Interactions on record — worth a quick check against your medications. Based on 6 of 7 ingredients. Check your meds →
Dietary supplement

Restful Sleep Ingredients & Drug Interactions

by Whole Foods Premier Formula

Restful Sleep label
See full label image
Capsule Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Restful Sleep against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Restful Sleep is a dietary supplement by Whole Foods Premier Formula with 7 active ingredients. Its ingredients are commonly taken for anxiety and stress, trouble sleeping, restlessness.Based on those ingredients, 1,198 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Valerian (Valeriana officinalis) Root Extract, Hops (Humulus lupulus) Flower Extract 6.6:1, Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:1. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

Jump to a section

Check Your Meds Against Restful Sleep by Whole Foods Premier Formula

Ask about any prescription or over-the-counter medication and we check it for interactions with Restful Sleep by Whole Foods Premier Formula — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Restful Sleep by Whole Foods Premier Formula

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Jul 11, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 7 of its 7 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Restful Sleep contains 7 active ingredients. Passionflower and valerian root are traditional herbal sleep aids supported by research showing they may help with insomnia and pre-procedural anxiety.

Hops flower, wild lettuce, and Jamaica dogwood are also included for their sedative properties, though evidence for hops and wild lettuce for sleep is insufficient to rate. L-theanine is an amino acid often used to promote relaxation and cognitive function.

The product also contains three inactive ingredients: a vegetable capsule, magnesium stearate (a binder), and silicon dioxide.

Does it work?

Moderate evidence
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Moderate

Some clinical evidence supports this product's ingredients for its stated purpose, but it isn't conclusive.

Why this rating?
  • The label markets this product for: Get to sleep quickly and improve sleep quality.
  • We looked for evidence on: Insomnia, Anxiety, Stress, Shift work disorder, Restless legs syndrome (RLS), Sleep onset latency — and 2 related terms.
  • The strongest evidence on file: Valerian is rated "Possibly Effective" for Insomnia (Natural Medicines).
  • Also on file: Passion Flower is rated "Possibly Effective" for Pre-procedural anxiety, Insomnia.
  • Also on file: Hops is rated "Insufficient Reliable Evidence To Rate" for Anxiety, Insomnia, Shift work disorder.

Passionflower and valerian root are both rated possibly effective for insomnia and possibly effective for pre-procedural anxiety based on available research. L-theanine is rated possibly effective for cognitive function, though it has insufficient evidence for use in age-related cognitive decline or Alzheimer's disease.

For hops, wild lettuce, and Jamaica dogwood, the evidence we hold does not establish effectiveness for any condition — the data either shows insufficient evidence or no rating.

The evidence, ingredient by ingredient Passion Flower Hops Wild Lettuce Theanine Valerian Jamaican Dogwood

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 5 of the 6 matched ingredients.
  • Pregnancy & breastfeeding safety ratings cover 6 of 6.
  • General safety write-ups exist for 6 of 6.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Passionflower and valerian are generally well tolerated for short-term use but can cause drowsiness, dizziness, and confusion. Valerian commonly causes vivid dreams and mental slowness; if you stop it after extended use, taper slowly to avoid withdrawal symptoms like anxiety and insomnia.

Wild lettuce has limited human safety data, and large amounts can cause sweating, increased heart rate, dizziness, and severe side effects. Jamaica dogwood can be toxic at higher doses.

L-theanine is generally well tolerated but may cause headaches or drowsiness. Hops may cause drowsiness; long-term safety is not well studied.

All ingredients except hops are rated possibly or likely unsafe in pregnancy and should be avoided. None of these ingredients have adequate safety data for breastfeeding.

Side effects, ingredient by ingredient Passion Flower Hops Wild Lettuce Theanine Valerian Jamaican Dogwood

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 6 of the 6 matched ingredients can interact with medications — Wild Lettuce, Jamaican Dogwood, Hops, Valerian, Passion Flower, among others.
  • The most serious interaction on file is rated Moderate.
  • For scale: 1,199 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Double-check any CNS depressants (sleeping pills, anxiety medications, opioids, sedating antihistamines, barbiturates, benzodiazepines like alprazolam) before taking this product — multiple ingredients here can cause additive sedation. Also ask your pharmacist about antihypertensive drugs (blood pressure medications), drugs metabolized through glucuronidation, and anticholinergic medications.

Avoid alcohol while taking this product.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with some supporting evidence for its stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

This product is designed for sleep support using traditional herbal ingredients. If you take sedating medications, antihypertensive drugs, or any prescription drug, check it with a pharmacist before starting — the sedative ingredients here can add to many medications' effects.

Avoid during pregnancy and breastfeeding. Talk to your pharmacist about whether this formula is right for your situation.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 7 of 7 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Restful Sleep, straight from the product label.

Brand Whole Foods Premier Formula
Barcode (UPC) 099482423162
Net contents 30 Vegetarian Capsule(s)
Market status On market
Date entered into DSLD Oct 25, 2013
DSLD ID 26554
Product type Botanical
Supplement form Capsule
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Restful Sleep by Whole Foods Premier Formula, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
1 Capsule(s)
UPC/BARCODE
099482423162
IngredientAmount% DV
Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:190 mg--
Hops (Humulus lupulus) Flower Extract 6.6:130 mg--
Wild Lettuce (Lactuca virosa) leaf extract18 mg--
Wild Lettuce (Lactuca virosa)10 mg--
L-Theanine50 mg--
Valerian (Valeriana officinalis) Root Extract200 mg--
Jamaica Dogwood (Piscidia piscipula) Root Extract12 mg--

Other ingredients: Vegetable Capsule, Magnesium Stearate, Silicon Dioxide

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

THIS STATEMENT HAS NOT BEEN EVALUATED BY THE FOOD AND DRUG ADMINISTRATION. THIS PRODUCT IS NOT INTENDED TO DIAGNOSE, TREAT, CURE, OR PREVENT ANY DISEASE.

General Statements

Get to sleep quickly and naturally, and improve the quality of your sleep with Restful Sleep. Wake up refreshed, energized and ready to take on the day.

PLEASE RECYCLE THIS BOTTLE

Relax and Sleep Wake Up Refreshed

Brand IP Statement(s)

(C) 2007 WHOLE FOOD MARKET IP, LP

Suntheanine(R), a patented form of L-Theanine, is a trademark of Taiyo International, Inc.

Seals/Symbols

{recycle} 1 PETE

100% PCR Post Consumer Recycled Bottle

(Q) WHOLE FOOD MARKET QUALITY STANDARDS

Precautions

Tamper evident; use only if seal is intact.

Produced in a facility that processes tree nuts, milk, egg, wheat, soy, fish, and shellfish ingredients.

Caution: If you are pregnant, lactating, or taking prescription drugs, consult your health care practitioner before using this product.

May impair your ability to drive or operate heavy equipment. Due to additive sedative effect, avoid using with alcohol.

KEEP OUT OF REACH OF CHILDREN.

General

LS93233WF.A04

Suggested/Recommended/Usage/Directions

Directions: Take one capsule 30-60 minutes before bedtime. If additional support is desired, take up to four capsules.

FDA Statement of Identity

DIETARY SUPPLEMENT

Formula

Produced in a facility that processes tree nuts, milk, egg, wheat, soy, fish, and shellfish ingredients.

Formulation

Contains no artificial colors, flavors or preservatives.

Storage

STORE IN A COOL, DRY PLACE.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Restful Sleep by Whole Foods Premier Formula label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Restful Sleep label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Restful Sleep by Whole Foods Premier Formula

These are the 7 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:1

Interacts with
836 drugs
90 mg per serving

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restless...

Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:1 monograph & interactions

Hops (Humulus lupulus) Flower Extract 6.6:1

Interacts with
863 drugs
30 mg per serving

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They ar...

Hops (Humulus lupulus) Flower Extract 6.6:1 monograph & interactions

Wild Lettuce (Lactuca virosa) leaf extract

Interacts with
393 drugs
18 mg per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Wild Lettuce (Lactuca virosa) leaf extract monograph & interactions

Wild Lettuce (Lactuca virosa)

Interacts with
393 drugs
10 mg per serving

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because i...

Wild Lettuce (Lactuca virosa) monograph & interactions

L-Theanine

Interacts with
565 drugs
50 mg per serving

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong dro...

L-Theanine monograph & interactions

Valerian (Valeriana officinalis) Root Extract

Interacts with
902 drugs
200 mg per serving Form: valerenic acids

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some...

Valerian (Valeriana officinalis) Root Extract monograph & interactions

Jamaica Dogwood (Piscidia piscipula) Root Extract

Interacts with
248 drugs
12 mg per serving

Jamaican dogwood is a tree bark traditionally used to promote sleep and ease pain, but high-quality human studies are lacking. It can be toxic in larg...

Jamaica Dogwood (Piscidia piscipula) Root Extract monograph & interactions

Other (inactive) ingredients: Vegetable Capsule, Magnesium Stearate, Silicon Dioxide. These complete the product’s ingredient list but are not active constituents.

Interaction report

Restful Sleep by Whole Foods Premier Formula Drug Interactions

Want to check YOUR meds against Restful Sleep?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,198Drugs
669 Moderate 529 Minor

Ingredients driving the most interactions

Valerian (Valeriana officinalis) Root Extract 902
Hops (Humulus lupulus) Flower Extract 6.6:1 863
Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:1 836
L-Theanine 565
Wild Lettuce (Lactuca virosa) leaf extract 393

Individual Drug Interactions

The ingredients in Restful Sleep interact with 1,198 drugs. Click any drug to see the details.

6 of the 7 ingredients in Restful Sleep interact with drugs. Each result below shows which ingredient is responsible. Valerian (Valeriana officinalis) Root Extract Hops (Humulus lupulus) Flower Extract 6.6:1 Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:1 L-Theanine Wild Lettuce (Lactuca virosa) leaf extract Jamaica Dogwood (Piscidia piscipula) Root Extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Restful Sleep with known interactions, here are the types of medications they can affect. Open any type for the detail — or search your exact drug in the checker above.

Valerian (Valeriana officinalis) Root Extract6 drug types · 902 drugs

Alcohol (Ethanol)

Valerian can have additive sedative effects when used concomitantly with alcohol.
Valerian has sedative effects. Theoretically, valerian might have an additive sedative effect when combined with alcohol. Excessive sedation has been reported in an alcohol-abusing individual who took valerian and Gingko biloba. However, the potential interaction between valerian and alcohol has been disputed in other research. Limited evidence suggests that a combination of valerian 160 mg and lemon balm 80 mg (Euvegal) does not cause further deterioration in reaction ability and reaction rate when taken with alcohol as compared to the effects of alcohol alone.

Likelihood Possible Evidence B
Alprazolam (Xanax)

Valerian can have additive sedative effects when used with alprazolam. Also, valerian in high doses might modestly increase alprazolam levels, though this is not likely to be clinically significant.
Valerian has sedative effects. Theoretically, valerian might cause additive sedation when combined with alprazolam. Also, a small pharmacokinetic study shows that taking valerian extract 1000 mg daily (providing 11 mg valerenic acid) might increase alprazolam levels by about 19%. This might be due to valerian's mild inhibition of cytochrome P450 3A4 (CYP3A4). Despite being statistically significant, this increase is not likely to be clinically significant.

Likelihood Possible Evidence B
Cns Depressants

Valerian can have additive sedative effects when used concomitantly with CNS depressant drugs.
Theoretically, concomitant use of valerian and drugs with sedative and anesthetic properties may cause additive therapeutic and adverse effects.

Likelihood Possible Evidence D
Glucuronidated Drugs

Valerian might weakly inhibit glucuronidation and increase concentrations of drugs metabolized by UGT1A1 and UGT2B7.
In vitro research shows that methanolic valerian extract and valerenic acid might competitively inhibit UDP-glucuronosyltransferase (UGT) 1A1 (UGT1A1) and UGT2B7.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP2D6.
Although some in vitro evidence suggests that valerian affects CYP2D6, clinical pharmacokinetic (PK) studies show that valerian is unlikely to affect the CYP2D6 enzyme. In one PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days did not affect the metabolism of dextromethorphan, a CYP2D6 substrate. In another PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of debrisoquine, an accepted CYP2D6 probe-substrate.

Likelihood Unlikely Evidence B
Cytochrome P450 3A4 (Cyp3A4) Substrates

Valerian does not seem to have a clinically relevant effect on levels of drugs metabolized by CYP3A4.
Although some in vitro evidence suggests that valerian extract might inhibit or induce CYP3A4, clinical pharmacokinetic (PK) studies show that valerian does not have a clinically significant effect on the CYP3A4 enzyme. In one PK study, taking valerian 125 mg three times daily for 28 days did not affect metabolism of midazolam, an accepted CYP3A4 probe-substrate. In another PK study, taking valerian 1000 mg (providing about 11 mg valerenic acid) nightly for 14 days modestly increases levels of alprazolam, a CYP3A4 substrate, suggesting mild inhibition of CYP3A4. However, this mild inhibition is unlikely to be clinically relevant.

Likelihood Possible Evidence B
Valerian (Valeriana officinalis) Root Extract full monograph & interactions

Hops (Humulus lupulus) Flower Extract 6.6:14 drug types · 863 drugs

Cns Depressants

Theoretically, concomitant use of hops with sedative drugs might cause additive sedation.
Some animal research shows that hops has sedative effects.

Likelihood Possible Evidence D
Estrogens

Theoretically, concomitant use of large amounts of hops might interfere with hormone replacement therapy due to competition for estrogen receptors.
In vitro research suggests that certain hops constituents can competitively bind to estrogen receptors. However, most hops extracts contain very small amounts of these constituents.

Likelihood Possible Evidence D
Cytochrome P450 1A2 (Cyp1A2) Substrates

Hops extract does not seem to affect the metabolism of CYP1A2 substrates.
In vitro research suggests that flavonoid constituents of hops inhibit CYP1A2 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, does not affect levels of caffeine, a CYP1A2 probe substrate.

Likelihood Unlikely Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, hops extract might alter metabolism of CYP3A4 substrates; however, this effect may not be clinically significant.
Animal research suggests that specific constituents of hops, called lupulones, can induce hepatic CYP3A4 enzyme activity. However, a pharmacokinetic study in healthy postmenopausal patients with normal metabolism shows that taking a standardized extract of spent hops containing prenylated phenols, as 59.5 mg twice daily for 2 weeks, decreases the concentration of alprazolam, a CYP3A4 probe substrate, by 7.6%. This reduction is unlikely to be clinically relevant.

Likelihood Possible Evidence D
Hops (Humulus lupulus) Flower Extract 6.6:1 full monograph & interactions

Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:13 drug types · 836 drugs

Cns Depressants

Concomitant use of passion flower with sedative drugs might cause additive effects and side effects.
Research in animals and humans shows that passion flower has sedative effects which can be additive when used with sedative medications like lorazepam.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, passion flower might decrease the effects of CYP3A4 substrates.
In vitro research suggests that passion flower can induce CYP3A4 enzymes, albeit to a much lower degree than rifampin, a known CYP3A4 inducer.

Likelihood Possible Evidence D
Organic Anion-Transporting Polypeptide Substrates (Oatp)

Theoretically, passion flower might reduce the bioavailability of OATP2B1 and OATP1A2 substrates.
In vitro research shows that the passion flower constituents apigenin and vitexin inhibit OATP2B1 and OATP1A2. This inhibition may be dose-dependent. One specific high-flavonoid passion flower extract (Valverde) seems to inhibit OATP2B1 and OATP1A2, while another extract with a lower flavonoid concentration (Arkocaps) shows less potent inhibition. OATPs are responsible for the uptake of drugs and other compounds into the body; however, the specific activities of OATP2B1 and OATP1A2 are not well characterized.

Likelihood Possible Evidence D
Passionflower (Passiflora incarnata) Leaf and Flower Extract 4:1 full monograph & interactions

L-Theanine3 drug types · 565 drugs

Antihypertensive Drugs

Theanine might lower blood pressure, potentiating the effects of antihypertensive drugs.
Animal research shows that theanine can lower blood pressure in spontaneously hypertensive animals. Theoretically, concomitant use of theanine and antihypertensive drugs might potentiate the antihypertensive activity.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, theanine might have additive sedative effects when used in conjunction with CNS depressants. However, it is unclear if this concern is clinically relevant.
Theoretically, theanine may compete with glutamate and/or increase plasma gamma-aminobutyric acid (GABA) levels, which could cause CNS depression. In one clinical study, some subjects taking oral theanine reported drowsiness.

Likelihood Unlikely Evidence D
Serotonergic Drugs

Clinical studies regarding the effects of L-theanine on serotonin levels are conflicting. Some studies suggest it can increase serotonin levels in the brain while others report that it may decrease them. Nevertheless, there have been no reports of l-theanine being a causative agent in serotonergic-related side effects or serotonin syndrome.

Likelihood Unlikely Evidence C
L-Theanine full monograph & interactions

Wild Lettuce (Lactuca virosa) leaf extract2 drug types · 393 drugs

Anticholinergic Drugs

Studies report varying evidence on whether or not wild lettuce contains hyoscyamine, an anticholinergic drug. If it does, it appears to be in very low amounts. Nevertheless, there have been case reports of individuals consuming large amounts of wild lettuce experiencing anticholinergic-related side effects, such as constipation, dry mouth, dizziness, and sweating. Therefore, if you are already taking a drug with anticholinergic effects, you should be cautious about combining it with wild lettuce as the risk of side effects may be increased.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, concomitant use with drugs with sedative effects might cause additive therapeutic effects and adverse effects.

Likelihood Possible Evidence D
Wild Lettuce (Lactuca virosa) leaf extract full monograph & interactions

Jamaica Dogwood (Piscidia piscipula) Root Extract1 drug type · 248 drugs

Cns Depressants

Jamaican dogwood may potentiate sedative effects.

Likelihood Possible Evidence D
Jamaica Dogwood (Piscidia piscipula) Root Extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Restful Sleep, from the product label.

Whole Foods Premier Formula

See all Whole Foods Premier Formula products
Name
Whole Foods Market
Street Address
550 Bowie Street
City
Austin
State
TX
ZipCode
78703
Web Address
www.wholefoodsmarket.com
Pharmacist Counseling Corner

Restful Sleep by Whole Foods Premier Formula: Common Questions

Does Restful Sleep by Whole Foods Premier Formula interact with any medications?
Yes. Based on its ingredients, Restful Sleep has a known interaction with 1,198 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Restful Sleep contains 7 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Is this safe to take during pregnancy?
No. Passionflower, wild lettuce, valerian, and L-theanine all lack adequate safety data and are rated best avoided in pregnancy. Jamaica dogwood is rated likely unsafe due to traditional concerns about effects on the uterus and lack of safety data. Talk with your doctor or pharmacist before considering any sleep supplement during pregnancy.
What's the difference between passionflower and valerian — are they the same thing?
No, they're two different plants with different active compounds, but both are sedative herbs included in this formula. Passionflower is possibly effective for insomnia and anxiety, while valerian is also possibly effective for insomnia. Using them together provides a blend of traditional sleep-supporting ingredients.
Can I take this if I'm already on a blood pressure medication?
Maybe, but you need to check first. L-theanine in this product may lower blood pressure and could potentiate your medication's effects. Talk to your pharmacist or doctor before adding this supplement to make sure your dosing stays safe.
Will this make me drowsy during the day?
Possibly. Passionflower, hops, valerian, and L-theanine can all cause drowsiness. If you do try this product, start in the evening and see how you feel before taking it during the day or before activities that require alertness.
What if I need to stop taking this — can I just quit?
If you've been using it for a while, it's better to taper your dose slowly rather than stop suddenly. Valerian in particular can cause withdrawal symptoms like anxiety, insomnia, and irritability if stopped abruptly after extended use.
Does this product have any fillers or other inactive ingredients I should know about?
Yes. Besides the active herbal ingredients, it contains a vegetable capsule, magnesium stearate (a binder), and silicon dioxide. If you have sensitivities to any of these, let your pharmacist know.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Restful Sleep label
Go deeper

The Full Monographs Behind Restful Sleep’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Passion Flower

Interacts with 836 drugs

Passion flower is a traditional calming herb that many people use for anxiety and sleep. Early studies hint it may help with mild anxiety and restlessness, but the evidence is limited and mo...

Read the full Passion Flower monograph → Herb & supplement monograph

Hops

Interacts with 863 drugs

Hops are most often used for sleep and mild anxiety, frequently combined with valerian, but the human evidence is limited and not very strong. They are generally well tolerated when used sho...

Read the full Hops monograph → Herb & supplement monograph

Wild Lettuce

Interacts with 393 drugs

Wild lettuce is a traditional herb used mainly for sleep, anxiety, and pain, but solid human research supporting these uses is very limited. Because its safety is not well studied, it should...

Read the full Wild Lettuce monograph → Herb & supplement monograph

Theanine

Interacts with 565 drugs

Theanine (usually L-theanine) is an amino acid found naturally in tea leaves that many people take to feel calmer and less stressed without strong drowsiness. Early research suggests it may...

Read the full Theanine monograph → Herb & supplement monograph

Valerian

Interacts with 902 drugs

Valerian is an herb whose root is widely used as a natural sleep aid and for calming nerves. The evidence is mixed and often weak, so it may help some people sleep but does not work reliably...

Read the full Valerian monograph → Herb & supplement monograph

Jamaican Dogwood

Interacts with 248 drugs

Jamaican dogwood is a tree bark traditionally used to promote sleep and ease pain, but high-quality human studies are lacking. It can be toxic in larger amounts and should be used cautiously...

Read the full Jamaican Dogwood monograph →
Sources

Sources & How We Checked

Restful Sleep's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 84 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Passion Flower 19 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
  3. Fisher AA, Purcell P, Le Couteur DG. Toxicity of Passiflora incarnata L. J Toxicol Clin Toxicol 2000;38:63-6.
  4. Akhondzadeh S, Naghavi HR, Shayeganpour A, et al. Passionflower in the treatment of generalized anxiety: a pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363-7. PubMed
  5. Farnsworth N, Bingel A, Cordell G, et al. Potential value of plants as sources of new antifertility agents I. J Pharm Sci 1975;64:535-98. DOI
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Hops 15 references
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Wild Lettuce 5 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
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Theanine 6 references
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Valerian 37 references
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  24. Carrasco MC, Vallejo JR, Pardo-de-Santayana M, et al. Interactions of Valeriana officinalis L. and Passiflora incarnata L. in a patient treated with lorazepam. Phytother Res. 2009 Dec;23:1795-6.
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See these in context on the Valerian monograph →

Jamaican Dogwood 2 references
  1. Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
  2. Della, Loggia R., Tubaro, A., and Redaelli, C. [Evaluation of the activity on the mouse CNS of several plant extracts and a combination of them]. Riv.Neurol. 1981;51(5):297-310.

See these in context on the Jamaican Dogwood monograph →

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DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

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