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Dietary supplement

Replenish Now Ingredients & Drug Interactions

by Natrol

Replenish Now label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Replenish Now against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Replenish Now is a dietary supplement by Natrol with 1 active ingredient. Its ingredients are commonly taken for digestive health and balance, diarrhea (including antibiotic-related), vaginal yeast and bacterial infections.Based on those ingredients, 182 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Lactobacillus Acidophilus. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Replenish Now by Natrol

Ask about any prescription or over-the-counter medication and we check it for interactions with Replenish Now by Natrol — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Replenish Now by Natrol

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Replenish Now contains one active ingredient: Lactobacillus acidophilus, a live beneficial bacterium (probiotic) that naturally occurs in the human gut and is intended to support digestive health. The product also contains several inactive ingredients — whey powder, cellulose, gelatin, water, and magnesium stearate — that serve as a base and binder for the capsule.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Replenish digestive and immune health.
  • We looked for evidence on: Antibiotic-associated diarrhea, Bacterial vaginosis, Clostridioides difficile infection, Lactose intolerance, Rotaviral diarrhea, Travelers' diarrhea — and 3 related terms.
  • The strongest evidence on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Antibiotic-associated diarrhea (Natural Medicines).
  • Also on file: Lactobacillus Acidophilus is rated "Possibly Effective" for Bacterial vaginosis.
  • Also on file: Lactobacillus Acidophilus is rated "Insufficient Reliable Evidence To Rate" for Lactose intolerance, Rotaviral diarrhea, Travelers' diarrhea, Vaginal candidiasis, and more.

The evidence for L. acidophilus shows mixed but promising results. It's rated possibly effective for irritable bowel syndrome (IBS), Helicobacter pylori infection, antibiotic-associated diarrhea, and bacterial vaginosis.

It's rated possibly ineffective for atopic disease (allergic conditions). For acute respiratory distress syndrome, there isn't enough reliable evidence to rate how well it works.

The evidence, ingredient by ingredient Lactobacillus Acidophilus

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Lactobacillus acidophilus is generally well tolerated in healthy adults and children. Some people taking it in combination with other probiotics report mild gastrointestinal side effects — things like stomach discomfort, bloating, gas, or diarrhea — but these are uncommon.

Because L. acidophilus is a live organism, there's a theoretical concern it could cause infection in people with weakened immune systems or certain conditions, though this is rare. Talk with your doctor before starting this product, especially if you have a compromised immune system or are at high risk for infection.

Side effects, ingredient by ingredient Lactobacillus Acidophilus

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Lactobacillus Acidophilus.
  • The most serious interaction on file is rated Moderate.
  • For scale: 182 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

If you take antibiotics, check with your pharmacist or doctor before starting this product. Antibiotics can reduce how well the probiotic works if taken at the same time, so you'll need to separate the doses.

Use the medication checker on this page to confirm your specific antibiotic.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Replenish Now is a single-ingredient probiotic that may help with digestive issues like IBS or antibiotic-associated diarrhea. The main thing to watch is timing if you're on antibiotics — you'll need to space them out so the antibiotic doesn't kill off the live bacteria in the supplement.

Check with your doctor or pharmacist about the right schedule for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 23, 2011.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Replenish Now, straight from the product label.

Brand Natrol
Net contents 10 Capsule(s)
Market status On market
Date entered into DSLD Dec 23, 2011
DSLD ID 3571
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Replenish Now by Natrol, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
2 Capsule(s)
Maximum serving Sizes:
2 Capsule(s)
Servings per container
5
IngredientAmount% DV
Lactobacillus Acidophilus200 mg--

Other ingredients: Whey Powder, Cellulose, Gelatin, Water, Magnesium Stearate

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions

Directions: On Friday, Saturday & Sunday (or any 3-day period), take two capsules, once daily, with a meal. For follow-up, take 2 capsules, once daily, with a meal on any 2-day period.

Brand IP Statement(s)

Step 3. Replenish Now(TM)

Contains: (1) Cleanse Now(TM) 10 Capsules (1) Detox Now(TM) 10 Capsules (1) Replenish Now(TM) 10 Capsules

Easy-to-Use This simple program is for busy people who may not find it convenient to follow a complex cleansing program over the duration of several weeks. If you don’t have that kind of time, or need to get results quickly for a special event, consider Natrol(R) AçaíBerry Weekend Cleanse. The 3-day regimen ensures that the cleansing process does not interfere with activities during the week. Start on Friday and be done by Monday morning. Try Natrol(R) AçaíBerry Weekend Cleanse. Smart Cleansing. Serious Results.

Smart Cleansing. Serious Results. AçaíBerry Weekend Cleanse is smart because the three step program supports digestive health quickly and effectively. Step 1. Cleanse Now(TM) Helps minimize occasional constipation and bloating. Step 2. Detox Now(TM) Helps reduce toxins. Provides liver support via antioxidant protection and cell regeneration. Step 3. Replenish Now(TM) Probiotics restore the friendly bacteria that protect and strengthen the GI tract.

Formulation

NO Yeast, Wheat, Corn, Egg, Soy, Glutens, Artificial Colors or Flavors, Added Sugar, Starch or Preservatives

FDA Statement of Identity

Dietary Supplement

Precautions

KEEP OUT OF REACH OF CHILDREN.

FDA Disclaimer Statement

These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

Storage

STORE IN A COOL, DRY PLACE.

General Statements

Cleansing Tips Inside

Easy-to-Use Cleansing Program Helps: ~Detoxify & Promote Waste Elimination ~ Minimize Bloating ~ Promote a Flatter Looking Stomach

NEW

Take this product if you feel that your: ~Jeans are tight around the waist, even if you haven’t gained weight ~Abdomen is bloated & uncomfortable

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Replenish Now by Natrol label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Replenish Now label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Replenish Now by Natrol

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size2 Capsule(s) Dosage formCapsule Servings per container5 Amounts shown are per serving.

Lactobacillus Acidophilus

Interacts with
182 drugs
200 mg per serving

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy p...

Lactobacillus Acidophilus monograph & interactions

Other (inactive) ingredients: Whey Powder, Cellulose, Gelatin, Water, Magnesium Stearate. These complete the product’s ingredient list but are not active constituents.

Interaction report

Replenish Now by Natrol Drug Interactions

Want to check YOUR meds against Replenish Now?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
182Drugs
182 Moderate

Ingredients driving the most interactions

Lactobacillus Acidophilus 182

Individual Drug Interactions

The ingredients in Replenish Now interact with 182 drugs. Click any drug to see the details.

1 of the 1 ingredient in Replenish Now interact with drugs. Each result below shows which ingredient is responsible. Lactobacillus Acidophilus

Each ingredient & the kinds of drugs it affects

For each ingredient in Replenish Now with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Lactobacillus Acidophilus1 drug type · 182 drugs

Antibiotic Drugs

Theoretically, taking Lactobacillus acidophilus with antibiotic drugs might decrease the effectiveness of L. acidophilus.
L. acidophilus preparations usually contain live and active organisms. Therefore, simultaneously taking antibiotics might kill a significant number of the organisms. Tell patients to separate administration of antibiotics and L. acidophilus preparations by at least two hours.

Likelihood Probable Evidence D
Lactobacillus Acidophilus full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Replenish Now, from the product label.

Natrol

See all Natrol products
Name
NATROL, Inc.
City
Chatsworth
State
CA
ZipCode
91311
Phone Number
800.262.8765
Web Address
www.natrol.com
Pharmacist Counseling Corner

Replenish Now by Natrol: Common Questions

Does Replenish Now by Natrol interact with any medications?
Yes. Based on its ingredients, Replenish Now has a known interaction with 182 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Replenish Now contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is Lactobacillus acidophilus?
It's a live beneficial bacterium that naturally lives in your gut. This probiotic is intended to support digestive health and may help with conditions like IBS or diarrhea caused by antibiotics.
Can I take this if I'm on antibiotics?
You can take both, but not at the same time. Antibiotics kill off the live bacteria in the probiotic, so they'll work against each other. Space them a few hours apart — your pharmacist can give you the exact timing based on which antibiotic you're taking.
Does it work for IBS?
Research shows it's possibly effective for irritable bowel syndrome, meaning there's some evidence it may help, but it's not a guaranteed fix. Your results may vary.
Are there side effects?
Most people tolerate it well, but some experience mild digestive upset like bloating, gas, or stomach discomfort when taking it with other probiotics. These side effects are uncommon.
Is it safe during pregnancy?
Lactobacillus acidophilus is rated possibly safe in pregnancy, but there isn't a lot of data. Talk with your doctor or midwife before starting it while pregnant to make sure it's right for you.
Is it safe while breastfeeding?
We don't have safety information on file for breastfeeding. Check with your doctor or lactation consultant before taking it.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Replenish Now is safe with your meds?

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Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Replenish Now label
Go deeper

The Full Monographs Behind Replenish Now’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Lactobacillus Acidophilus

Interacts with 182 drugs

Lactobacillus acidophilus is a 'friendly' bacterium used as a probiotic to support gut and vaginal health. It is generally well tolerated in healthy people, and there is reasonable evidence...

Read the full Lactobacillus Acidophilus monograph →
Sources

Sources & How We Checked

Replenish Now's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 15 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Lactobacillus Acidophilus 15 references
  1. Pierce A. The American Pharmaceutical Association Practical Guide to Natural Medicines. New York: The Stonesong Press, 1999:19.
  2. Begtrup LM, de Muckadell OB, Kjeldsen J, Christensen RD, Jarbøl DE. Long-term treatment with probiotics in primary care patients with irritable bowel syndrome--a randomised, double-blind, placebo controlled trial. Scand J Gastroenterol 2013;48(10):1127-35 PubMed
  3. Chatterjee S, Kar P, Das T, Ray S, Gangulyt S, Rajendiran C, Mitra M. Randomised placebo-controlled double blind multicentric trial on efficacy and safety of Lactobacillus acidophilus LA-5 and Bifidobacterium BB-12 for prevention of antibiotic-associated
  4. Shavakhi A, Tabesh E, Yaghoutkar A, Hashemi H, Tabesh F, Khodadoostan M,Minakari M, Shavakhi S, Gholamrezaei A. The effects of multistrain probiotic compound on bismuth-containing quadruple therapy for Helicobacter pylori infection: a randomized placebo-c
  5. Karamali M, Dadkhah F, Sadrkhanlou M, et al. Effects of probiotic supplementation on glycaemic control and lipid profiles in gestational diabetes: a randomized, double-blind, placebo-controlled trial. Diabetes Metab 2016;42(4):234-41. PubMed
  6. Badehnoosh B, Karamali M, Zarrati M, et al. The effects of probiotic supplementation on biomarkers of inflammation, oxidative stress and pregnancy outcomes in gestational diabetes. J Matern Fetal Neonatal Med. 2018 May;31(9):1128-1136.
  7. Kumar S, Kumar R, Rohilla L, Jacob N, Yadav J, Sachdeva N. A high potency multi-strain probiotic improves glycemic control in children with new-onset type 1 diabetes mellitus: A randomized, double-blind, and placebo-controlled pilot study. Pediatr Diabete
  8. Shahriari A, Karimi E, Shahriari M, Aslani N, Khooshideh M, Arab A. The effect of probiotic supplementation on the risk of gestational diabetes mellitus among high-risk pregnant women: A parallel double-blind, randomized, placebo-controlled clinical trial PubMed
  9. Xiao SD, Zhang DZ, Lu H, et al. Multicenter, randomized, controlled trial of heat-killed Lactobacillus acidophilus LB in patients with chronic diarrhea. Adv Ther. 2003;20(5):253-60.
  10. Rossi F, Amadoro C, Gasperi M, Colavita G. Lactobacilli infection case reports in the last three years and safety implications. Nutrients. 2022;14(6):1178. PubMed
  11. Ozer M, Goksu SY, Shahverdiani A, Mustafa M. Lactobacillus acidophilus-induced endocarditis and associated splenic abscess. Case Rep Infect Dis 2020;2020:1382709.
  12. Sadrin S, Sennoune S, Gout B, et al. A 2-strain mixture of Lactobacillus acidophilus in the treatment of irritable bowel syndrome: A placebo-controlled randomized clinical trial. Dig Liver Dis 2020;52(5):534-540. PubMed
  13. Stoffer JN, Slingsby TJ, Giuliari GP. Lactobacillus acidophilus endophthalmitis after intravitreal bevacizumab injection requiring intraocular lens explantation. Can J Ophthalmol 2022;57(1):e21-e22. PubMed
  14. Cukovic-Cavka S, Likic R, Francetic I, Rustemovic N, Opacic M, Vucelic B. Lactobacillus acidophilus as a cause of liver abscess in a NOD2/CARD15-positive patient with Crohn's disease. Digestion 2006;73(2-3):107-10.
  15. Hui J, Ren Y, Wang Y, Han Q. Lactobacillus acidophilus endophthalmitis postcataract operation: A case report with a literature review. Ocul Immunol Inflamm 2023.

See these in context on the Lactobacillus Acidophilus monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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