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Dietary supplement

Pregnenolone Ingredients & Drug Interactions

by HoltraCeuticals

Pregnenolone label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Pregnenolone against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Pregnenolone is a dietary supplement by HoltraCeuticals with 1 active ingredient. Its ingredients are commonly taken for memory and cognitive support, anxiety and stress, anti-aging.Based on those ingredients, 82 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Pregnenolone. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Pregnenolone by HoltraCeuticals

Ask about any prescription or over-the-counter medication and we check it for interactions with Pregnenolone by HoltraCeuticals — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Pregnenolone by HoltraCeuticals

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement contains one active ingredient: pregnenolone, a naturally occurring hormone that your body makes and uses as a starting point to produce other steroid hormones like estrogen, progesterone, and testosterone. The capsule itself is made with gelatin, magnesium stearate, and rice flour as inactive ingredients.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Pregnenolone product and its label doesn't state a use — see Pregnenolone's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for pregnenolone isn't established in the data we hold. The facts list several conditions it's been studied for—including alcohol use disorder, Alzheimer's disease, autism spectrum disorder, back pain, and bipolar disorder—but all carry a rating of insufficient reliable evidence, meaning the research so far hasn't been strong enough to confirm whether it actually works for any of them.

The evidence, ingredient by ingredient Pregnenolone

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Pregnenolone is generally well tolerated when taken by mouth, but it is a hormone with limited human safety data, so use it only under guidance from a healthcare professional. The most common side effects reported in trials include acne, agitation, diarrhea, drowsiness, excitement, hair loss, sweating, and tremor.

Rarer reports include skin abscesses, rashes with burning sensations (possibly from sun sensitivity), changes in mood, and shifts in appetite. The safety data advises against pregnenolone during pregnancy due to unknown risks to the baby.

There isn't enough safety information to know whether it's safe while breastfeeding, so talk with your doctor or pharmacist for personalized advice.

Side effects, ingredient by ingredient Pregnenolone

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Pregnenolone.
  • The most serious interaction on file is rated Moderate.
  • For scale: 82 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking pregnenolone, check with your doctor or pharmacist if you use estrogens, progestins, progesterone, testosterone therapy, or benzodiazepines (anti-anxiety and sleep medications). All of these have documented Moderate-severity interactions: pregnenolone may strengthen the effects of hormones and may reduce the calming effects of benzodiazepines.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Pregnenolone may be worth discussing with your doctor if you're interested in exploring it for a specific condition, but the evidence for its effectiveness hasn't been established yet in our data. If you take any hormone therapy, anti-anxiety medication, or birth control, check with your doctor or pharmacist before starting—this supplement can interact with those drug types.

Because it's a hormone with limited safety research, it needs professional oversight.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Jul 21, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Pregnenolone, straight from the product label.

Brand HoltraCeuticals
Barcode (UPC) 837654693704
Net contents 90 Capsule(s)
Market status On market
Date entered into DSLD Jul 21, 2022
DSLD ID 270842
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years), Women (not pregnant or lactating)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Pregnenolone by HoltraCeuticals, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
Servings per container
90
UPC/BARCODE
837654693704
IngredientAmount% DV
Pregnenolone100 mg--

Other ingredients: Gelatin, Magnesium Stearate, Rice Flour

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Suggested use: As a dietary supplement, take 1 capsule per day, or as directed by your physician.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Precautions

Warning: Do not use if pregnant or nursing. If you are taking prescription medications, or have been diagnosed with an illness or disease, consult a physician before using this product.

Not intended for use in persons under 18 years of age. Keep out of reach of children.

Do not use if safety seal is damaged or missing.

Storage

Store in a cool, dry place.

Seals/Symbols

GMP Good Manufacturing Practice

Made in USA

Formulation

Adrenal and metabolic support

Brand IP Statement(s)

Holtorf Medical Group Center for hormone imbalance, hypothyroidism and fatigue

FDA Statement of Identity

Dietary Supplement

General Statements

To reorder visit: HoltraCeuticals.com

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Pregnenolone by HoltraCeuticals label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Pregnenolone label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Pregnenolone by HoltraCeuticals

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container90 Amounts shown are per serving.

Pregnenolone

Interacts with
82 drugs
100 mg per serving

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sol...

Pregnenolone monograph & interactions

Other (inactive) ingredients: Gelatin, Magnesium Stearate, Rice Flour. These complete the product’s ingredient list but are not active constituents.

Interaction report

Pregnenolone by HoltraCeuticals Drug Interactions

Want to check YOUR meds against Pregnenolone?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
82Drugs
82 Moderate

Ingredients driving the most interactions

Pregnenolone 82

Individual Drug Interactions

The ingredients in Pregnenolone interact with 82 drugs. Click any drug to see the details.

1 of the 1 ingredient in Pregnenolone interact with drugs. Each result below shows which ingredient is responsible. Pregnenolone

Each ingredient & the kinds of drugs it affects

For each ingredient in Pregnenolone with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Pregnenolone5 drug types · 82 drugs

Benzodiazepines

Concomitant use of pregnenolone may reduce the effects of benzodiazepines.
Very preliminary clinical research shows that chronic use of pregnenolone reduces sedative effects of diazepam when compared with chronic use of placebo. This effect may be related to the activity of pregnenolone at GABAA receptors.

Likelihood Probable Evidence B
Estrogens

Theoretically, taking pregnenolone might enhance the effects of estrogens.
Pregnenolone is a precursor for several steroid hormones, including estrogens.

Likelihood Possible Evidence D
Progesterone

Theoretically, taking pregnenolone might enhance the effects of progesterone.
In humans, some research shows that oral administration of pregnenolone can increase levels of progesterone. However, other research shows no effect on progesterone levels. It is possible the impact of pregnenolone on progesterone levels may be dose dependent.

Likelihood Possible Evidence D
Progestin

Theoretically, taking pregnenolone might enhance the effects of progestin.
Pregnenolone is a precursor for several steroid hormones, including progestin.

Likelihood Possible Evidence D
Testosterone

Theoretically, taking pregnenolone might enhance the effects of testosterone.
Pregnenolone is a precursor for several steroid hormones, including testosterone. However, preliminary clinical research shows that taking pregnenolone 30-500 mg orally daily for up to 8 weeks does not affect testosterone levels.

Likelihood Possible Evidence D
Pregnenolone full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Pregnenolone, from the product label.

HoltraCeuticals

See all HoltraCeuticals products
Name
Holtorf Medical Group
Street Address
2232 E. Maple Ave.
City
El Segundo
State
CA
ZipCode
90245
Phone Number
(310) 375-2705
Web Address
HoltraCeuticals.com
Pharmacist Counseling Corner

Pregnenolone by HoltraCeuticals: Common Questions

Does Pregnenolone by HoltraCeuticals interact with any medications?
Yes. Based on its ingredients, Pregnenolone has a known interaction with 82 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Pregnenolone contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take pregnenolone if I'm on birth control?
No—not without checking with your doctor first. Pregnenolone is a precursor to estrogens and progestins (both in birth control), and it may enhance their effects, which could change how your birth control works or increase side effects. Talk with your doctor or pharmacist before combining them.
What side effects should I watch for?
The most common ones are acne, agitation, diarrhea, drowsiness, tremor, and sweating. Less common reports include hair loss, skin abscesses, mood changes, and appetite shifts. If you notice a rash or burning sensation on your hands or back, especially after sun exposure, let your healthcare provider know.
Is pregnenolone safe during pregnancy?
No. The safety data advises against pregnenolone during pregnancy because the risks to the baby aren't known. If you're pregnant or planning to become pregnant, talk with your doctor or pharmacist before taking this product.
Will pregnenolone help my memory or Alzheimer's disease?
The evidence isn't established in our data. While pregnenolone has been studied for Alzheimer's disease, the research so far hasn't been strong enough to confirm whether it actually works. Talk with your doctor about whether it might be worth trying for your situation.
Can I take pregnenolone with my anxiety medication?
You'll need to check with your doctor first. Pregnenolone may reduce how well benzodiazepines (like diazepam) work, which could weaken the calming effect. Your doctor can tell you whether this product is right for you.
Is it safe to breastfeed while taking pregnenolone?
There isn't enough safety information to know either way. Talk with your doctor or pharmacist for personalized advice if you're breastfeeding or planning to breastfeed.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Pregnenolone label
Go deeper

The Full Monographs Behind Pregnenolone’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Pregnenolone

Interacts with 82 drugs

Pregnenolone is a hormone your body makes naturally and a building block for other hormones like cortisol, DHEA, estrogen, and testosterone. It is sold as a supplement for memory, mood, and...

Read the full Pregnenolone monograph →
Sources

Sources & How We Checked

Pregnenolone's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Pregnenolone 6 references
  1. Devlin TM, ed. Textbook of Biochemistry With Clinical Correlations. third ed. New York: Wiley-Liss Inc., 1992.
  2. Fung LK, Libove RA, Phillips J, Haddad F, Hardan AY.Brief report: an open-label study of the neurosteroid pregnenolone in adults with autism spectrum disorder. J Autism Dev Disord 2014;44(11):2971-7. PubMed
  3. Brown ES, Park J, Marx CE, et al. A randomized, double-blind, placebo-controlled trial of pregnenolone for bipolar depression. Neuropsychopharmacology 2014;39(12):2867-73. PubMed
  4. Ritsner MS, Gibel A, Shleifer T, et al. Pregnenolone and dehydroepiandrosterone as an adjunctive treatment in schizophrenia and schizoaffective disorder: an 8-week, double-blind, randomized, controlled, 2-center, parallel-group trial. J Clin Psychiatry 20 PubMed
  5. Meieran SE, Reus VI, Webster R, Shafton R, Wolkowitz OM. Chronic pregnenolone effects in normal humans: attenuation of benzodiazepine-induced sedation. Psychoneuroendocrinology 2004;29(4):486-500. PubMed
  6. Marx CE, Keefe RS, Buchanan RW, et al. Proof-of-concept trial with the neurosteroid pregnenolone targeting cognitive and negative symptoms in schizophrenia. Neuropsychopharmacology 2009;34(8):1885-903. PubMed

See these in context on the Pregnenolone monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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