Interactions on record — worth a quick check against your medications. Based on 2 of 5 ingredients. Check your meds →
Dietary supplement

Pre Wrek Fruit Punch Ingredients & Drug Interactions

by Swole

Pre Wrek Fruit Punch label
See full label image
Powder Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pre Wrek Fruit Punch against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pre Wrek Fruit Punch is a dietary supplement by Swole with 5 active ingredients. Its ingredients are commonly taken for constipation, diarrhea, high cholesterol.Based on those ingredients, 2,059 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Dietary Fiber, Chromium. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Pre Wrek Fruit Punch by Swole

Ask about any prescription or over-the-counter medication and we check it for interactions with Pre Wrek Fruit Punch by Swole — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
Prefer a human? Send your question to our licensed pharmacists — free, answered by email within 24 hours.

HelloPharmacist Scorecard of Pre Wrek Fruit Punch by Swole

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 3 of its 4 active ingredients.

Pre Wrek Fruit Punch contains 3 active ingredients. The one we have full data on is chromium, a mineral that plays a role in blood sugar control and is used in this product as a pre-workout supplement.

The other two actives — PREWREK Pump Matrix and SWOLE Muscle Matrix — are blended proprietary ingredients we don't have detailed information on. The product also contains inactive ingredients (fillers and flavoring): citric acid, natural and artificial flavors, sucralose, acesulfame potassium, and FD&C Red #40.

Does it work?

Insufficient evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Insufficient

There isn't enough reliable clinical evidence to rate this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: supports athletic performance mental focus and muscle power.
  • We looked for evidence on: Athletic performance, Cognitive impairment, endurance, vascularity, stamina.
  • The closest evidence on file: Chromium is rated "Insufficient Reliable Evidence To Rate" for Athletic performance (Natural Medicines).
  • Also on file: Chromium is rated "Insufficient Reliable Evidence To Rate" for Cognitive impairment.

Chromium is likely effective for treating chromium deficiency. For diabetes and blood sugar control, the evidence rates it as possibly effective — some research suggests it may help, especially in people whose type 2 diabetes isn't well controlled.

For prediabetes (impaired glucose tolerance), schizophrenia, and high blood pressure, chromium rates as possibly ineffective in the data we hold. We don't have effectiveness data for the PREWREK Pump Matrix or SWOLE Muscle Matrix ingredients.

The evidence, ingredient by ingredient Black Psyllium Chromium

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Chromium is generally well tolerated at typical supplement doses. The most common side effects are gastrointestinal irritation, headaches, insomnia, irritability, and mood changes.

Serious adverse effects are rare but have included kidney and liver damage, a muscle breakdown condition called rhabdomyolysis, and low blood platelet counts (thrombocytopenia). Skin rashes and urticaria (hives) have also been reported, particularly with chromium picolinate or chromium chloride in people with a chromium contact allergy.

During pregnancy, small amounts of chromium from food or a prenatal vitamin are considered likely safe, but extra supplement doses should be avoided unless your doctor recommends them. Lactation data rates chromium as likely safe.

There is limited safety data on higher supplement doses, so talk with your doctor or pharmacist before taking extra chromium beyond what's in a prenatal vitamin.

Side effects, ingredient by ingredient Black Psyllium Chromium

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Black Psyllium, Chromium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; heart-rhythm medications; lithium.
  • For scale: 2,060 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist or doctor if you take insulin, antidiabetes drugs (medications for type 2 diabetes), or levothyroxine (thyroid hormone replacement). Moderate interactions are documented with all three.

If you regularly use NSAIDs or aspirin, flag those as well — they're minor interactions but worth confirming.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with insufficient evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pre Wrek Fruit Punch may be worth considering if you're looking for a pre-workout supplement, but if you take insulin, diabetes medication, or thyroid hormone (levothyroxine), you should check with your own doctor or pharmacist before starting it — the chromium could affect how your medications work. If you take pain relievers like ibuprofen or aspirin regularly, mention that too.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Nov 21, 2012.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pre Wrek Fruit Punch, straight from the product label.

Brand Swole
Barcode (UPC) 728028161748
Net contents 349 g
Market status On market
Date entered into DSLD Nov 21, 2012
DSLD ID 15901
Product type Other Combinations
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pre Wrek Fruit Punch by Swole, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
7 Gram(s)
Maximum serving Sizes:
7 Gram(s)
Servings per container
50
UPC/BARCODE
728028161748
IngredientAmount% DV
Calories5 {Calories}--
Total Carbohydrates1 g--
Sugar0 g--
Calories from Fat0 {Calories}--
Dietary Fiber0 g--
Saturated Fat0 g--
Cholesterol0 mg--
Total Fat0 g--
Chromium120 mcg100%
PREWREK Pump Matrix3155 mg--
SWOLE Muscle Matrix237 mg--

Other ingredients: Citric Acid, Natural & Artificial flavors, Sucralose, Acesulfame Potassium, FD&C Red #40

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

INTRODUCING SWOLE'S MAXIMUM STRENGTH PRE-WORKOUT FORMULA! - SUPPORTS NITRIC OXIDE PRODUCTION - INCREASES PUMPS & VASCULARITY - MENTAL ALERTNESS & FOCUS - PROMOTES POWER & FUELS MUSCLE - TASTES GREAT & DISSOLVES QUICKLY - HELPS STAMINA & ENDURANCE

FEATURED IN PREWREK'S PROPRIETARY FORMULA:

Contents may settle after shipping. Shake container prior to each use to redistribute ingredients.

50 FULL SERVINGS

ULTIMATE- PRE-WORKOUT MATRIX

MADE IN USA

Maximum Strength

Seals/Symbols

CREATINE AAB

CarnoSyn(R) Carnosine Synthesizer

Razberi-K

Creapure(R)

SWOLE(R) SPORTS NUTRITION

Precautions

Before using this product consult with your physician if you are using any prescription medication or over the counter medication or if you have any pre-existing medical condition including but not limited to: high or low blood pressure, cardiac arrhythmia, stroke, heart, liver, kidney or thyroid disease, seizure disorder, psychiatric disease, diabetes, difficulty urinating due to prostate enlargement or if you are taking a MAOI (Monoamine Oxidase Inhibitor) or any other medication.

Discontinue use and consult your health care professional if you experience any adverse reaction to this product. Do not exceed recommended serving. Do not use if safety seal is broken or missing.

This product is produced in a facility that may also process ingredients containing milk, eggs, soy beans, shellfish, fish, tree nuts, wheat and peanuts.

KEEP OUT OF THE REACH OF CHILDREN.

CAUTION: This product is only intended to be consumed by adults 18 years of age or older.

DO NOT USE IF SAFETY SEAL IS DAMAGED OR MISSING.

Storage

STORE IN A COOL, DRY PLACE.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Suggested/Recommended/Usage/Directions

SUGGESTED USE: As an adult supplement, mix 1 scoop with 8 to 10 ounces of water and consume 30 to 45 minutes prior to training. Do not take more than 2 scoops at a time and/or 3 servings in a 24 hour period. Exceeding the suggested dosage size or frequency is not recommended and may lead to negative side effects.

Brand IP Statement(s)

Creapure is a Registered Trademark of AlzChem, LLC and use of it's license under US Parent # 5,719,319 Carnosyn(R) is a Registered Trademark of Natural Alternatives International, Inc. Creatine AAB(R) is a Registered Trademark of Integrity Nutraceuticals Razberi K(R) is a Registered Trademark of Integrity Netraceuticals

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pre Wrek Fruit Punch by Swole label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pre Wrek Fruit Punch label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pre Wrek Fruit Punch by Swole

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size7 Gram(s) Dosage formPowder Servings per container50 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

0 g per serving

Dietary Fiber

Interacts with
2,025 drugs
0 g per serving

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. I...

Dietary Fiber monograph & interactions

Chromium

Interacts with
178 drugs
120 mcg per serving Form: Chromium Picolinate

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control i...

Chromium monograph & interactions

PREWREK Pump Matrix

3155 mg per serving Form: Caffeine Anhydrous, CarnoSyn, L-Arginine Alpha Ketoglutarate 1:1, L-Arginine Hydrochloride, Raspberry Ketones, Sceletium tortuosum Extract, Theobromine

SWOLE Muscle Matrix

237 mg per serving Form: Creapure(R), Creatine Alpha Amino-Butyrate 2:1, L-Citrulline-DL-Malate 1:1, L-Histidine, L-Tyrosine

Other (inactive) ingredients: Citric Acid, Natural & Artificial flavors, Sucralose, Acesulfame Potassium, FD&C Red #40. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pre Wrek Fruit Punch by Swole Drug Interactions

Want to check YOUR meds against Pre Wrek Fruit Punch?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
2,059Drugs
92 Moderate 1,967 Minor

Ingredients driving the most interactions

Dietary Fiber 2,025
Chromium 178

Individual Drug Interactions

The ingredients in Pre Wrek Fruit Punch interact with 2,059 drugs. Click any drug to see the details.

2 of the 5 ingredients in Pre Wrek Fruit Punch interact with drugs. Each result below shows which ingredient is responsible. Dietary Fiber Chromium

Each ingredient & the kinds of drugs it affects

For each ingredient in Pre Wrek Fruit Punch with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Dietary Fiber7 drug types · 2,025 drugs

Carbamazepine (Tegretol)

Theoretically, black psyllium might reduce the effects of carbamazepine and increase the risk for convulsions.
Theoretically, black psyllium might reduce carbamazepine absorption. A preliminary study using blond psyllium reported decreased carbamazepine bioavailability due to binding of the drug to psyllium, as well as reduction of available fluid in the gut for dissolution of the drug. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Lithium

Theoretically, taking black psyllium at the same time as lithium might reduce lithium absorption.
The fiber in black psyllium might reduce lithium absorption and plasma levels. Some case reports describe a reduction in plasma lithium levels with concomitant administration of blond psyllium. This was reversed when psyllium was stopped. This interaction may also occur with black psyllium.

Likelihood Probable Evidence D
Metformin (Glucophage)

Theoretically, black psyllium might increase the therapeutic and adverse effects of metformin.
Animal research shows that concurrent consumption of blond psyllium with metformin slows and increases the absorption of metformin. This interaction may also occur with black psyllium. To avoid changes in absorption, take psyllium 30-60 minutes after metformin.

Likelihood Possible Evidence D
Olanzapine (Zyprexa)

Theoretically, taking black psyllium at the same time as olanzapine might reduce olanzapine absorption.
The fiber in black psyllium might decrease the absorption of olanzapine. A single case report describes a reduction in the effectiveness of olanzapine when it was concomitantly administered with an unspecified type of psyllium 3 grams orally twice daily. This effect was reversed when psyllium was stopped.

Likelihood Possible Evidence D
Digoxin (Lanoxin)

Theoretically, taking black psyllium at the same time as digoxin might reduce digoxin absorption and decrease digoxin levels.
Psyllium might bind digoxin in the gut. However, some clinical evidence suggests that psyllium does not impact digoxin absorption.

Likelihood Unlikely Evidence B
Ethinyl Estradiol

Theoretically, taking black psyllium at the same time as ethinyl estradiol might alter levels of estradiol.
Concurrent use of blond psyllium with ethinyl estradiol results in a slight increase in the extent of ethinyl estradiol absorption and a slower rate of absorption. This is unlikely to be clinically significant.

Likelihood Unlikely Evidence D
Oral Drugs

Theoretically, psyllium might increase, decrease, or have no effect on the absorption of oral drugs.
Psyllium seems to have variable effects on drug absorption. To avoid changes in absorption, take psyllium 30-60 minutes after oral medications. Animal research shows that blond psyllium delays and increases the absorption of metformin and ethinyl estradiol. Case reports and animal research suggest that blond psyllium might reduce absorption of lithium, digoxin, olanzapine, and carbamazepine. Finally, some pharmacokinetic studies show that psyllium does not affect the absorption of levothyroxine or warfarin. Although many of these studies evaluated blond psyllium, the fiber content in black psyllium may have similar effects.

Likelihood Possible Evidence B
Dietary Fiber full monograph & interactions

Chromium5 drug types · 178 drugs

Antidiabetes Drugs

Theoretically, chromium may have additive effects with antidiabetic agents and increase the risk of hypoglycemia.
Some research shows that taking chromium might lower blood glucose levels, especially in patients with poorly controlled type 2 diabetes.

Likelihood Possible Evidence A
Insulin

Theoretically, concomitant use of chromium and insulin might increase the risk of hypoglycemia.
In clinical research, chromium has been shown to increase insulin sensitivity,

Likelihood Possible Evidence B
Levothyroxine (Synthroid, Others)

Chromium might bind levothyroxine in the intestinal tract and decrease levothyroxine absorption.
Clinical research in healthy volunteers shows that taking chromium picolinate 1000 mcg with levothyroxine 1 mg decreases serum levels of levothyroxine by 17% when compared to taking levothyroxine alone. Advise patients to take levothyroxine at least 30 minutes before or 3-4 hours after taking chromium.

Likelihood Probable Evidence B
Aspirin

Theoretically, aspirin might increase chromium absorption.
Animal research suggests that aspirin may increase chromium absorption and chromium levels in the blood.

Likelihood Possible Evidence D
Nonsteroidal Anti-Inflammatory Drugs (Nsaids)

NSAIDs might increase chromium levels in the body.
Drugs that are prostaglandin inhibitors, such as NSAIDs, seem to increase chromium absorption and retention.

Likelihood Possible Evidence D
Chromium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pre Wrek Fruit Punch, from the product label.

Swole

See all Swole products
Name
Swole Sports Nutrition(TM)
Phone Number
1.888.796.5376
Web Address
www.swolesports.com
Pharmacist Counseling Corner

Pre Wrek Fruit Punch by Swole: Common Questions

Does Pre Wrek Fruit Punch by Swole interact with any medications?
Yes. Based on its ingredients, Pre Wrek Fruit Punch has a known interaction with 2,059 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pre Wrek Fruit Punch contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Does chromium actually lower blood sugar?
Research suggests chromium is possibly effective for diabetes, especially in people whose type 2 diabetes isn't well controlled. Some studies show it may lower blood glucose levels. That said, the evidence isn't conclusive, and it's not a replacement for your diabetes medication — it's a supplement to potentially add to your regimen, with your doctor's approval.
Can I take this with my levothyroxine (thyroid pill)?
Not at the same time. Chromium can bind to levothyroxine in your gut and reduce how much your body absorbs — one study showed a 17% drop in levothyroxine levels. If you take thyroid medication, talk with your pharmacist about timing them several hours apart, or ask whether this product is right for you.
What side effects might I get from chromium?
Most commonly, gastrointestinal upset, headaches, insomnia, irritability, and mood changes. Serious side effects are rare but can include kidney or liver damage and low blood platelet counts. If you notice unusual bruising, bleeding, or swelling, or if your mood or sleep changes significantly, stop and contact your doctor.
Is it safe to take while pregnant?
Small amounts of chromium from food or a prenatal vitamin are considered likely safe. But extra supplement doses beyond that haven't been well studied in pregnancy, so it's best to avoid this product unless your doctor specifically recommends it. Talk with your doctor before starting.
What are PREWREK Pump Matrix and SWOLE Muscle Matrix?
Those are proprietary blends — formulas the manufacturer doesn't fully disclose on the label. We don't have interaction or effectiveness data for them, so we can't tell you exactly what they do or what they contain. The ingredient list would be on the product packaging.
Will this interact with ibuprofen or aspirin?
Chromium may increase how much you absorb from these pain relievers, but that's a minor interaction. Still, if you use NSAIDs or aspirin regularly, mention this product to your pharmacist so they can keep an eye on how it all works together.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pre Wrek Fruit Punch is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pre Wrek Fruit Punch label
Go deeper

The Full Monographs Behind Pre Wrek Fruit Punch’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Black Psyllium

Interacts with 2,025 drugs

Black psyllium is a soluble-fiber supplement made from the seeds of a Plantago plant, used mostly to ease constipation and support digestive health. It is best known and most studied for rel...

Read the full Black Psyllium monograph → Herb & supplement monograph

Chromium

Interacts with 178 drugs

Chromium is an essential trace mineral involved in how the body handles sugar and fat. Some studies suggest it may modestly help blood sugar control in certain people with type 2 diabetes, b...

Read the full Chromium monograph →
Sources

Sources & How We Checked

Pre Wrek Fruit Punch's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 71 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Black Psyllium 18 references
  1. McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
  2. Gruenwald J, Brendler T, Jaenicke C. PDR for Herbal Medicines. 1st ed. Montvale, NJ: Medical Economics Company, Inc., 1998.
  3. Covington TR, et al. Handbook of Nonprescription Drugs. 11th ed. Washington, DC: American Pharmaceutical Association, 1996.
  4. Etman M. Effect of a bulk forming laxative on the bioavailablility of carbamazepine in man. Drug Dev Ind Pharm 1995;21:1901-6.
  5. Perlman BB. Interaction between lithium salts and ispaghula husk. Lancet 1990;335:416.
  6. Vaswani SK, Hamilton RG, Valentine MD, Adkinson NF. Psyllium laxative-induced anaphylaxis, asthma, and rhinitis. Allergy 1996;51:266-8. PubMed
  7. Lantner RR, Espiritu BR, Zumerchik P, Tobin MC. Anaphylaxis following ingestion of a psyllium-containing cereal. JAMA 1990;264:2534-6. DOI
  8. Kaplan MJ. Anaphylactic reaction to "Heartwise." N Engl J Med 1990;323:1072-3. DOI
  9. Nordstrom M, Melander A, Robertsson E, Steen B. Influence of wheat bran and of a bulk-forming ispaghula cathartic on the bioavailability of digoxin in geriatric in-patients. Drug Nutr Interact 1987;5:67-9..
  10. Robinson DS, Benjamin DM, McCormack JJ. Interaction of warfarin and nonsystemic gastrointestinal drugs. Clin Pharmacol Ther 1971;12:491-5. PubMed
  11. Garcia JJ, Fernandez N, Diez MJ, et al. Influence of two dietary fibers in the oral bioavailability and other pharmacokinetic parameters of ethinyloestradiol. Contraception 2000;62:253-7. PubMed
  12. Fernandez N, Lopez C, Díez R, et al. Drug interactions with the dietary fiber Plantago ovata husk. Expert Opin Drug Metab Toxicol 2012;8(11):1377-86.
  13. Semen plantaginis in: WHO Monographs on Selected Medicinal Plants, volume 1. World Health Organization, Geneva, 1999. Available at http://apps.who.int/medicinedocs/en/d/Js2200e/. Accessed November 26, 1026.
  14. Code of Federal Regulations, Title 21 (21CFR 101.17). Food labeling warning, notice, and safe handling statements. Available at www.ecfr.gov/cgi-bin/text-idx?SID=20f647d3b74161501f46564b915b4048&mc=true&node=se21.2.101_117&rgn=div8. Accessed December 3, 2
  15. Code of Federal Regulations, Title 21 (21CFR 201.319). Specific labeling requirements - water-soluble gums, hydrophilic gums, and hydrophilic mucilloids. Available at www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?fr=201.319. Accessed Dece
  16. Diez R, Garcia JJ, Diez MJ, Sierra M, Sahagun AM, Fernandez N. Influence of Plantago ovata husk (dietary fiber) on the bioavailability and other pharmacokinetic parameters of metformin in diabetic rabbits. BMC Complement Altern Med. 2017 Jun 7;17(1):298. PubMed
  17. Chiu AC, Sherman SI. Effects of pharmacological fiber supplements on levothyroxine absorption. Thyroid. 1998;8(8):667-71. PubMed
  18. Merrick C, Madden CA, Capurso NA. A Case of Blunted Orally Disintegrating Olanzapine Effect Due to Coadministered Psyllium. J Clin Psychiatry 2021;82(2):20cr13633. PubMed

See these in context on the Black Psyllium monograph →

Chromium 53 references
  1. Cerulli J, Grabe DW, Gauthier I, et al. Chromium picolinate toxicity. Ann Pharmacother 1998;32:428-31. PubMed
  2. Urberg M, Zemel MB. Evidence for synergism between chromium and nicotinic acid in the control of glucose tolerance in elderly humans. Metabolism 1987;36:896-9. PubMed
  3. Mohamedshah FY, Moser-Veillon PB, Yamini S, et al. Distribution of a stable isotope of chromium (53Cr) in serum, urine, and breast milk in lactating women. Am J Clin Nutr 1998;67:1250-5. PubMed
  4. Wasser WG, Feldman NS, D'Agati VD. Chronic renal failure after ingestion of over-the-counter chromium picolinate. [letter]. Ann Intern Med 1997;126:410. PubMed
  5. Mertz W. Interaction of chromium with insulin: a progress report. Nutr Rev 1998;56:174-7. PubMed
  6. Anderson RA. Chromium, glucose intolerance and diabetes. J Am Coll Nutr 1998;17:548-55. PubMed
  7. McLeod MN, Gaynes BN, Golden RN. Chromium potentiation of antidepressant pharmacotherapy for dysthymic disorder in 5 patients. J Clin Psych 1999;60:237-40. PubMed
  8. Fowler JF Jr. Systemic contact dermatitis caused by oral chromium picolinate. Cutis 2000;65:116. DOI
  9. Trent LK, Thieding-Cancel D. Effects of chromium picolinate on body composition. J Sports Med Phys Fitness 1995;35:273-80.
  10. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press, 2002.
  11. Rabinovitz H, Friedensohn A, Leibovitz A, et al. Effect of chromium supplementation on blood glucose and lipid levels in type 2 diabetes mellitus elderly patients. Int J Vitam Nutr Res 2004;74:178-82. PubMed
  12. Lanca S, Alves A, Vieira AI, et al. Chromium-induced toxic hepatitis. Eur J Intern Med 2002;13:518-20. PubMed
  13. Kockler DR, McCarthy MW, Lawson CL. Seizure activity and unresponsiveness after hydroxycut ingestion. Pharmacotherapy 2001;21:647-51.. PubMed
  14. Davidson JR, Abraham K, Connor KM, McLeod MN. Effectiveness of chromium in atypical depression: a placebo-controlled trial. Biol Psychiatry 2003;53:261-4.. PubMed
  15. Food Standards Agency. Medicines and Healthcare products Regulatory Agency (MHRA). Expert Group on Vitamins and Minerals. Available at: http://cot.food.gov.uk/sites/default/files/vitmin2003.pdf.
  16. Mouser JF, Hak EB, Helms RA, et al. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm 1999;56:1950-6. PubMed
  17. Stevens T, Qadri A, Zein NN. Two patients with acute liver injury associated with use of the herbal weight-loss supplement hydroxycut. Ann Intern Med 2005;142:477-8. PubMed
  18. Wani S, Weskamp C, Marple J, Spry L. Acute tubular necrosis associated with chromium picolinate-containing dietary supplement. Ann Pharmacother 2006;40:563-6. PubMed
  19. Kleefstra N, Houweling ST, Jansman FG, et al. Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial. Diabetes Care 2006;29: PubMed
  20. Martin J, Wang ZQ, Zhang XH, et al. Chromium picolinate supplementation attenuates body weight gain and increases insulin sensitivity in subjects with type 2 diabetes. Diabetes Care 2006;29:1826-32. PubMed
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