy phosphatides, including phosphatidylcholine, each capsule powerfully promotes healthy brain-nerve signaling, neurotransmitter production and overall cognitive health.
Phosphatidylserine/DMAE Complex with activated soy phosphatides
Formulation
Free from artificial colors and artificial preservatives. Gluten free
Vegan
Brain support
Storage
Keep tightly closed in a cool, dry place.
Precautions
Keep out of reach of children.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.
FDA Statement of Identity
Dietary Supplement
Suggested/Recommended/Usage/Directions
Directions: Two capsules once daily.
Brand IP Statement(s)
Copyright Natural Organics
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Phosphatidylserine DMAE Complex by NaturesPlus label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Phosphatidylserine DMAE Complex by NaturesPlus
These are the 6 active ingredients this product is made of. Select any to open its full monograph.
Serving size2 Capsulet(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Dimethylaminoethanol Bitartrate
Interacts with219 drugs
Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...
Dimethylaminoethanol Bitartrate monograph & interactionsPhosphatidylserine
Interacts with219 drugs
Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...
Phosphatidylserine monograph & interactionsActivated Soy Phosphatides
- › Phosphatidylcholine
- › Cephalin
- › Phosphoinositides
- › Glycosphingolipids
Other (inactive) ingredients: Cellulose, Magnesium Stearate, Microcrystalline Cellulose, Silica, Water, Purified. These complete the product’s ingredient list but are not active constituents.
Phosphatidylserine DMAE Complex by NaturesPlus Drug Interactions
HelloPharmacist Interaction Report
NaturesPlus Phosphatidylserine DMAE Complex interacts with medications through its phosphatidylserine and dimethylaminoethanol bitartrate (DMAE) content.
The most serious concern is a Moderate interaction with anticholinergic drugs — medications that block acetylcholine — where phosphatidylserine may reduce how well these drugs work by increasing acetylcholine levels in the body.
Read the full breakdown — every affected drug type, severity by severity
Both phosphatidylserine and DMAE can theoretically increase acetylcholine effects. With cholinergic drugs (which boost acetylcholine), phosphatidylserine poses a Moderate risk of additive effects and side effects, while DMAE poses a Minor risk.
With anticholinergic drugs, phosphatidylserine also carries a Moderate concern about reduced effectiveness, and DMAE a Minor one.
We could not check three other ingredients — cephalin, phosphoinositides, and glycosphingolipids — because we hold no interaction data for them. Altogether, these interactions span 219 individual medications.
Use the medication checker on this page to look up your specific prescriptions before you start.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Phosphatidylserine DMAE Complex?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Phosphatidylserine DMAE Complex interact with 219 drugs. Click any drug to see the details.
2 of the 6 ingredients in Phosphatidylserine DMAE Complex interact with drugs. Each result below shows which ingredient is responsible. Dimethylaminoethanol Bitartrate Phosphatidylserine
Belladonna, Caffeine, Ergotamine, PentobarbitalMicomp PB
How Belladonna, Caffeine, Ergotamine, Pentobarbital interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Belladonna, Caffeine, Ergotamine, Pentobarbital interactionBelladonna, Ergotamine Tartrate, Phenobarbital
How Belladonna, Ergotamine Tartrate, Phenobarbital interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Belladonna, Ergotamine Tartrate, Phenobarbital interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Belladonna, Ergotamine Tartrate, Phenobarbital interactionBelladonna, Ergotamine, PhenobarbitalBellergal-S
How Belladonna, Ergotamine, Phenobarbital interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Belladonna, Ergotamine, Phenobarbital interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Belladonna, Ergotamine, Phenobarbital interactionBelladonna, OpiumB & O Supprettes
How Belladonna, Opium interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Belladonna, Opium interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Belladonna, Opium interactionBelladonna, PhenobarbitalBellophen, Susano
How Belladonna, Phenobarbital interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Belladonna, Phenobarbital interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Belladonna, Phenobarbital interactionBenzhydrocodone, AcetaminophenApadaz
How Benzhydrocodone, Acetaminophen interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Benzhydrocodone, Acetaminophen interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Benzhydrocodone, Acetaminophen interactionBenztropineCogentin, Cogentin Injection
How Benztropine interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Benztropine interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Benztropine interactionBethanechol ChlorideUrecholine
How Bethanechol Chloride interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineCholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Read the full Phosphatidylserine + Bethanechol Chloride interactionDimethylaminoethanol BitartrateCholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Bethanechol Chloride interactionBiperidenAkineton, Akineton Injection
How Biperiden interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Biperiden interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Biperiden interactionBromodiphenhydramineAmbodryl
How Bromodiphenhydramine interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Bromodiphenhydramine interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Bromodiphenhydramine interactionBuclizineBucladin-S Softab
How Buclizine interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Buclizine interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Buclizine interactionButabarbital, Hyoscyamine, PhenazopyridinePyridium Plus
How Butabarbital, Hyoscyamine, Phenazopyridine interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Butabarbital, Hyoscyamine, Phenazopyridine interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Butabarbital, Hyoscyamine, Phenazopyridine interactionCaffeine, Diphenhydramine, Ergotamine (prescription Drug)Ergodryl
How Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Caffeine, Diphenhydramine, Ergotamine (prescription Drug) interactionCamphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, ValerianNevrotose #3
How Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Camphor, Hyoscyamine, Passif, Phenobarbital, Scopolamine, Valerian interactionCarbacholCarbastat
How Carbachol interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineCholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Read the full Phosphatidylserine + Carbachol interactionDimethylaminoethanol BitartrateCholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Carbachol interactionCarbetapentane Tannate, Chlorpheniramine TannateTussi-12
How Carbetapentane Tannate, Chlorpheniramine Tannate interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Carbetapentane Tannate, Chlorpheniramine Tannate interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Carbetapentane Tannate, Chlorpheniramine Tannate interactionCarbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine TannateQuadratuss, Ry Tuss, Rynatuss, Tri Tannate Plus
How Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Carbetapentane Tannate, Chlorpheniramine Tannate, Ephedrine Tannate, Phenylephrine Tannate interactionCarbetapentane, Chlorpheniramine, PhenylephrineRicotuss
How Carbetapentane, Chlorpheniramine, Phenylephrine interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Carbetapentane, Chlorpheniramine, Phenylephrine interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Carbetapentane, Chlorpheniramine, Phenylephrine interactionCarbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium GuaiacolsulfonateCophene-X
How Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Carbetapentane, Chlorpheniramine, Phenylephrine, Phenylpropanolamine, Potassium Guaiacolsulfonate interactionCarbinoxamine MaleateKarbinal ER
How Carbinoxamine Maleate interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Carbinoxamine Maleate interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Carbinoxamine Maleate interactionCarphenazineProketazin
How Carphenazine interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Carphenazine interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Carphenazine interactionCevimelineEvoxac
How Cevimeline interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineCholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Read the full Phosphatidylserine + Cevimeline interactionDimethylaminoethanol BitartrateCholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Cevimeline interactionChlordiazepoxideLibrium
How Chlordiazepoxide interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlordiazepoxide interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlordiazepoxide interactionChlordiazepoxide, Clidinium BromideLibrax
How Chlordiazepoxide, Clidinium Bromide interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlordiazepoxide, Clidinium Bromide interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlordiazepoxide, Clidinium Bromide interactionChlormezanoneTrancopal
How Chlormezanone interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlormezanone interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlormezanone interactionChlorpheniramineChlor-Trimeton, Teldrin
How Chlorpheniramine interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlorpheniramine interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlorpheniramine interactionChlorpheniramine Maleate, Dextromethorphan HydrobromideCoricidin HBP Cough & Cold, Coricidin II Cough & Cold, Pediatric Vicks Formula 44m Cough & Cold Relief
How Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlorpheniramine Maleate, Dextromethorphan Hydrobromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlorpheniramine Polistirex, Codeine Polistirex interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlorpheniramine Polistirex, Codeine Polistirex interactionChlorpheniramine Tannate, Phenylephrine TannateRicobid
How Chlorpheniramine Tannate, Phenylephrine Tannate interacts with Phosphatidylserine DMAE Complex — through 2 ingredients. Tap an ingredient for the detail:
PhosphatidylserineAnticholinergic Drugs Moderate
Interaction Summary
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Read the full Phosphatidylserine + Chlorpheniramine Tannate, Phenylephrine Tannate interactionDimethylaminoethanol BitartrateAnticholinergic Drugs Minor
Interaction Summary
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Read the full Dimethylaminoethanol Bitartrate + Chlorpheniramine Tannate, Phenylephrine Tannate interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Phosphatidylserine DMAE Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Dimethylaminoethanol Bitartrate
Anticholinergic Drugs
Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.
Cholinergic Drugs
Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.
Phosphatidylserine
Anticholinergic Drugs
Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.
Cholinergic Drugs
Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.
Brand information
Manufacturer and brand details for Phosphatidylserine DMAE Complex, from the product label.
NaturesPlus
See all NaturesPlus products- Name
- Natural Organics Laboratories, Inc. makers of Nature's Plus
- Street Address
- 9500 New Horizons Blvd
- City
- Amityville
- State
- New York
- ZipCode
- 11701
- Web Address
- www.naturesplus.com
Phosphatidylserine DMAE Complex by NaturesPlus: Common Questions
Does Phosphatidylserine DMAE Complex by NaturesPlus interact with any medications?
How can one product interact with so many drugs?
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What is phosphatidylserine and why is it in this product?
What does DMAE do?
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What side effects should I watch for?
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Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
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The Full Monographs Behind Phosphatidylserine DMAE Complex’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Deanol
Interacts with 219 drugsDeanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limited or mixed. It can cause side effects in...
Read the full Deanol monograph → Herb & supplement monographPhosphatidylserine
Interacts with 219 drugsPhosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinking. Some research suggests possible bene...
Read the full Phosphatidylserine monograph → Herb & supplement monographPhosphatidylcholine
Phosphatidylcholine is a phospholipid that is part of every cell membrane and a source of choline. People take it for liver, brain, and gut health, but solid human evidence is limited for mo...
Read the full Phosphatidylcholine monograph →Sources & How We Checked
Phosphatidylserine DMAE Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 39 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Phosphatidylcholine 15 references
- Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
- Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
- Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
- Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
- Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
- Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
- Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
- Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
- Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
- Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
- Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
- Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
- Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
- Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed
Deanol 15 references
- Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
- Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
- Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
- George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
- Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
- de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
- Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
- Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
- Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
- Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
- Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
- Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
- Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
- Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
- Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.
Phosphatidylserine 9 references
- Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
- Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
- Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
- Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
- Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
- Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
- Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
- Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
- Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC