Interactions on record — worth a quick check against your medications. Based on 3 of 6 ingredients. Check your meds →
Dietary supplement

Phosphatidylserine DMAE Complex Ingredients & Drug Interactions

by NaturesPlus

Capsule Category: Other Combinations
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Phosphatidylserine DMAE Complex is a dietary supplement by NaturesPlus with 6 active ingredients. Its ingredients are commonly taken for memory and focus, mood and mental clarity, adhd-type symptoms.Based on those ingredients, 219 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dimethylaminoethanol Bitartrate, Phosphatidylserine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Phosphatidylserine DMAE Complex by NaturesPlus

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 2 of its 6 active ingredients.
  • “Activated Soy Phosphatides” is listed as a grouped ingredient — the label gives one combined amount (550 mg) without saying how much of each component you get.

This product contains 6 active ingredients designed to support brain health and cell function. Phosphatidylserine and phosphatidylcholine are phospholipids — fatty compounds found in cell membranes that play a role in nerve communication.

Dimethylaminoethanol bitartrate (DMAE) is thought to increase levels of acetylcholine, a neurotransmitter. The formula also includes cephalin and phosphoinositides, which are related phospholipid compounds, plus activated soy phosphatides as a plant-derived phospholipid blend.

The inactive ingredients are cellulose, microcrystalline cellulose, magnesium stearate, silica, and purified water — standard capsule materials and binders.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Brain health and memory support.
  • We looked for evidence on: Age-related cognitive decline, Attention deficit-hyperactivity disorder (ADHD), Cognitive function, Dementia, Memory, mental clarity — and 2 related terms.
  • The strongest evidence on file: Phosphatidylserine is rated "Possibly Effective" for Age-related cognitive decline (Natural Medicines).
  • Also on file: Phosphatidylcholine is rated "Insufficient Reliable Evidence To Rate" for Memory, Dementia.
  • Also on file: Deanol is rated "Insufficient Reliable Evidence To Rate" for Attention deficit-hyperactivity disorder (ADHD), Cognitive function.

Phosphatidylserine is rated possibly effective for age-related cognitive decline and Alzheimer disease. Phosphatidylcholine is rated possibly effective for ulcerative colitis, though the evidence for Alzheimer disease, NAFLD, alcohol-related liver disease, and anxiety is insufficient.

For DMAE, the evidence is less encouraging — it's rated likely ineffective for Alzheimer disease and tardive dyskinesia (a movement disorder), and evidence is insufficient for ADHD, athletic performance, and aging skin. For the other ingredients in this blend — cephalin, phosphoinositides, and glycosphingolipids — no effectiveness ratings are on file in our data.

The evidence, ingredient by ingredient Deanol Phosphatidylserine Phosphatidylcholine

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 3 of the 3 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 3 of 3.
  • General safety write-ups exist for 3 of 3.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phosphatidylserine and phosphatidylcholine are generally well tolerated when taken by mouth, though high doses can cause digestive upset. Common side effects reported with phosphatidylserine include flatulence, nausea, headache, and insomnia — especially at higher doses.

Phosphatidylcholine may cause altered taste, bloating, diarrhea, nausea, and vomiting. DMAE is generally tolerated but may cause abdominal cramps, diarrhea, drowsiness, nausea, or vomiting; higher doses (over 1,000 mg daily) have been linked to mood changes in people with psychiatric conditions.

For pregnancy: there isn't enough data to know whether phosphatidylserine or DMAE are safe; discuss this with your doctor. For breastfeeding: safety data on all three is insufficient — talk with your healthcare provider first.

Choline (from phosphatidylcholine) is needed during pregnancy, but supplement safety beyond food sources isn't well studied.

Side effects, ingredient by ingredient Deanol Phosphatidylserine Phosphatidylcholine

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 3 matched ingredients can interact with medications — Deanol, Phosphatidylserine.
  • The most serious interaction on file is rated Moderate.
  • For scale: 219 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check with your doctor or pharmacist if you take anticholinergic drugs (used for bladder control, motion sickness, or certain digestive issues) — phosphatidylserine poses a Moderate risk of reducing their effectiveness. Also mention any cholinergic drugs (which boost acetylcholine); phosphatidylserine carries a Moderate risk of adding to their effects, and DMAE a Minor one.

No other interaction categories are documented in our data for the ingredients we could check.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may be worth considering if you're interested in supporting cognitive function and you don't take anticholinergic or cholinergic medications. Because of the Moderate interaction risk with those drug classes, check your medications carefully before starting — your doctor or pharmacist can confirm whether this supplement is appropriate for you.

If you're pregnant or breastfeeding, discuss it with your healthcare provider first, since safety data is limited.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 3 of 6 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 24, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Phosphatidylserine DMAE Complex, straight from the product label.

Brand NaturesPlus
Barcode (UPC) 097467051805
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Oct 24, 2023
DSLD ID 298569
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Phosphatidylserine DMAE Complex by NaturesPlus, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsulet(s)
Maximum serving Sizes:
2 Capsulet(s)
Servings per container
30
UPC/BARCODE
097467051805
IngredientAmount% DV
Phosphatidylcholine0 NP--
Dimethylaminoethanol Bitartrate100 mg--
Phosphatidylserine100 mg--
Cephalin0 NP--
Phosphoinositides0 NP--
Activated Soy Phosphatides550 mg--
Glycosphingolipids0 NP--

Other ingredients: Cellulose, Magnesium Stearate, Microcrystalline Cellulose, Silica, Water, Purified

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Phosphatidylserine/DMAE Complex is a fast-acting blend of the very best brain health-supporting nutrients available. Providing a diversified, highly specialized combination of phosphatidylserine, DMAE and activated soy phosphatides, including phosphatidylcholine, each capsule powerfully promotes healthy brain-nerve signaling, neurotransmitter production and overall cognitive health.

Phosphatidylserine/DMAE Complex with activated soy phosphatides

Formulation

Free from artificial colors and artificial preservatives. Gluten free

Vegan

Brain support

Storage

Keep tightly closed in a cool, dry place.

Precautions

Keep out of reach of children.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Two capsules once daily.

Brand IP Statement(s)

Copyright Natural Organics

See for yourself

Phosphatidylserine DMAE Complex by NaturesPlus label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Phosphatidylserine DMAE Complex by NaturesPlus

These are the 6 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Capsulet(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Dimethylaminoethanol Bitartrate

Interacts with
219 drugs
100 mg per serving

Deanol (DMAE) is a compound related to choline that is marketed for memory, focus, and mood, but solid human evidence for most of these uses is limite...

Dimethylaminoethanol Bitartrate monograph & interactions

Phosphatidylserine

Interacts with
219 drugs
100 mg per serving Form: Soy

Phosphatidylserine is a natural fat-like compound found in cell membranes, especially in the brain, and it is sold mainly to support memory and thinki...

Phosphatidylserine monograph & interactions

Activated Soy Phosphatides

550 mg per serving Form: Soy

Other (inactive) ingredients: Cellulose, Magnesium Stearate, Microcrystalline Cellulose, Silica, Water, Purified. These complete the product’s ingredient list but are not active constituents.

Interaction report

Phosphatidylserine DMAE Complex by NaturesPlus Drug Interactions

Want to check YOUR meds against Phosphatidylserine DMAE Complex?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
219Drugs
219 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Phosphatidylserine DMAE Complex with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dimethylaminoethanol Bitartrate2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, deanol might decrease the effectiveness of anticholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D
Cholinergic Drugs

Theoretically, deanol might increase the effects and adverse effects of cholinergic drugs.
Deanol is thought to increase acetylcholine levels.

Likelihood Unlikely Evidence D

Phosphatidylserine2 drug types · 219 drugs

Anticholinergic Drugs

Theoretically, phosphatidylserine might decrease the effectiveness anticholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically interfere with the activity of anticholinergic agents.

Likelihood Possible Evidence B
Cholinergic Drugs

Theoretically, phosphatidylserine might have additive effects with cholinergic drugs.
Phosphatidylserine is thought to increase acetylcholine levels, which could theoretically lead to additive cholinergic effects when used with cholinergic drugs.

Likelihood Possible Evidence B
The maker

Brand information

Manufacturer and brand details for Phosphatidylserine DMAE Complex, from the product label.

NaturesPlus

See all NaturesPlus products
Name
Natural Organics Laboratories, Inc. makers of Nature's Plus
Street Address
9500 New Horizons Blvd
City
Amityville
State
New York
ZipCode
11701
Web Address
www.naturesplus.com
Pharmacist Counseling Corner

Phosphatidylserine DMAE Complex by NaturesPlus: Common Questions

Does Phosphatidylserine DMAE Complex by NaturesPlus interact with any medications?
Yes. Based on its ingredients, Phosphatidylserine DMAE Complex has a known interaction with 219 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Phosphatidylserine DMAE Complex contains 6 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is phosphatidylserine and why is it in this product?
Phosphatidylserine is a fatty compound found in cell membranes that helps nerve cells communicate. It's included because research suggests it may help with age-related cognitive decline and possibly Alzheimer disease, though the evidence for other brain-related conditions in this product is still being studied.
What does DMAE do?
DMAE is thought to increase acetylcholine, a neurotransmitter involved in memory and focus. However, research shows it's likely ineffective for Alzheimer disease and tardive dyskinesia, and evidence for ADHD and athletic performance is still insufficient.
Can I take this if I'm pregnant?
There isn't enough safety data to know whether phosphatidylserine or DMAE are safe during pregnancy. Talk with your doctor before taking this — they can help you weigh whether it's right for you.
What side effects should I watch for?
The most common reported side effects are digestive — nausea, flatulence, diarrhea, and bloating. Headache, insomnia, drowsiness, and abdominal cramps have also been reported. Most are mild, but if you experience mood changes or worsening symptoms, stop and contact your healthcare provider.
Is this safe to take long-term?
Phosphatidylserine is generally well tolerated, but long-term safety hasn't been fully established in studies. If you're considering long-term use, discuss it with your doctor or pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Phosphatidylserine DMAE Complex is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Phosphatidylserine DMAE Complex label
Sources

Sources & How We Checked

Phosphatidylserine DMAE Complex's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 39 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phosphatidylcholine 15 references
  1. Domino EF, May WW, Demetriou S, et al. Lack of clinically significant improvement of patients with tardive dyskinesia following phosphatidylcholine therapy. Biol Psychiatry 1985;20:1189-96. PubMed
  2. Aronson PJ, Lorincz AL. Promotion of palmar sweating with oral phosphatidylcholine. Acta Derm Venereol 1985;65:19-24. DOI
  3. Hexsel DM, Serra M, de Oliveira Dal'Forno T, et al. Cosmetic uses of injectable phosphatidylcholine on the face. Otolaryngol Clin North Am 2005;38:1119-29. PubMed
  4. Kopera D, Binder B, Toplak H, et al. Histopathologic changes after intralesional application of phosphatidylcholine for lipoma reduction: report of a case. Am J Dermatopathol 2006;28:331-3. PubMed
  5. Rittes PG. The use of phosphatidylcholine for correction of lower lid bulging due to prominent fat pads. Dermatol Surg 2001;27:391-2. PubMed
  6. Rotunda AM, Kolodney MS. Mesotherapy and phosphatidylcholine injections: historical clarification and review. Dermatol Surg 2006;32:465-80. PubMed
  7. Hexsel D, Serra M, Mazzuco R, et al. Phosphatidylcholine in the treatment of localized fat. J Drugs Dermatol 2003;2:511-8.
  8. Hasengschwandtner F. Phosphatidylcholine treatment to induce lipolysis. Cosmet Dermatol 2005;4:308-13. PubMed
  9. Rittes PG. The use of phosphatidylcholine for correction of localized fat deposits. Aesthetic Plast Surg 2003;27:315-8. PubMed
  10. Ablon G, Rotunda AM. Treatment of lower eyelid fat pads using phosphatidylcholine: clinical trial and review. Dermatol Surg 2004;30:422-7. PubMed
  11. Loguercio C, Andreone P, Brisc C, et al. Silybin combined with phosphatidylcholine and vitamin E in patients with nonalcoholic fatty liver disease: a randomized controlled trial. Free Radic Biol Med 2012;52(9):1658-65. PubMed
  12. Panos, J. M., Palson, R., Johnson, R., Portmann, B., and Williams, R. Polyunsaturated phosphatidylcholine for acute alcoholic hepatitis: a double blind randomized placebo controlled trial. Eur.J.Gastroenterol 1990;2:351-355.
  13. Stremmel W, Braun A, Hanemann A, Ehehalt R, Autschbach F, Karner M. Delayed release phosphatidylcholine in chronic-active ulcerative colitis: a randomized, double-blinded, dose finding study. J Clin Gastroenterol 2010;44(5):e101-7. PubMed
  14. Stremmel W, Ehehalt R, Autschbach F, Karner M. Phosphatidylcholine for steroid-refractory chronic ulcerative colitis: a randomized trial. Ann Intern Med. 2007;147(9):603-10. PubMed
  15. Stremmel W, Vural H, Evliyaoglu O, Weiskirchen R. Delayed Release Phosphatidylcholine is Effective for Treatment of Ulcerative Colitis: A Meta-Analysis. Dig Dis 2021;39(5):508-515. PubMed

See these in context on the Phosphatidylcholine monograph →

Deanol 15 references
  1. Davies C, Maidment S, Hanley P, et al. Dimethylaminoethanol (DMAE). HSE. Risk assessment document; EH72/2;1997. (TOXLINE).
  2. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp 1974;16:1238-42.
  3. Pieralisi G, Ripari P, Vecchiet L. Effects of a standardized ginseng extract combined with dimethylaminoethanol bitartrate, vitamins, minerals, and trace elements on physical performance during exercise. Clin Ther 1991;13:373-82.
  4. George J, Pridmore S, Aldous D. Double blind controlled trial of deanol in tardive dyskinesia. Aust N Z J Psychiatry 1981;15:68-71. PubMed
  5. Penovich P, Morgan JP, Kerzner B, et al. Double-blind evaluation of deanol in tardive dyskinesia. JAMA 1978;239:1997-8. DOI
  6. de Montigny C, Chouinard G, Annable L. Ineffectiveness of deanol in tardive dyskinesia: a placebo controlled study. Psychopharmacology (Berl) 1979;65:219-23. PubMed
  7. Lindeboom SF, Lakke JP. Deanol and physostigmine in the treatment of L-dopa-induced dyskinesias. Acta Neurol Scand 1978;58:134-8. PubMed
  8. Jus A, Villeneuve A, Gautier J, et al. Deanol, lithium and placebo in the treatment of tardive dyskinesia. A double-blind crossover study. Neuropsychobiology 1978;4:140-9. PubMed
  9. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther 1975;17:534-40. PubMed
  10. Fisman M, Mersky H, Helmes E. Double-blind trial of 2-dimethylaminoethanol in Alzheimer's disease. Am J Psychiatry 1981;138:970-2. PubMed
  11. Ferris SH, Sathananthan G, Gershon S, et al. Senile dementia: treatment with deanol. J Am Geriatr Soc 1977;25:241-4. PubMed
  12. Haug BA, Holzgraefe M. Orofacial and respiratory tardive dyskinesia: potential side effects of 2-dimethylaminoethanol (deanol)? Eur Neurol 1991;31:423-5. PubMed
  13. Casey DE. Mood alterations during deanol therapy. Psychopharmacology (Berl) 1979;62:187-91. PubMed
  14. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses 1988;26:255-7. PubMed
  15. Osol A, Hoover JE, eds. Remington's Pharmaceutical Science, 15th ed. Easton, PA: Mack Publishing Company, 1975.

See these in context on the Deanol monograph →

Phosphatidylserine 9 references
  1. Crook T, Petrie W, Wells C, Massari DC. Effects of phosphatidylserine in Alzheimer's disease. Psychopharmacol Bull 1992;28:61-6.
  2. Pepping J. Phosphatidylserine. Am J Health-Syst Pharm 1999;56:2038,2043-4.
  3. Kidd PM. Phosphatidylserine; Membrane nutrient for memory. A clinical and mechanistic assessment. Altern Med Rev 1996;1:70-84.
  4. Kim HY, Akbar M, Lau A, et al. Inhibition of neuronal apoptosis by docosahexaenoic acid (22:6n-3). Role of phosphatidylserine in antiapoptotic effect. J Biol Chem 2000;275:35215-23.. PubMed
  5. Zanotti A, Valzelli L, Toffano G. Chronic phosphatidylserine treatment improves spatial memory and passive avoidance in aged rats. Psychopharmacology (Berl) 1989;99:316-21.. PubMed
  6. Schreiber S, Kampf-Sherf O, Gorfine M, et al. An open trial of plant-source derived phosphatydilserine for treatment of age-related cognitive decline. Isr J Psychiatry Relat Sci 2000;37:302-7.
  7. Pepping, J. Phosphatidylserine. Am J Health Syst.Pharm. 10-15-1999;56(20):2038, 2043-2038, 2044.
  8. Monteverde, A., Gnemmi, P., Rossi, F., Monteverde, A., and Finali, G. C. Selegiline in the treatment of mild to moderate Alzheimer-type dementia. Clin.Ther 1990;12(4):315-322.
  9. Vakhapova V, Cohen T, Richter Y, Herzog Y, Kam Y, Korczyn AD. Phosphatidylserine containing omega-3 Fatty acids may improve memory abilities in nondemented elderly individuals with memory complaints: results from an open-label extension study. Dement Geri PubMed

See these in context on the Phosphatidylserine monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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