Interactions on record — worth a quick check against your medications. Based on 2 of 4 ingredients. Check your meds →
Dietary supplement

Puncture Vine 40% Saponins Ingredients & Drug Interactions

by Herb Xtra

Puncture Vine 40% Saponins label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Puncture Vine 40% Saponins against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Puncture Vine 40% Saponins is a dietary supplement by Herb Xtra with 4 active ingredients. Its ingredients are commonly taken for joint and bone health, skin, hair, and nail support, source of dietary protein.Based on those ingredients, 259 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Puncture Vine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Puncture Vine 40% Saponins by Herb Xtra

Ask about any prescription or over-the-counter medication and we check it for interactions with Puncture Vine 40% Saponins by Herb Xtra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Puncture Vine 40% Saponins by Herb Xtra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 3, 2026

What’s inside

Partial disclosure
Ingredient Transparency · database check
Partial

Most active ingredients list an amount, but at least one is hidden in a blend or missing.

Why this rating?
  • The label discloses an exact amount for 2 of its 4 active ingredients.

This product contains 4 ingredients total. The active ingredient is puncture vine (tribulus) at 40% saponins — the plant compounds thought to be responsible for its effects.

The other three ingredients are gelatin (the capsule material), maltodextrin, and water — inactive ingredients that help deliver and bind the formula. Puncture vine is a plant used traditionally to support sexual function and athletic performance, though the research backing these uses is mixed.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: sexual function and athletic performance support.
  • We looked for evidence on: Athletic performance, Erectile dysfunction (ED), Exercise-induced muscle damage, Exercise-induced muscle soreness, Male infertility, Sexual dysfunction — and 2 related terms.
  • The strongest evidence on file: Tribulus is rated "Possibly Effective" for Sexual dysfunction (Natural Medicines).
  • Also on file: Tribulus is rated "Possibly Ineffective" for Athletic performance.
  • Also on file: Tribulus is rated "Insufficient Reliable Evidence To Rate" for Erectile dysfunction (ED), Male infertility, Exercise-induced muscle damage.

For sexual dysfunction, puncture vine is rated possibly effective — meaning some clinical research supports its use, though the evidence isn't airtight. For athletic performance, it's rated possibly ineffective — the data doesn't show much benefit.

For benign prostatic hyperplasia (enlarged prostate), we don't have enough reliable evidence to rate it either way.

The evidence, ingredient by ingredient Gelatin Tribulus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Puncture vine is often well tolerated in the short term in healthy adults, but quality data and long-term safety information are limited. The most common side effects are gastrointestinal — abdominal pain, cramping, nausea, vomiting, diarrhea, and constipation — though in one study these complaints happened at similar rates in people taking puncture vine and those on placebo.

Rare serious effects including liver and kidney injury, seizures, and chronic painful erection have been reported. Gelatin is generally well tolerated orally and may cause belching, bloating, upset stomach, or unpleasant taste in some people; in rare cases it can trigger allergic reactions including hives, swelling, wheezing, or anaphylaxis (particularly in people sensitized through gelatin in foods or vaccines).

Puncture vine safety during pregnancy is not established and the data advises against it because it may affect hormones. For breastfeeding, reliable safety information is lacking — it should be avoided.

For gelatin, pregnancy is rated likely safe to possibly safe, and lactation is rated likely safe, though supplement doses have little research behind them — talk with your doctor or pharmacist before using either during pregnancy or breastfeeding.

Side effects, ingredient by ingredient Gelatin Tribulus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Tribulus.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 259 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking Puncture Vine, double-check with your doctor or pharmacist if you're on blood pressure medications, diabetes medications, or lithium. All three carry Moderate-severity interactions: blood pressure drugs and diabetes drugs may work too well (dropping your pressure or blood sugar too low), and lithium levels may rise and require dose adjustment.

No interactions are documented for the gelatin capsule.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glancePartially disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Puncture Vine may be worth considering if you're exploring options for sexual function and want to try a traditionally used herbal approach. However, you should be cautious if you take blood pressure medications, diabetes medications, or lithium — the interactions are documented and potentially significant.

Before adding this to your routine, check your medications with your own doctor or pharmacist to make sure it's right for you.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Puncture Vine 40% Saponins, straight from the product label.

Brand Herb Xtra
Barcode (UPC) 777949998797
Net contents 60 Capsule(s); 350 mg
Market status On market
Date entered into DSLD Jan 25, 2013
DSLD ID 17606
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Puncture Vine 40% Saponins by Herb Xtra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
777949998797
IngredientAmount% DV
Gelatin0 NP--
Maltodextrin60 mg--
Water0 NP--
Puncture Vine350 mg--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General

H880608

General Statements

Tribulus terristris STANDARDIZED

Suggested/Recommended/Usage/Directions

Use: As a Herbal Supplement: 1 capsule 3 times daily with a glass of water.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Puncture Vine 40% Saponins by Herb Xtra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Puncture Vine 40% Saponins label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Puncture Vine 40% Saponins by Herb Xtra

These are the 4 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gelatin

No known
interactions
0 NP per serving

Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most heal...

Gelatin monograph & interactions

Maltodextrin

60 mg per serving

Water

0 NP per serving

Puncture Vine

Interacts with
259 drugs
350 mg per serving Form: Saponins

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims...

Puncture Vine monograph & interactions
Interaction report

Puncture Vine 40% Saponins by Herb Xtra Drug Interactions

Want to check YOUR meds against Puncture Vine 40% Saponins?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
259Drugs
259 Moderate

Ingredients driving the most interactions

Puncture Vine 259

Individual Drug Interactions

The ingredients in Puncture Vine 40% Saponins interact with 259 drugs. Click any drug to see the details.

1 of the 4 ingredients in Puncture Vine 40% Saponins interact with drugs. Each result below shows which ingredient is responsible. Puncture Vine

Each ingredient & the kinds of drugs it affects

For each ingredient in Puncture Vine 40% Saponins with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Puncture Vine3 drug types · 259 drugs

Antidiabetes Drugs

Taking tribulus with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that Tribulus can lower blood glucose levels in adults with type 2 diabetes who are taking antidiabetes medications.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, taking tribulus with antihypertensive drugs might increase the risk of hypotension.
Animal research shows that tribulus can lower blood pressure by inhibiting angiotensin-converting enzyme (ACE). Tribulus has also demonstrated hypotensive effects in pre-hypertensive adults.

Likelihood Possible Evidence D
Lithium

Theoretically, tribulus might increase the levels and clinical effects of lithium.
Tribulus is thought to have diuretic properties. Due to these potential diuretic effects, tribulus might reduce excretion and increase levels of lithium. The dose of lithium might need to be decreased.

Likelihood Probable Evidence D
Puncture Vine full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Puncture Vine 40% Saponins, from the product label.

Herb Xtra

See all Herb Xtra products
Name
GOURMET NUTRITION F.B. INC.
City
STE-JULIE
State
QUEBEC
ZipCode
J3E 1Z2
Pharmacist Counseling Corner

Puncture Vine 40% Saponins by Herb Xtra: Common Questions

Does Puncture Vine 40% Saponins by Herb Xtra interact with any medications?
Yes. Based on its ingredients, Puncture Vine 40% Saponins has a known interaction with 259 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Puncture Vine 40% Saponins contains 4 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take this if I'm pregnant or breastfeeding?
Puncture vine should be avoided during pregnancy because safety isn't established and it may affect hormones. It should also be avoided while breastfeeding due to lack of reliable safety data. The gelatin capsule is rated likely safe in pregnancy and lactation, but talk with your doctor or pharmacist for personalized guidance on the product as a whole.
What side effects might I notice?
The most common ones are gastrointestinal — abdominal pain, cramping, nausea, vomiting, diarrhea, or constipation — though in one study these happened at similar rates as placebo. The gelatin capsule may cause belching, bloating, or upset stomach. Rare serious effects from puncture vine include liver and kidney injury, seizures, and chronic painful erection; allergic reactions to gelatin (hives, swelling, wheezing) are rare but possible, especially in people sensitized to gelatin through vaccines or foods.
Does puncture vine actually work for sexual dysfunction?
Puncture vine is rated possibly effective for sexual dysfunction, meaning some clinical research supports it, but the evidence isn't definitive. Results vary from person to person.
Will this help my athletic performance?
Puncture vine is rated possibly ineffective for athletic performance — the research doesn't show much benefit for that use.
What is gelatin, and is it safe?
Gelatin is a protein derived from animal collagen and is widely used as a food ingredient and capsule material. Orally it's generally well tolerated, though some people report belching, bloating, or upset stomach. Allergic reactions are rare but can occur, especially in people previously sensitized to gelatin through vaccines or foods.
Are there any fillers or other ingredients I should know about?
This product has no inactive other ingredients listed beyond the gelatin capsule, maltodextrin, and water that deliver the active puncture vine. If you have sensitivities, check the label or speak with your pharmacist.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Puncture Vine 40% Saponins is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Puncture Vine 40% Saponins label
Go deeper

The Full Monographs Behind Puncture Vine 40% Saponins’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gelatin

Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most health uses, the evidence is limited or mixe...

Read the full Gelatin monograph → Herb & supplement monograph

Tribulus

Interacts with 259 drugs

Tribulus is a plant supplement most often marketed to boost libido, testosterone, and athletic performance, but the human evidence behind these claims is weak and inconsistent. It is general...

Read the full Tribulus monograph →
Sources

Sources & How We Checked

Puncture Vine 40% Saponins's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 21 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gelatin 11 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Schwick HG, Heide K. Immunochemistry and immunology of collagen and gelatin. Bibl Haematol 1969;33:111-25. PubMed
  3. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. PubMed
  4. Kelso JM. The gelatin story. J Allergy Clin Immunol 1999;103:200-2.
  5. Nakayama T, Aizawa C, Kuno-Sakai H. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allerg PubMed
  6. Sakaguchi M, Inouye S. Anaphylaxis to gelatin-containing rectal suppositories. J Allergy Clin Immunol 2001;108:1033-4. PubMed
  7. PDR Electronic Library. Montvale, NJ: Medical Economics Company, Inc., 2001.
  8. de la Fuente Tornero E, Vega Castro A, de Sierra Hernández PÁ, et al. Kounis syndrome during anesthesia: Presentation of indolent systemic mastocytosis: A case report. A Case Rep. 2017;8(9):226-228. PubMed
  9. Ventura Spagnolo E, Calapai G, Minciullo PL, Mannucci C, Asmundo A, Gangemi S. Lethal anaphylactic reaction to intravenous gelatin in the course of surgery. Am J Ther. 2016;23(6):e1344-e1346. PubMed
  10. Li Y, He H, Yang L, Li X, Li D, Luo S. Therapeutic effect of Colla corii asini on improving anemia and hemoglobin compositions in pregnant women with thalassemia. Int J Hematol. 2016;104(5):559-565. PubMed
  11. Coury JR, Skaggs KF, Marciano GF, et al. Intraoperative Anaphylaxis to the Bovine Flowable Gelatin Matrix: A Report of 2 Cases. JBJS Case Connect 2022;12(1). PubMed

See these in context on the Gelatin monograph →

Tribulus 10 references
  1. Sharifi AM, Darabi R, Akbarloo N. Study of antihypertensive mechanism of Tribulus terrestris in 2K1C hypertensive rats: role of tissue ACE activity. Life Sci 2003;73:2963-71. PubMed
  2. Walker D, Bird A, Flora T, O'Sullivan B. Some effects of feeding Tribulus terrestris, Ipomoea lonchophylla and the seed of Abelmoschus ficulneus on fetal development and the outcome of pregnancy in sheep. Reprod Fertil Dev 1992;4:135-44. PubMed
  3. Al-Ali M, Wahbi S, Twaij H, Al-Badr A. Tribulus terrestris: preliminary study of its diuretic and contractile effects and comparison with Zea mays. J Ethnopharmacol 2003;85:257-60. PubMed
  4. Tabakova, P., Dimitrov, M., Ognyanov, K., and et al. Clinical study of Tribestan in females with endocrine sterility. Documentation for Registration (unpublished) 1999.
  5. Akhtari E, Raisi F, Keshavarz M, et al. Tribulus terrestris for treatment of sexual dysfunction in women: randomized double-blind placebo-controlled study. Daru 2014;22:40. PubMed
  6. Ryan M, Lazar I, Nadasdy GM, et al. Acute kidney injury and hyperbilirubinemia in a young male after ingestion of Tribulus terrestris. Clin Nephrol 2015;83(3):177-83. PubMed
  7. Postigo S, Lima SM, Yamada SS, et al. Assessment of the effects of Tribulus terrestris on sexual function of menopausal women. Rev Bras Ginecol Obstet 2016;38(3):140-6. PubMed
  8. Talasaz AH, Abbasi MR, Abkhiz S, Dashti-Khavidaki S. Tribulus terrestris-induced severe nephrotoxicity in a young healthy male. Nephrol Dial Tranplant 2010;25(11):3792-3. PubMed
  9. Samani NB, Jokar A, Soveid M, Heydari M, Mosavat SH. Efficacy of the hydroalcoholic extract of Tribulus terrestris on the serum glucose and lipid profile of women with diabetes mellitus: a double-blind randomized placebo-controlled clinical trial. J Evid
  10. Siddiqui MA, Itrat M, Mobeen A, Khan MI. Efficacy of khar-i-khasak (Tribulus terrestris Linn.) in prehypertension: a randomized, double-blind, placebo-controlled trial. J Complement Integr Med. 2021.

See these in context on the Tribulus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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