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Dietary supplement

Preggie Naturals Chews Ingredients & Drug Interactions

by Three Lollies

Preggie Naturals Chews label
See full label image
Other (e.g. Tea Bag) Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Preggie Naturals Chews against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Preggie Naturals Chews is a dietary supplement by Three Lollies with 3 active ingredients. Its ingredients are commonly taken for morning sickness in pregnancy, premenstrual syndrome (pms), preventing or treating b6 deficiency.Based on those ingredients, 210 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Vitamin B6. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Preggie Naturals Chews by Three Lollies

Ask about any prescription or over-the-counter medication and we check it for interactions with Preggie Naturals Chews by Three Lollies — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Preggie Naturals Chews by Three Lollies

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Preggie Naturals Chews contains 2 active ingredients. Vitamin B6 (pyridoxine) is the main one—it's a B vitamin that plays a role in nerve function and metabolism.

The other ingredient is a proprietary blend, whose contents and amounts we don't have on file. The product also contains several inactive ingredients (fillers and binders): brown rice syrup, dried cane syrup, palm oil, corn starch, sunflower lecithin, natural flavors, beetroot, natural caramel, and cayenne pepper.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Ease morning sickness in pregnancy.
  • We looked for evidence on: Pregnancy-induced nausea and vomiting, Gastroenteritis-associated nausea and vomiting.
  • The strongest evidence on file: Vitamin B6 is rated "Possibly Effective" for Pregnancy-induced nausea and vomiting (Natural Medicines).
  • Also on file: Vitamin B6 is rated "Insufficient Reliable Evidence To Rate" for Gastroenteritis-associated nausea and vomiting.

Vitamin B6 is effective for treating sideroblastic anemia (a blood disorder affecting red blood cells) and for correcting vitamin B6 deficiency itself. It's also effective for pyridoxine-dependent epilepsy, a rare seizure condition.

For other uses, the evidence is weaker: it's likely effective for lowering high homocysteine (a blood marker), and possibly effective for pregnancy-related nausea and vomiting. We have no effectiveness data on file for the proprietary blend.

The evidence, ingredient by ingredient Vitamin B6

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Vitamin B6 is generally well tolerated in doses under 100 mg daily. Common side effects at higher doses include abdominal pain, headache, heartburn, nausea, vomiting, and sleepiness.

At very high doses or with long-term use, it can damage nerves (sensory neuropathy)—this risk increases with doses over 1,000 mg daily or cumulative doses of 1,000 grams or more, though nerve damage can occur at lower doses too. These chews are often used at recommended levels for morning sickness, but only under a doctor's guidance.

We have no pregnancy or breastfeeding safety data on file for the proprietary blend ingredient. Talk with your doctor or pharmacist about whether this product is right for you during pregnancy.

Side effects, ingredient by ingredient Vitamin B6

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Vitamin B6.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: Parkinson's medications.
  • For scale: 210 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take seizure medications (phenytoin or phenobarbital), blood pressure medications, amiodarone (a heart rhythm drug), or levodopa for Parkinson's—especially if you're not also taking carbidopa. These are the main medication types where vitamin B6 could cause problems.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Preggie Naturals Chews may help with pregnancy-related nausea, and vitamin B6 at standard doses is generally well tolerated. If you take seizure medications, blood pressure drugs, amiodarone, or levodopa (without carbidopa), you'll need to check with your pharmacist first—this product could interfere with how they work.

Your pharmacist can tell you whether it's safe for your specific situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 25, 2018.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Preggie Naturals Chews, straight from the product label.

Brand Three Lollies
Barcode (UPC) 695342999053
Net contents 15 All Natural Chew(s)
Market status On market
Date entered into DSLD Apr 25, 2018
DSLD ID 175233
Product type Other Combinations
Supplement form Other (e.g. Tea Bag)
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Kosher, Pregnant Women
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Preggie Naturals Chews by Three Lollies, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Pregnant and Lactating
Minimum serving Sizes:
1 Chew(s)
Maximum serving Sizes:
1 Chew(s)
Servings per container
15
UPC/BARCODE
695342999053
IngredientAmount% DV
Calories25 Calorie(s)--
Total Carbohydrates5 Gram(s)2%
Sugar3 Gram(s)--
Calories from Fat5 Calorie(s)--
Vitamin B610 mg500%
Proprietary Blend6 mg--

Other ingredients: Brown Rice syrup, dried Cane syrup, Palm Oil, Corn Starch, Sunflower Lecithin, Natural flavors, Vitamin B6, Beetroot, natural Caramel, Cayenne Pepper

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Directions For Use: For oral consumption only.

Manufactured on equipment used to process dairy, peanut, almond, walnut, pecan, nutmeg and soy protein.

Suggested/Recommended/Usage/Directions

Directions For Use: For oral consumption only. Let dissolve in mouth, chew slowly.

FDA Disclaimer Statement

The statements contained herein have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Formula

K

Contains 10mg of B6

Try Preggie Naturals, the original morning sickness chew made especially for pregnant women.

Seals/Symbols

K

Made in America

General Statements

The natural way to ease morning sickness!

All natural

Doctor recommended Raspberry Ginger Greenapple

Developed by healthcare professionals to provide relief from morning sickness. Preggie Naturals are effective due to our special formulation of essential oils, vitamins and unique delivery method.

Preggie Naturals are also helpful for dry mouth and provide a nice energy boost.

3 delicious all natural flavors

Formulation

Drug-free

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Preggie Naturals Chews by Three Lollies label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Preggie Naturals Chews label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Preggie Naturals Chews by Three Lollies

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Chew(s) Dosage formOther (e.g. Tea Bag) Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Sugar

3 Gram(s) per serving

Vitamin B6

Interacts with
210 drugs
10 mg per serving Form: Pyridoxine Hydrochloride

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is b...

Vitamin B6 monograph & interactions

Proprietary Blend

6 mg per serving Form: Essential Oils

Other (inactive) ingredients: Brown Rice syrup, Dried Cane syrup, Palm Oil, Corn Starch, Sunflower Lecithin, Natural flavors, Vitamin B6, Beetroot, Natural Caramel, Cayenne Pepper. These complete the product’s ingredient list but are not active constituents.

Interaction report

Preggie Naturals Chews by Three Lollies Drug Interactions

Want to check YOUR meds against Preggie Naturals Chews?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
210Drugs
205 Moderate 5 Minor

Ingredients driving the most interactions

Vitamin B6 210

Individual Drug Interactions

The ingredients in Preggie Naturals Chews interact with 210 drugs. Click any drug to see the details.

1 of the 3 ingredients in Preggie Naturals Chews interact with drugs. Each result below shows which ingredient is responsible. Vitamin B6

Each ingredient & the kinds of drugs it affects

For each ingredient in Preggie Naturals Chews with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Vitamin B65 drug types · 210 drugs

Amiodarone (Cordarone)

Theoretically, vitamin B6 might increase the photosensitivity caused by amiodarone.
Despite initial case reports suggesting that pyridoxine may have a protective effect against amiodarone-induced photosensitivity, preliminary clinical research suggests that pyridoxine may actually exacerbate this adverse effect.

Likelihood Possible Evidence B
Antihypertensive Drugs

Theoretically, vitamin B6 may have additive effects when used with antihypertensive drugs.
Research in hypertensive rats shows that vitamin B6 can decrease systolic blood pressure. Similarly, clinical research in patients with hypertension shows that taking high doses of vitamin B6 may reduce systolic and diastolic blood pressure, possibly by reducing plasma levels of epinephrine and norepinephrine.

Likelihood Possible Evidence B
Phenobarbital (Luminal)

High doses of vitamin B6 may reduce the levels and clinical effects of phenobarbital.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenobarbital, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenobarbital to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Phenytoin (Dilantin)

High doses of vitamin B6 may reduce the levels and clinical effects of phenytoin.
Preliminary clinical evidence suggests that vitamin B6 200 mg daily can reduce plasma levels of phenytoin, possibly by increasing metabolism. It is not known whether lower doses have any effect. Advise people taking phenytoin to avoid high doses of vitamin B6.

Likelihood Possible Evidence D
Levodopa

Vitamin B6 may increase the metabolism of levodopa when taken alone, but not when taken in conjunction with carbidopa.
Vitamin B6 (pyridoxine) enhances the metabolism of levodopa, reducing its clinical effects. However, this interaction does not occur when carbidopa is used concurrently with levodopa (Sinemet). Therefore, it is not likely to be a problem in most people.

Likelihood Unlikely Evidence D
Vitamin B6 full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Preggie Naturals Chews, from the product label.

Three Lollies

See all Three Lollies products
Name
Three Lollies, LLC
Street Address
6520 Platt, #573
City
West Hills
State
CA
ZipCode
91307
Phone Number
866-773-4443
Web Address
www.threelollies.com
Pharmacist Counseling Corner

Preggie Naturals Chews by Three Lollies: Common Questions

Does Preggie Naturals Chews by Three Lollies interact with any medications?
Yes. Based on its ingredients, Preggie Naturals Chews has a known interaction with 210 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Preggie Naturals Chews contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is it safe to take this during pregnancy?
Vitamin B6 is often used for morning sickness at standard doses, but only under a doctor's guidance. We don't have safety data on the proprietary blend. Talk with your doctor or pharmacist before starting—they can advise you based on your individual pregnancy and any medications you take.
What are the side effects?
At the doses in this product, side effects are usually minimal. At higher doses, people may notice abdominal pain, headache, heartburn, nausea, vomiting, or sleepiness. Very high doses or long-term use can cause nerve damage (tingling or numbness), though this is rare at lower amounts.
Does vitamin B6 actually help with morning sickness?
Vitamin B6 is possibly effective for pregnancy-related nausea and vomiting, meaning the evidence suggests it may help, but it's not as firmly proven as some other uses. Your doctor can tell you if it's worth trying for your situation.
Can I take this with my seizure medication?
Not without checking first. High doses of vitamin B6 can lower blood levels of seizure medications like phenytoin and phenobarbital, making them less effective. Talk to your pharmacist before starting this product.
What is the proprietary blend?
The label lists it as a blend, but the exact ingredients and amounts aren't disclosed to us. We can't check it for interactions or side effects. If you have specific health concerns, ask the manufacturer or your pharmacist what's in it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Preggie Naturals Chews label
Go deeper

The Full Monographs Behind Preggie Naturals Chews’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Vitamin B6

Interacts with 210 drugs

Vitamin B6 (pyridoxine) is an essential water-soluble vitamin that your body needs for metabolism, brain function, and making red blood cells. It is best known for helping with pregnancy-rel...

Read the full Vitamin B6 monograph →
Sources

Sources & How We Checked

Preggie Naturals Chews's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 32 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Vitamin B6 32 references
  1. Hansten PD, Horn JR. Drug Interactions Analysis and Management. Vancouver, WA: Applied Therapeutics Inc., 1997 and updates.
  2. Yates AA, Schlicker SA, Suitor CW. Dietary reference intakes: The new basis for recommendations for calcium and related nutrients, B vitamins, and choline. J Am Diet Assoc 1998;98:699-706. PubMed
  3. Geerling BJ, Dagnelie PC, Badart-Smook A, et al. Diet as a risk factor for the development of ulcerative colitis. Am J Gastroenterol 2000;95:1008-13. PubMed
  4. South M. Neonatal seizures after pyridoxine use -- reply. Lancet 1999;354:2083. PubMed
  5. Food and Nutrition Board, Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline (2000). Washington, DC: National Academy Press, 2000. Available at: http://b
  6. Baxter P, Aicardi J. Neonatal seizures after pyridoxine use. Lancet 1999;354:2082-3. PubMed
  7. Bendich A, Cohen M. Vitamin B6 safety issues. Ann N Y Acad Sci 1990;585:321-30.
  8. Schaumburg H, Kaplan J, Windebank A. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med 1983;309:445-8. PubMed
  9. Gordon N. Pyridoxine dependency: an update. Dev Med Child Neurol 1997;39:63-5. PubMed
  10. Lewis PJ. Pain in the hand and wrist. Pyridoxine supplements may help patients with carpal tunnel syndrome. BMJ 1995;310:1534. PubMed
  11. Kaufman G. Pyridoxine against amiodarone-induced photosensitivity (letter). Lancet 1984;1:51-2. PubMed
  12. Mulrow JP, Mulrow CD, McKenna WJ. Pyridoxine and amiodarone-induced photosensitivity. Ann Intern Med 1985;103:68-9. PubMed
  13. Kawada A, Kashima A, Shiraishi H, et al. Pyridoxine-induced photosensitivity and hypophosphatasia. Dermatology 2000;201:356-60.. PubMed
  14. Vasile A, Goldberg R, Kornberg B. Pyridoxine toxicity: report of a case. J Am Osteopath Assoc 1984;83:790-1. DOI
  15. Hansson O, Sillanpaa M. Pyridoxine and serum concentration of phenytoin and phenobarbitone. Lancet 1976;1:256. DOI
  16. Jansen T, Romiti R, Kreuter A, Altmeyer P. Rosacea fulminans triggered by high-dose vitamins B6 and B12. J Eur Acad Dermatol Venereol 2001;15:484-5..
  17. Chittumma P, Kaewkiattikun K, Wiriyasiriwach B. Comparison of the effectiveness of ginger and vitamin B6 for treatment of nausea and vomiting in early pregnancy: a randomized double-blind controlled trial. J Med Assoc Thai 2007;90:15-20.
  18. Hatzitolios, A., Iliadis, F., Katsiki, N., and Baltatzi, M. Is the anti-hypertensive effect of dietary supplements via aldehydes reduction evidence based? A systematic review. Clin Exp.Hypertens. 2008;30(7):628-639. PubMed
  19. Vasdev, S., Ford, C. A., Parai, S., Longerich, L., and Gadag, V. Dietary vitamin B6 supplementation attenuates hypertension in spontaneously hypertensive rats. Mol.Cell Biochem. 1999;200(1-2):155-162.
  20. de, Vogel S., Dindore, V., van, Engeland M., Goldbohm, R. A., van den Brandt, P. A., and Weijenberg, M. P. Dietary folate, methionine, riboflavin, and vitamin B-6 and risk of sporadic colorectal cancer. J Nutr 2008;138(12):2372-2378. PubMed
  21. Hagen, I., Nesheim, B. I., and Tuntland, T. No effect of vitamin B-6 against premenstrual tension. A controlled clinical study. Acta Obstet.Gynecol.Scand. 1985;64(8):667-670. PubMed
  22. Aybak, M., Sermet, A., Ayyildiz, M. O., and Karakilcik, A. Z. Effect of oral pyridoxine hydrochloride supplementation on arterial blood pressure in patients with essential hypertension. Arzneimittelforschung. 1995;45(12):1271-1273.
  23. Lal, K. J., Dakshinamurti, K., and Thliveris, J. The effect of vitamin B6 on the systolic blood pressure of rats in various animal models of hypertension. J Hypertens. 1996;14(3):355-363. PubMed
  24. Lauritzen CH, Reuter HD, Repges R, Bohnert K, and Schmidt U. Treatment of premenstrual tension syndrome with Vitex agnus castus. Controlled, double-blind study versus pyridoxine. Phytomed 1997;4(3):183-189. PubMed
  25. Fonseca VA, Lavery LA, Thethi TK, et al. Metanx in type 2 diabetes with peripheral neuropathy: A randomized trial. Am J Med 2013;126(2):141-9. PubMed
  26. Hankey GJ, Eikelboom JW, Yi Q, et al. Treatment with B vitamins and incidence of cancer in patients with previous stroke or transient ischemic attack: Results of a randomized placebo-controlled trial. Stroke 2012;43(6):1572-7. PubMed
  27. Hoyer-Kuhn H, Kohbrok S, Volland R, Franklin J, Hero B, Beck BB, Hoppe B. Vitamin B6 in primary hyperoxaluria I: first prospective trial after 40 years of practice. Clin J Am Soc Nephrol. 2014 Mar;9(3):468-77. PubMed
  28. Mahmoud A, Tabassum S, Al Enazi S, et al. Amelioration of levetiracetam-induced behavioral side effects by pyridoxine. A randomized double blind controlled study. Pediatr Neurol 2021;119:15-21. PubMed
  29. Gupta M, Gallante B, Bamberger JN, et al. Prospective randomized evaluation of idiopathic hyperoxaluria treatments. J Endourol 2021;35(12):1844-1851. PubMed
  30. Li H, Chen M, Liang S, et al. Excessive vitamin B6 during treatment is related to poor prognosis of patients with nasopharyngeal carcinoma: A U-shaped distribution suggests low dose supplement. Clin Nutr 2021;40(4):2293-2300. PubMed
  31. Tanigawa J, Nabatame S, Tominaga K, et al. High-dose pyridoxine treatment for inherited glycosylphosphatidylinositol deficiency. Brain Dev 2021;43(6):680-687. PubMed
  32. Committee on Practice Bulletins-Obstetrics. ACOG Practice Bulletin No. 189: Nausea And Vomiting Of Pregnancy. Obstet Gynecol. 2018;131(1):e15-e30. PubMed

See these in context on the Vitamin B6 monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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