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Dietary supplement

Probiotics + Prebiotics Ingredients & Drug Interactions

by Chemical Free Body

Probiotics + Prebiotics label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Probiotics + Prebiotics against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Probiotics + Prebiotics is a dietary supplement by Chemical Free Body with 5 active ingredients. Its ingredients are commonly taken for constipation, irritable bowel syndrome (ibs), diarrhea.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Bacillus coagulans, Bacillus subtilis. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Probiotics + Prebiotics by Chemical Free Body

Ask about any prescription or over-the-counter medication and we check it for interactions with Probiotics + Prebiotics by Chemical Free Body — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Probiotics + Prebiotics by Chemical Free Body

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 5 active ingredients.
  • “Proprietary Probiotic Blend” is a proprietary blend — the label gives one combined amount (1,000 mg) without saying how much of each component you get.

This product contains 5 active ingredients: four live Bacillus bacterial strains (Bacillus coagulans, Bacillus clausii, Bacillus subtilis, Bacillus licheniformis, and Bacillus indicus) plus a proprietary probiotic blend. These are probiotics—friendly bacteria meant to support your gut health.

The capsule itself is made from vegetable material.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: regulate bowel movements and boost immune system.
  • We looked for evidence on: Constipation, Diarrhea, Flatulence, Irritable bowel syndrome (IBS), Antibiotic-associated diarrhea, Travelers' diarrhea — and 4 related terms.
  • The strongest evidence on file: Bacillus Coagulans is rated "Possibly Effective" for Constipation (Natural Medicines).
  • Also on file: Bacillus Coagulans is rated "Possibly Effective" for Irritable bowel syndrome (IBS).
  • Also on file: Bacillus Subtilis is rated "Possibly Effective" for Antibiotic-associated diarrhea.

The evidence is mixed depending on which strain and which condition you're asking about. Bacillus coagulans is possibly effective for constipation and irritable bowel syndrome (IBS), but the evidence isn't strong enough to rate it for antibiotic-associated diarrhea, athletic performance, cancer, or fatty liver disease.

Bacillus subtilis is possibly effective for antibiotic-associated diarrhea but lacks reliable evidence for athletic performance, cirrhosis, constipation, eczema, and diabetes. For the other strains in the blend, we don't have effectiveness ratings on file.

The evidence, ingredient by ingredient Bacillus Coagulans Bacillus Subtilis

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

These probiotics are generally well tolerated in healthy adults, but the evidence and product quality vary, and there isn't enough safety data overall to say they're without risk. The main concern is that live microbial products have been linked to serious infections—bacteremia and sepsis—in people with weakened immune systems, central lines, severe illness, or premature infants.

In otherwise healthy people with intact immunity, that risk appears much lower, but it's not zero. One clinical trial reported a headache with Bacillus subtilis; diarrhea has been reported rarely.

There's not enough pregnancy and lactation data on file for these ingredients—talk to your doctor or pharmacist before using if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Bacillus Coagulans Bacillus Subtilis

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 2 of the 2 matched ingredients can interact with medications — Bacillus Coagulans, Bacillus Subtilis.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Antibiotics (Moderate severity) — they can kill the live bacteria in this product and reduce its effectiveness. Space your antibiotic dose several hours away from this supplement, and ask your pharmacist for the exact timing based on which antibiotic you're taking.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This supplement may help with constipation and IBS symptoms if you're generally healthy with a working immune system. If you're on antibiotics, don't take this at the same time—space them out by several hours.

If you're immunocompromised, severely ill, have a central line, or are pregnant or breastfeeding, check with your doctor first.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Aug 23, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Probiotics + Prebiotics, straight from the product label.

Brand Chemical Free Body
Barcode (UPC) 860004002833
Net contents 60 Capsule(s)
Market status On market
Date entered into DSLD Aug 23, 2022
DSLD ID 271792
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegan, Vegetarian, Adult (18 - 50 Years), Gluten Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Probiotics + Prebiotics by Chemical Free Body, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
30
UPC/BARCODE
860004002833
IngredientAmount% DV
Bacillus coagulans0 NP--
Proprietary Probiotic Blend1000 mg--
Bacillus clausii0 NP--
Bacillus subtilis0 NP--
Bacillus licheniformis0 NP--
Bacillus indicus0 NP--

Other ingredients: Vegetable Capsules

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

5 billion probiotic "spores" + prebiotic that survive stomach acid, unlike traditional probiotics. Our spore formula helps regulate BMs with no bloating or diarrhea promoting weight loss and boosting your immune system.

Vegan

Non-GMO Gluten-free

Gut relief & repair

No magnesium stearate, no silicon dioxide, no dicalcium phosphate

Seals/Symbols

NOSG Naturally Occurring Standards Group

Made in the USA

Suggested/Recommended/Usage/Directions

Suggested use: Adults take Week 1: 1 cap every other day Week 2: 1 cap daily - week 3+: 2 caps daily

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Please recycle

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Probiotics + Prebiotics by Chemical Free Body label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Probiotics + Prebiotics label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Probiotics + Prebiotics by Chemical Free Body

These are the 5 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Proprietary Probiotic Blend

1000 mg per serving

Other (inactive) ingredients: Vegetable Capsules. These complete the product’s ingredient list but are not active constituents.

Interaction report

Probiotics + Prebiotics by Chemical Free Body Drug Interactions

Want to check YOUR meds against Probiotics + Prebiotics?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Bacillus coagulans 182
Bacillus subtilis 182

Individual Drug Interactions

The ingredients in Probiotics + Prebiotics interact with 182 drugs. Click any drug to see the details.

2 of the 5 ingredients in Probiotics + Prebiotics interact with drugs. Each result below shows which ingredient is responsible. Bacillus coagulans Bacillus subtilis

Each ingredient & the kinds of drugs it affects

For each ingredient in Probiotics + Prebiotics with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Bacillus coagulans1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking antibiotics with Bacillus coagulans might decrease the effectiveness of B. coagulans.
B. coagulans preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. coagulans preparations by at least two hours.

Likelihood Probable Evidence D
Bacillus coagulans full monograph & interactions

Bacillus subtilis1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Bacillus subtilis with antibiotic drugs might decrease the effectiveness of B. subtilis.
Since B. subtilis preparations usually contain live and active organisms, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and B. subtilis preparations by at least 2 hours.

Likelihood Probable Evidence D
Bacillus subtilis full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Probiotics + Prebiotics, from the product label.

Chemical Free Body

See all Chemical Free Body products
Name
Chemical Free Body LLC.
Street Address
16869 SW 65th Ave. #158
City
Lake Oswego
State
OR
ZipCode
97035
Phone Number
1 888-368-9898
Web Address
www.chemicalfreebody.com
Pharmacist Counseling Corner

Probiotics + Prebiotics by Chemical Free Body: Common Questions

Does Probiotics + Prebiotics by Chemical Free Body interact with any medications?
Yes. Based on its ingredients, Probiotics + Prebiotics has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Probiotics + Prebiotics contains 5 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this with my antibiotic?
Not at the same time. Antibiotics will kill the live bacteria in this product and make it less effective. Take your antibiotic and this supplement several hours apart—ask your pharmacist for the right schedule based on your specific antibiotic.
Is this safe if I have a weakened immune system?
There have been rare cases of serious bacterial infections in people with weakened immunity who took similar live probiotic products. If your immune system is compromised, talk to your doctor before starting this.
What are these Bacillus strains for?
They're probiotics—live, friendly bacteria meant to support gut health. Bacillus coagulans and Bacillus subtilis have some evidence for constipation and certain types of diarrhea, but the evidence isn't strong across the board.
Are there any side effects?
In clinical trials, headache was reported with one strain, and diarrhea has been reported rarely. Most healthy adults tolerate these products well, though quality and safety can vary by brand and strain.
Can I take this while pregnant or breastfeeding?
We don't have enough safety data on these specific ingredients to say either way. Talk to your doctor or pharmacist before using if you're pregnant or breastfeeding.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Probiotics + Prebiotics is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Probiotics + Prebiotics label
Go deeper

The Full Monographs Behind Probiotics + Prebiotics’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Bacillus Coagulans

Interacts with 182 drugs

Bacillus coagulans is a spore-forming probiotic that survives stomach acid well and may help with some digestive problems such as IBS, constipation, and certain types of diarrhea. The eviden...

Read the full Bacillus Coagulans monograph → Herb & supplement monograph

Bacillus Subtilis

Interacts with 182 drugs

Bacillus subtilis is a spore-forming probiotic bacterium found in soil and some fermented foods, and it is used mainly to support gut health and digestion. Early research is promising for ce...

Read the full Bacillus Subtilis monograph →
Sources

Sources & How We Checked

Probiotics + Prebiotics's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 30 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Bacillus Coagulans 20 references
  1. Saxelin M, Chuang NH, Chassy B, et al. Lactobacilli and bacteremia in southern Finland 1989-1992. Clin Infect Dis 1996;22:564-6. PubMed
  2. Tynkkynen S, Singh KV, Varmanen P. Vancomycin resistance factor of Lactobacillus rhamnosus GG in relation to enterococcal vancomycin resistance (van) genes. Int J Food Microbiol 1998;41:195-204. PubMed
  3. Klein G, Zill E, Schindler R, et al. Peritonitis associated with vancomycin-resistant Lactobacillus rhamnosus in a continuous ambulatory peritoneal dialysis patient; organism identification, antibiotic therapy, and case report. J Clin Microbiol 1998;36:
  4. Kalima P, Masterton RG, Roddie PH, et al. Lactobacillus rhamnosus infection in a child following bone marrow transplant. J Infect 1996;32:165-7. PubMed
  5. Goldin BR. Health Benefits of probiotics. Br J Nutr 1998;80:S203-7. DOI
  6. Rautio M, Jousimies-Somer H, Kauma H, et al. Liver abscess due to Lactobacillus rhamnosus strain indistinguishable from L. rhamnosus strain GG. Clin Infect Dis 1999;28:1159-60.
  7. MacGregor G, Smith AJ, Thakker B, Kinsella J. Yoghurt biotherapy: contraindicated in immunosuppressed patients? Postgrad Med J 2002;78:366-7. PubMed
  8. Land MH, Rouster-Stevens K, Woods CR, et al. Lactobacillus sepsis associated with probiotic therapy. Pediatrics 2005;115:178-81.
  9. De Groote MA, Frank DN, Dowell E, et al. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J 2005;24:278-80. PubMed
  10. Vahabnezhad E, Mochon AB, Wozniak LJ, Ziring DA. Lactobacillus bacteremia associated with probiotic use in a pediatric patient with ulcerative colitis. J Clin Gastroenterol. 2013;47(5):437-9. PubMed
  11. Pruccoli G, Silvestro E, Pace Napoleone C, Aidala E, Garazzino S, Scolfaro C. Are probiotics safe? Bifidobacterium bacteremia in a child with severe heart failure. Infez Med. 2019;27(2):175-178.
  12. Sendil S, Shrimanker I, Mansoora Q, Goldman J, Nookala VK. Lactobacillus rhamnosus bacteremia in an immunocompromised renal transplant patient. Cureus. 2020;12(2):e6887. PubMed
  13. Albarillo FS, Shah U, Joyce C, Slade D. Lactobacillus rhamnosus Infection: A single-center 4-year descriptive analysis. J Glob Infect Dis. 2020;12(3):119-123. PubMed
  14. Pasala S, Singer L, Arshad T, Roach K. Lactobacillus endocarditis in a healthy patient with probiotic use. IDCases. 2020;22:e00915. PubMed
  15. Agrawal S, Tuchman ES, Bruce MJ, Theodorou ME. Fatal Lactobacillus endocarditis in a patient with transcatheter aortic valve replacement. BMJ Case Rep. 2020;13(11):e236835.
  16. Antoun M, Hattab Y, Akhrass FA, Hamilton LD. Uncommon pathogen, Lactobacillus, causing infective endocarditis: Case report and review. Case Rep Infect Dis. 2020;2020:8833948. PubMed
  17. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  18. Franko B, Vaillant M, Recule C, Vautrin E, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics. Med Mal Infect. 2013;43(4):171-3. PubMed
  19. Campbell RE, Miller A, Afroze A. Native valve endocarditis secondary to Lactobacillus paracasei bacteremia. Consultant. 2020;60(9):27-8. DOI
  20. Kato K, Funabashi N, Takaoka H, et al. Lactobacillus paracasei endocarditis in a consumer of probiotics with advanced and severe bicuspid aortic valve stenosis complicated with diffuse left ventricular mid-layer fibrosis. Int J Cardiol. 2016;224:157-161. PubMed

See these in context on the Bacillus Coagulans monograph →

Bacillus Subtilis 10 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Lampropoulos PK, Gkentzi D, Tzifas S, Dimitriou G. Neonatal sepsis due to Bacillus subtilis. Cureus 2021;13(9):e17692. PubMed
  3. La Jeon Y, Yang JJ, Kim MJ, et al. Combined Bacillus licheniformis and Bacillus subtilis infection in a patient with oesophageal perforation. J Med Microbiol 2012;61(Pt 12):1766-1769. PubMed
  4. Wallet F, Crunelle V, Roussel-Delvallez M, Fruchart A, Saunier P, Courcol RJ. Bacillus subtilis as a cause of cholangitis in polycystic kidney and liver disease. Am J Gastroenterol 1996;91(7):1477-8.
  5. Velasco E, Martins CA, Tabak D, Bouzas LF. "Bacillus subtilis" infection in a patient submitted to a bone marrow transplantation. Rev Paul Med 1992;110(3):116-7.
  6. Kato A, Yoshifuji A, Komori K, et al. A case of Bacillus subtilis var. natto bacteremia caused by ingestion of natto during COVID-19 treatment in a maintenance hemodialysis patient with multiple myeloma. J Infect Chemother 2022;28(8):1212-1215. PubMed
  7. Freedman KE, Hill JL, Wei Y, et al. Examining the gastrointestinal and immunomodulatory effects of the novel probiotic Bacillus subtilis DE111. Int J Mol Sci 2021;22(5):2453. PubMed
  8. Lefevre M, Racedo SM, Denayrolles M, et al. Safety assessment of Bacillus subtilis CU1 for use as a probiotic in humans. Regul Toxicol Pharmacol 2017;83:54-65. PubMed
  9. Hanifi A, Culpepper T, Mai V, et al. Evaluation of Bacillus subtilis R0179 on gastrointestinal viability and general wellness: a randomised, double-blind, placebo-controlled trial in healthy adults. Benef Microbes 2015;6(1):19-27. PubMed
  10. Tokano M, Tarumoto N, Imai K, et al. A case of bacterial meningitis caused by Bacillus subtilis var. natto. Intern Med. 2022. Epub ahead of print.

See these in context on the Bacillus Subtilis monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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