Interactions on record — worth a quick check against your medications. Based on 5 of 8 ingredients. Check your meds →
Dietary supplement

Relax Sleep Formula Ingredients & Drug Interactions

by CATALO

Relax Sleep Formula label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Relax Sleep Formula against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Relax Sleep Formula is a dietary supplement by CATALO with 8 active ingredients. Its ingredients are commonly taken for replacing fluids and electrolytes, preventing dehydration during exercise or illness, treating low blood sodium (under medical care).Based on those ingredients, 1,130 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian Extract, Natural, Passionflower Extract, Natural, Suntheanine. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Relax Sleep Formula by CATALO

Ask about any prescription or over-the-counter medication and we check it for interactions with Relax Sleep Formula by CATALO — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Relax Sleep Formula by CATALO

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 5 of its 5 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

This formula has five active ingredients. Sodium is an electrolyte your body needs in small amounts.

Suntheanine (theanine) is an amino acid thought to support relaxation without drowsiness. Cyracos is a standardized lemon balm extract.

Passionflower extract and valerian extract are both herbs traditionally used to promote calm and sleep. The product also contains inactive ingredients — plant cellulose, calcium phosphate, stearic acid, and several other fillers and binders that give the tablet its form.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: reduce stress, promote relaxation and improve sleep.
  • We looked for evidence on: Anxiety, Generalized anxiety disorder (GAD), Stress, Insomnia, Headache, Tension headache — and 4 related terms.
  • The strongest evidence on file: Lemon Balm is rated "Possibly Effective" for Stress (Natural Medicines).
  • Also on file: Valerian is rated "Possibly Effective" for Insomnia.
  • Also on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety, Insomnia.

The evidence for this formula's sleep-support claims is mixed. Valerian and passion flower are each rated possibly effective for insomnia, and passion flower also shows possibly effective evidence for pre-procedural anxiety.

Lemon balm is possibly effective for stress. Theanine is possibly effective for cognitive function, though that's not a sleep claim.

Sodium, valerian, and passion flower all have insufficient evidence for some conditions like anxiety disorders and restless legs. The formula as a whole has not been studied as a combination, so we cannot say how well these ingredients work together.

The evidence, ingredient by ingredient Sodium Theanine Lemon Balm Passion Flower Valerian

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 5 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 5 of 5.
  • General safety write-ups exist for 5 of 5.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Sodium is well tolerated in normal dietary amounts but high intake is linked to high blood pressure and heart strain — avoid sodium supplements without medical advice. Theanine is generally well tolerated short-term in healthy adults but long-term safety isn't well studied; it may cause headaches or drowsiness.

Lemon balm is generally well tolerated for short-term use but can cause dizziness and sedation (though no more often than placebo). Passion flower is generally well tolerated but commonly causes drowsiness, dizziness, and confusion; a rare case of heart rhythm problems was reported.

Valerian is generally well tolerated short-term but may cause dizziness, drowsiness, and vivid dreams; long-term safety is unclear, and abrupt discontinuation after extended use can trigger withdrawal symptoms like anxiety and insomnia — taper slowly if you've used it chronically. Regarding pregnancy and breastfeeding, sodium is rated possibly unsafe; theanine, lemon balm, passion flower, and valerian all lack sufficient safety data, so it's best to avoid them in pregnancy and while breastfeeding unless your doctor advises otherwise.

Side effects, ingredient by ingredient Sodium Theanine Lemon Balm Passion Flower Valerian

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 5 of the 5 matched ingredients can interact with medications — Lemon Balm, Valerian, Passion Flower, Theanine, Sodium.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: lithium.
  • For scale: 1,131 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, verify your blood pressure medications, sleeping pills and other central nervous system depressants, anti-anxiety drugs (especially alprazolam), lithium, corticosteroids, thyroid hormone replacement, and alcohol with your pharmacist. Sodium in this formula is the single biggest concern with blood pressure and other medications listed above.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Relax Sleep Formula may help you wind down, but it's not appropriate if you take blood pressure medications, sleeping pills, anti-anxiety drugs, lithium, corticosteroids, thyroid hormone, or alcohol — all need a conversation with your pharmacist first. If you're pregnant, planning to become pregnant, or breastfeeding, talk to your doctor before using this product.

Check your medications below.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 5 of 5 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Feb 22, 2024.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Relax Sleep Formula, straight from the product label.

Brand CATALO
Net contents 30 Tablet(s); 22.7 Gram(s)
Market status On market
Date entered into DSLD Feb 22, 2024
DSLD ID 303118
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Vegetarian, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Relax Sleep Formula by CATALO, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Tablet(s)
Maximum serving Sizes:
2 Tablet(s)
Servings per container
15
IngredientAmount% DV
Protein0 Gram(s)--
Sodium0.3 mg--
Total Fat0 Gram(s)--
Carbohydrates0.8 Gram(s)--
Saturated Fat0 Gram(s)--
Trans Fat0 Gram(s)--
Sugars0 Gram(s)--
Energy3.4 Kcal--
Suntheanine100 mg--
Cyracos250 mg--
Passionflower Extract, Natural250 mg--
Valerian Extract, Natural250 mg--

Other ingredients: Plant Cellulose, Di-Calcium Phosphate, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Confectioner's Glaze, Hydroxypropyl Cellulose, Hypromellose, Polyethylene Glycol, Carnauba Wax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formula

Clinically proven patented ingredients

CATALO Relax Sleep Formula is made from a proprietary blend of natural ingredients that includes Suntheanine L-Theanine, Natural Lemon Balm extract, natural Passionflower extract and natural Valerian extract. Suntheanine L-Theanine is produced via a patented process, which is clinically proven to promote mental alertness and non-drowsy relaxation through the increase of calming Alpha brain waves. The Cyracos natural Lemon Balm extract is clinically proven to actively reduce stress associated symptoms and initial insomnia. Together with natural Valerian extract as a sleeping aid and natural Passionflower extract, it is a natural, safe, and non-addictive dietary supplement for stress relief and sleeping quality. 1. Ito, K, ET AL. 1998, Nogeikagaku Kaishi, Vol. 72:153. 2. Juneja, L., et al. 1999, Trends Food Sci Tech, Vol. 10,pp.199-204. 3 Cases, J., et al. 2011, Mediterr J Nutr Metab, Vol4, pp.211-218.

Suntheanine cyracos

FDA Statement of Identity

Dietary Supplement

Formulation

Main functions: Reduce stress & promote relaxation without drowsiness Induce sleep and improve quality of sleep Relive gastrointestinal discomfort caused by nervousness

Suitable for: Nervousness or stressful conditions, sleeping difficulty, insomnia, bad quality of sleep, headaches, intestinal discomfort & irritable bowel that caused by nervousness

Made in USA

Suggested/Recommended/Usage/Directions

Serving directions Adults: Take 2 tablets daily, preferably 30 minutes before bedtime

Storage

Storage Keep in a dry and cool place Avoid direct sunlight

Precautions

Pregnant women should consult your healthcare practitioner prior to use

Brand IP Statement(s)

Sutheanine is a registered trademark of Taiyo International, Inc. Cyracos is registered trademark of Naturex, Inc.

Seals/Symbols

cGMP Current Good Manufacturing Practices

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Relax Sleep Formula by CATALO label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Relax Sleep Formula label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Relax Sleep Formula by CATALO

These are the 8 active ingredients this product is made of. Select any to open its full monograph.

Serving size2 Tablet(s) Dosage formTablet Or Pill Servings per container15 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Protein

0 Gram(s) per serving

Sodium

Interacts with
205 drugs
0.3 mg per serving

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets g...

Sodium monograph & interactions

Carbohydrates

0.8 Gram(s) per serving

Energy

3.4 Kcal per serving

Suntheanine

Interacts with
565 drugs
100 mg per serving Form: L-Theanine

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

Suntheanine monograph & interactions

Cyracos

Interacts with
264 drugs
250 mg per serving Form: Lemon Balm Extract, Natural

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold so...

Cyracos monograph & interactions

Passionflower Extract, Natural

Interacts with
836 drugs
250 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passionflower Extract, Natural monograph & interactions

Valerian Extract, Natural

Interacts with
902 drugs
250 mg per serving

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Valerian Extract, Natural monograph & interactions

Other (inactive) ingredients: Plant Cellulose, Di-Calcium Phosphate, Stearic Acid, Croscarmellose Sodium, Magnesium Stearate, Silicon Dioxide, Confectioner's Glaze, Hydroxypropyl Cellulose, Hypromellose, Polyethylene Glycol, Carnauba Wax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Relax Sleep Formula by CATALO Drug Interactions

Want to check YOUR meds against Relax Sleep Formula?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,130Drugs
556 Moderate 574 Minor

Ingredients driving the most interactions

Valerian Extract, Natural 902
Passionflower Extract, Natural 836
Suntheanine 565
Cyracos 264
Sodium 205

Individual Drug Interactions

The ingredients in Relax Sleep Formula interact with 1,130 drugs. Click any drug to see the details.

5 of the 8 ingredients in Relax Sleep Formula interact with drugs. Each result below shows which ingredient is responsible. Valerian Extract, Natural Passionflower Extract, Natural Suntheanine Cyracos Sodium

Each ingredient & the kinds of drugs it affects

For each ingredient in Relax Sleep Formula with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Valerian Extract, Natural6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian Extract, Natural full monograph & interactions

Passionflower Extract, Natural3 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower Extract, Natural full monograph & interactions

Suntheanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
Suntheanine full monograph & interactions

Cyracos2 drug types · 264 drugs

Cns Depressants

Theoretically, concomitant use of lemon balm might have additive effects with CNS depressant drugs.
Lemon balm seems to have CNS depressant activity in animals and in humans.

Likelihood Possible Evidence B
Thyroid Hormone

Theoretically, lemon balm might interfere with thyroid hormone replacement therapy.
In vitro, constituents of lemon balm extract bind to thyroid stimulating hormone (TSH), preventing TSH receptor-binding and leading to the inhibition of TSH-stimulated adenylate cyclase activity. In animals, lemon balm extract has been shown to decrease levels of circulating TSH and inhibit thyroid secretion.

Likelihood Possible Evidence D
Cyracos full monograph & interactions

Sodium7 drug types · 205 drugs

Antihypertensive Drugs

Theoretically, a high intake of dietary sodium might reduce the effectiveness of antihypertensive drugs.
High intake of dietary sodium can increase systolic and diastolic blood pressure. Also, high intake of sodium may necessitate increased use of antihypertensive medications to achieve blood pressure control in some patients, such as those with chronic kidney disease.

Likelihood Probable Evidence A
Corticosteroids

Concomitant use of mineralocorticoids and some glucocorticoids with sodium supplements might increase the risk of hypernatremia.
Mineralocorticoids and some glucocorticoids (corticosteroids) cause sodium retention. This effect is dose-related and depends on mineralocorticoid potency. It is most common with hydrocortisone, cortisone, and fludrocortisone, followed by prednisone and prednisolone.

Likelihood Possible Evidence D
Didanosine (Videx)

Concomitant use of didanosine with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia.
Didanosine formulations contain a significant amount of sodium.

Likelihood Probable Evidence C
Lithium

Altering dietary intake of sodium might alter the levels and clinical effects of lithium.
High sodium intake can reduce plasma concentrations of lithium by increasing lithium excretion. Reducing sodium intake can significantly increase plasma concentrations of lithium and cause lithium toxicity in patients being treated with lithium carbonate. Stabilizing sodium intake is shown to reduce the percentage of patients with lithium level fluctuations above 0.8 mEq/L. Patients taking lithium should avoid significant alterations in their dietary intake of sodium.

Likelihood Probable Evidence B
Sodium Phosphates

Theoretically, concomitant use of sodium phosphate with sodium supplements might increase the risk of hypernatremia.
Use of high doses (> 45 mL in 24 hours) of sodium phosphate, such as those used for bowel cleansing before surgery, can lead to serious electrolyte disturbances, including hypernatremia. The risk of hypernatremia is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Sodium-Containing Drugs

Concomitant use of sodium-containing drugs with additional sodium from dietary or supplemental sources may increase the risk of hypernatremia and long-term sodium-related complications.
The Chronic Disease Risk Reduction (CDRR) intake level of 2.3 grams of sodium daily indicates the intake at which it is believed that chronic disease risk increases for the apparently healthy population. Some medications contain high quantities of sodium. When used in conjunction with sodium supplements or high-sodium diets, the CDRR may be exceeded. Additionally, concomitant use may increase the risk for hypernatremia; this risk is highest in the elderly and people with other risk factors for electrolyte disturbances.

Likelihood Possible Evidence D
Tolvaptan (Samsca)

Theoretically, concomitant use of tolvaptan with sodium might increase the risk of hypernatremia.
Tolvaptan is a vasopressin receptor 2 antagonist that is used to increase sodium levels in patients with hyponatremia. Patients taking tolvaptan should use caution with the use of sodium salts such as sodium chloride.

Likelihood Probable Evidence C
Sodium full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Relax Sleep Formula, from the product label.

CATALO

See all CATALO products
Name
CATALO Natural Health Foods
Street Address
5/F, Suite C-D, 15 Cheung Shun St.
City
Hong Kong
Phone Number
(852) 3556 8686
Web Address
CATALO.com
Pharmacist Counseling Corner

Relax Sleep Formula by CATALO: Common Questions

Does Relax Sleep Formula by CATALO interact with any medications?
Yes. Based on its ingredients, Relax Sleep Formula has a known interaction with 1,130 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Relax Sleep Formula contains 8 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Will this make me drowsy during the day?
Drowsiness is possible — theanine, lemon balm, passion flower, and especially valerian can all cause daytime drowsiness, dizziness, or mental slowness in some people. Start with a low dose to see how you tolerate it, and don't drive or operate machinery until you know how it affects you.
Can I take this if I'm on a blood pressure medication?
Not without checking with your pharmacist first. Sodium in this product can reduce how well your blood pressure medication works, and theanine may lower your blood pressure on its own, creating unpredictable effects. You need personalized advice based on your specific medication and dose.
What is Suntheanine and why is it in a sleep formula?
Suntheanine is a form of theanine, an amino acid that may promote relaxation and calm. It's possibly effective for cognitive function; it's not a typical sleep ingredient like valerian, but it's included here to support overall relaxation.
Is this safe to take long-term?
Long-term safety isn't well studied for most of these ingredients — theanine, lemon balm, passion flower, and valerian all lack solid long-term data. Valerian in particular can cause withdrawal symptoms if you stop abruptly after prolonged use, so you'd need to taper slowly. Talk to your pharmacist about how long you plan to use it.
Can I take this with alcohol?
No. Valerian, passion flower, and lemon balm all can add to alcohol's sedative effects and increase drowsiness and impaired judgment. Avoid alcohol while taking this product.
Is this safe during pregnancy or breastfeeding?
No. Sodium is rated possibly unsafe, and theanine, lemon balm, passion flower, and valerian all lack enough safety data — it's best to avoid this product in pregnancy and while breastfeeding. Talk to your doctor before using if you fall into either group.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Relax Sleep Formula label
Go deeper

The Full Monographs Behind Relax Sleep Formula’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Sodium

Interacts with 205 drugs

Sodium is an essential mineral and electrolyte your body needs to balance fluids, support nerves, and help muscles work. Most people in modern diets get more than enough—often too much—from...

Read the full Sodium monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Lemon Balm

Interacts with 264 drugs

Lemon balm is a gentle, lemon-scented mint-family herb traditionally used to ease stress, support sleep, and calm digestion, and topically for cold sores. Early studies are promising but gen...

Read the full Lemon Balm monograph → Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph →
Sources

Sources & How We Checked

Relax Sleep Formula's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 112 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Sodium 38 references
  1. Garabedian-Ruffalo SM, Ruffalo RL. Drug and nutrient interactions. Am Fam Physician 1986;33:165-74.
  2. Food and Drug Administration Science Background: Safety of Sodium Phosphates Oral Solution. September 17, 2001. Available at: http://www.fda.gov/cder/drug/safety/sodiumphospate.htm
  3. Coton T, Mallaret C, Coilliot C, Carre D, Guisset M. Severe acute ulcerated gastritis induced by salt. Presse Med 2009;38(3):499-500. PubMed
  4. Frings-Meuthen P, Buehlmeier J, Baecker N, et al. High sodium chloride intake exacerbates immobilization-induced bone resorption and protein losses. J Appl Physiol 2011;111(2):537-542. PubMed
  5. Frings-Meuthen P, Baecker N, Heer M. Low-grade metabolic acidosis may be the cause of sodium chloride-induced exaggerated bone resorption. J Bone Miner Res 2008;23(4):517-524. PubMed
  6. Alam S, Johnson AG. A meta-analysis of randomised controlled trials (RCT) among healthy normotensive and essential hypertensive elderly patients to determine the effect of high salt (NaCl) diet of blood pressure. J Hum Hypertens 1999;13(6):367-74.
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Lemon Balm 12 references
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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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