Interactions on record — worth a quick check against your medications. Based on 2 of 3 ingredients. Check your meds →
Dietary supplement

Eyebright Ingredients & Drug Interactions

by Herb Xtra

Eyebright label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Eyebright against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Eyebright is a dietary supplement by Herb Xtra with 3 active ingredients. Its ingredients are commonly taken for joint and bone health, skin, hair, and nail support, source of dietary protein.Based on those ingredients, 86 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Eyebright. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Eyebright by Herb Xtra

Ask about any prescription or over-the-counter medication and we check it for interactions with Eyebright by Herb Xtra — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Eyebright by Herb Xtra

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 30, 2026

What’s inside

Low disclosure
Ingredient Transparency · database check
Low

Most active ingredients don't disclose an individual amount — you can't tell how much of each you're getting.

Why this rating?
  • The label discloses an exact amount for 0 of its 3 active ingredients.

Herb Xtra's Eyebright is a 3-ingredient capsule. The active ingredient is eyebright — an herb traditionally used for eye and respiratory symptoms, though the evidence for it isn't well established yet.

The other ingredients are gelatin (the capsule material) and water.

Does it work?

Not established
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not established

The graded evidence we hold for these ingredients covers different conditions than the ones this product is marketed for, so there's no established rating for its stated use.

Why this rating?
  • The label markets this product for: eye health and comfort.
  • We looked for evidence on: Asthenopia (eye strain), Conjunctivitis, Blepharitis, Allergic rhinitis (hay fever), eye irritation, eye redness — and 1 related terms.
  • The closest evidence on file: Eyebright is rated "Insufficient Reliable Evidence To Rate" for Allergic rhinitis (hay fever) (Natural Medicines).
  • Also on file: Eyebright is rated "Insufficient Reliable Evidence To Rate" for Blepharitis, Asthenopia (eye strain), Conjunctivitis.

The evidence for eyebright isn't established in the data we hold. The facts show insufficient reliable evidence to rate it for allergic rhinitis (hay fever), common cold, cough, pharyngitis, rhinosinusitis, or cancer.

If you're considering it for one of those reasons, talk with your doctor about what the research actually supports.

The evidence, ingredient by ingredient Gelatin Eyebright

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 2 of the 2 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 2 of 2.
  • General safety write-ups exist for 2 of 2.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Orally, eyebright has been reported to cause confusion, headache, nausea, constipation, cough, shortness of breath, and nasal congestion in some people. Gelatin (the capsule) is generally well tolerated but can cause belching, bloating, indigestion, and unpleasant taste; rarely, it may trigger allergic reactions in people sensitive to gelatin, including urticaria, angioedema, wheezing, or anaphylaxis.

During pregnancy, the safety of eyebright has not been established — the data advises against it. While breastfeeding, there isn't enough safety information, so it's best avoided.

Talk with your doctor or pharmacist before using this product if you're pregnant or breastfeeding.

Side effects, ingredient by ingredient Gelatin Eyebright

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 2 matched ingredients can interact with medications — Eyebright.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: diabetes medications.
  • For scale: 86 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antidiabetes drugs (blood sugar medications), double-check with your doctor or pharmacist before adding this product — eyebright may increase the risk of low blood sugar.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFormula with limited ingredient disclosure with no established evidence rating for its marketed use. Moderate medication interactions have been identified, and safety information is well characterized.

Herb Xtra's Eyebright is mainly a concern if you take antidiabetes drugs — the eyebright may lower your blood sugar further. The herb itself hasn't been proven effective for its traditional uses yet.

Before starting, check your medications against the tool on this page or talk it over with your doctor or pharmacist, especially if you have diabetes.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 2 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Eyebright, straight from the product label.

Brand Herb Xtra
Barcode (UPC) 777949998513
Net contents 100 Capsule(s); 450 mg
Market status On market
Date entered into DSLD Feb 25, 2013
DSLD ID 17621
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Eyebright by Herb Xtra, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
777949998513
IngredientAmount% DV
Gelatin0 NP--
Water0 NP--
Eyebright0 NP--

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Precautions

Excessive misuse may cause adverse effects.

Caution: Do not consume during pregnancy.

Suggested/Recommended/Usage/Directions

Use: As a Herbal Supplement: 1 capsule 3 times daily with a glass of water.

General

H320500

General Statements

Euphrasia officinalis

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Eyebright by Herb Xtra label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Eyebright label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Eyebright by Herb Xtra

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Gelatin

No known
interactions
0 NP per serving

Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most heal...

Gelatin monograph & interactions

Water

0 NP per serving

Eyebright

Interacts with
86 drugs
0 NP per serving

Eyebright is a traditional herb long used for minor eye irritation, redness, and allergy symptoms, but high-quality human studies are very limited. Th...

Eyebright monograph & interactions
Interaction report

Eyebright by Herb Xtra Drug Interactions

Want to check YOUR meds against Eyebright?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
86Drugs
86 Moderate

Ingredients driving the most interactions

Eyebright 86

Individual Drug Interactions

The ingredients in Eyebright interact with 86 drugs. Click any drug to see the details.

1 of the 3 ingredients in Eyebright interact with drugs. Each result below shows which ingredient is responsible. Eyebright

Each ingredient & the kinds of drugs it affects

For each ingredient in Eyebright with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Eyebright1 drug type · 86 drugs

Antidiabetes Drugs

Theoretically, eyebright might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that eyebright lowers blood glucose levels.

Likelihood Possible Evidence D
Eyebright full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Eyebright, from the product label.

Herb Xtra

See all Herb Xtra products
Name
GOURMET NUTRITION F.B. INC.
City
Ste-Julie
State
Quebec
ZipCode
J3E 1Z2
Pharmacist Counseling Corner

Eyebright by Herb Xtra: Common Questions

Does Eyebright by Herb Xtra interact with any medications?
Yes. Based on its ingredients, Eyebright has a known interaction with 86 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Eyebright contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is eyebright actually used for?
Eyebright is traditionally used for eye and respiratory symptoms like allergic rhinitis (hay fever) and cough, but the evidence to back up those uses isn't well established yet. We don't have solid data showing it works for those conditions.
Can I use this if I take diabetes medication?
Animal research suggests eyebright lowers blood glucose, so it might increase your risk of low blood sugar if you're on antidiabetes drugs. Talk with your doctor or pharmacist before starting — they can help you decide if it's right for you and whether your medications need monitoring.
What side effects should I expect?
Eyebright has been reported to cause confusion, headache, nausea, constipation, cough, and nasal congestion when taken by mouth. The gelatin capsule itself can cause belching, bloating, and indigestion in some people.
Is this safe during pregnancy or breastfeeding?
No — eyebright's safety hasn't been established during pregnancy, so it's best avoided. There also isn't enough safety information for breastfeeding. Talk with your doctor or pharmacist before use if you're pregnant or nursing.
Can I put this directly in my eyes?
No. Using eyebright directly in the eye, especially from a homemade or non-sterile preparation, carries a real risk. Taking it by mouth (as a capsule) is what the data covers here.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Eyebright is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Eyebright label
Go deeper

The Full Monographs Behind Eyebright’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Gelatin

Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most health uses, the evidence is limited or mixe...

Read the full Gelatin monograph → Herb & supplement monograph

Eyebright

Interacts with 86 drugs

Eyebright is a traditional herb long used for minor eye irritation, redness, and allergy symptoms, but high-quality human studies are very limited. There is not enough reliable evidence to c...

Read the full Eyebright monograph →
Sources

Sources & How We Checked

Eyebright's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Gelatin 11 references
  1. Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
  2. Schwick HG, Heide K. Immunochemistry and immunology of collagen and gelatin. Bibl Haematol 1969;33:111-25. PubMed
  3. Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. PubMed
  4. Kelso JM. The gelatin story. J Allergy Clin Immunol 1999;103:200-2.
  5. Nakayama T, Aizawa C, Kuno-Sakai H. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allerg PubMed
  6. Sakaguchi M, Inouye S. Anaphylaxis to gelatin-containing rectal suppositories. J Allergy Clin Immunol 2001;108:1033-4. PubMed
  7. PDR Electronic Library. Montvale, NJ: Medical Economics Company, Inc., 2001.
  8. de la Fuente Tornero E, Vega Castro A, de Sierra Hernández PÁ, et al. Kounis syndrome during anesthesia: Presentation of indolent systemic mastocytosis: A case report. A Case Rep. 2017;8(9):226-228. PubMed
  9. Ventura Spagnolo E, Calapai G, Minciullo PL, Mannucci C, Asmundo A, Gangemi S. Lethal anaphylactic reaction to intravenous gelatin in the course of surgery. Am J Ther. 2016;23(6):e1344-e1346. PubMed
  10. Li Y, He H, Yang L, Li X, Li D, Luo S. Therapeutic effect of Colla corii asini on improving anemia and hemoglobin compositions in pregnant women with thalassemia. Int J Hematol. 2016;104(5):559-565. PubMed
  11. Coury JR, Skaggs KF, Marciano GF, et al. Intraoperative Anaphylaxis to the Bovine Flowable Gelatin Matrix: A Report of 2 Cases. JBJS Case Connect 2022;12(1). PubMed

See these in context on the Gelatin monograph →

Eyebright 4 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
  3. Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
  4. Porchezhian, E., Ansari, S. H., and Shreedharan, N. K. Antihyperglycemic activity of Euphrasia officinale leaves. Fitoterapia 2000;71(5):522-526. PubMed

See these in context on the Eyebright monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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