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Dietary supplement

Pregnenolone 50 mg Ingredients & Drug Interactions

by Emerald Labs

Pregnenolone 50 mg label
See full label image
Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone 50 mg against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone 50 mg is a dietary supplement by Emerald Labs with 2 active ingredients. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 204 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Tocotriene Complex, Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone 50 mg by Emerald Labs

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone 50 mg by Emerald Labs — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone 50 mg by Emerald Labs

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This product contains 2 active ingredients. Pregnenolone is a hormone precursor your body naturally makes; it sits at the top of the steroid hormone pathway and can be converted into estrogens, progesterone, testosterone, and other hormones.

Tocotriene Complex is a form of vitamin E that acts as an antioxidant. The capsule itself is made from vegetable material.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: Memory, cognition, stress, and anti-aging support.
  • We looked for evidence on: Age-related cognitive decline, Memory, Aging, Stress, Fatigue, Menopausal symptoms — and 4 related terms.
  • The closest evidence on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Fatigue (Natural Medicines).
  • Also on file: Pregnenolone is rated "Insufficient Reliable Evidence To Rate" for Memory, Menopausal symptoms, Stress, Aging.
  • Also on file: Tocotrienols is rated "Insufficient Reliable Evidence To Rate" for Age-related cognitive decline, Postmenopausal conditions.

The evidence for pregnenolone is incomplete. Our data shows insufficient reliable evidence to rate it for alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, and bipolar disorder — meaning studies haven't established whether it works for these uses.

The Tocotriene Complex is possibly effective for diabetes, though possibly ineffective for high cholesterol.

The evidence, ingredient by ingredient Pregnenolone Tocotrienols

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it's a hormone with limited human safety data — you should use it only under guidance from a healthcare professional. The most common side effects reported include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

Less commonly, skin rashes (possibly light-sensitive), depressive mood, and appetite changes have been reported. The safety data advises against pregnenolone during pregnancy due to unknown risks, and there isn't enough information to recommend it while breastfeeding.

The Tocotriene Complex is generally well tolerated in studies with no adverse effects reported in oral trials; however, long-term safety at supplement doses is not well established. Pregnancy and breastfeeding safety data for tocotrienols is limited, so avoid supplemental doses unless your doctor advises otherwise.

Side effects, ingredient by ingredient Pregnenolone Tocotrienols

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Pregnenolone, Tocotrienols.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 204 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check if you use benzodiazepines (like diazepam) — pregnenolone may reduce how well they work. Also flag estrogens, progestins, progesterone, and testosterone medications, where pregnenolone might enhance effects.

If you take blood thinners or antiplatelet drugs, mention the Tocotriene Complex component, which carries a small bleeding risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone is a hormone supplement that should only be used under professional guidance because safety data is limited and it interacts with several medication classes. If you take benzodiazepines, hormone medications, or blood thinners, talk to your pharmacist before starting this product.

Anyone considering pregnenolone should have a conversation with their healthcare provider about whether it's right for them.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jun 20, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone 50 mg, straight from the product label.

Brand Emerald Labs
Barcode (UPC) 743650100224
Net contents 60 Vegetable Cap(s)
Market status On market
Date entered into DSLD Jun 20, 2024
DSLD ID 302731
Product type Other Combinations
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Women (not pregnant or lactating), Gluten Free, Dairy Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone 50 mg by Emerald Labs, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
60
UPC/BARCODE
743650100224
IngredientAmount% DV
Pregnenolone50 mg--
Tocotriene Complex225 mg--

Other ingredients: Vegetable Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Pregnenolone is naturally produced in the body by the adrenal glands. Pregnenolone is often called the "The Master Hormone" because it can be converted into many other steroidal hormones. Because production levels slow with age, supplementation may help to support more youthful Pregnenolone levels.

General Statements

Emerald Labs is family owned and operated since our beginnings in 1996.

Doctor-Formulated

Formulation

We are committed to providing your family with additive-free formulas and superior nutrient forms in therapeutic amounts.

Guaranteed Micronized

Clinical Potency

Made with Non-GMO Ingredients No Magnesium Stearate Gluten-Free

Vegan Formula

Easy-to-Swallow Capsule

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent disease.

Precautions

Allergy Information: product is manufactured in a facility that processes milk, egg, soy, tree nuts, fish and shellfish.

Consult a physician or licensed qualified health care professional before using this product if you have, or have a family history of, prostate cancer, prostate enlargement, heart disease, low "good" cholesterol (HDL), or if you are using any other dietary supplement, prescription drug, or over-the-counter drug. Do not use if pregnant or nursing.

Do not exceed recommended serving. Exceeding recommended serving may cause serious adverse health effects. Possible side effects include acne, hair loss, hair growth on the face (in women), aggressiveness, irritability, and increased levels of estrogen.

Warning: Not for use by individuals under the age of 18 years.

Discontinue use and call a physician or licensed qualified health care professional immediately if you experience rapid heartbeat, dizziness, blurred vision, or other similar symptoms.

Brand IP Statement(s)

Copyright 2021 Emerald Labs, Inc. Emerald Labs The Additive-Free Company

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: Adults, take one (1) to two (2) capsules daily with food or as directed by a health care practitioner.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone 50 mg by Emerald Labs label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone 50 mg label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone 50 mg by Emerald Labs

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container60 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Pregnenolone

Interacts with
82 drugs
50 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Tocotriene Complex

Interacts with
122 drugs
225 mg per serving

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early resea...

Tocotriene Complex monograph & interactions

Other (inactive) ingredients: Vegetable Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone 50 mg by Emerald Labs Drug Interactions

Want to check YOUR meds against Pregnenolone 50 mg?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
204Drugs
82 Moderate 122 Minor

Ingredients driving the most interactions

Tocotriene Complex 122
Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone 50 mg interact with 204 drugs. Click any drug to see the details.

2 of the 2 ingredients in Pregnenolone 50 mg interact with drugs. Each result below shows which ingredient is responsible. Tocotriene Complex Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone 50 mg with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Tocotriene Complex1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Concomitant use of tocotrienols with anticoagulant or antiplatelet agents might increase the risk of bleeding. However, this has not been reported in humans.
Taking tocotrienols orally inhibits experimentally-induced platelet aggregation in humans. Theoretically tocotrienols might increase the risk of bleeding if taken with antiplatelet or anticoagulant drugs. However, tocotrienols 400-800 mg daily have been used with aspirin and/or clopidogrel for 1 year with no clear cumulative antiplatelet effects and no reports of bleeding.

Likelihood Unlikely Evidence B
Tocotriene Complex full monograph & interactions

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone 50 mg, from the product label.

Emerald Labs

See all Emerald Labs products
Name
Emerald Labs
Street Address
20600 Belshaw Ave.
City
Carson
State
CA
ZipCode
90746
Phone Number
800-436-4366
Web Address
www.emeraldlabs.com
Pharmacist Counseling Corner

Pregnenolone 50 mg by Emerald Labs: Common Questions

Does Pregnenolone 50 mg by Emerald Labs interact with any medications?
Yes. Based on its ingredients, Pregnenolone 50 mg has a known interaction with 204 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone 50 mg contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pregnenolone if I'm pregnant or breastfeeding?
The safety data advises against pregnenolone during pregnancy due to unknown risks. For breastfeeding, there isn't enough information, so avoid it unless your doctor says otherwise. Talk with your healthcare provider before using this product if you're pregnant, planning pregnancy, or nursing.
What side effects should I watch for?
The most common ones reported are acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor. Less often, skin rashes, changes in mood, and appetite changes have occurred. If you notice any of these, let your pharmacist or doctor know.
What is pregnenolone used for?
Our data doesn't establish reliable evidence that pregnenolone works for the conditions listed — alcohol use disorder, Alzheimer's disease, autism, back pain, and bipolar disorder all lack sufficient research. Talk with your healthcare provider about whether this is the right choice for what you're dealing with.
What's the tocotrienol in this product for?
Tocotrienols are a form of vitamin E that act as antioxidants. Our data shows the Tocotriene Complex is possibly effective for diabetes, though possibly ineffective for high cholesterol. Long-term safety at supplement doses isn't well established yet.
Why do I need a healthcare professional to use this?
Pregnenolone is a hormone with limited human safety data, and it interacts with several important medication types — including sedatives and hormone medications. A healthcare professional can help you weigh the risks and benefits for your specific situation.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Pregnenolone 50 mg is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone 50 mg label
Go deeper

The Full Monographs Behind Pregnenolone 50 mg’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph → Herb & supplement monograph

Tocotrienols

Interacts with 122 drugs

Tocotrienols are a less common form of vitamin E with strong antioxidant activity studied mostly for cholesterol, liver, and heart health. Early research is interesting but far from conclusi...

Read the full Tocotrienols monograph →
Sources

Sources & How We Checked

Pregnenolone 50 mg's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 10 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Tocotrienols 4 references
  1. Mensink RP, van Houwelingen AC, Kromhout D, Hornstra G. A vitamin E concentrate rich in tocotrienols had no effect on serum lipids, lipoproteins, or platelet function in men with mildly elevated serum lipid concentrations. Am J Clin Nutr 1999;69:213-9. PubMed
  2. Baumann LS, Spencer JS. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg 1999;25:311-5. PubMed
  3. Khoo TL, Halim AS, Zakaria Z, Mat Saad AZ, Wu LY, Lau HY. A prospective, randomised, double-blinded trial to study the efficacy of topical tocotrienol in the prevention of hypertrophic scars. J Plast Reconstr Aesthet Surg. 2011 Jun;64(6):e137-45. Epub 201 PubMed
  4. Slivka A, Rink C, Paoletto D, Sen CK. Platelet function in stroke/transient ischemic attack patients treated with tocotrienol. FASEB J. 2020;34(9):11838-11843. PubMed

See these in context on the Tocotrienols monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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