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Dietary supplement

Probiotic Plus Prebiotic Natural Berry Flavor Ingredients & Drug Interactions

by Member's Mark

Powder Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
The interaction bottom line Most serious interaction: Moderate

Probiotic Plus Prebiotic Natural Berry Flavor is a dietary supplement by Member's Mark with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Probiotic Blend. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

HelloPharmacist Scorecard of Probiotic Plus Prebiotic Natural Berry Flavor by Member's Mark

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 2 active ingredients.
  • “Probiotic Blend” is a proprietary blend — the label gives one combined amount (1,000,000,000 Cell(s)) without saying how much of each component you get.

This powder contains 2 active probiotic ingredients: Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, plus a Probiotic Blend of additional species. These are live microorganisms intended to support gut health.

The inactive ingredients are natural flavors, citric acid, dextrose, sucrose, microcrystalline cellulose, maltodextrin, and water — standard excipients for taste and texture.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use — see Bifidobacterium Longum's own graded uses on its monograph.

Why this rating?
  • The label markets this product for: digestive health and immune function.
  • We looked for evidence on: Antibiotic-associated diarrhea, Constipation, Diarrhea, Inflammatory bowel disease (IBD), Irritable bowel syndrome (IBS), Lactose intolerance — and 4 related terms.
  • The closest evidence on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Bifidobacterium Longum is rated "Insufficient Reliable Evidence To Rate" for Common cold, Constipation, Diarrhea, Ulcerative colitis, and more.

The evidence for Bifidobacterium longum in this product is not yet established in our data. We hold insufficient reliable evidence to rate it for age-related cognitive decline, hay fever, antibiotic-associated diarrhea, generalized anxiety, asthma, or athletic performance.

We could not check the effectiveness data for Lactobacillus rhamnosus GG or the Probiotic Blend components.

The evidence, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Bifidobacterium longum is generally well tolerated in healthy people, but caution is needed if you're seriously ill or have a weakened immune system — those groups carry a small risk of rare infection (bacteremia) with the organism itself. Safety data are limited overall, so use it only with your doctor's guidance.

Rarely, people taking it have reported abdominal discomfort, bloating, flatulence, constipation, or a dry cough. Limited safety data exist for breastfeeding, so check with your doctor before using it while nursing.

Side effects, ingredient by ingredient Lactobacillus Acidophilus Bifidobacterium Longum

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Bifidobacterium Longum.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before you take this product, double-check your antibiotic drugs with your doctor or pharmacist — timing the doses separately from this supplement matters. We could not check one of the active ingredients (Lactobacillus rhamnosus GG) for interactions, so mention all your medications when you ask.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

This product may help support gut health, but evidence for specific benefits isn't yet established in our data. It's generally well tolerated in healthy people, but if you take antibiotics, you'll need to space them apart from this supplement — and definitely talk with your doctor or pharmacist first if you're immunocompromised or seriously ill.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jul 24, 2015.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotic Plus Prebiotic Natural Berry Flavor, straight from the product label.

Brand Member's Mark
Barcode (UPC) 078742094625
Net contents 60 Direct Dose Stick Packet(s)
Market status On market
Date entered into DSLD Jul 24, 2015
DSLD ID 47256
Product type Non-nutrient/non-botanical
Supplement form Powder
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years), Children more than 1 but less than 4
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotic Plus Prebiotic Natural Berry Flavor by Member's Mark, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Gram(s)
Maximum serving Sizes:
1 Gram(s)
UPC/BARCODE
078742094625
IngredientAmount% DV
Lactobacillus rhamnosus GG0 NP--
Probiotic Blend1000000000 Cell(s)--
Bifidobacterium longum BB5360 NP--

Other ingredients: Natural flavors, Citric Acid, Dextrose, Sucrose, Microcrystalline Cellulose, Maltodextrin, Water

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Probiotic + Prebiotic offers more complete support for digestive health and immune function.*

Prebiotic fiber - stimulates probiotic growth and maximizes colonization of beneficial flora.*

It's the easy, tasty and healthy way to support your digestive system.*

100% MONEY BACK GUARANTEE SUPERIOR QUALITY AND PERFORMANCE

We would like to hear from you with any comments or suggestions. In the continental U.S. or Canada, you can call us at 1-888-698-5034 from 8:30 a.m. to 5:30 p.m. EST Monday - Friday.

202871/SAM646498

Supports Digestive and Immune Health*

1 billion cells

- Dissolves directly in mouth - no water needed - Great tasting berry flavor

Health Benefits Digestive* Immunity* Wellness*

Product of Denmark.

Formula

Formulated with the two most scientifically-studied probiotic strains: - Lactobacillus rhamnosus GG - the most scientifically studied probiotic strain, helps replenish beneficial flora in the gut.* - Bifidobacterium lungum BB536 - focuses support in the lower intestinal tract to promote immune function.*

FDA Disclaimer Statement

**These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Seals/Symbols

M Member's Mark(R) QUALITY GUARANTEED

FDA Statement of Identity

dietary supplement

Suggested/Recommended/Usage/Directions

Suggested use: To support digestive and immune health for children 2 and up: Take one (1) stick packet daily. To support digestive and immune health and for occasional digestive distress for adults: Take one to two (1-2) stick packets daily. For ages 4 and up: Tear open perforation at top of stick packet. Empty contents directly onto tongue, let dissolve and swallow. Stick packet contents may also be stirred into cool beverage or sprinkled onto food. Children under the age of 4 should only dissolve into beverage or sprinkle on food, under adult supervision.

Precautions

Warning: Pregnant or nursing women, individuals taking any medication(s) or persons who have a health condition should consult their physician before using this product.

Keep out of the reach of children.

For your protection, do not use if stick packet is torn or open.

Storage

Store in a cool, dry place away from direct sunlight. Keep at room temperature or below.

See for yourself

Probiotic Plus Prebiotic Natural Berry Flavor by Member's Mark label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

What’s inside

The Ingredients in Probiotic Plus Prebiotic Natural Berry Flavor by Member's Mark

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Gram(s) Dosage formPowder Amounts shown are per serving.

Probiotic Blend

Interacts with
182 drugs
1000000000 Cell(s) per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Probiotic Blend monograph & interactions

Other (inactive) ingredients: Natural flavors, Citric Acid, Dextrose, Sucrose, Microcrystalline Cellulose, Maltodextrin, Water. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotic Plus Prebiotic Natural Berry Flavor by Member's Mark Drug Interactions

Want to check YOUR meds against Probiotic Plus Prebiotic Natural Berry Flavor?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotic Plus Prebiotic Natural Berry Flavor with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Probiotic Blend1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
The maker

Brand information

Manufacturer and brand details for Probiotic Plus Prebiotic Natural Berry Flavor, from the product label.

Member's Mark

Name
Sam's West, Inc.
City
Bentonville
State
AR
ZipCode
72716
Pharmacist Counseling Corner

Probiotic Plus Prebiotic Natural Berry Flavor by Member's Mark: Common Questions

Does Probiotic Plus Prebiotic Natural Berry Flavor by Member's Mark interact with any medications?
Yes. Based on its ingredients, Probiotic Plus Prebiotic Natural Berry Flavor has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotic Plus Prebiotic Natural Berry Flavor contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this at the same time as my antibiotic?
Not ideally. The antibiotic can kill the live probiotic organisms in this powder, which would reduce its effectiveness. Talk with your doctor or pharmacist about spacing the doses apart — they can tell you the right timing for your specific antibiotic.
What are these ingredients supposed to do?
The active ingredients are live probiotic bacteria (Lactobacillus rhamnosus GG and Bifidobacterium longum BB536, plus others in the blend) — these are microorganisms meant to support your gut health. The evidence for specific health benefits isn't established yet in our data.
Is it safe if I'm pregnant or breastfeeding?
Bifidobacterium longum is rated possibly safe in pregnancy and lactation, but limited safety data exist for breastfeeding specifically. Talk with your doctor before using this while nursing — they know your full health picture and can advise you.
Can I take this if I have a weakened immune system?
Caution is needed. Healthy people generally tolerate it well, but those with serious illness or immune problems carry a small risk of rare infection from the live organisms themselves. Check with your doctor before starting it.
What side effects are possible?
Most people have no problems, but rarely some have reported abdominal discomfort, bloating, flatulence, constipation, or a dry cough when taking Bifidobacterium longum. These are uncommon, but mention them to your doctor if they occur.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotic Plus Prebiotic Natural Berry Flavor is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotic Plus Prebiotic Natural Berry Flavor label
Sources

Sources & How We Checked

Probiotic Plus Prebiotic Natural Berry Flavor's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 36 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Bifidobacterium Longum 21 references
  1. Ha GY, Yang CH, Kim H, Chong Y. Case of sepsis caused by Bifidobacterium longum. J Clin Microbiol 1999;37:1227-8.
  2. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  3. Xiao JZ, Takahashi S, Odamaki T, et al. Antibiotic susceptibility of bifidobacterial strains distributed in the Japanese market. Biosci Biotechnol Biochem. 2010;74(2):336-42. PubMed
  4. Rautava S, Kainonen E, Salminen S, Isolauri E. Maternal probiotic supplementation during pregnancy and breast-feeding reduces the risk of eczema in the infant. J Allergy Clin Immunol. 2012;130(6):1355-60. PubMed
  5. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  6. Pellonperä O, Vahlberg T, Mokkala K, et al. Weight gain and body composition during pregnancy: a randomised pilot trial with probiotics and/or fish oil. Br J Nutr. 2020 Nov 4:1-11. PubMed
  7. Pellonperä O, Mokkala K, Houttu N, et al. Efficacy of fish oil and/or probiotic intervention on the incidence of gestational diabetes mellitus in an at-risk group of overweight and obese women: A randomized, placebo-controlled, double-blind clinical trial PubMed
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Esaiassen E, Hjerde E, Cavanagh JP, Simonsen GS, Klingenberg C; Norwegian Study Group on Invasive Bifidobacterial Infections. Bifidobacterium bacteremia: Clinical characteristics and a genomic approach to assess pathogenicity. J Clin Microbiol. 2017;55(7) PubMed
  10. Enomoto T, Sowa M, Nishimori K, et al. Effects of bifidobacterial supplementation to pregnant women and infants in the prevention of allergy development in infants and on fecal microbiota. Allergol Int 2014;63(4):575-85. PubMed
  11. US Food and Drug Administration (FDA). Dear Healthcare Provider Letter: Warning Regarding Use of Probiotics in Preterm Infants. September 2023. Available at: https://www.fda.gov/media/172606/download?attachment. Accessed November 1, 2023.
  12. Pillai A, Tan J, Paquette V, Panczuk J. Does probiotic bacteremia in premature infants impact clinically relevant outcomes? A case report and updated review of literature. Clin Nutr ESPEN. 2020;39:255-259. PubMed
  13. Sabaté JM, Iglicki F. Effect of Bifidobacterium longum 35624 on disease severity and quality of life in patients with irritable bowel syndrome. World J Gastroenterol 2022;28(7):732-744.
  14. Malaguarnera M, Greco F, Barone G, Gargante MP, Malaguarnera M, Toscano MA. Bifidobacterium longum with fructo-oligosaccharide (FOS) treatment in minimal hepatic encephalopathy: a randomized, double-blind, placebo-controlled study. Dig Dis Sci 2007;52(11) PubMed
  15. Zbinden A, Zbinden R, Berger C, Arlettaz R. Case series of Bifidobacterium longum bacteremia in three preterm infants on probiotic therapy. Neonatology 2015;107(1):56-9.
  16. Tamaki H, Nakase H, Inoue S, et al. Efficacy of probiotic treatment with Bifidobacterium longum 536 for induction of remission in active ulcerative colitis: A randomized, double-blinded, placebo-controlled multicenter trial. Dig Endosc 2016;28(1):67-74.
  17. Bertelli C, Pillonel T, Torregrossa A, et al. Bifidobacterium longum bacteremia in preterm infants receiving probiotics. Clin Infect Dis 2015;60(6):924-7. PubMed
  18. Esaiassen E, Cavanagh P, Hjerde E, Simonsen GS, Støen R, Klingenberg C. Bifidobacterium longum subspecies infantis bacteremia in 3 extremely preterm infants receiving probiotics. Emerg Infect Dis 2016;22(9):1664-6.
  19. Tena D, Losa C, Medina MJ, Sáez-Nieto JA. Peritonitis caused by Bifidobacterium longum: case report and literature review. Anaerobe 2014;27:27-30. PubMed
  20. Sangkanjanavanich S, Pradubpongsa P, Mitthamsiri W, Sangasapaviliya A, Boonpiyathad T. Bifidobacterium infantis 35624 efficacy in patients with uncontrolled asthma: A randomized placebo-controlled trial. Ann Allergy Asthma Immunol 2022;129(6):790-792. PubMed
  21. Wilson HL, Ong CW. Bifidobacterium longum vertebrodiscitis in a patient with cirrhosis and prostate cancer. Anaerobe 2017;47:47-50. PubMed

See these in context on the Bifidobacterium Longum monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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