PQ ProQuil Ingredients & Drug Interactions
by AlchemLife
What is this page for?
First and foremost: checking PQ ProQuil against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
PQ ProQuil is a dietary supplement by AlchemLife with 3 active ingredients. Its ingredients are commonly taken for benign prostatic hyperplasia (bph) symptoms, overactive bladder, eye and skin health (vitamin a source).Based on those ingredients, 175 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Saw Palmetto Oil, Pumpkin seed oil. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against PQ ProQuil by AlchemLife
Ask about any prescription or over-the-counter medication and we check it for interactions with PQ ProQuil by AlchemLife — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of PQ ProQuil by AlchemLife
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
PQ ProQuil contains three active ingredients: pumpkin seed oil, pygeum G361 PhytoExtract, and saw palmetto oil. These are formulated into softgel capsules alongside several inactive ingredients including flax seed oil, sunflower lecithin, olive oil, gelatin, glycerin, and other excipients.
Does it work?
Strong evidence
Pumpkin seed oil is possibly effective for benign prostatic hyperplasia (BPH, or enlarged prostate), but evidence is insufficient to rate it for hair loss, bladder inflammation (interstitial cystitis), parasite infections, or urinary tract infections. Pygeum extract is likely effective for BPH, though evidence for Alzheimer's disease, malaria, sexual desire, and psychosis is insufficient.
Saw palmetto oil's evidence is mixed: it's possibly effective for transurethral resection of the prostate (TURP), but possibly ineffective for BPH itself, and evidence is insufficient for other conditions.
How safe is it?
Well-documented data
Pumpkin seed oil is generally well tolerated; the most common side effects in trials were mild abdominal discomfort, diarrhea, nausea, and vomiting. Rare cases of severe nausea, vomiting, and diarrhea have been linked to high concentrations of a compound called cucurbitacin found in wild or bitter-tasting pumpkins.
There are also two isolated case reports of temporary hair loss after eating bitter pumpkin or squash. Pygeum and saw palmetto are also generally well tolerated; saw palmetto's common side effects include abdominal pain, constipation, decreased libido, diarrhea, dizziness, fatigue, headache, nausea, and vomiting.
Rare reports of heart-related effects such as irregular heartbeat, high blood pressure, and chest pain have been noted with saw palmetto, though causation is unclear. For pregnancy: pumpkin seed oil has insufficient safety data — talk with your doctor or pharmacist before using it.
Pygeum and saw palmetto should both be avoided during pregnancy due to hormonal effects and lack of safety data. For breastfeeding: safety data for concentrated pumpkin supplements and pygeum are insufficient or lacking — discuss with your doctor or pharmacist.
Saw palmetto should be avoided while breastfeeding.
Meds to double-check
Moderate interaction found
Check with your doctor or pharmacist before taking this product if you're on blood thinners or antiplatelet drugs (saw palmetto may increase bleeding risk — Moderate severity), birth control pills or estrogen replacement (saw palmetto may reduce effectiveness — Moderate severity), or lithium (pumpkin seed oil may raise levels — Moderate severity).
The bottom line
Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
PQ ProQuil is oriented toward prostate and urinary health; pumpkin seed oil and pygeum show some supporting evidence for BPH. If you take blood thinners, birth control, estrogen therapy, or lithium, you'll need to check with your doctor or pharmacist before starting this product because of the documented interactions.
Pregnant or breastfeeding individuals should also discuss it with their healthcare provider first.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Dec 26, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about PQ ProQuil, straight from the product label.
| Brand | AlchemLife |
|---|---|
| Barcode (UPC) | 866078000232 |
| Net contents | 15 Softgel(s) |
| Market status | On market |
| Date entered into DSLD | Dec 26, 2020 |
| DSLD ID | 241602 |
| Product type | Botanical |
| Supplement form | Softgel Capsule |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult Male (18-50 Years) |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for PQ ProQuil by AlchemLife, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Pumpkin seed oil | 100 mg | -- |
| Pygeum G361 PhytoExtract | 100 mg | -- |
| Saw Palmetto Oil | 100 mg | -- |
Other ingredients: Flax seed Oil, Zinc Oxide, Sunflower Lecithin, Olive Oil, Aerosil-200, Gelatin, Glycerin, Caramel color
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Developed with PhytoAdvance Technology
Natural prostate support Supports a healthy prostate Supports normal urinary flow. Frequency & voiding No decrease in libido
ProQuil is a natural support product that may help alleviate symptoms of prostate issues by harnessing the potential benefits associated with extracts of pygeum, pumpkin seed oil and saw palmetto oil.
Made in USA
FDA Statement of Identity
Dietary Supplement
Brand IP Statement(s)
ProQuil is trademarked by Alchem International SA
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement consume 1 softgel daily.
Precautions
Consult with a licensed healthcare professional before taking any dietary supplements.
Keep out of reach of children.
To report a serious event about this product or obtain information contact us at 800-201-1081
Storage
Store in a cool, dry place.
FDA Disclaimer Statement
These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
PQ ProQuil by AlchemLife label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in PQ ProQuil by AlchemLife
These are the 3 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Softgel(s) Dosage formSoftgel Capsule Servings per container15 Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Pumpkin seed oil
Interacts with1 drug
Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...
Pumpkin seed oil monograph & interactionsPygeum G361 PhytoExtract
No knowninteractions
Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some st...
Pygeum G361 PhytoExtract monograph & interactionsSaw Palmetto Oil
Interacts with174 drugs
Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...
Saw Palmetto Oil monograph & interactionsOther (inactive) ingredients: Flax seed Oil, Zinc Oxide, Sunflower Lecithin, Olive Oil, Aerosil-200, Gelatin, Glycerin, Caramel color. These complete the product’s ingredient list but are not active constituents.
PQ ProQuil by AlchemLife Drug Interactions
HelloPharmacist Interaction Report
PQ ProQuil by AlchemLife contains three active ingredients, two of which interact with medications: pumpkin seed oil and saw palmetto oil.
The most serious interaction involves saw palmetto with blood thinners (anticoagulants) and antiplatelet drugs — saw palmetto may prolong bleeding time and increase your bleeding risk if you're on these medications. Altogether, these interactions span 175 individual medications.
Read the full breakdown — every affected drug type, severity by severity
Saw palmetto also interacts with estrogens and birth control pills (contraceptive drugs), potentially reducing their effectiveness through antiestrogenic effects. Pumpkin seed oil can increase lithium levels by reducing how your kidneys excrete it, which may require a dose adjustment if you take lithium for mood disorders.
Pygeum G361 PhytoExtract, the third active ingredient, has no documented interactions in our data. Before you start this product, check your exact medications using the search tool on this page, especially if you take blood thinners, birth control, estrogen replacement, or lithium.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against PQ ProQuil?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in PQ ProQuil interact with 175 drugs. Click any drug to see the details.
2 of the 3 ingredients in PQ ProQuil interact with drugs. Each result below shows which ingredient is responsible. Saw Palmetto Oil Pumpkin seed oil
Cyproterone Acetate, Ethinyl EstradiolDiane-35, Dianette
How Cyproterone Acetate, Ethinyl Estradiol interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Cyproterone Acetate, Ethinyl Estradiol interactionDalteparinFragmin
How Dalteparin interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Dalteparin interactionDanaparoidOrgaran
How Danaparoid interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Danaparoid interactionDefibrotide SodiumDefitelio
How Defibrotide Sodium interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Defibrotide Sodium interactionDesogestrel, Ethinyl EstradiolDesogen, Marvelon, Marvelon 21, Marvelon 28, Mircette, Ortho-Cept +2 more
How Desogestrel, Ethinyl Estradiol interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens, Contraceptive Drugs Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Desogestrel, Ethinyl Estradiol interactionDiclofenacZorvolex
How Diclofenac interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Diclofenac interactionDiclofenac PotassiumCambia, Cataflam, Cataflam IR, Voltaren Rapide, Voltarol Rapid
How Diclofenac Potassium interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Diclofenac Potassium interactionDiclofenac SodiumAcoflam, Acoflam 75 SR, Acoflam Retard, Defenac, Defenac Retard, Defenac SR +40 more
How Diclofenac Sodium interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Diclofenac Sodium interactionDiclofenac Sodium, MisoprostolArthrotec 50, Arthrotec 75
How Diclofenac Sodium, Misoprostol interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Diclofenac Sodium, Misoprostol interactionDiclofenac EpolamineFlector, Licart
How Diclofenac Epolamine interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Diclofenac Epolamine interactionDicumarolDicumarol
How Dicumarol interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Dicumarol interactionDiphenhydramine Hydrochloride, Naproxen SodiumAleve PM
How Diphenhydramine Hydrochloride, Naproxen Sodium interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Diphenhydramine Hydrochloride, Naproxen Sodium interactionDipyridamoleDipyridamole, Persantin, Persantin Injection, Persantin Retard, Persantine
How Dipyridamole interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Dipyridamole interactionDrospirenoneDrospirenone
How Drospirenone interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilContraceptive Drugs Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of contraceptive drugs.
Read the full Saw Palmetto Oil + Drospirenone interactionDrospirenone, EstetrolNextstellis
How Drospirenone, Estetrol interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens, Contraceptive Drugs Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Drospirenone, Estetrol interactionDrospirenone, Ethinyl EstradiolAngeliq, Gianvi, Yasmin
How Drospirenone, Ethinyl Estradiol interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens, Contraceptive Drugs Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Drospirenone, Ethinyl Estradiol interactionEdoxabanSavaysa
How Edoxaban interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Edoxaban interactionEffientPrasugrel
How Effient interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Effient interactionEnoxaparinLovenox
How Enoxaparin interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Enoxaparin interactionEptifibatideIntegrilin
How Eptifibatide interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Eptifibatide interactionEsomeprazole, NaproxenVimovo
How Esomeprazole, Naproxen interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Read the full Saw Palmetto Oil + Esomeprazole, Naproxen interactionEsterified EstrogensEstratab, Menest
How Esterified Estrogens interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Esterified Estrogens interactionEsterified Estrogens, MethyltestosteroneEstratest
How Esterified Estrogens, Methyltestosterone interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Esterified Estrogens, Methyltestosterone interactionEstradiolDivigel, Elestrin, Estrace, Estraderm, Estring, Evamist +6 more
How Estradiol interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Estradiol interactionEstradiol, MedroxyprogesteroneDivitren
How Estradiol, Medroxyprogesterone interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Estradiol, Medroxyprogesterone interactionEstradiol, Norethindrone AcetateActivella
How Estradiol, Norethindrone Acetate interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Estradiol, Norethindrone Acetate interactionEstradiol, NorgestimateOrtho-Prefest
How Estradiol, Norgestimate interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Estradiol, Norgestimate interactionEstradiol, ProgesteroneBijuvanda
How Estradiol, Progesterone interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Estradiol, Progesterone interactionEstrogenEstrogen
How Estrogen interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Estrogen interactionEstroneOrtho-Est
How Estrone interacts with PQ ProQuil — through 1 ingredient. Tap an ingredient for the detail:
Saw Palmetto OilEstrogens Moderate
Interaction Summary
Saw palmetto might reduce the effectiveness of estrogens.
Read the full Saw Palmetto Oil + Estrone interactionEach ingredient & the kinds of drugs it affects
For each ingredient in PQ ProQuil with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Saw Palmetto Oil
Anticoagulant/Antiplatelet Drugs
Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.
Contraceptive Drugs
Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.
Estrogens
Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.
Pumpkin seed oil
Lithium
Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.
Brand information
Manufacturer and brand details for PQ ProQuil, from the product label.
AlchemLife
See all AlchemLife products- Name
- Alchem USA
- Street Address
- 1500 Market Street, FL-12 STE 44
- City
- Philadelphia
- State
- PA
- ZipCode
- 19103
- Phone Number
- 800-201-1081
PQ ProQuil by AlchemLife: Common Questions
Does PQ ProQuil by AlchemLife interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
What is pumpkin seed oil supposed to do in this product?
Can I take this if I'm on birth control?
What are the most common side effects?
Is this safe to take during pregnancy?
Can I take this if I'm on blood thinners?
What is pygeum extract, and what does it do?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if PQ ProQuil is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind PQ ProQuil’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Pumpkin
Interacts with 1 drugPumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...
Read the full Pumpkin monograph → Herb & supplement monographPygeum
Pygeum is an extract from the bark of the African cherry tree that is most often used to ease urinary symptoms linked to an enlarged prostate. Some studies suggest modest benefit for these s...
Read the full Pygeum monograph → Herb & supplement monographSaw Palmetto
Interacts with 174 drugsSaw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...
Read the full Saw Palmetto monograph →Sources & How We Checked
PQ ProQuil's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 30 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Pumpkin 5 references
- Marks L, Partin AW, Epstein JI, et al. Effects of a saw palmetto herbal blend in men with symptomatic benign prostatic hyperplasia. J Urol 2000;163:1451-6. DOI
- Cho YH, Lee SY, Jeong DW, et al. Effect of pumpkin seed oil on hair growth in men with androgenetic alopecia: a randomized, double-blind, placebo-controlled trial. Evid Based Complement Alternat Med 2014;2014:549721. PubMed
- Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of pumpkin seed in men with lower urinary tract symptoms due to benign prostatic hyperplasia in the one-year, randomized, placebo-controlled GRANU study. Urol Int 2015;94(3):286-95 PubMed
- Assouly P. Hair loss associated with cucurbit poisoning. JAMA Dermatol. 2018 May 1;154(5):617-618. PubMed
- Gawryjolek J, Ludwig H, Zbikowska-Götz M, Bartuzi Z, Krogulska A. Anaphylaxis after consumption of pumpkin seeds in a 2-y-old child tolerant to its pulp: A case study. Nutrition 2021;89:111272. PubMed
Pygeum 3 references
- Ishani A, MacDonald R, Nelson D, et al. Pygeum africanum for the treatment of patients with benign prostatic hyperplasia: a systematic review and quantitative meta-analysis. Am J Med 2000;109:654-64.. PubMed
- Wilt T, Ishani A, Mac Donald R, et al. Pygeum africanum for benign prostatic hyperplasia. Cochrane Database Syst Rev 2002;CD001044.. PubMed
- Andro M and Riffaud J. Pygeum africanum extract for the treatment of patients with benign prostatic hyperplasia: a review of 25 years of published experience. Curr Ther Res 1995;56(8):796-817. DOI
Saw Palmetto 22 references
- Wilt TJ, Ishani A, Stark G, et al. Saw palmetto extracts for treatment of benign prostatic hyperplasia: a systematic review. JAMA 1998;280:1604-9. PubMed
- Carraro JC, Raynaud JP, Koch G, et al. Comparison of phytotherapy (Permixon) with finasteride in the treatment of benign prostate hyperplasia: a randomized international study of 1,098 patients. Prostate 1996;29:231-40. DOI
- Di Silverio F, D'Eramo G, Lubrano C, et al. Evidence that Serenoa repens extract displays an antiestrogenic activity in prostatic tissue of benign prostatic hypertrophy patients. Eur Urol 1992;21:309-14. PubMed
- Stepanov VN, Siniakova LA, Sarrazin B, Raynaud JP. Efficacy and tolerability of the lipidosterolic extract of Serenoa repens (Permixon) in benign prostatic hyperplasia: a double-blind comparison of two dosage regimens. Adv Ther 1999;16:231-41.
- Cheema P, El-Mefty O, Jazieh AR. Intraoperative haemorrhage associated with the use of extract of Saw Palmetto herb: a case report and review of literature. J Intern Med 2001;250:167-9. PubMed
- Jibrin I, Erinle A, Saidi A, Aliyu ZY. Saw palmetto-induced pancreatitis. South Med J 2006;99:611-2. PubMed
- Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia. J Altern Complement Med 2002
- Avins AL, Bent S, Staccone S, et al. A detailed safety assessment of a saw palmetto extract. Complement Ther Med 2008;16:147-54. PubMed
- Morgia, G., Mucciardi, G., Gali, A., Madonia, M., Marchese, F., Di, Benedetto A., Romano, G., Bonvissuto, G., Castelli, T., Macchione, L., and Magno, C. Treatment of chronic prostatitis/chronic pelvic pain syndrome category IIIA with Serenoa repens plus
- Aliaev, IuG, Vinarov, A. Z., Lokshin, K. L., and Spivak, L. G. [Efficiency and safety of prostamol-Uno in patients with chronic abacterial prostatitis]. Urologiia. 2006;(1):47-50.
- Agbabiaka, T. B., Pittler, M. H., Wider, B., and Ernst, E. Serenoa repens (saw palmetto): a systematic review of adverse events. Drug Saf 2009;32(8):637-647. PubMed
- Wargo, K. A., Allman, E., and Ibrahim, F. A possible case of saw palmetto-induced pancreatitis. South.Med.J. 2010;103(7):683-685. PubMed
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