Major interaction on record — check this product against your medications before combining. Based on 1 of 3 ingredients. Check your meds →
Dietary supplement

RNA 100/DNA 100 Ingredients & Drug Interactions

by Solgar

RNA 100/DNA 100 label
See full label image
Tablet Or Pill Category: Other Combinations
Most serious interaction: Major
Clinical methodology reviewed by · Updated Sep 16, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking RNA 100/DNA 100 against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Major

RNA 100/DNA 100 is a dietary supplement by Solgar with 3 active ingredients. Its ingredients are commonly taken for source of b vitamins, diarrhea (certain types), cold and flu support.Based on those ingredients, 136 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Debittered Brewer's Yeast. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against RNA 100/DNA 100 by Solgar

Ask about any prescription or over-the-counter medication and we check it for interactions with RNA 100/DNA 100 by Solgar — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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Computed from our clinical databases

HelloPharmacist Scorecard of RNA 100/DNA 100 by Solgar

Four independent checks of what is known — a summary of the available information, not a grade of the product itself.

Evidence for Intended Use
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

The stated purpose hasn't been mapped to our evidence data yet.

Why this rating?
  • We haven't mapped this product's purpose to our evidence data yet — it'll be graded on the next content refresh.
Ingredient Transparency
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 3 of its 3 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.
Known Interaction Concern
Major identified

At least one ingredient has a documented Major-severity interaction. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Brewer's Yeast.
  • The most serious interaction on file is rated Major.
  • Some involve high-stakes drug classes: diabetes medications; lithium.
  • For scale: 136 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.
Safety Information
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

HelloPharmacist summaryFully disclosed formula with no assessable stated purpose. Major medication interactions have been identified, and safety information is well characterized.

Assessment coverage: 1 of 3 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Oct 21, 2017.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about RNA 100/DNA 100, straight from the product label.

Brand Solgar
Barcode (UPC) 033984023208
Net contents 100 Tablet(s)
Market status Off market
Date entered into DSLD Oct 21, 2017
DSLD ID 79645
Product type Other Combinations
Supplement form Tablet Or Pill
Dietary claims / uses All Other
Intended target group(s) Vegetarian, Adult (18 - 50 Years), Dairy Free, Sugar Free
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for RNA 100/DNA 100 by Solgar, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Tablet(s)
Maximum serving Sizes:
1 Tablet(s)
UPC/BARCODE
033984023208
IngredientAmount% DV
Debittered Brewer's Yeast525 mg--
RNA100 mg--
DNA100 mg--

Other ingredients: Vegetable Cellulose, Stearic Acid, Silica

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation

Free Of: Dairy, soy, sugar, sodium, artificial flavor, sweetener, preservatives and color.

Suitable for vegetarians

Brand IP Statement(s)

2013 Solgar, Inc.

General

SOLGB72320 01B

General Statements

Since 1947

Brewer's yeast is derived from wheat.

FDA Statement of Identity

Dietary Supplement

Suggested/Recommended/Usage/Directions

Suggested Use: As a dietary supplement for adults, take one (1) tablet daily, preferably with a meal, or as directed by a healthcare practitioner.

Precautions

If you are pregnant, nursing, taking any medications or have any medical condition, please consult your healthcare practitioner before taking any dietary supplement.

Avoid this product if you are allergic to yeast.

Discontinue use and consult your healthcare practitioner if any adverse reactions occur.

Keep out of reach of children.

Do not use if outer bottle seal is missing or damaged.

Storage

Store at room temperature.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

RNA 100/DNA 100 by Solgar label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

RNA 100/DNA 100 label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in RNA 100/DNA 100 by Solgar

These are the 3 active ingredients this product is made of. Select any to open its full monograph.

Serving size1 Tablet(s) Dosage formTablet Or Pill Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Debittered Brewer's Yeast

Interacts with
136 drugs
525 mg per serving

Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S. boulardii) is used for some...

Debittered Brewer's Yeast monograph & interactions

RNA

100 mg per serving Form: Ribonucleic Acid

DNA

100 mg per serving Form: Deoxyribonucleic Acid

Other (inactive) ingredients: Vegetable Cellulose, Stearic Acid, Silica. These complete the product’s ingredient list but are not active constituents.

Interaction report

RNA 100/DNA 100 by Solgar Drug Interactions

RNA 100/DNA 100 contains 3 ingredients, and 1 of them has known drug interactions. Altogether it interacts with 136 medications. Here’s the picture, then you can look up your own drug.

Want to check YOUR meds against RNA 100/DNA 100?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
136Drugs
9 Major 87 Moderate 40 Minor

Ingredients driving the most interactions

Debittered Brewer's Yeast 136

Individual Drug Interactions

The ingredients in RNA 100/DNA 100 interact with 136 drugs. Click any drug to see the details.

1 of the 3 ingredients in RNA 100/DNA 100 interact with drugs. Each result below shows which ingredient is responsible. Debittered Brewer's Yeast

Each ingredient & the kinds of drugs it affects

For each ingredient in RNA 100/DNA 100 with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Debittered Brewer's Yeast4 drug types · 136 drugs

Monoamine Oxidase Inhibitors (Maois)

Theoretically, taking brewer's yeast with MAOIs might increase the risk of hypertension.
Brewer's yeast contains tyramine. Taking brewer's yeast with MAOIs might increase the risk for hypertensive crisis.

Likelihood Likely Evidence D
Antidiabetes Drugs

Taking brewer's yeast with antidiabetes drugs might increase the risk of hypoglycemia.
Clinical research shows that taking chromium-containing brewer's yeast can decrease levels of blood glucose in diabetic patients being treated with antidiabetes drugs.

Likelihood Possible Evidence B
Lithium

Theoretically, taking brewer's yeast with lithium might cause additive effects and side effects.
Some brewer's yeast products contains lithium.

Likelihood Possible Evidence D
Antifungals

Theoretically, taking antifungals with some brewer's yeast products might decrease the effectiveness of brewer's yeast.
Some brewer's yeast products contain live yeast. Therefore, simultaneously taking antifungals might kill a significant number of the organisms.

Likelihood Possible Evidence D
Debittered Brewer's Yeast full monograph & interactions
The maker

Brand information

Manufacturer and brand details for RNA 100/DNA 100, from the product label.

Solgar

See all Solgar products
Name
Solgar, Inc.
Street Address
500 Willow Tree Road
City
Leonia
State
NJ
ZipCode
07605
Phone Number
1-877-765-4274
Web Address
www.solgar.com
Pharmacist Counseling Corner

RNA 100/DNA 100 by Solgar: Common Questions

Does RNA 100/DNA 100 by Solgar interact with any medications?
Yes. Based on its ingredients, RNA 100/DNA 100 has a known interaction with 136 medications, including 9 rated major. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
RNA 100/DNA 100 contains 3 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if RNA 100/DNA 100 is safe with your meds?

Our pharmacists answer your medication & supplement questions — free.

Ask a pharmacist

Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

RNA 100/DNA 100 label
Go deeper

The Full Monographs Behind RNA 100/DNA 100’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Brewer's Yeast

Interacts with 136 drugs

Brewer's yeast is a nutrient-rich fungus that provides B vitamins, protein, and minerals, and a related yeast product (S. boulardii) is used for some types of diarrhea. Most other health cla...

Read the full Brewer's Yeast monograph →
Sources

Sources & How We Checked

RNA 100/DNA 100's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 6 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Brewer's Yeast 6 references
  1. Blumenthal M, ed. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Trans. S. Klein. Boston, MA: American Botanical Council, 1998.
  2. Lewis SJ, Freedman AR. Review article: the use of biotherapeutic agents in the prevention and treatment of gastrointestinal disease. Aliment Pharmacol Ther 1998;12:807-22. PubMed
  3. Bahijiri, S. M., Mira, S. A., Mufti, A. M., and Ajabnoor, M. A. The effects of inorganic chromium and brewer's yeast supplementation on glucose tolerance, serum lipids and drug dosage in individuals with type 2 diabetes. Saudi.Med.J. 2000;21(9):831-837. DOI
  4. Schrauzer, G. N. and de, Vroey E. Effects of nutritional lithium supplementation on mood. A placebo-controlled study with former drug users. Biol.Trace Elem.Res. 1994;40(1):89-101. PubMed
  5. Gayathri R, Aruna T, Malar S, Shilpa B, Dhanasekar KR. Efficacy of Saccharomyces cerevisiae CNCM I-3856 as an add-on therapy for irritable bowel syndrome. Int J Colorectal Dis. 2020;35(1):139-145. PubMed
  6. Mourey F, Decherf A, Jeanne JF, et al. Saccharomyces cerevisiae I-3856 in irritable bowel syndrome with predominant constipation. World J Gastroenterol 2022;28(22):2509-2522.

See these in context on the Brewer's Yeast monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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