Interactions on record — worth a quick check against your medications. Check your meds →
Dietary supplement

Prostate Nutritional Support Ingredients & Drug Interactions

by NutriCology

Prostate Nutritional Support label
See full label image
Softgel Capsule Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Prostate Nutritional Support against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Prostate Nutritional Support is a dietary supplement by NutriCology with 7 active ingredients. Its ingredients are commonly taken for heart health, prostate health, antioxidant support.Based on those ingredients, 526 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are BioResponse DIM, Saw Palmetto extract, Stinging Nettle (root) extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Prostate Nutritional Support by NutriCology

Ask about any prescription or over-the-counter medication and we check it for interactions with Prostate Nutritional Support by NutriCology — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Prostate Nutritional Support by NutriCology

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This supplement has 7 active ingredients: lycopene, beta-sitosterol, zinc, stinging nettle root extract, pumpkin seed oil, saw palmetto extract, and BioResponse DIM (diindolylmethane). Lycopene and beta-sitosterol are compounds that may support prostate health; zinc is an essential mineral; stinging nettle and pumpkin seed oil are plant extracts traditionally used for urinary and prostate function; saw palmetto is a popular herbal ingredient for prostate symptoms; and DIM is a compound derived from cruciferous vegetables.

The softgels also contain inactive ingredients including gelatin, glycerin, beeswax, and carob extract.

Does it work?

Strong evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Strong

Clinical evidence supports at least one of this product's ingredients for its stated purpose.

Why this rating?
  • The label markets this product for: Prostate nutritional support.
  • We looked for evidence on: Benign prostatic hyperplasia (BPH), Chronic prostatitis and chronic pelvic pain syndrome (CP/CPPS), Erectile dysfunction (ED), Urinary symptoms, Prostate health, Lower urinary tract symptoms.
  • The strongest evidence on file: Beta-sitosterol is rated "Likely Effective" for Benign prostatic hyperplasia (BPH) (Natural Medicines).
  • Also on file: Pumpkin is rated "Possibly Effective" for Benign prostatic hyperplasia (BPH).
  • Also on file: Saw Palmetto is rated "Possibly Ineffective" for Benign prostatic hyperplasia (BPH).

The evidence for this product's ingredients is mixed. Beta-sitosterol is likely effective for benign prostatic hyperplasia (BPH) and possibly effective for heart health.

Lycopene is possibly effective for prostate cancer prevention but possibly ineffective for bladder cancer and diabetes. For BPH specifically—the main prostate condition—stinging nettle is rated possibly effective, pumpkin seed oil is possibly effective, and saw palmetto is rated possibly ineffective.

Zinc is effective for zinc deficiency itself but has insufficient evidence for most other uses. DIM and the other ingredients lack enough reliable evidence to rate their effectiveness.

None of the ingredients has been proven ineffective for general prostate health, but the body of evidence supporting most of them remains limited.

The evidence, ingredient by ingredient Lycopene Beta-sitosterol Zinc Stinging Nettle Pumpkin Saw Palmetto Diindolylmethane

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 7 of the 7 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 7 of 7.
  • General safety write-ups exist for 7 of 7.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Most of these ingredients are generally well tolerated at standard doses. Lycopene supplements may cause digestive upset (diarrhea, nausea, gas) and should be avoided in pregnancy and breastfeeding due to insufficient safety data.

Beta-sitosterol is generally well tolerated but may cause constipation, diarrhea, gas, or nausea, and should be avoided in pregnancy and breastfeeding. Zinc is safe below the tolerable upper limit of 40 mg daily; higher doses can cause nausea, metallic taste, diarrhea, and long-term use above recommended limits may deplete copper.

Stinging nettle is usually well tolerated but should be avoided in pregnancy and breastfeeding; rare cases of liver injury have been reported. Pumpkin seed oil is generally safe but should be avoided in pregnancy and breastfeeding due to lack of safety data.

Saw palmetto is well tolerated but must be avoided in pregnancy and is marked likely unsafe for breastfeeding. DIM is generally well tolerated short-term but should be avoided in pregnancy; a rare case of DRESS (a severe rash with systemic symptoms) has been reported, as has one stroke case in a patient with multiple risk factors.

Common side effects across ingredients include diarrhea, nausea, gas, and abdominal discomfort.

Side effects, ingredient by ingredient Lycopene Beta-sitosterol Zinc Stinging Nettle Pumpkin Saw Palmetto Diindolylmethane

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 7 matched ingredients can interact with medications — Lycopene, Stinging Nettle, Pumpkin, Saw Palmetto, Zinc, among others.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; diabetes medications; lithium.
  • For scale: 526 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, check with your pharmacist if you take any of the following: blood thinners or antiplatelet drugs like warfarin or aspirin (moderate risk with lycopene, saw palmetto, and stinging nettle); blood sugar medications (moderate risk with stinging nettle); diuretics or lithium (moderate risk with stinging nettle and pumpkin seed oil); antibiotics including quinolones, tetracyclines, cephalexin (moderate risk with zinc); penicillamine; HIV medications like ritonavir, integrase inhibitors, or bictegravir/emtricitabine/tenofovir alafenamide (moderate risk with zinc); estrogens or hormonal contraceptives (moderate risk with saw palmetto and DIM); cisplatin (moderate risk with zinc); or other medications metabolized by CYP1A2 enzymes (minor risk with DIM). Spacing doses several hours apart from antibiotics and zinc may reduce the risk.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with clinical evidence supporting its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product may appeal to men concerned about prostate health, particularly those with benign prostatic hyperplasia, since beta-sitosterol, pumpkin seed oil, and stinging nettle have some evidence behind them. If you take blood thinners, blood sugar medications, lithium, estrogen-based therapies, or certain antibiotics, you'll need to talk with your pharmacist or doctor first—several ingredients interact with these drugs.

Pregnant women and those breastfeeding should avoid this product. If you have a sensitive stomach, start slowly and watch for digestive side effects.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 22, 2022.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Prostate Nutritional Support, straight from the product label.

Brand NutriCology
Barcode (UPC) 713947541900
Net contents 60 Softgel(s)
Market status On market
Date entered into DSLD Jan 22, 2022
DSLD ID 258704
Product type Other Combinations
Supplement form Softgel Capsule
Dietary claims / uses Nutrient, All Other, Structure/Function
Intended target group(s) Women (not pregnant or lactating), Adult Male (18-50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Prostate Nutritional Support by NutriCology, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Softgel(s)
Maximum serving Sizes:
2 Softgel(s)
Servings per container
30
UPC/BARCODE
713947541900
IngredientAmount% DV
Calories10 Calorie(s)--
Calories from Fat10 Calorie(s)--
Lycopene15 mg--
Total Fat1 Gram(s)2%
Beta-Sitosterol120 mg--
Zinc10 mg91%
Stinging Nettle (root) extract300 mg--
Pumpkin seed Oil893 mg--
Saw Palmetto extract320 mg--
BioResponse DIM300 mg--

Other ingredients: Gelatin, Glycerin, Water, Purified, yellow Beeswax, Carob extract, Zinc Oxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Contains BioResponse DIM, a stable bioavailable form of diindolylmethane (DIM), combined with saw palmetto, stinging nettles, beta-sitasterol, lycopene, pumpkin see oil, and zinc.

Suggested/Recommended/Usage/Directions

Suggested Use As a dietary supplement, 2 softgels daily with food, or as directed by a healthcare practitioner.

Precautions

Do not use this product if you are pregnant, lactating, or using birth control pills. Persons taking prescription medications should consult a healthcare professional before use.

Keep out of reach of children.

Harmless changes in urine may occur.

Brand IP Statement(s)

BioResponse DIM is a proprietary, enhanced bioavailability complex containting diindolylmethane licensed from BioResponse, L.L.C., Boulder, Colorado.

NutriCology Innovative Nutrition

Storage

Keep in a cool, dry place, tightly capped.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

FDA Statement of Identity

Dietary Supplement

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Prostate Nutritional Support by NutriCology label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Prostate Nutritional Support label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Prostate Nutritional Support by NutriCology

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Softgel(s) Dosage formSoftgel Capsule Servings per container30 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Lycopene

Interacts with
122 drugs
15 mg per serving

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible hear...

Lycopene monograph & interactions

Beta-Sitosterol

No known
interactions
120 mg per serving

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Eviden...

Beta-Sitosterol monograph & interactions

Zinc

Interacts with
67 drugs
10 mg per serving Form: Zinc Citrate Dihydrate

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but suppleme...

Zinc monograph & interactions

Stinging Nettle (root) extract

Interacts with
164 drugs
300 mg per serving

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence...

Stinging Nettle (root) extract monograph & interactions

Pumpkin seed Oil

Interacts with
1 drug
893 mg per serving

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The...

Pumpkin seed Oil monograph & interactions

Saw Palmetto extract

Interacts with
174 drugs
320 mg per serving Form: Fatty Acids

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no bett...

Saw Palmetto extract monograph & interactions

BioResponse DIM

Interacts with
269 drugs
300 mg per serving Form: Diindolylmethane, Phosphatidylcholine, Silica, Vitamin E

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and...

BioResponse DIM monograph & interactions

Other (inactive) ingredients: Gelatin, Glycerin, Water, Purified, Yellow Beeswax, Carob extract, Zinc Oxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Prostate Nutritional Support by NutriCology Drug Interactions

Want to check YOUR meds against Prostate Nutritional Support?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
526Drugs
398 Moderate 128 Minor

Ingredients driving the most interactions

BioResponse DIM 269
Saw Palmetto extract 174
Stinging Nettle (root) extract 164
Lycopene 122
Zinc 67

Individual Drug Interactions

The ingredients in Prostate Nutritional Support interact with 526 drugs. Click any drug to see the details.

6 of the 7 ingredients in Prostate Nutritional Support interact with drugs. Each result below shows which ingredient is responsible. BioResponse DIM Saw Palmetto extract Stinging Nettle (root) extract Lycopene Zinc Pumpkin seed Oil

Each ingredient & the kinds of drugs it affects

For each ingredient in Prostate Nutritional Support with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

BioResponse DIM3 drug types · 269 drugs

Diuretic Drugs

Theoretically, diindolylmethane might increase the risk of hyponatremia if used with sodium-depleting diuretics.
Large doses of diindolylmethane (600 mg daily) have been associated with two cases of asymptomatic hyponatremia in clinical research.

Likelihood Possible Evidence B
Estrogens

Theoretically, diindolylmethane might increase or decrease the effects of estrogens.
Diindolylmethane might have mild estrogenic or antiestrogenic effects. Theoretically, large amounts of diindolylmethane might interfere with hormone replacement therapy.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Theoretically, diindolylmethane might lower serum levels of CYP1A2 substrates.
In vitro evidence suggests that diindolylmethane can induce CYP1A2. Theoretically, it might increase metabolism of CYP1A2 substrates and lower serum concentrations. This interaction has not been reported in humans.

Likelihood Unlikely Evidence D
BioResponse DIM full monograph & interactions

Saw Palmetto extract3 drug types · 174 drugs

Anticoagulant/Antiplatelet Drugs

Saw palmetto might increase the risk of bleeding with anticoagulant or antiplatelet drugs.
Saw palmetto is reported to prolong bleeding time. Theoretically, it might increase the risk of bleeding when used concomitantly with anticoagulant or antiplatelet drugs.

Likelihood Possible Evidence D
Contraceptive Drugs

Saw palmetto might reduce the effectiveness of contraceptive drugs.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with contraceptive drugs taken concomitantly.

Likelihood Possible Evidence B
Estrogens

Saw palmetto might reduce the effectiveness of estrogens.
Saw palmetto might have antiestrogenic effects. Theoretically, it might interfere with estrogens taken concomitantly.

Likelihood Possible Evidence B
Saw Palmetto extract full monograph & interactions

Stinging Nettle (root) extract4 drug types · 164 drugs

Antidiabetes Drugs

Theoretically, stinging nettle might have additive effects with antidiabetes drugs.
Clinical research shows that stinging nettle might decrease blood glucose levels in patients with diabetes.

Likelihood Possible Evidence B
Diuretic Drugs

Theoretically, combining stinging nettle with diuretic drugs may have additive effects.
Animal research suggests that the above ground parts and roots of stinging nettle may have a diuretic effect.

Likelihood Possible Evidence D
Lithium

Theoretically, stinging nettle might reduce excretion and increase levels of lithium.
Animal research suggests that stinging nettle has diuretic and natriuretic properties, which could alter the excretion of lithium. The dose of lithium might need to be decreased.

Likelihood Possible Evidence D
Warfarin (Coumadin)

There is some concern that stinging nettle might decrease the effects of anticoagulant drugs such as warfarin.
Stinging nettle contains a significant amount of vitamin K. When taken in large quantities, this might interfere with the activity of warfarin.

Likelihood Possible Evidence D
Stinging Nettle (root) extract full monograph & interactions

Lycopene1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking lycopene with anticoagulant or antiplatelet drugs might increase the risk of bleeding.
In vitro research shows that lycopene has antiplatelet effects.

Likelihood Possible Evidence D
Lycopene full monograph & interactions

Zinc10 drug types · 67 drugs

Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy)

Theoretically, zinc might decrease levels of bictegravir/emtricitabine/tenofovir alafenamide by reducing its absorption.
Advise patients that bictegravir/emtricitabine/tenofovir alafenamide should be taken at least 2 hours before or 6 hours after zinc containing products.

Likelihood Probable Evidence D
Cephalexin (Keflex)

Zinc might decrease cephalexin levels by chelating with cephalexin in the gut and preventing its absorption.
A pharmacokinetic study shows that zinc sulfate 250 mg taken concomitantly with cephalexin 500 mg decreases peak levels of cephalexin by 31% and reduces the exposure to cephalexin by 27%. Also, taking zinc sulfate 3 hours before cephalexin decreases peak levels of cephalexin by 11% and reduces the exposure to cephalexin by 18%. By decreasing cephalexin levels, zinc might increase the risk of treatment failure. This effect does not occur when zinc is taken 3 hours after the cephalexin dose. To avoid an interaction, advise patients take zinc sulfate 3 hours after taking cephalexin.

Likelihood Probable Evidence B
Cisplatin (Platinol-Aq)

Theoretically, zinc might interfere with the therapeutic effects of cisplatin.
Animal research suggests that zinc stimulates tumor cell production of the protein metallothionein, which binds and inactivates cisplatin. It is not known whether zinc supplements or high dietary zinc intake can cause clinically significant interference with cisplatin therapy. Cisplatin might also increase zinc excretion.

Likelihood Possible Evidence D
Integrase Inhibitors

Theoretically, taking zinc along with integrase inhibitors might decrease the levels and clinical effects of these drugs.
Zinc is a divalent cation. Pharmacokinetic studies have shown that other divalent cations such as calcium and iron can decrease blood levels of the integrase inhibitor dolutegravir through chelation.

Likelihood Possible Evidence D
Penicillamine (Cuprimine, Depen)

Zinc might reduce the levels and clinical effects of penicillamine.
By forming an insoluble complex with penicillamine, zinc interferes with penicillamine absorption and activity. Zinc supplements reduce the efficacy of low-dose penicillamine (0.5-1 gram/day), but do not seem to affect higher doses (1-2.75 gram/day), provided dosing times are separated. Advise patients to take zinc and penicillamine at least 2 hours apart.

Likelihood Probable Evidence B
Quinolone Antibiotics

Zinc can decrease the levels and clinical effects of quinolones antibiotics.
Quinolones form complexes with zinc in the gastrointestinal tract, reducing absorption of both the quinolone and zinc if taken at the same time. Advise patients to take these drugs at least 2 hours before, or 4-6 hours after, zinc supplements.

Likelihood Probable Evidence B
Ritonavir (Norvir)

Zinc modestly reduces levels of ritonavir.
Clinical research shows that zinc might reduce serum ritonavir levels by chelating with ritonavir in the gut and preventing its absorption. In patients with HIV, ritonavir is taken with atazanavir to prevent the metabolism and increase the effects of atazanavir. A pharmacokinetic study shows that, in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate (Solvazinc tablets) 125 mg as a single dose or as multiple daily doses for 2 weeks reduces plasma levels of ritonavir by about 16%. However, atazanavir levels still remains high enough to prevent HIV virus replication. Therefore, the decrease in ritonavir levels is not likely to be clinically significant.

Likelihood Probable Evidence B
Tetracycline Antibiotics

Zinc might reduce levels of tetracycline antibiotics.
Tetracyclines form complexes with zinc in the gastrointestinal tract, which can reduce absorption of both the tetracycline and zinc when taken at the same time. Taking zinc sulfate 200 mg with tetracycline reduces absorption of the antibiotic by 30% to 40%. Demeclocycline and minocycline cause a similar interaction. However, doxycycline does not seem to interact significantly with zinc. Advise patients to take tetracyclines at least 2 hours before, or 4-6 hours after, zinc supplements to avoid any interactions.

Likelihood Probable Evidence B
Amiloride (Midamor)

Amiloride can modestly reduce zinc excretion and increase zinc levels.
Clinical research shows that amiloride can reduce urinary zinc excretion, especially at doses of 10 mg per day or more. This zinc-sparing effect can help to counteract zinc losses caused by thiazide diuretics, but it is unlikely to cause zinc toxicity at usual amiloride doses. The other potassium-sparing diuretics, spironolactone (Aldactone) and triamterene (Dyrenium), do not seem to have a zinc-sparing effect.

Likelihood Probable Evidence B
Atazanavir (Reyataz)

Zinc modestly reduces levels of atazanavir, although this effect does not seem to be clinically significant.
Clinical research shows that zinc might decrease serum atazanavir levels by chelating with atazanavir in the gut and preventing its absorption. Although a single dose of zinc sulfate (Solvazinc tablets) 125 mg orally does not affect atazanavir concentrations in patients being treated with atazanavir/ritonavir, co-administration of zinc sulfate 125 mg daily for 2 weeks reduces plasma levels of atazanavir by about 22% in these patients. However, despite this decrease, atazanavir levels still remain at high enough concentrations for the prevention of HIV virus replication.

Likelihood Probable Evidence B
Zinc full monograph & interactions

Pumpkin seed Oil1 drug type · 1 drug

Lithium

Pumpkin might reduce excretion and increase levels of lithium.
Pumpkin is thought to have diuretic properties. Theoretically, this might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Pumpkin seed Oil full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Prostate Nutritional Support, from the product label.

NutriCology

See all NutriCology products
Name
NutriCology
City
South Salt Lake
State
UT
ZipCode
84115
Phone Number
800.545.9960
Web Address
www.nutricology.com
Pharmacist Counseling Corner

Prostate Nutritional Support by NutriCology: Common Questions

Does Prostate Nutritional Support by NutriCology interact with any medications?
Yes. Based on its ingredients, Prostate Nutritional Support has a known interaction with 526 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Prostate Nutritional Support contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm on warfarin or another blood thinner?
Not without checking first. Lycopene, saw palmetto, and stinging nettle in this product all carry a moderate interaction risk with blood thinners—they may increase bleeding. Talk to your pharmacist or doctor before starting; they may advise spacing doses or avoiding the product altogether.
Does this actually work for an enlarged prostate?
Some ingredients have more evidence than others. Beta-sitosterol and pumpkin seed oil are both possibly effective for BPH, and stinging nettle is possibly effective. Saw palmetto, which is commonly used for this, is actually rated possibly ineffective in the data we hold. No single ingredient is a guaranteed fix, and results vary.
Is it safe to take while pregnant or breastfeeding?
No. Lycopene, beta-sitosterol, stinging nettle, and pumpkin seed oil should all be avoided during pregnancy and breastfeeding due to insufficient safety data. Saw palmetto is marked likely unsafe for breastfeeding. DIM is marked likely safe in pregnancy, but data during breastfeeding is lacking. Talk to your OB or doctor before considering any supplement while pregnant or nursing.
What are the most common side effects?
Digestive complaints are most frequent: diarrhea, constipation, nausea, gas, and abdominal discomfort. These are usually mild and reversible. Zinc can cause a metallic taste. If you have a sensitive stomach, start with a lower dose or take it with food.
Can I take this with my antibiotic?
It depends on which antibiotic. Zinc in this product can reduce absorption of quinolone, tetracycline, and cephalexin antibiotics by up to 30–40%. If you're on one of these, space your zinc dose at least 2–4 hours before or 4–6 hours after the antibiotic. Other antibiotics may be safer; ask your pharmacist.
Will this interfere with my birth control?
Saw palmetto in this product theoretically might reduce the effectiveness of hormonal contraceptives because it may have antiestrogenic effects. This isn't a proven interaction, but it's a concern worth discussing with your doctor or pharmacist before you start, especially if contraceptive reliability is important to you.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Prostate Nutritional Support label
Go deeper

The Full Monographs Behind Prostate Nutritional Support’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lycopene

Interacts with 122 drugs

Lycopene is a red plant pigment and antioxidant found mainly in tomatoes and other red fruits. Eating lycopene-rich foods is linked with possible heart and prostate benefits, but evidence fr...

Read the full Lycopene monograph → Herb & supplement monograph

Beta-sitosterol

Beta-sitosterol is a plant sterol that may modestly lower LDL ('bad') cholesterol and may help ease urinary symptoms from an enlarged prostate. Evidence is moderate for these uses and weaker...

Read the full Beta-sitosterol monograph → Herb & supplement monograph

Zinc

Interacts with 67 drugs

Zinc is an essential mineral that your body needs for immune function, wound healing, taste, and smell. Most people get enough from food, but supplements can help correct or prevent a defici...

Read the full Zinc monograph → Herb & supplement monograph

Stinging Nettle

Interacts with 164 drugs

Stinging nettle is a common plant used as food and in traditional medicine, most often for prostate symptoms, allergies, and joint pain. The evidence is mixed and mostly preliminary, so it i...

Read the full Stinging Nettle monograph → Herb & supplement monograph

Pumpkin

Interacts with 1 drug

Pumpkin is a nutritious squash, and its seeds and seed oil are the parts most often used as supplements, mainly for urinary and prostate symptoms. The evidence for these uses is limited and...

Read the full Pumpkin monograph → Herb & supplement monograph

Saw Palmetto

Interacts with 174 drugs

Saw palmetto is a plant extract most often used for urinary symptoms linked to an enlarged prostate (BPH). The best research suggests it works no better than a placebo for most men, though i...

Read the full Saw Palmetto monograph → Herb & supplement monograph

Diindolylmethane

Interacts with 269 drugs

Diindolylmethane (DIM) is a compound made when your body digests cruciferous vegetables, and it is sold as a supplement mainly for hormone balance and cancer prevention. Although early lab s...

Read the full Diindolylmethane monograph →
Sources

Sources & How We Checked

Prostate Nutritional Support's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 169 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lycopene 10 references
  1. Sharma, J. B., Kumar, A., Kumar, A., Malhotra, M., Arora, R., Prasad, S., and Batra, S. Effect of lycopene on pre-eclampsia and intra-uterine growth retardation in primigravidas. Int J Gynaecol.Obstet. 2003;81(3):257-262. PubMed
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  14. Mantovani, F. Serenoa repens in benign prostatic hypertrophy: analysis of 2 Italian studies. Minerva Urol.Nefrol. 2010;62(4):335-340.
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See these in context on the Saw Palmetto monograph →

Diindolylmethane 14 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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