Interactions on record — worth a quick check against your medications. Based on 1 of 8 ingredients. Check your meds →
Dietary supplement

Potent-Bac Ingredients & Drug Interactions

by Physician's Strength

Potent-Bac label
See full label image
Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Potent-Bac against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Potent-Bac is a dietary supplement by Physician's Strength with 8 active ingredients. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus acidophilus W22. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Potent-Bac by Physician's Strength

Ask about any prescription or over-the-counter medication and we check it for interactions with Potent-Bac by Physician's Strength — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Potent-Bac by Physician's Strength

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 8 active ingredients.
  • “Proprietary Blend Winclove 505” is a proprietary blend — the label doesn't break down how much of each component you get.

Potent-Bac is a powder probiotic blend with eight active bacterial strains — living microorganisms designed to support your gut. The product includes two Bifidobacterium species (W51 and W52), five Lactobacillus species (acidophilus W22, salivarius W24, plantarum W21, and paracasei W20), plus Enterococcus faecium W54 and Lactococcus lactis W19.

These are grouped partly under a proprietary blend called Winclove 505. The inactive ingredients are mainly carbohydrates and minerals (maize starch, maltodextrin, fructooligosaccharides, inulin, and others) that serve as food and carriers for the live strains, along with vanilla flavor.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: digestive health and probiotic support.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Colic, Constipation, Inflammatory bowel disease (IBD) — and 4 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis, Irritable bowel syndrome (IBS).
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Constipation, Inflammatory bowel disease (IBD), Lactose intolerance, Necrotizing enterocolitis (NEC).

For Lactobacillus acidophilus, the ingredient we could check, the evidence is mixed. It's rated Possibly Effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

It's rated Possibly Ineffective for atopic disease (allergic conditions), and there isn't enough reliable evidence to rate it for acute respiratory distress syndrome. We don't have effectiveness ratings for the other seven strains in this product.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Gastrointestinal side effects from this strain in combination with other probiotics — like stomach discomfort, abdominal pain, bloating, flatulence, diarrhea, vomiting, or burping — can occur but are uncommon.

There's a theoretical concern that live probiotic organisms could cause serious infection in patients with compromised immunity, though these cases are rare and usually involve bacteria that were already present in the body. Because data are limited and safety varies by person, check with your doctor before starting.

For pregnancy, Lactobacillus acidophilus is rated Possibly Safe. Lactation safety data isn't on file for this ingredient.

Talk with your doctor or pharmacist if you're pregnant or nursing and want personalized advice.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotic drugs, check with your doctor or pharmacist before starting Potent-Bac. Antibiotics can kill the live organisms in this product.

Timing the two doses apart can help, so ask about the best schedule for your situation.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This eight-strain probiotic powder is targeted at gut health and is generally well tolerated in healthy people. If you take antibiotics, space them away from this product so the medication can work and the probiotics survive.

Check your medications against the interaction tool on this page, and talk it over with your doctor or pharmacist before you start — especially if you have a weakened immune system or are pregnant or nursing.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 8 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2023.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Potent-Bac, straight from the product label.

Brand Physician's Strength
Barcode (UPC) 850032454605
Net contents 100 Gram(s)
Market status On market
Date entered into DSLD Aug 23, 2023
DSLD ID 296830
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Potent-Bac by Physician's Strength, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
3 Gram(s)
Maximum serving Sizes:
3 Gram(s)
Servings per container
33
UPC/BARCODE
850032454605
IngredientAmount% DV
Bifidobacterium lactis W510 NP--
Bifidobacterium lactis W520 NP--
Lactobacillus salivarius W240 NP--
Lactobacillus acidophilus W220 NP--
Lactobacillus plantarum W210 NP--
Enterococcus faecium W540 NP--
Proprietary Blend Winclove 5050 NP--
Lactobacillus paracasei W200 NP--
Lactococcus lactis W190 NP--

Other ingredients: Maize Starch, Maltodextrin, Fructooligosaccharides, Inulin, Maize Dextrin, Protein, Potassium Chloride, Magnesium Sulfate, Bacterial Strains, Amylase, Vanilla Flavor, Manganese Sulfate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: Dissolve 1 teaspoon in lukewarm water. Take at least one hour before or after using oil of wild oregano or Oregacillin. Best taken at bedtime.

Formula

Potent-Bac contains the most extensively researched probiotic available: Winclove 505 (formerly Ecologic 500). Potent-Bac has been clinically demonstrated to readily implant in humans and, therefore, is an aid in digestive issues an support.

Winclove 505 Probiotic High Implantation Power >1x10^9 (1billion) winclove 505 per gram

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Formulation

Doctor's Formula

Non-GMO

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Potent-Bac by Physician's Strength label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Potent-Bac label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Potent-Bac by Physician's Strength

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size3 Gram(s) Dosage formPowder Servings per container33 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Blend Winclove 505

0 NP per serving
  • › Bifidobacterium lactis W51
  • › Bifidobacterium lactis W52
  • › Lactobacillus salivarius W24
  • › Lactobacillus acidophilus W22
  • › Lactobacillus plantarum W21
  • › Enterococcus faecium W54
  • › Lactobacillus paracasei W20
  • › Lactococcus lactis W19

Other (inactive) ingredients: Maize Starch, Maltodextrin, Fructooligosaccharides, Inulin, Maize Dextrin, Protein, Potassium Chloride, Magnesium Sulfate, Bacterial Strains, Amylase, Vanilla Flavor, Manganese Sulfate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Potent-Bac by Physician's Strength Drug Interactions

Want to check YOUR meds against Potent-Bac?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus acidophilus W22 182

Individual Drug Interactions

The ingredients in Potent-Bac interact with 182 drugs. Click any drug to see the details.

1 of the 8 ingredients in Potent-Bac interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus acidophilus W22

Each ingredient & the kinds of drugs it affects

For each ingredient in Potent-Bac with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus acidophilus W221 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus acidophilus W22 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Potent-Bac, from the product label.

Physician's Strength

See all Physician's Strength products
Name
Physician's Strength
Street Address
13900 W. Polo Trail Drive
City
Lake Forest
State
IL
ZipCode
60045
Phone Number
1-800-473-8460
Web Address
www.physicians-strength.com
Pharmacist Counseling Corner

Potent-Bac by Physician's Strength: Common Questions

Does Potent-Bac by Physician's Strength interact with any medications?
Yes. Based on its ingredients, Potent-Bac has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Potent-Bac contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What are these bacterial strains supposed to do?
They're live organisms meant to support your gut health. For Lactobacillus acidophilus — the one we have evidence on — the data suggests it may help with irritable bowel syndrome, certain infections, antibiotic-associated diarrhea, and bacterial vaginosis. We don't have effectiveness ratings for the other seven strains.
Can I take this with my antibiotic?
Not at the same time. Antibiotics kill the live organisms in this product, so you'll want to separate them — maybe a few hours apart. Your doctor or pharmacist can give you a specific schedule that works for your antibiotic and this probiotic.
What side effects might I get?
Digestive side effects like bloating, stomach discomfort, flatulence, or diarrhea can happen, but they're uncommon. In rare cases, especially in people with weakened immunity, probiotics could theoretically cause serious infection — which is why it's worth checking with your doctor first.
Is it safe if I'm pregnant?
Lactobacillus acidophilus is rated Possibly Safe in pregnancy. We don't have safety data on file for the other seven strains. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy — they can weigh your individual situation.
How many strains are in here, and what do they all do?
There are eight strains total: two Bifidobacterium, five Lactobacillus, Enterococcus faecium, and Lactococcus lactis. We have effectiveness and safety data for Lactobacillus acidophilus, but we haven't reviewed the others, so we don't know what evidence supports them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Potent-Bac is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Potent-Bac label
Go deeper

The Full Monographs Behind Potent-Bac’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Potent-Bac's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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