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Dietary supplement

Potassium Iodide 65 mg Ingredients & Drug Interactions

by Safrel

Potassium Iodide 65 mg label
See full label image
Tablet Or Pill Category: Mineral
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potassium Iodide 65 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potassium Iodide 65 mg is a dietary supplement by Safrel with 1 active ingredient. Its ingredients are commonly taken for preventing or treating low potassium (hypokalemia), supporting healthy blood pressure, muscle cramps.Based on those ingredients, 62 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Potassium Iodide. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Potassium Iodide 65 mg by Safrel

Ask about any prescription or over-the-counter medication and we check it for interactions with Potassium Iodide 65 mg by Safrel — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Potassium Iodide 65 mg by Safrel

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Safrel Potassium Iodide contains one active ingredient: potassium iodide at 65 mg per tablet. The remaining ingredients are inactive excipients—dicalcium phosphate, hypromellose, microcrystalline cellulose, magnesium stearate, croscarmellose sodium, silicon dioxide, and stearic acid—used as binders, fillers, and stabilizers to form the tablet.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Potassium product and its label doesn't state a use — see Potassium's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

We hold no effectiveness data for this product in our monograph, so we cannot tell you what it's designed to do or how well it works.

The evidence, ingredient by ingredient Potassium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Potassium is generally well tolerated when taken by mouth, though some people experience gastrointestinal discomfort—abdominal pain, belching, diarrhea, flatulence, nausea, or vomiting. In rare cases, especially with high doses, dangerously elevated blood potassium can trigger heart rhythm problems (arrhythmias), heart block, low blood pressure (hypotension), and confusion.

The risk is highest in people with kidney disease, since their kidneys cannot clear excess potassium the way healthy ones do. During pregnancy, dietary potassium is fine, but this supplement should be used only under medical guidance.

The same goes for breastfeeding—check with your doctor first. High potassium can be dangerous for both you and your baby.

Side effects, ingredient by ingredient Potassium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Potassium.
  • The most serious interaction on file is rated Moderate.
  • For scale: 62 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before using this product, check whether you take potassium-sparing diuretics, ACE inhibitors, or angiotensin receptor blockers (ARBs)—all three can raise blood potassium to unsafe levels when combined with this supplement. If you're unsure of your medication names, use the interaction checker below or ask your pharmacist.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product works only if your doctor or pharmacist has specifically recommended potassium supplementation for you. If you take any blood pressure medication, diuretic, or have kidney disease, do not start this supplement without talking to your pharmacist or doctor first.

Potassium imbalance can cause serious heart problems.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Sep 25, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potassium Iodide 65 mg, straight from the product label.

Brand Safrel
Barcode (UPC) 850012520825
Net contents 60 Tablet(s)
Market status On market
Date entered into DSLD Sep 25, 2024
DSLD ID 318393
Product type Mineral
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potassium Iodide 65 mg by Safrel, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
30
UPC/BARCODE
850012520825
IngredientAmount% DV
Potassium Iodide65 mg--

Other ingredients: Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Stearic Acid

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Caution Do not exceed suggested use.

Do not take if you are allergic to iodine, have dermatitis herpetiformis or hypocomplementemia vasculitis, or have nodular thyroid disease with heart disease.

If you are pregnant, may become pregnant, breastfeeding, have a thyroid condition, or are taking any medication, consult a physician before use.

In case of overdose, swollen salivary glands, stomach upset, skin rash or allergic reaction discontinue use immediately and consult a physician.

Do no use if seal under cap is broken or missing.

For short term use

Storage

Storage Store at room temperature 59 degrees - 86 degrees F (15 degrees - 30 degrees C). Keep bottle tightly closed.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration (FDA). This product is not intended to diagnose, treat, cure or prevent any disease.

General Statements

Questions or Comments: Call 1-844-384-3723

Formulation

Non GMO

Made in USA

No: Milk, egg, fish, crustacean shellfish, tree nuts, peanuts, yeast, artificial colors, flavors or preservatives.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Directions: Take one (2) tablets daily preferably with a meal or as directed by a healthcare professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potassium Iodide 65 mg by Safrel label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potassium Iodide 65 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potassium Iodide 65 mg by Safrel

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container30 Amounts shown are per serving.

Potassium Iodide

Interacts with
62 drugs
65 mg per serving

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanc...

Potassium Iodide monograph & interactions

Other (inactive) ingredients: Dicalcium Phosphate, Hypromellose, Microcrystalline Cellulose, Magnesium Stearate, Croscarmellose Sodium, Silicon Dioxide, Stearic Acid. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potassium Iodide 65 mg by Safrel Drug Interactions

Want to check YOUR meds against Potassium Iodide 65 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
62Drugs
62 Moderate

Ingredients driving the most interactions

Potassium Iodide 62

Individual Drug Interactions

The ingredients in Potassium Iodide 65 mg interact with 62 drugs. Click any drug to see the details.

1 of the 1 ingredient in Potassium Iodide 65 mg interact with drugs. Each result below shows which ingredient is responsible. Potassium Iodide

Each ingredient & the kinds of drugs it affects

For each ingredient in Potassium Iodide 65 mg with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Potassium Iodide3 drug types · 62 drugs

Ace Inhibitors (Aceis)

Using ACEIs with high doses of potassium increases the risk of hyperkalemia.
ACEIs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Angiotensin Receptor Blockers (Arbs)

Using ARBs with high doses of potassium increases the risk of hyperkalemia.
ARBs block the actions of the renin-angiotensin-aldosterone system and reduce potassium excretion. Concomitant use of these drugs with potassium supplements increases the risk of hyperkalemia. However, concomitant use of these drugs with moderate dietary potassium intake (about 3775-5200 mg daily) does not increase serum potassium levels.

Likelihood Likely Evidence C
Potassium-Sparing Diuretics

Concomitant use increases the risk of hyperkalemia.
Using potassium-sparing diuretics with potassium supplements increases the risk of hyperkalemia.

Likelihood Likely Evidence C
Potassium Iodide full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potassium Iodide 65 mg, from the product label.

Safrel

See all Safrel products
Name
Safrel Pharmaceuticals LLC
City
Bridgewater
State
NJ
ZipCode
08807
Phone Number
1-844-334-3723
Web Address
www.safrel.com
Pharmacist Counseling Corner

Potassium Iodide 65 mg by Safrel: Common Questions

Does Potassium Iodide 65 mg by Safrel interact with any medications?
Yes. Based on its ingredients, Potassium Iodide 65 mg has a known interaction with 62 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potassium Iodide 65 mg contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is potassium iodide safe during pregnancy?
Potassium from your normal diet is fine during pregnancy. But supplements like this one should only be used under medical guidance during pregnancy. Talk with your doctor or midwife before taking it.
Is it safe to take while breastfeeding?
Dietary potassium is appropriate. For supplements, check with your doctor first—they'll advise based on your individual situation.
What side effects might I experience?
Most commonly, abdominal pain, belching, diarrhea, gas, nausea, or vomiting. In rare cases—especially at high doses—dangerously high blood potassium can cause heart rhythm problems, low blood pressure, or confusion. People with kidney disease face higher risk.
Why does this product interact with blood pressure pills?
ACE inhibitors, ARBs, and potassium-sparing diuretics all reduce how much potassium your kidneys excrete. Adding a potassium supplement on top pushes levels too high, which can damage your heart. That's why you need your doctor's approval.
Can I take this if I have kidney disease?
Potassium supplements are risky for people with kidney disease because damaged kidneys cannot clear excess potassium safely. Your doctor or nephrologist must approve it before you start.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potassium Iodide 65 mg is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potassium Iodide 65 mg label
Go deeper

The Full Monographs Behind Potassium Iodide 65 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Potassium

Interacts with 62 drugs

Potassium is an essential mineral your body needs for nerve signals, muscle function, and a steady heartbeat, and most people get enough from a balanced diet rich in fruits and vegetables. P...

Read the full Potassium monograph →
Sources

Sources & How We Checked

Potassium Iodide 65 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 12 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Potassium 12 references
  1. McEvoy GK, ed. AHFS Drug Information. Bethesda, MD: American Society of Health-System Pharmacists, 1998.
  2. Gennaro A. Remington: The Science and Practice of Pharmacy. 19th ed. Lippincott: Williams & Wilkins, 1996.
  3. Whelton PK, He J, Cutler JA, et al. Effects of oral potassium on blood pressure. Meta-analysis of randomized controlled clinical trials. JAMA 1997;277:1624-32. PubMed
  4. Phillips, C. O., Kashani, A., Ko, D. K., Francis, G., and Krumholz, H. M. Adverse effects of combination angiotensin II receptor blockers plus angiotensin-converting enzyme inhibitors for left ventricular dysfunction: a quantitative review of data from ra DOI
  5. Altieri, P. I., Herrero, C., Suero, R., and Ortiz, A. Bleeding duodenal ulcer in a patient taking slow-releasing potassium tablets. Bol.Asoc.Med P.R. 1977;69(8):276.
  6. Raf, L. E. Enteric-coated potassium chloride tablets and ulcer of the small intestine. Acta Chir Scand Suppl 1967;(374):1-87.
  7. Potassium chloride oral solution [package insert]. Allentown, PA: Lehigh Valley Technologies, Inc.; 2014.
  8. Potassium chloride injection [package insert]. Lake Forest, IL: Hospira Inc.; 2009.
  9. Patel RB, Tannenbaum S, Viana-Tejedor A, et al. Serum potassium levels, cardiac arrhythmias, and mortality following non-ST-elevation myocardial infarction or unstable angina: insights from MERLIN-TIMI 36. Eur Heart J Acute Cardiovasc Care 2017 Feb;6(1):1 PubMed
  10. Malta D, Arcand J, Ravindran A, Floras V, Allard JP, Newton GE. Adequate intake of potassium does not cause hyperkalemia in hypertensive individuals taking medications that antagonize the renin angiotensin aldosterone system. Am J Clin Nutr 2016 Oct;104(4 PubMed
  11. Keskin M, Kaya A, Tatlisu MA, et al. The effect of serum potassium level on in-hospital and long-term mortality in ST elevation myocardial infarction. Int J cardiol. 2016 Oct 15;221:505-10.
  12. Stallings VA, Harrison M, Oria M; Committee to Review the Dietary Reference Intakes for Sodium and Potassium, Food and Nutrition Board, Health and Medicine Division, National Academies of Sciences, Engineering, and Medicine. Washington (DC): National Acad

See these in context on the Potassium monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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