Aloe Vera Ingredients & Drug Interactions
by Solgar
What is this page for?
First and foremost: checking Aloe Vera against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Aloe Vera is a dietary supplement by Solgar with 2 active ingredients. Its ingredients are commonly taken for minor burns and skin irritation, wound healing, constipation.Based on those ingredients, 461 medications have a known interaction with it, the most serious rated major. The ingredients most likely to interact are Aloe vera extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Aloe Vera by Solgar
Ask about any prescription or over-the-counter medication and we check it for interactions with Aloe Vera by Solgar — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
Ask the Pharmacist
A licensed pharmacist will answer your question by email — free, usually within 24 hours.
Got it — thank you!
A licensed pharmacist will answer within 24 hours. Keep an eye on your email (worth checking spam, just in case).
HelloPharmacist Scorecard of Aloe Vera by Solgar
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
Solgar's Aloe Vera capsule contains two active ingredients: aloe vera extract and aloe vera powder. Both deliver the plant's compounds, which are traditionally used to support digestive health and skin wellness.
The capsule also holds inactive ingredients—vegetable cellulose, microcrystalline cellulose, vegetable magnesium stearate, and stearic acid—which are common binding and capsule materials.
Does it work?
Moderate evidence
The evidence behind aloe vera for several uses is classed as Possibly Effective in our data. That includes acne, obesity, diabetes, psoriasis, burns, and constipation.
Possibly Effective means preliminary research is promising, but larger, more rigorous trials are needed to be certain. This product is not a substitute for medical care if you have any of these conditions.
How safe is it?
Well-documented data
Aloe products are generally well tolerated at typical doses, but oral aloe latex—the yellow compound inside the leaf—carries a higher risk of side effects, especially at high doses or with long-term use. Common effects orally include abdominal pain, cramps, and diarrhea.
Long-term overuse can lead to serious problems: potassium loss (hypokalemia), muscle weakness, irregular heartbeat, and pigment spots in the bowel lining (pseudomelanosis coli), which usually reverse once you stop. The safety data advises against taking aloe by mouth during pregnancy because it may stimulate the uterus and act as a strong laxative.
Avoid it while breastfeeding as well—there isn't enough safety data and the laxative effects are a concern.
Meds to double-check
Major interaction found
Before you take Solgar's Aloe Vera, double-check if you're on digoxin or other heart rhythm medications (Major severity), then blood thinners or warfarin, diabetes drugs, water pills, or stimulant laxatives (all Moderate). Aloe can also weaken some medications that your liver processes, like certain antidepressants and pain relievers (Minor severity).
Use the medication search tool on this page with your exact prescriptions.
The bottom line
Scorecard at a glanceFully disclosed formula with some supporting evidence behind its ingredients' uses. Major medication interactions have been identified, and safety information is well characterized.
Aloe vera works best if you're looking at preliminary evidence for digestive support or skin health and you don't take heart, blood-thinning, diabetes, or water-pill medications. If you're on any prescription, check it against our medication tool first.
Talk to your pharmacist before starting, especially if you're pregnant, breastfeeding, or taking anything daily.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 2 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 23, 2020.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Aloe Vera, straight from the product label.
| Brand | Solgar |
|---|---|
| Barcode (UPC) | 033984037380 |
| Net contents | 100 Vegetable Capsule(s) |
| Market status | On market |
| Date entered into DSLD | Apr 23, 2020 |
| DSLD ID | 218865 |
| Product type | Botanical |
| Supplement form | Capsule |
| Dietary claims / uses | All Other |
| Intended target group(s) | Vegetarian, Adult (18 - 50 Years), Gluten Free, Dairy Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Aloe Vera by Solgar, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Aloe vera extract | 1.2 mg | -- |
| Aloe vera powder | 308 mg | -- |
Other ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Stearic Acid
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Formulation
Solgar Full Potency Herbs include traditional herbal extracts in a base of active herbs to ensure that the full benefits are derived from the herbs. These products combine the advantages of both herbs and their active principles in the form of dry extracts. Our herbal formulas are specially prepared to include all the naturally occurring, synergistic constituents of the herb and not just selected, isolated active phytochemicals. Solgar’s herbal products offer the highest quality, purest herbs available worldwide.
Suitable for vegetarians
Free of: Gluten, wheat, dairy, soy, yeast, sugar, sodium, artificial flavor, sweetener, preservatives and color.
Brand IP Statement(s)
2014 Solgar, Inc.
General Statements
Solgar since 1947
Formula
Full potency herbs (Aloe barbadensis)
Solgar's KOF-K certification #K-1250
FDA Statement of Identity
Dietary Supplement
Seals/Symbols
K Parve (Kosher)
Suggested/Recommended/Usage/Directions
Suggested Use: As a dietary supplement for adults, take one (1) vegetable capsule one to two times daily, preferably with meals or as directed by a healthcare practitioner.
Precautions
Notice: This product contains Aloe Vera (Aloe barbadensis). Read and follow directions carefully. Do not use if you have or develop diarrhea, loose stools, or abdominal pain because Aloe Vera may worsen these conditions and be harmful to your health.
Consult your physician if you have frequent diarrhea or if you are pregnant, nursing, taking medication, or have a medical condition.
Limit use to no more than 1 to 2 weeks.
Not Intended for use by persons under the age of 18. Keep out of reach of children.
Do not use if outer bottle seal is missing or damaged.
Storage
Store at room temperature.
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Aloe Vera by Solgar label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Aloe Vera by Solgar
These are the 2 active ingredients this product is made of. Select any to open its full monograph.
Serving size1 Vegetarian Capsule(s) Dosage formCapsule Amounts shown are per serving.
Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.
Aloe vera extract
Interacts with461 drugs
Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...
Aloe vera extract monograph & interactionsAloe vera powder
Interacts with461 drugs
Aloe vera gel is widely used on the skin for minor burns and irritation, and some research suggests it may help. Aloe latex (the yellow part) is a str...
Aloe vera powder monograph & interactionsOther (inactive) ingredients: Vegetable Cellulose, Microcrystalline Cellulose, Vegetable Magnesium Stearate, Stearic Acid. These complete the product’s ingredient list but are not active constituents.
Aloe Vera by Solgar Drug Interactions
HelloPharmacist Interaction Report
Solgar's Aloe Vera has documented interactions with several important medication types, and the most serious one is with digoxin (a heart rhythm medication).
Aloe can increase potassium loss from your body, which raises the risk of digoxin toxicity and serious side effects. This is a Major interaction and worth discussing with your doctor or pharmacist before you start.
Read the full breakdown — every affected drug type, severity by severity
Aloe also interacts with blood thinners (anticoagulants and antiplatelet drugs) at Moderate severity — it may increase bleeding risk. If you take warfarin specifically, aloe's laxative effect can cause diarrhea, which boosts warfarin's strength and bleeding risk.
You'll also want to check if you're on diabetes medications, water pills (diuretics), or stimulant laxatives; aloe interacts with all three at Moderate severity. With diabetes drugs, aloe may lower blood sugar too far.
With diuretics and laxatives, it compounds the loss of fluid and electrolytes, especially potassium.
Aloe also induces a liver enzyme (CYP1A2) that clears certain medications, which may weaken them — this is Minor severity but worth knowing. Altogether, these interactions span 460 individual medications.
Use the medication checker on this page to look up your exact prescriptions before you take this product.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Aloe Vera?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Aloe Vera interact with 461 drugs. Click any drug to see the details.
1 of the 2 ingredients in Aloe Vera interact with drugs. Each result below shows which ingredient is responsible. Aloe vera extract
DigoxinDigitek, Lanoxicaps, Lanoxin
How Digoxin interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderDigoxin (lanoxin) Major
Interaction Summary
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Read the full Aloe Vera Powder + Digoxin interactionAbciximabReoPro
How Abciximab interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Abciximab interactionAbrocitinibCibinqo
How Abrocitinib interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Abrocitinib interactionAcarboseGlucobay, Prandase, Precose
How Acarbose interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Powder + Acarbose interactionAcenocoumarolSintrom
How Acenocoumarol interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Acenocoumarol interactionAcetaminophen, AspirinGemnisyn
How Acetaminophen, Aspirin interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderCytochrome P450 1a2 (cyp1a2) Substrates, Anticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe Vera Powder + Acetaminophen, Aspirin interactionAcetaminophen, Aspirin, CaffeineExcedrin, Excedrin Extra Strength, Excedrin Migraine
How Acetaminophen, Aspirin, Caffeine interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Acetaminophen, Aspirin, Caffeine interactionAcetaminophen, Caffeine, PyrilamineMidol Max Strength Menstrual
How Acetaminophen, Caffeine, Pyrilamine interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe Vera Powder + Acetaminophen, Caffeine, Pyrilamine interactionAcetaminophen, IbuprofenCombogesic
How Acetaminophen, Ibuprofen interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Acetaminophen, Ibuprofen interactionAcetaminophen, Pamabrom, PyrilamineMidol Max Strength PMS, Pamprin, Pamprin ES
How Acetaminophen, Pamabrom, Pyrilamine interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderCytochrome P450 1a2 (cyp1a2) Substrates, Diuretic Drugs Moderate
Interaction Summary
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
Read the full Aloe Vera Powder + Acetaminophen, Pamabrom, Pyrilamine interactionAcetazolamideAk-Zol, Diamox
How Acetazolamide interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Powder + Acetazolamide interactionAcetohexamideDymelor
How Acetohexamide interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Powder + Acetohexamide interactionAcetylsalicylic AcidEntrophen
How Acetylsalicylic Acid interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Acetylsalicylic Acid interactionAlbiglutideTanzeum
How Albiglutide interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Powder + Albiglutide interactionAlogliptinNesina
How Alogliptin interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Powder + Alogliptin interactionAlogliptin, MetforminKazano
How Alogliptin, Metformin interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Powder + Alogliptin, Metformin interactionAlogliptin, PioglitazoneOseni
How Alogliptin, Pioglitazone interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Powder + Alogliptin, Pioglitazone interactionAlteplase, TpaActilyse, Activase
How Alteplase, Tpa interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Alteplase, Tpa interactionAluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium HydroxideAscriptin Codeine #2
How Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Aluminum Hydroxide, Aspirin, Codeine Phosphate, Magnesium Hydroxide interactionAluminum Hydroxide, Aspirin, Magnesium HydroxideAscriptin
How Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Aluminum Hydroxide, Aspirin, Magnesium Hydroxide interactionAmiloride, HydrochlorothiazideAmil-Co, Amilzide, Moduret 25, Moduretic
How Amiloride, Hydrochlorothiazide interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Powder + Amiloride, Hydrochlorothiazide interactionAmmonium ChlorideAmmonium Chloride
How Ammonium Chloride interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderDiuretic Drugs Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Read the full Aloe Vera Powder + Ammonium Chloride interactionAnacaulase-bcdbNexoBrid
How Anacaulase-bcdb interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Anacaulase-bcdb interactionAnagrelideAgrylin
How Anagrelide interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs, Cytochrome P450 1a2 (cyp1a2) Substrates Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Anagrelide interactionAnisindioneMiradon
How Anisindione interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Anisindione interactionAntidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) InhibitorGlyxambi
How Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAntidiabetes Drugs Moderate
Interaction Summary
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Read the full Aloe Vera Powder + Antidiabetes, Dipeptidyl Peptidase-4 (dpp-iv) Inhibitor interactionAntithrombin IiiThrombate III
How Antithrombin Iii interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Antithrombin Iii interactionApixabanEliquis
How Apixaban interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Apixaban interactionArgatrobanArgatroban
How Argatroban interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderAnticoagulant/antiplatelet Drugs Moderate
Interaction Summary
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
Read the full Aloe Vera Powder + Argatroban interactionArmodafinilNuvigil
How Armodafinil interacts with Aloe Vera — through 1 ingredient. Tap an ingredient for the detail:
Aloe Vera PowderStimulant Laxatives Moderate
Interaction Summary
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Read the full Aloe Vera Powder + Armodafinil interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Aloe Vera with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Aloe vera extract
Digoxin (Lanoxin)
Theoretically, aloe latex might increase the risk of adverse effects when taken with cardiac glycosides.
Overuse of aloe latex can increase the risk of adverse effects from cardiac glycoside drugs, such as digoxin, due to potassium depletion. Overuse of aloe, along with cardiac glycoside drugs, can increase the risk of toxicity.
Anticoagulant/Antiplatelet Drugs
Theoretically, aloe gel might increase the risk of bleeding when taken with anticoagulant or antiplatelet drugs.
In vitro research shows that aloe gel can inhibit platelet aggregation. This inhibition was greater than that seen with celecoxib, but less than that seen with aspirin.
Antidiabetes Drugs
Aloe might increase the risk of hypoglycemia when taken with antidiabetes drugs.
Preliminary clinical research suggests aloe gel might lower blood glucose levels and have additive effects when used with antidiabetes drugs. Monitor blood glucose levels closely.
Diuretic Drugs
Theoretically, aloe latex might increase the risk of hypokalemia when taken with diuretic drugs.
Overuse of aloe latex might compound diuretic-induced potassium loss, increasing the risk of hypokalemia.
Stimulant Laxatives
Theoretically, aloe latex might increase the risk for fluid and electrolyte loss when taken with stimulant laxatives.
Due to cathartic laxative effects of aloe latex, concomitant use with other stimulant laxatives might compound fluid and electrolyte loss.
Warfarin (Coumadin)
Theoretically, aloe latex might increase the risk of bleeding when taken with warfarin.
Aloe latex has stimulant laxative effects. In some people aloe latex can cause diarrhea. Diarrhea can increase the effects of warfarin, increase international normalized ratio (INR), and increase the risk of bleeding. Advise patients who take warfarin not to take excessive amounts of aloe vera.
Cytochrome P450 1A2 (Cyp1A2) Substrates
Theoretically, aloe might decrease the levels and clinical effects of CYP1A2 substrates.
In vitro research shows that aloe extract induces CYP1A2 enzymes.
Brand information
Manufacturer and brand details for Aloe Vera, from the product label.
Solgar
See all Solgar products- Name
- Solgar, Inc.
- Street Address
- 500 Willow Tree Road
- City
- Leonia
- State
- NJ
- ZipCode
- 07605
- Phone Number
- 1-877-765-4274
- Web Address
- www.solgar.com
Aloe Vera by Solgar: Common Questions
Does Aloe Vera by Solgar interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Can I take this if I'm pregnant or breastfeeding?
What are the most common side effects?
Does aloe vera actually work for constipation or blood sugar?
Why does this interact with so many medications?
Is this safe to take long-term?
What's the difference between aloe latex and aloe gel?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Aloe Vera is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Aloe Vera’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Aloe Vera's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 41 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Aloe 41 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- Wichtl MW. Herbal Drugs and Phytopharmaceuticals. Ed. N.M. Bisset. Stuttgart: Medpharm GmbH Scientific Publishers, 1994.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Nusko G, Schneider B, Schneider I, et al. Anthranoid laxative use is not a risk factor for colorectal neoplasia: results of a prospective case control study. Gut 2000;46:651-5. PubMed
- Luyckx VA, Ballantine R, Claeys M, et al. Herbal remedy-associated acute renal failure secondary to Cape aloes. Am J Kidney Dis 2002;39:E13. PubMed
- Rajasekaran S, Sivagnanam K, Ravi K, Subramanian S. Hypoglycemic effect of Aloe vera gel on streptozotocin-induced diabetes in experimental rats. J Med Food 2004;7:61-6.
- Williams MS, Burk M, Loprinzi CL, et al. Phase III double-blind evaluation of an aloe vera gel as a prophylactic agent for radiation-induced skin toxicity. Int J Radiat Oncol Biol Phys 1996;36:345-9. PubMed
- Vogler BK, Ernst E. Aloe vera: a systematic review of its clinical effectiveness. Br J Gen Pract 1999;49:823-8.
- Bottenberg MM, Wall GC, Harvey RL, Habib S. Oral aloe vera-induced hepatitis. Ann Pharmacother 2007;41:1740-3. PubMed
- Rabe C, Musch A, Schirmacher P, et al. Acute hepatitis induced by an Aloe vera preparation: a case report. World J Gastroenterol 2005;11:303-4. PubMed
- Kanat O, Ozet A, Ataergin S. Aloe vera-induced acute toxic hepatitis in a healthy young man. Eur J Int Med 2006;17:589. PubMed
- Mueller SO, Stopper H. Characterization of the genotoxicity of anthraquinones in mammalian cells. Biochim Biophys Acta 1999;1428:406-14. PubMed
- Schorkhuber M, Richter M, Dutter A, et al. Effect of anthraquinone laxatives on the proliferation and urokinase secretion of normal, premalignant and malignant colonic epithelial cells. Eur J Cancer 1998;34:1091-8. PubMed
- Yang HN, Kim DJ, Kim YM, et al. Aloe-induced toxic hepatitis. J Korean Med Sci 2010;25:492-5. PubMed
- Choonhakarn C, Busaracome P, Sripanidkulchai B, et al. A prospective, randomized clinical trial comparing topical aloe vera with 0.1% triamcinolone acetonide in mild to moderate plaque psoriasis. J.Eur.Acad.Dermatol.Venereol. 2010;24:168-72. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. IV. Mechanism of cathartic effect. (3). Biol Pharm Bull. 1994;17:495-7. PubMed
- Ishii Y, Tanizawa H, Takino Y. Studies of aloe. V. Mechanism of cathartic effect. (4). Biol Pharm Bull. 1994;17:651-3. PubMed
- Nelemans FA. Clinical and toxicological aspects of anthraquinone laxatives. Pharmacology. 1976;14 Suppl 1:73-7. PubMed
- Paulsen E, Korsholm L, Brandrup F. A double-blind, placebo-controlled study of a commercial Aloe vera gel in the treatment of slight to moderate psoriasis vulgaris. J Eur Acad Dermatol Venereol. 2005;19:326-31.
- Huseini HF, Kianbakht S, Hajiaghaee R, et al. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med. 2012;78:311-6
- Ferreira, M., Teixeira, M., Silva, E., and Selores, M. Allergic contact dermatitis to Aloe vera. Contact Dermatitis 2007;57(4):278-279.
- Choonhakarn, C., Busaracome, P., Sripanidkulchai, B., and Sarakarn, P. The efficacy of aloe vera gel in the treatment of oral lichen planus: a randomized controlled trial. Br J Dermatol 2008;158(3):573-577. PubMed
- Baretta, Z., Ghiotto, C., Marino, D., and Jirillo, A. Aloe-induced hypokalemia in a patient with breast cancer during chemotherapy. Ann.Oncol. 2009;20(8):1445-1446. PubMed
- Hunter, D. and Frumkin, A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis 1991;47(3):193-196.
- Alvarez-Perea, A., Garcia, A. P., Hernandez, A. L., de, Barrio M., and Baeza, M. L. Urticaria due to aloe vera: a new sensitizer? Ann.Allergy Asthma Immunol. 2010;105(5):404-405. PubMed
- Hogan, D. J. Widespread dermatitis after topical treatment of chronic leg ulcers and stasis dermatitis. CMAJ. 2-15-1988;138(4):336-338.
- Savchak VI. Acute bullous allergic dermatitis due to local application of aloe leaves. Vestnik Dermatologii i Venerologii 1977;12:44-45.
- Nakamura, T. and Kotajima, S. Contact dermatitis from aloe arborescens. Contact Dermatitis 1984;11(1):51. PubMed
- Shoji, A. Contact dermatitis to Aloe arborescens. Contact Dermatitis 1982;8(3):164-167. PubMed
- Morrow, D. M., Rapaport, M. J., and Strick, R. A. Hypersensitivity to aloe. Arch Dermatol. 1980;116(9):1064-1065. DOI
- Cosmetic Ingredient Review Expert Panel. Final report on the safety assessment of AloeAndongensis Extract, Aloe Andongensis Leaf Juice,aloe Arborescens Leaf Extract, Aloe Arborescens Leaf Juice, Aloe Arborescens Leaf Protoplasts, Aloe Barbadensis Flower E
- Bhalang K, Thunyakitpisal P, Rungsirisatean N. Acemannan, a polysaccharide extracted from Aloe vera, is effective in the treatment of oral aphthous ulceration. J Altern Complement Med 2013;19(5):429-34.
- Hajheydari Z, Saeedi M, Morteza-Semnani K, Soltani A. Effect of Aloe vera topical gel combined with tretinoin in treatment of mild and moderate acne vulgaris: a randomized, double-blind, prospective trial. J Dermatolog Treat 2014;25(2):123-9.
- Jiménez-Encarnación E, Ríos G, Muñoz-Mirabal A, Vilá LM. Euforia-induced acute hepatitis in a patient with scleroderma. BMJ Case Rep 2012;2012. PubMed
- Lee J, Lee MS, Nam KW. Acute toxic hepatitis caused by an aloe vera preparation in a young patient: a case report with a literature review. Korean J Gastroenterol 2014;64(1):54-8. PubMed
- Guo X, Mei N. Aloe Vera - A Review of Toxicity and Adverse Clinical Effects. J Environ Sci Health C Environ Carcinog Ecotoxicol Rev 2016;34(2):77-96.
- Hoogenboom TCH, Patel N, Cook NA, Williams R, Taylor-Robinson SD, Lim AKP. The effect of Aloe vera juice on liver enzymes and hepatic structure in a healthy population. Integr Med (Encinitas) 2020;19(3):30-4.
- Mushtaq S, Mushtaq Z, Sarfraz J, et al. Comparison of effect of aloe vera gel with aspirin and celecoxib on platelet aggregation. Professional Med J. 2020; 27(5):973-978. DOI
- Haron MH, Dale O, Martin K, et al. Evaluation of the Herb-Drug Interaction Potential of Commonly Used Botanicals on the US Market with Regard to PXR- and AhR-Mediated Influences on CYP3A4 and CYP1A2. J Diet Suppl 2022. PubMed
- Sabbaghzadegan S, Soltani MH, Kamalinejad M, Bahrami M, Kabir A, Dadmehr M. The effect of a standardized capsule of Aloe vera gel on the quality of life in patients with systolic heart failure: A randomized double-blind placebo-controlled clinical trial.
- Lewis ED, Crowley DC, Guthrie N, Evans M. Healthy adults supplemented with a nutraceutical formulation containing Aloe vera gel, rosemary and Poria cocos enhances the effect of influenza vaccination in a randomized, triple-blind, placebo-controlled trial. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC