Chlorophyll Ingredients & Drug Interactions
by Herb Xtra
What is this page for?
First and foremost: checking Chlorophyll against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Chlorophyll is a dietary supplement by Herb Xtra with 4 active ingredients. Its ingredients are commonly taken for joint and bone health, skin, hair, and nail support, source of dietary protein.Based on those ingredients, 585 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Alfalfa leaf filler, Chlorophyll. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Chlorophyll by Herb Xtra
Ask about any prescription or over-the-counter medication and we check it for interactions with Chlorophyll by Herb Xtra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Chlorophyll by Herb Xtra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Low disclosure
Herb Xtra Chlorophyll contains 4 ingredients. The active component is chlorophyll itself — the green pigment in plants — along with alfalfa leaf as a filler.
The product also contains gelatin (the capsule material) and water.
Does it work?
Couldn't assess
The evidence we hold doesn't establish that chlorophyll works for any condition — we have insufficient reliable evidence for genital herpes, wound healing, shingles, nonmelanoma skin cancer, and pancreatitis. Alfalfa and gelatin likewise show insufficient evidence or possibly ineffective ratings for their potential uses.
If you're considering this product for a specific health goal, it's worth asking your pharmacist what the research actually supports.
How safe is it?
Well-documented data
Chlorophyll is generally well tolerated in short-term use, but high-quality safety data are limited. The main documented side effect is photosensitization — sensitivity to sun damage — and in rare cases, pseudoporphyria (a condition resembling porphyria) has been reported after oral use.
Gelatin is widely used in food and generally well tolerated; the most common side effects are belching, bloating, and indigestion. Alfalfa can cause abdominal discomfort, diarrhea, and gas — especially in the first week of use.
During pregnancy, the safety data advises against chlorophyll and alfalfa at supplement doses, though gelatin is likely safe. During breastfeeding, there isn't enough data on chlorophyll or alfalfa to recommend them, while gelatin has limited research on supplement doses.
Meds to double-check
Major interaction found
Before taking Herb Xtra Chlorophyll, double-check it with your pharmacist if you take warfarin or other blood thinners — the alfalfa can reduce their effectiveness (Major severity). Also flag if you use photosensitizing drugs, birth control pills, hormone therapy, immunosuppressants, or diabetes medications, as the alfalfa and chlorophyll may affect how they work (Moderate severity for all).
The bottom line
Scorecard at a glanceFormula with limited ingredient disclosure with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.
This product is generally well tolerated for short-term use, but it does interact with blood thinners and several other medication types. If you take warfarin, birth control, hormone therapy, diabetes drugs, immunosuppressants, or photosensitizing medications, check with your pharmacist first.
Avoid it if you're pregnant or breastfeeding unless your doctor advises otherwise. Talk to your pharmacist about whether the evidence supports what you're hoping it'll do.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 3 of 4 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Jan 25, 2013.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Chlorophyll, straight from the product label.
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Chlorophyll by Herb Xtra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Gelatin | 0 NP | -- |
| Chlorophyll | 0 NP | -- |
| Water | 0 NP | -- |
| Alfalfa leaf filler | 0 NP | -- |
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements
Lot # : 02601ACY Exp.: 09 2005
Suggested/Recommended/Usage/Directions
Use: As a Herbal Supplement: 1 capsule 3 times daily at mealtime with a glass of water.
General
H313400
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Chlorophyll by Herb Xtra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Chlorophyll by Herb Xtra
These are the 4 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Gelatin
No knowninteractions
Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most heal...
Gelatin monograph & interactionsChlorophyll
Interacts with337 drugs
Chlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reduc...
Chlorophyll monograph & interactionsWater
Alfalfa leaf filler
Interacts with583 drugs
Alfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence for most of...
Alfalfa leaf filler monograph & interactionsChlorophyll by Herb Xtra Drug Interactions
HelloPharmacist Interaction Report
Herb Xtra Chlorophyll has documented interactions with several medication types, the most serious being blood thinners like warfarin — the alfalfa leaf filler contains high amounts of vitamin K, which can reduce how well warfarin works to prevent clots.
This is a Major-severity interaction and means if you take warfarin, you'll want to check with your pharmacist or doctor before using this product.
Read the full breakdown — every affected drug type, severity by severity
The chlorophyll and alfalfa in this supplement also interact with photosensitizing drugs (medications that make your skin more sensitive to sun damage) at Moderate severity — using them together might increase that sensitivity. Alfalfa also theoretically affects birth control pills, hormone therapy (estrogens), drugs that suppress your immune system, and diabetes medications, all at Moderate severity.
The concern with diabetes drugs is that alfalfa may lower your blood sugar, raising the risk of low blood sugar (hypoglycemia), so if you're diabetic you'd want to monitor closely.
We could not check the water in this product for interactions. Altogether, these interactions span 585 individual medications.
Use the interaction checker below with your exact medications before starting — it'll tell you if any of yours are affected.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Chlorophyll?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Chlorophyll interact with 585 drugs. Click any drug to see the details.
2 of the 4 ingredients in Chlorophyll interact with drugs. Each result below shows which ingredient is responsible. Alfalfa leaf filler Chlorophyll
WarfarinWarfarin
How Warfarin interacts with Chlorophyll — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf FillerWarfarin (coumadin) Major
Interaction Summary
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Read the full Alfalfa Leaf Filler + Warfarin interactionWarfarin SodiumCoumadin, Panwarfin, Sofarin
How Warfarin Sodium interacts with Chlorophyll — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf FillerWarfarin (coumadin) Major
Interaction Summary
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Read the full Alfalfa Leaf Filler + Warfarin Sodium interaction6-mercaptopurinePurinethol
How 6-mercaptopurine interacts with Chlorophyll — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf FillerImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa Leaf Filler + 6-mercaptopurine interactionAbrocitinibCibinqo
How Abrocitinib interacts with Chlorophyll — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf FillerImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa Leaf Filler + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Chlorophyll — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf FillerAntidiabetes Drugs Moderate
Interaction Summary
Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Alfalfa Leaf Filler + Acarbose interactionAcepromazineAtravet
How Acepromazine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acepromazine interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acepromazine interactionAcetaminophen, Brompheniramine, PhenylpropanolamineDimetapp Cold and Flu
How Acetaminophen, Brompheniramine, Phenylpropanolamine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Brompheniramine, Phenylpropanolamine interactionAcetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, PhenylephrineHycomine Compound
How Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Caffeine, Chlorpheniramine, Hydrocodone, Phenylephrine interactionAcetaminophen, Chlorpheniramine Maleate, Dextromethorphan HbrVicks Formula 44M Cough, Cold & Flu Relief
How Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine Maleate, Dextromethorphan Hbr interactionAcetaminophen, Chlorpheniramine, Codeine, PhenylephrineColrex
How Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Codeine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, DextromethorphanCoricidin II Extra Strength Cold and Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan interactionAcetaminophen, Chlorpheniramine, Dextromethorphan HydrobromideCoricidin HBP Maximum Strength Flu
How Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Dextromethorphan Hydrobromide interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PhenylpropanolamineMulti Symptom Cold Relief
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Dextromethorphan, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Dextromethorphan, PseudoephedrineChildren's Tylenol Cold Plus Cough, Tylenol Cold Ex Strength
How Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Dextromethorphan, Pseudoephedrine interactionAcetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, SalicylamideRhinogesic GG
How Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Guaifenesin, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylephrineAlka-Seltzer PLUS, Histex SR, Protid
How Acetaminophen, Chlorpheniramine, Phenylephrine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Phenylephrine interactionAcetaminophen, Chlorpheniramine, Phenylephrine, SalicylamideRhinogesic, Rhinogesic JR
How Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylephrine, Salicylamide interactionAcetaminophen, Chlorpheniramine, PhenylpropanolamineAlumadrine, Conex, Sinadrin Max Strength, Sinulin
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylpropanolamine interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, OpiumHista-Derfule
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Opium interactionAcetaminophen, Chlorpheniramine, Phenylpropanolamine, PhenyltoloxamineNorel Plus
How Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Phenylpropanolamine, Phenyltoloxamine interactionAcetaminophen, Chlorpheniramine, PseudoephedrineAlka-Seltzer PLUS Liquid Gels, Children's Tylenol Cold, Codimal, Comtrex, Extra Strength Tylenol Allergy Sinus, Lorsin +3 more
How Acetaminophen, Chlorpheniramine, Pseudoephedrine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Chlorpheniramine, Pseudoephedrine interactionAcetaminophen, Dexbrompheniramine, PseudoephedrineSinadrin Plus
How Acetaminophen, Dexbrompheniramine, Pseudoephedrine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Dexbrompheniramine, Pseudoephedrine interactionAcetaminophen, DiphenhydramineTylenol PM, Tylenol PM Ex Strength
How Acetaminophen, Diphenhydramine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Diphenhydramine interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Diphenhydramine interactionAcetaminophen, Diphenhydramine, PseudoephedrineChildren's Tylenol Allergy, Cold Control, Contac Night Allergy Relief
How Acetaminophen, Diphenhydramine, Pseudoephedrine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Diphenhydramine, Pseudoephedrine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Ibuprofen interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Ibuprofen interactionAcetaminophen, Phenylephrine, ChlorpheniramineSuper Cold Tabs
How Acetaminophen, Phenylephrine, Chlorpheniramine interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetaminophen, Phenylephrine, Chlorpheniramine interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetaminophen, Phenylephrine, Chlorpheniramine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetazolamide interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
Alfalfa Leaf FillerPhotosensitizing Drugs, Antidiabetes Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acetohexamide interactionChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acetohexamide interactionAcitretinSoriatane
How Acitretin interacts with Chlorophyll — through 2 ingredients. Tap an ingredient for the detail:
ChlorophyllPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Read the full Chlorophyll + Acitretin interactionAlfalfa Leaf FillerPhotosensitizing Drugs Moderate
Interaction Summary
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Read the full Alfalfa Leaf Filler + Acitretin interactionAdalimumabHumira
How Adalimumab interacts with Chlorophyll — through 1 ingredient. Tap an ingredient for the detail:
Alfalfa Leaf FillerImmunosuppressants Moderate
Interaction Summary
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
Read the full Alfalfa Leaf Filler + Adalimumab interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Chlorophyll with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.
Alfalfa leaf filler
Warfarin (Coumadin)
Theoretically, alfalfa might reduce the anticoagulant activity of warfarin.
Alfalfa contains a large amount of vitamin K. This could theoretically interfere with the activity of warfarin.
Antidiabetes Drugs
Theoretically, alfalfa might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Animal research suggests that alfalfa decreases blood sugar in diabetic mice. Also, in one case report, a diabetic patient experienced hypoglycemia after consuming alfalfa extract. Monitor blood glucose levels closely. Dose adjustments might be necessary.
Contraceptive Drugs
Theoretically, alfalfa might interfere with the activity of contraceptive drugs.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.
Estrogens
Theoretically, alfalfa might interfere with hormone therapy.
Alfalfa contains coumestrol, a phytoestrogen, and isoflavonoids, which have estrogenic effects.
Immunosuppressants
Theoretically, alfalfa might decrease the efficacy of immunosuppressive therapy.
In vitro research and human case reports suggest that alfalfa may have immunostimulant effects.
Photosensitizing Drugs
Theoretically, concomitant use of alfalfa with photosensitizing drugs might have additive effects.
Animal research suggests that excessive doses of alfalfa may increase photosensitivity, possibly due to its chlorophyll content. It is unclear if this effect would be clinically relevant in humans.
Chlorophyll
Methotrexate (Trexall, Others)
Theoretically, chlorophyll may reduce the clearance of methotrexate.
In one case report, a 54-year-old male developed delayed clearance of intravenous high-dose methotrexate with concomitant use of chlorophyll. When chlorophyll was stopped 2 days prior to methotrexate treatment, methotrexate clearance was unaffected.
Photosensitizing Drugs
Theoretically, concomitant use of chlorophyll with photosensitizing drugs may have additive effects.
Chlorophyll has been reported to cause photosensitization. In two case reports, pseudoporphyria developed after oral intake of chlorophyll. Theoretically, concomitant use with other photosensitizing drugs may exacerbate this effect.
Brand information
Manufacturer and brand details for Chlorophyll, from the product label.
Herb Xtra
See all Herb Xtra products- Name
- GOURMET NUTRITION F.B. INC.
- City
- Ste-Julie
- State
- Quebec
- ZipCode
- J3E 1Z2
Chlorophyll by Herb Xtra: Common Questions
Does Chlorophyll by Herb Xtra interact with any medications?
How can one product interact with so many drugs?
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Does this product actually work?
Why does this product have alfalfa in it?
Should I be concerned about the photosensitization side effect?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Chlorophyll is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Chlorophyll’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Gelatin
Gelatin is a protein made from animal collagen, used as a food, a capsule ingredient, and a supplement for joint, skin, and bone health. For most health uses, the evidence is limited or mixe...
Read the full Gelatin monograph → Herb & supplement monographChlorophyll
Interacts with 337 drugsChlorophyll is the green pigment found in plants and algae, and supplements often use a stable form called chlorophyllin. It is most studied for reducing body and fecal odor and as a topical...
Read the full Chlorophyll monograph → Herb & supplement monographAlfalfa
Interacts with 583 drugsAlfalfa is a nutrient-rich legume that people use for high cholesterol, menopause symptoms, and general wellness, but solid human evidence for most of these uses is limited. It is best avoid...
Read the full Alfalfa monograph →Sources & How We Checked
Chlorophyll's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 48 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Gelatin 11 references
- Lewis CJ. Letter to reiterate certain public health and safety concerns to firms manufacturing or importing dietary supplements that contain specific bovine tissues. FDA. Available at: www.cfsan.fda.gov/~dms/dspltr05.html.
- Schwick HG, Heide K. Immunochemistry and immunology of collagen and gelatin. Bibl Haematol 1969;33:111-25. PubMed
- Moskowitz RW. Role of collagen hydrolysate in bone and joint disease.Semin Arthritis Rheum 2000;30:87-99. PubMed
- Kelso JM. The gelatin story. J Allergy Clin Immunol 1999;103:200-2.
- Nakayama T, Aizawa C, Kuno-Sakai H. A clinical analysis of gelatin allergy and determination of its causal relationship to the previous administration of gelatin-containing acellular pertussis vaccine combined with diphtheria and tetanus toxoids. J Allerg PubMed
- Sakaguchi M, Inouye S. Anaphylaxis to gelatin-containing rectal suppositories. J Allergy Clin Immunol 2001;108:1033-4. PubMed
- PDR Electronic Library. Montvale, NJ: Medical Economics Company, Inc., 2001.
- de la Fuente Tornero E, Vega Castro A, de Sierra Hernández PÁ, et al. Kounis syndrome during anesthesia: Presentation of indolent systemic mastocytosis: A case report. A Case Rep. 2017;8(9):226-228. PubMed
- Ventura Spagnolo E, Calapai G, Minciullo PL, Mannucci C, Asmundo A, Gangemi S. Lethal anaphylactic reaction to intravenous gelatin in the course of surgery. Am J Ther. 2016;23(6):e1344-e1346. PubMed
- Li Y, He H, Yang L, Li X, Li D, Luo S. Therapeutic effect of Colla corii asini on improving anemia and hemoglobin compositions in pregnant women with thalassemia. Int J Hematol. 2016;104(5):559-565. PubMed
- Coury JR, Skaggs KF, Marciano GF, et al. Intraoperative Anaphylaxis to the Bovine Flowable Gelatin Matrix: A Report of 2 Cases. JBJS Case Connect 2022;12(1). PubMed
Chlorophyll 5 references
- Mathews-Roth MM. Carotenoids in erythropoietic protoporphyria and other photosensitivity diseases. Ann N Y Acad Sci, 1993; 691:127-38. PubMed
- Belen'kii, G. B. and Krikun, B. L. [Treatment of herpes simplex and herpes zoster by chlorophyll preparations]. Sov.Med. 1971;34(1):151-152.
- Brooks SL, Sanders J, Seymour JF, Mellor JD. A case of delayed methotrexate clearance following administration of a complementary medication containing chlorophyll. J Oncol Pharm Pract. 2014 Jun;20(3):225-8. PubMed
- Rossi E, Borchard K, Cole JM. Pseudoporphyria following self-medication with chlorophyll. Australas J Dermatol. 2015 Feb;56(1):47-8. PubMed
- Zhao CY, Frew JW, Muhaidat J, et al. Chlorophyll-induced pseudoporphyria with ongoing photosensitivity after cessation - a case series of four patients. J Eur Acad Dermatol Venereol 2016;30(7):1239-42. PubMed
Alfalfa 32 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- Kurzer MS, Xu X. Dietary phytoestrogens. Annu Rev Nutr 1997;17:353-81. PubMed
- Farber JM, Carter AO, Varughese PV, et al. Listeriosis traced to the consumption of alfalfa tablets and soft cheese [Letter to the Editor]. N Engl J Med 1990;322:338. PubMed
- Molgaard J, von Schenck H, Olsson AG. Alfalfa seeds lower low density lipoprotein cholesterol and apolipoprotein B concentrations in patients with type II hyperlipoproteinemia. Atherosclerosis 1987;65:173-9. PubMed
- Light TD, Light JA. Acute renal transplant rejection possibly related to herbal medications. Am J Transplant 2003;3:1608-9. PubMed
- Prete PE. The mechanism of action of L-canavanine in inducing autoimmune phenomena. Arthritis Rheum 1985;28:1198-200. PubMed
- Alcocer-Varela J, Iglesias A, Llorente L, Alarcon-Segovia D. Effects of L-canavanine on T cells may explain the induction of systemic lupus erythematosus by alfalfa. Arthritis Rheum 1985;28:52-7. PubMed
- Roberts JL, Hayashi JA. Exacerbation of SLE associated with alfalfa ingestion. N Engl J Med 1983;308:1361. DOI
- Feingold, R. M. Should we fear "health foods"? Arch Intern Med 7-12-1999;159(13):1502. PubMed
- Taormina, P. J., Beuchat, L. R., and Slutsker, L. Infections associated with eating seed sprouts: an international concern. Emerg.Infect.Dis 1999;5(5):626-634. PubMed
- Backer, H. D., Mohle-Boetani, J. C., Werner, S. B., Abbott, S. L., Farrar, J., and Vugia, D. J. High incidence of extra-intestinal infections in a Salmonella Havana outbreak associated with alfalfa sprouts. Public Health Rep. 2000;115(4):339-345. PubMed
- Mohle-Boetani J, Werner B, Polumbo M, and et al. From the Centers for Disease Control and Prevention. Alfalfa sprouts-- Arizona, California, Colorado, and New Mexico, February-April, 2001. JAMA 2-6-2002;287(5):581-582.
- Howard, M. B. and Hutcheson, S. W. Growth dynamics of Salmonella enterica strains on alfalfa sprouts and in waste seed irrigation water. Appl.Environ.Microbiol. 2003;69(1):548-553.
- Winthrop, K. L., Palumbo, M. S., Farrar, J. A., Mohle-Boetani, J. C., Abbott, S., Beatty, M. E., Inami, G., and Werner, S. B. Alfalfa sprouts and Salmonella Kottbus infection: a multistate outbreak following inadequate seed disinfection with heat and chl
- Strapp, C. M., Shearer, A. E., and Joerger, R. D. Survey of retail alfalfa sprouts and mushrooms for the presence of Escherichia coil O157:H7, Salmonella, and Listeria with BAX, and evaluation of this polymerase chain reaction-based system with experimen
- Akaogi, J., Barker, T., Kuroda, Y., Nacionales, D. C., Yamasaki, Y., Stevens, B. R., Reeves, W. H., and Satoh, M. Role of non-protein amino acid L-canavanine in autoimmunity. Autoimmun.Rev 2006;5(6):429-435. PubMed
- Burden and causes of foodborne disease in Australia: Annual report of the OzFoodNet network, 2005. Commun.Dis Intell. 2006;30(3):278-300.
- Shemesh, M., Lindner, H. R., and Ayalon, N. Affinity of rabbit uterine oestradiol receptor for phyto-oestrogens and its use in a competitive protein-binding radioassay for plasma coumestrol. J Reprod.Fertil. 1972;29(1):1-9. PubMed
- Elakovich, S. D. and Hampton, J. M. Analysis of coumestrol, a phytoestrogen, in alfalfa tablets sold for human consumption. J Agric.Food Chem. 1984;32(1):173-175. PubMed
- Malinow, M. R., Bardana, E. J., Jr., Pirofsky, B., Craig, S., and McLaughlin, P. Systemic lupus erythematosus-like syndrome in monkeys fed alfalfa sprouts: role of a nonprotein amino acid. Science 4-23-1982;216(4544):415-417. PubMed
- Malinow, M. R., McLaughlin, P., and Stafford, C. Alfalfa seeds: effects on cholesterol metabolism. Experientia 5-15-1980;36(5):562-564. PubMed
- Farnsworth, N. R. Alfalfa pills and autoimmune diseases. Am J Clin Nutr. 1995;62(5):1026-1028. DOI
- Herbert, V. and Kasdan, T. S. Alfalfa, vitamin E, and autoimmune disorders. Am J Clin Nutr 1994;60(4):639-640.
- Mahon, B. E., Ponka, A., Hall, W. N., Komatsu, K., Dietrich, S. E., Siitonen, A., Cage, G., Hayes, P. S., Lambert-Fair, M. A., Bean, N. H., Griffin, P. M., and Slutsker, L. An international outbreak of Salmonella infections caused by alfalfa sprouts grow
- Gray, A. M. and Flatt, P. R. Pancreatic and extra-pancreatic effects of the traditional anti- diabetic plant, Medicago sativa (lucerne). Br J Nutr. 1997;78(2):325-334.
- Van Beneden, C. A., Keene, W. E., Strang, R. A., Werker, D. H., King, A. S., Mahon, B., Hedberg, K., Bell, A., Kelly, M. T., Balan, V. K., Mac Kenzie, W. R., and Fleming, D. Multinational outbreak of Salmonella enterica serotype Newport infections due to
- Rubenstein AH, Levin NW, and Elliott GA. Manganese-induced hypoglycemia. Lancet 1962;1348-1351.
- Kaufman W. Alfalfa seed dermatitis. JAMA 1954;155(12):1058-1059. PubMed
- Ponka A, Andersson Y, Siitonen A, and et al. Salmonella in alfalfa sprouts. Lancet 1995;345:462-463. PubMed
- Puschner B, Chen X, Read D, Affolter VK. Alfalfa hay induced primary photosensitization in horses. Vet J. 2016 May;211:32-8. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC