Major interaction on record — check this product against your medications before combining. Based on 5 of 9 ingredients. Check your meds →
Dietary supplement

Platinum Hydro Builder Chocolate Shake Ingredients & Drug Interactions

by ON Optimum Nutrition

Platinum Hydro Builder Chocolate Shake label
See full label image
Powder Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Platinum Hydro Builder Chocolate Shake against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

Platinum Hydro Builder Chocolate Shake is a dietary supplement by ON Optimum Nutrition with 9 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,049 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Dietary Fiber, Sodium, Calcium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition

Ask about any prescription or over-the-counter medication and we check it for interactions with Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Platinum Hydro Builder Chocolate Shake has 6 active ingredients. The shake provides sodium and calcium for electrolyte and bone support, micronized Creapure Creatine Monohydrate for muscle strength and athletic performance, and BetaPower Natural Betaine for homocysteine metabolism.

It also contains a Micronized Amino Acid Matrix and an Enzyme Complex to support protein breakdown and absorption. The remaining ingredients are inactive—protein blend, cocoa, natural and artificial flavors, creamer, gum blend, lecithin, salt, polydextrose, sucralose, and acesulfame potassium—which serve as the shake's base, texture, and sweetening agents.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: muscle building and recovery support.
  • We looked for evidence on: Athletic performance, Exercise-induced muscle damage, Muscle breakdown, Muscle strength, lean body mass, post-workout recovery — and 1 related terms.
  • The strongest evidence on file: Creatine is rated "Possibly Effective" for Athletic performance (Natural Medicines).
  • Also on file: Creatine is rated "Possibly Effective" for Muscle strength.
  • Also on file: Calcium is rated "Insufficient Reliable Evidence To Rate" for Exercise-induced muscle damage.

Calcium in this product is effective for preventing low blood calcium and managing high potassium, and likely effective for osteoporosis. Creatine is possibly effective for muscle strength, athletic performance, and sarcopenia (age-related muscle loss), but possibly ineffective for Huntington disease and osteopenia (low bone density).

Betaine is effective for homocystinuria (a rare metabolic disorder) and possibly effective for high homocysteine levels. Sodium's clinical roles (cystic fibrosis support and amphotericin B side effect prevention) are beyond the typical use of a protein shake.

The evidence for betaine in depression, GERD, and fatty liver disease is insufficient to establish benefit.

The evidence, ingredient by ingredient Black Psyllium Sodium Calcium Creatine Betaine Anhydrous

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Calcium and creatine are generally well tolerated at recommended amounts. Creatine's most common side effects are dehydration, diarrhea, muscle cramps, and water retention; rare serious concerns include kidney damage and muscle breakdown.

Betaine is generally well tolerated but can cause body odor, nausea, vomiting, diarrhea, and stomach upset. Sodium is safe in normal dietary amounts but high intake is linked to high blood pressure and heart strain; the serious adverse effects of excess sodium include worsened cardiovascular and kidney disease.

Creatine should be avoided during pregnancy, and safety data for creatine and betaine during breastfeeding are insufficient—talk with your doctor or pharmacist before using if you're pregnant or nursing.

Side effects, ingredient by ingredient Black Psyllium Sodium Calcium Creatine Betaine Anhydrous

Meds to double-check

Major interaction found
Known Interaction Concern · database check
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 3 of the 5 matched ingredients can interact with medications — Black Psyllium, Calcium, Sodium.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: heart-rhythm medications; lithium.
  • For scale: 2,050 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your doctor or pharmacist if you take HIV integrase inhibitors (dolutegravir, elvitegravir), blood pressure medications, lithium, intravenous ceftriaxone, levothyroxine (thyroid medication), sotalol (heart rhythm drug), diltiazem or other calcium-channel blockers, calcipotriene (psoriasis treatment), corticosteroids, didanosine, tolvaptan, sodium phosphate laxatives, or HIV medication raltegravir. The interactions range from Major to Moderate in severity.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Major medication interactions have been identified, and safety information is well characterized.

This shake is designed for muscle building and athletic performance through creatine and amino acids, with added electrolytes. If you take any blood pressure medication, lithium, HIV drugs, thyroid medication, heart medications, or an antibiotic like ceftriaxone, talk with your doctor or pharmacist before starting—the sodium and calcium here may affect how those medications work.

Pregnant or nursing mothers should check with their healthcare provider first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Platinum Hydro Builder Chocolate Shake, straight from the product label.

Brand ON Optimum Nutrition
Net contents 2.52 lb; 1144 g
Market status On market
Date entered into DSLD Jan 25, 2013
DSLD ID 17605
Product type Other Combinations
Supplement form Powder
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
52 Gram(s)
Maximum serving Sizes:
52 Gram(s)
Servings per container
22
IngredientAmount% DV
Calories180 {Calories}--
Total Carbohydrates8 g3%
Sugar2 g--
Calories from Fat25 {Calories}--
Total Fat2.5 g4%
Dietary Fiber2 g8%
Protein30 g--
Saturated Fat2 g10%
Sodium350 mg15%
Cholesterol50 mg17%
Calcium200 mg20%
micronized Creapure Creatine Monohydrate5 g--
BetaPower(TM) Natural Betaine2.5 g--
Micronized Amino Acid Matrix2 g--
Enzyme Complex200 mg--

Other ingredients: Protein Blend, Creamer, Cocoa, Natural and Artificial flavors, Gum Blend, Lecithin, Salt, Polydextrose, Sucralose, Acesulfame Potassium

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

COMPREHENSIVE MUSCLE CONSTRUCTOR FORMULA** ENZYME COMPLEX FULL-SPECTRUM DIGESTION BLEND BETAPOWER(TM) NATURAL BETAINE AUGMENTED MUSCLE PERFORMANCE & ENDURANCE MICRONIZED CREAPURE(R) CREATINE ENHANCED TRAINING CAPACITY & LEAN BODY MASS MICRONIZED AMINO ACID MATRIX FAST-ACTING FREE FORM BCAAS, GLUTAMINE, ARGININE, CITRULLINE, CARNITINE, TAURINE & ALANINE CREAPEP(TM) ENHANCED STAGED-PROTEIN BLEND CREAPEP(TM) NUTRIENT DELIVERY PEPTIDES + HYDROLYZED WHEY PROTEIN ISOLATE + HYDROLYZED EGG + MICELLAR CASEIN

- Slow-Digesting Micellar Casein Protein • Over 13.5 Grams of Essential Amino Acids (EAAs) for Recovery & Rebuilding • 5 Grams of Micronized Creapure(R) Creatine to Help Support Increases in Lean Body Mass • 2.5 Grams of BetaPower(TM) Natural Betaine to Help Improve Strength, Energy, and Power • Comprehensive Enzyme Complex to Help Support Digestion • Micronized BCAAs, Glutamine, Arginine, and Citrulline

SLOW-DIGESTING MICELLAR CASEIN PROTEIN

CONTAINS CreaPep(TM)

30G PROTEIN 5G CREAPURE(R) CREATINE 13.5G ESSENTIAL AMINO ACIDS 2.5G BETAPOWER(TM) BETAINE

Brand IP Statement(s)

- Patent-Pending CreaPep(TM) Peptides for Enhanced Nutrient Delivery - Fast-Acting Hydrolyzed Proteins: HYDROWHEY(R) & HYDROEGG(TM)

EXCLUSIVE CREAPEP(TM) NUTRIENT DELIVERY PEPTIDE FAST-ACTING HYDROWHEY(R) AND HYDROEGG(TM) PROTEINS

CreaPep(TM) is a trademark of Glanbia plc betaPOWER(TM) Natural Betaine is a trademark of Danisco A/S Creapure(R) is a registered trademark of AlzChem Trostberg GmbH

(C)2011 OPTIMUM NUTRITION, INC

General Statements

TYPICAL AMINO ACID PROFILE (milligrams per serving) ESSENTAILl AMINO ACIDS (EAAs) Tryptophan 471 Valine • 1825 Threonine 1821 Isoleucine • 1982 Leucine • 3250 Lysine 2579 Phenylalanine 990 Methionine 656 CONDITIONALLY ESSENTIAL AMINO ACIDS (CAAs) Arginine • 1848 Cystine 532 Tyrosine 975 Histidine 554 Proline 1889 Glutamine & • Precursors 6037 NONESSENTIAL AMINO ACIDS (NAAs) Aspartic Acid 2773 Serine 1459 Glycine 534 Alanine • 1345 • Naturally occuring and added

Helps support muscle building and recovery when used in conjunction with resistance training and a sensible diet

BONUS SIZE 10% MORE FREE

ADVANCED LEAN MUSCLE REBUILDING AND RECOVERY COMPLEX

OCCASION PRODUCT MORNING PLATINUM HYDROWHEY(R) POST-WORKOUT PLATINUM HYDROBUILDER(TM) BED TIME GOLD STANDARD 100% CASEIN(TM)

ALL-IN-ONE MUSCLE-BUILDING SUPPORT COMPLEX • Premium Staged-Protein Blend

MANUFACTURED IN THE USA

22 SERVINGS

COMPLETE PROTEIN MUSCLE CONSTRUCTOR

Naturally & Artificially Flavored

CONTENTS SOLD BY WEIGHT NOT VOLUME.

SERVING SCOOP INCLUDED, BUT MAY SETTLE TO THE BOTTOM DURING SHIPPING

Seals/Symbols

ON(TM)

Suggested/Recommended/Usage/Directions

DIRECTIONS: PLATINUM HYDROBUILDER(TM) is INSTANTIZED, so it always mixes up completely and easily. Simply add 1 scoop of PLATINUM HYDROBUILDER(TM) to a blender, shaker cup or glass filled with 8 ounces of cold water, milk, or your favorite beverage and blend, shake, or stir for 20-30 seconds or until powder is dissolved. TIP: Adjust the intensity of your PLATINUM HYDROBUILDER(TM) shake by varying the amount of liquid you use to prepare it.

For a slightly thicker consistency with bolder flavor, mix each scoop with 6 ounces of liquid. For a milder tasting less sweet shake, use 10 ounces of liquid per scoop.

SUGGESTED USE: For post-workout recovery, consume one serving of PLATINUM HYDROBUILDER(TM) within an hour of completing your training. On non-training days, PLATINUM HYDROBUILDER(TM) may be taken in the morning or between meals.

Precautions

KEEP OUT OF REACH OF CHILDREN.

CHECK WITH A QUALIFIED HEALTHCARE PROFESSIONAL BEFORE TAKING THIS PRODUCT IF YOU ARE PREGNANT, NURSING A BABY, UNDER 18 YEARS OF AGE, OR IF YOU HAVE ANY KNOWN OR SUSPECTED MEDICAL CONDITION(S) AND/OR ARE TAKING ANY PRESCRIPTION OR OTC MEDICATION(S).

ALLERGEN INFORMATION: CONTAINS MILK, EGG AND SOY (LECITHIN) INGREDIENTS.

General

11-024-674

FDA Disclaimer Statement

These statements have not been evaluated by the FDA. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

DIETARY SUPPLEMENT

Storage

STORE IN A COOL, DRY PLACE.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Platinum Hydro Builder Chocolate Shake label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition

These are the 9 active ingredients this product is made of. Select any to open its full monograph.

Serving size52 Gram(s) Dosage formPowder Servings per container22 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

2 g per serving

Dietary Fiber

Interacts with
2,025 drugs
2 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Protein

30 g per serving

Sodium

Interacts with
205 drugs
350 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Calcium

Interacts with
168 drugs
200 mg per serving

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet f...

Calcium monograph & interactions

Micronized Creapure Creatine Monohydrate

No known
interactions
5 g per serving

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity ac...

Micronized Creapure Creatine Monohydrate monograph & interactions

BetaPower(TM) Natural Betaine

No known
interactions
2.5 g per serving

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and a...

BetaPower(TM) Natural Betaine monograph & interactions

Micronized Amino Acid Matrix

2 g per serving Form: L-Alanine, L-Arginine, Micronized, L-Carnitine Tartrate, L-Citrulline, Micronized, L-Glutamine, Micronized, Micronized Branched Chain Amino Acids, Taurine

Enzyme Complex

200 mg per serving Form: Amylase, Beet, Cellulase, Lactase, Lipase, Protease

Other (inactive) ingredients: Protein Blend, Creamer, Cocoa, Natural and Artificial flavors, Gum Blend, Lecithin, Salt, Polydextrose, Sucralose, Acesulfame Potassium. These complete the product’s ingredient list but are not active constituents.

Interaction report

Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition Drug Interactions

Want to check YOUR meds against Platinum Hydro Builder Chocolate Shake?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,049Drugs
7 Major 309 Moderate 1,733 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Sodium 205
Calcium 168

Individual Drug Interactions

The ingredients in Platinum Hydro Builder Chocolate Shake interact with 2,049 drugs. Click any drug to see the details.

3 of the 9 ingredients in Platinum Hydro Builder Chocolate Shake interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Sodium Calcium

Each ingredient & the kinds of drugs it affects

For each ingredient in Platinum Hydro Builder Chocolate Shake with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions

Calcium18 drug types · 168 drugs

Ceftriaxone (Rocephin)

Co-administration of intravenous calcium and ceftriaxone can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys.
Avoid administering intravenous calcium in any form, such as parenteral nutrition or Lactated Ringers, within 48 hours of intravenous ceftriaxone. Case reports in neonates show that administering intravenous ceftriaxone and calcium can result in precipitation of a ceftriaxone-calcium salt in the lungs and kidneys. In several cases, neonates have died as a result of this interaction. So far there are no reports in adults; however, there is still concern that this interaction might occur in adults.

Likelihood Probable Evidence D
Dolutegravir (Tivicay)

Calcium seems to reduce levels of dolutegravir.
Advise patients to take dolutegravir either 2 hours before or 6 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium carbonate 1200 mg concomitantly with dolutegravir 50 mg reduces plasma levels of dolutegravir by almost 40%. Calcium appears to decrease levels of dolutegravir through chelation.

Likelihood Probable Evidence B
Elvitegravir (Vitekta)

Calcium seems to reduce levels of elvitegravir.
Advise patients to take elvitegravir either 2 hours before or 2 hours after taking calcium supplements. Pharmacokinetic research suggests that taking calcium along with elvitegravir can reduce blood levels of elvitegravir through chelation.

Likelihood Probable Evidence B
Aluminum

Calcium citrate might increase aluminum absorption and toxicity. Other types of calcium do not increase aluminum absorption.
Calcium citrate can increase the absorption of aluminum when taken with aluminum hydroxide. The increase in aluminum levels may become toxic, particularly in individuals with kidney disease. However, the effect of calcium citrate on aluminum absorption is due to the citrate anion rather than calcium cation. Calcium acetate does not appear to increase aluminum absorption.

Likelihood Possible Evidence B
Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Calcium might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption when taken in a fasting state.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide and calcium can be taken together if taken with food. However, if taken on an empty stomach, bictegravir/emtricitabine/tenofovir alafenamide should not be taken with, or 2 hours after, calcium containing products.

Likelihood Probable Evidence D
Bisphosphonates

Calcium reduces the absorption of bisphosphonates.
Advise patients to take bisphosphonates at least 30 minutes before calcium, but preferably at a different time of day. Calcium supplements decrease absorption of bisphosphonates.

Likelihood Probable Evidence C
Calcipotriene (Dovonex)

Taking calcipotriene with calcium might increase the risk for hypercalcemia.
Calcipotriene is a vitamin D analog used topically for psoriasis. It can be absorbed in sufficient amounts to cause systemic effects, including hypercalcemia. Theoretically, combining calcipotriene with calcium supplements might increase the risk of hypercalcemia.

Likelihood Possible Evidence B
Digoxin (Lanoxin)

Using intravenous calcium with digoxin might increase the risk of fatal cardiac arrhythmias.
Hypercalcemia increases the risk of fatal cardiac arrhythmias with digoxin. However, one retrospective analysis of clinical data suggests that intravenous calcium does not increase the risk of dysrhythmias or mortality in patients receiving digoxin.

Likelihood Possible Evidence B
Diltiazem (Cardizem, Others)

Theoretically, calcium may reduce the therapeutic effects of diltiazem.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, calcium might increase this risk of hypercalcemia and reduce the effectiveness of diltiazem.

Likelihood Probable Evidence D
Levothyroxine (Synthroid, Others)

Calcium seems to reduce the absorption and effectiveness of levothyroxine.
Advise patients to take levothyroxine and calcium supplements at least 4 hours apart. Calcium reduces levothyroxine absorption, probably by forming insoluble complexes. Calcium carbonate supplements reduce effectiveness of levothyroxine in patients with hypothyroidism.

Likelihood Probable Evidence B
Lithium

Theoretically, concomitant use of calcium and lithium may increase this risk of hypercalcemia.
Clinical research suggests that long-term use of lithium may cause hypercalcemia in 10% to 60% of patients. Theoretically, concomitant use of lithium and calcium supplements may further increase this risk.

Likelihood Possible Evidence B
Quinolone Antibiotics

Calcium seems to reduce the absorption of quinolone antibiotics.
Advise patients to take oral quinolones at least 2 hours before or 4-6 hours after calcium supplements or calcium-fortified foods. Taking calcium at the same time as oral quinolones can reduce quinolone absorption. Calcium binds to quinolones in the gut.

Likelihood Probable Evidence B
Raltegravir (Isentress)

Calcium may reduce levels of raltegravir.
Pharmacokinetic research shows that taking a single dose of calcium carbonate 3000 mg along with raltegravir 400 mg twice daily modestly decreases the mean area under the curve of raltegravir, but the decrease does not necessitate a dose adjustment of raltegravir. However, a case of elevated HIV-1 RNA levels and documented resistance to raltegravir has been reported for a patient taking calcium carbonate 1 gram three times daily plus vitamin D3 (cholecalciferol) 400 IU three times daily in combination with raltegravir 400 mg twice daily for 11 months. It is thought that calcium reduced raltegravir levels by chelation, leading to treatment failure.

Likelihood Possible Evidence B
Sotalol (Betapace)

Calcium seems to reduce the absorption of sotalol.
Advise patients to separate doses by at least 2 hours before or 4-6 hours after calcium. Calcium appears to reduce the absorption of sotalol, probably by forming insoluble complexes.

Likelihood Possible Evidence B
Tetracycline Antibiotics

Calcium seems to reduce the absorption of tetracycline antibiotics.
Advise patients to take oral tetracyclines at least 2 hours before, or 4-6 hours after calcium supplements. Taking calcium at the same time as oral tetracyclines can reduce tetracycline absorption. Calcium binds to tetracyclines in the gut.

Likelihood Probable Evidence C
Thiazide Diuretics

Taking calcium along with thiazides might increase the risk of hypercalcemia and renal failure.
Thiazides reduce calcium excretion by the kidneys. Using thiazides along with moderately large amounts of calcium carbonate increases the risk of milk-alkali syndrome (hypercalcemia, metabolic alkalosis, renal failure). Patients may need to have their serum calcium levels and/or parathyroid function monitored regularly.

Likelihood Probable Evidence C
Verapamil (Calan, Others)

Theoretically, calcium may reduce the therapeutic effects of verapamil.
Hypercalcemia can reduce the effectiveness of verapamil in atrial fibrillation. Theoretically, use of calcium supplements may increase this risk of hypercalcemia and reduce the effectiveness of verapamil.

Likelihood Probable Evidence D
Calcium Channel Blockers

Intravenous calcium may decrease the effects of calcium channel blockers; oral calcium is unlikely to have this effect.
Intravenous calcium is used to decrease the effects of calcium channel blockers in the management of overdose. Intravenous calcium gluconate has been used before intravenous verapamil (Isoptin) to prevent or reduce the hypotensive effects without affecting the antiarrhythmic effects. But there is no evidence that dietary or supplemental calcium when taken orally interacts with calcium channel blockers.

Likelihood Unlikely Evidence D
Calcium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Platinum Hydro Builder Chocolate Shake, from the product label.

ON Optimum Nutrition

See all ON Optimum Nutrition products
Name
ON(TM) Consumer Affairs
City
Sunrise
State
FL
ZipCode
33325
Phone Number
(630) 236-0097
Web Address
TrueStrength.com
Pharmacist Counseling Corner

Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition: Common Questions

Does Platinum Hydro Builder Chocolate Shake by ON Optimum Nutrition interact with any medications?
Yes. Based on its ingredients, Platinum Hydro Builder Chocolate Shake has a known interaction with 2,049 medications, including 7 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Platinum Hydro Builder Chocolate Shake contains 9 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this shake help me build muscle?
The creatine and amino acids are possibly effective for muscle strength and athletic performance, especially with consistent training and adequate protein intake. Creatine is well studied for these goals in healthy adults.
Can I take this if I'm pregnant or breastfeeding?
Creatine should be avoided during pregnancy because safety hasn't been established. Calcium is likely safe in recommended amounts during pregnancy and lactation, but betaine and creatine data for breastfeeding are insufficient. Talk with your doctor or pharmacist about what's right for you.
What are the common side effects of creatine in this shake?
The most common are dehydration, diarrhea, muscle cramps, and water retention. These are usually mild and dose-dependent. Stay hydrated and start with the recommended serving.
Does this shake contain any fillers or unnecessary ingredients?
The inactive ingredients (cocoa, flavors, gum blend, lecithin, salt, polydextrose, sucralose, acesulfame potassium, protein blend, and creamer) are typical for a chocolate protein shake—they provide texture, taste, and mixing ability. They're not active ingredients but are standard in this type of product.
Is this safe if I have kidney problems?
Creatine should be used cautiously by people with kidney issues, as a rare but serious concern is kidney damage. Talk with your doctor or pharmacist before using if you have kidney disease or reduced kidney function.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Platinum Hydro Builder Chocolate Shake label
Go deeper

The Full Monographs Behind Platinum Hydro Builder Chocolate Shake’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Calcium

Interacts with 168 drugs

Calcium is an essential mineral your body needs for strong bones, nerve signaling, and muscle function, and supplements can help fill gaps when diet falls short. Most people do best getting...

Read the full Calcium monograph → Herb & supplement monograph

Creatine

Creatine is one of the most studied sports supplements, with solid evidence that it can boost strength and performance during short, high-intensity activities like weightlifting and sprintin...

Read the full Creatine monograph → Herb & supplement monograph

Betaine Anhydrous

Betaine anhydrous (also called trimethylglycine) is a compound found in foods like beets, spinach, and whole grains, and is sold as a supplement and as a prescription medicine for a rare gen...

Read the full Betaine Anhydrous monograph →
Sources

Sources & How We Checked

Platinum Hydro Builder Chocolate Shake's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 215 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
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  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
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  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Sodium 38 references
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See these in context on the Sodium monograph →

Calcium 62 references
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See these in context on the Calcium monograph →

Creatine 86 references
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Betaine Anhydrous 11 references
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