Sassafras Alcohol Free Ingredients & Drug Interactions
by Herbal Terra
What is this page for?
First and foremost: checking Sassafras Alcohol Free against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.
Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy
Sassafras Alcohol Free is a dietary supplement by Herbal Terra with 1 active ingredient. Its ingredients are commonly taken for digestive complaints, cold and flu symptoms, joint and muscle aches.Based on those ingredients, 275 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Sassafras Leaf Extract, Dry. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.
Check Your Meds Against Sassafras Alcohol Free by Herbal Terra
Ask about any prescription or over-the-counter medication and we check it for interactions with Sassafras Alcohol Free by Herbal Terra — and tell you which ingredient is responsible.
AI summaries are generated from our interaction database for education only — always confirm with your pharmacist. How we use AI
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HelloPharmacist Scorecard of Sassafras Alcohol Free by Herbal Terra
Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.
What’s inside
Full disclosure
The active ingredient is sassafras leaf extract, dry, so this is a single-ingredient liquid. Its safrole content is the main reason for the safety concerns covered below.
The inactive ingredients listed are glycerin and water.
Does it work?
Couldn't assess
We hold no effectiveness ratings for sassafras leaf extract, so the evidence for its use is not established in the data we hold.
How safe is it?
Well-documented data
Sassafras is generally regarded as unsafe for use in medicinal amounts, and any benefit may not outweigh the risk of toxicity. Its safrole content is linked to cancer and liver toxicity, and the FDA has banned it in food.
Oral use can cause sweating and hot flashes, and large amounts of sassafras oil have been linked to hallucinations, shakes, vomiting, and more serious harm. Topical use can cause contact dermatitis (skin irritation).
Pregnancy and breastfeeding are rated as likely unsafe. Our safety notes advise against use during pregnancy and while breastfeeding, so please talk with your own doctor or pharmacist before considering this product.
Meds to double-check
Moderate interaction found
Double-check with your own doctor or pharmacist before taking this product if you use sedatives (CNS depressants), rated Moderate, or drugs that speed up the liver enzyme CYP1A2 (CYP1A2 inducers), also rated Moderate. The CYP1A2 interaction has not been reported in humans, but the data still flags it.
Omeprazole (Prilosec) is listed as an example.
The bottom line
Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.
This product is generally not recommended based on the safety data we hold, given the safrole content and its links to liver toxicity and cancer. Anyone who is pregnant, breastfeeding, or taking sedatives or medications that affect liver enzymes should be especially careful.
Please talk it over with your own doctor or pharmacist before deciding whether to use it.
Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI
Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Dec 21, 2024.
This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed
General information
Key facts about Sassafras Alcohol Free, straight from the product label.
| Brand | Herbal Terra |
|---|---|
| Barcode (UPC) | 7238360578324 |
| Net contents | 2 Fluid Ounce(s); 60 mL |
| Market status | On market |
| Date entered into DSLD | Dec 21, 2024 |
| DSLD ID | 324523 |
| Product type | Botanical |
| Supplement form | Liquid |
| Dietary claims / uses | All Other, Structure/Function |
| Intended target group(s) | Adult (18 - 50 Years), Gluten Free, Sugar Free |
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.
Supplement Facts
The label details for Sassafras Alcohol Free by Herbal Terra, sourced from the NIH Dietary Supplement Label Database.
Supplement Facts
| Ingredient | Amount | % DV |
|---|---|---|
| Sassafras Leaf Extract, Dry | 1156 mg | -- |
Other ingredients: Glycerin, Water
Tap any ingredient to jump to its full detail below.
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
Suggested/Recommended/Usage/Directions
Shake well before use. Adults take up to 30 drops (1 mL, one full squeeze of the dropper bulb) in 3-4 fl. oz. of juice or water up to 4 times a day.
Precautions
We recommend to seek expert medical advice before taking. May have contraindications and cause adverse reaction.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications.
Consult a physician before giving to children under 18, before using during pregnancy, if nursing, or if you are on any medications. Keep out of the reach of children!
Do not use if you are allergic to any ingredients.
Storage
Store in a cool, dry, dark place.
FDA Disclaimer Statement
This product has not been evaluated by the FDA and is not intended to diagnose, treat, cure or prevent any disease.
Formulation
cGMP Made in compliance with cGMP 21 CFR 111 in an FDA registered and inspected facility.
Sugar free
Expertly extracted 100% natural Premium product
No alcohol (ethyl), artificial ingredients, color additives, fillers or binders.
Natural Gluten free
Formula
Sassafras albidum
FDA Statement of Identity
Herbal Supplement
Seals/Symbols
Made in USA
Is this label outdated? Report a formula or label change and our pharmacy team will review it.
Sassafras Alcohol Free by Herbal Terra label
The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.
Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.
View the full label (PDF)The Ingredients in Sassafras Alcohol Free by Herbal Terra
This is the 1 active ingredient this product is made of. Select it to open its full monograph.
Serving size1 mL Dosage formLiquid Servings per container60 Amounts shown are per serving.
Sassafras Leaf Extract, Dry
Interacts with275 drugs
Sassafras is an aromatic North American tree whose root bark and oil were once popular in teas and as a flavoring, but it contains safrole, a compound...
Sassafras Leaf Extract, Dry monograph & interactionsOther (inactive) ingredients: Glycerin, Water. These complete the product’s ingredient list but are not active constituents.
Sassafras Alcohol Free by Herbal Terra Drug Interactions
HelloPharmacist Interaction Report
Sassafras Alcohol Free by Herbal Terra interacts with medications through its sassafras leaf extract, dry, which is its only ingredient.
The most serious interaction we have on file is Moderate and involves sedatives (CNS depressants). Theoretically, taking sassafras with drugs that cause drowsiness may add to their sedative effects.
Read the full breakdown — every affected drug type, severity by severity
The second documented interaction is also Moderate and involves drugs that speed up a liver enzyme called CYP1A2 (CYP1A2 inducers). Lab research suggests these drugs might increase the toxicity of safrole, the compound in sassafras of concern, but this has not been reported in humans, and it is not known whether these drugs increase the toxicity of sassafras itself.
Omeprazole (Prilosec) is an example. Altogether, these interactions span 275 individual medications.
To see whether your exact medications are covered, use the search tool on this page.
Check your own medications below · Editorial policy · How we use AI
Want to check YOUR meds against Sassafras Alcohol Free?
Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.
Go to the checkerIngredients driving the most interactions
Individual Drug Interactions
The ingredients in Sassafras Alcohol Free interact with 275 drugs. Click any drug to see the details.
1 of the 1 ingredient in Sassafras Alcohol Free interact with drugs. Each result below shows which ingredient is responsible. Sassafras Leaf Extract, Dry
Celecoxib, TramadolSeglentis
How Celecoxib, Tramadol interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Celecoxib, Tramadol interactionCenobamateXcopri
How Cenobamate interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Cenobamate interactionCetirizineCetirizine, Quzyttir, Zyrtec
How Cetirizine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Cetirizine interactionChloral HydrateChloral Hydrate
How Chloral Hydrate interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Chloral Hydrate interactionChlordiazepoxideLibrium
How Chlordiazepoxide interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Chlordiazepoxide interactionChlordiazepoxide, Clidinium BromideLibrax
How Chlordiazepoxide, Clidinium Bromide interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Chlordiazepoxide, Clidinium Bromide interactionChlorpheniramine Maleate, Hydrocodone BitartrateVituz
How Chlorpheniramine Maleate, Hydrocodone Bitartrate interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Chlorpheniramine Maleate, Hydrocodone Bitartrate interactionChlorpheniramine Polistirex, Codeine PolistirexTuzistra XR
How Chlorpheniramine Polistirex, Codeine Polistirex interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Chlorpheniramine Polistirex, Codeine Polistirex interactionChlorpheniramine, Hydrocodone, PseudoephedrineTussend
How Chlorpheniramine, Hydrocodone, Pseudoephedrine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Chlorpheniramine, Hydrocodone, Pseudoephedrine interactionChlorpromazineThorazine, Thorazine Spansules
How Chlorpromazine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Chlorpromazine interactionClobazamFrisium, Onfi, Sympazan
How Clobazam interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Clobazam interactionClonazepamCeberclon, Klonopin, Rivotril
How Clonazepam interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Clonazepam interactionClorazepateTranxene, Tranxene SD, Tranxene T-Tab
How Clorazepate interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Clorazepate interactionCodeine PhosphateCodeine
How Codeine Phosphate interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Codeine Phosphate interactionCodeine Phosphate, GuaifenesinBrontex, Robitussin AC
How Codeine Phosphate, Guaifenesin interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Codeine Phosphate, Guaifenesin interactionCodeine Phosphate, PseudoephedrineKg Fed, Nucofed
How Codeine Phosphate, Pseudoephedrine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Codeine Phosphate, Pseudoephedrine interactionCodeine Phosphate, Pseudoephedrine, TriprolidineCoActifed
How Codeine Phosphate, Pseudoephedrine, Triprolidine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Codeine Phosphate, Pseudoephedrine, Triprolidine interactionCodeine SulfateCodeine Sulfate
How Codeine Sulfate interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Codeine Sulfate interactionCodeine, PapaverineCopavin
How Codeine, Papaverine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Codeine, Papaverine interactionCodeine, ParacetamolCo-codamol
How Codeine, Paracetamol interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Codeine, Paracetamol interactionCyamemazineTercian
How Cyamemazine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Cyamemazine interactionDaridorexantQuviviq
How Daridorexant interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Daridorexant interactionDarunavirPrezista
How Darunavir interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Leaf Extract, Dry + Darunavir interactionDarunavir, CobicistatPrezcobix
How Darunavir, Cobicistat interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Leaf Extract, Dry + Darunavir, Cobicistat interactionDarunavir, Cobicistat, Emtricitabine, Tenofovir AlafenamideSymtuza
How Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Leaf Extract, Dry + Darunavir, Cobicistat, Emtricitabine, Tenofovir Alafenamide interactionDarunavir, RitonavirDarunavir, Ritonavir
How Darunavir, Ritonavir interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Leaf Extract, Dry + Darunavir, Ritonavir interactionDasabuvir Sodium, Ombitasvir, Paritaprevir, RitonavirViekira XR
How Dasabuvir Sodium, Ombitasvir, Paritaprevir, Ritonavir interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Leaf Extract, Dry + Dasabuvir Sodium, Ombitasvir, Paritaprevir, Ritonavir interactionDehydrocholic Acid, Homatropine Methylbromide, PhenobarbitalG.B.S.
How Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCytochrome P450 1a2 (cyp1a2) Inducers, Cns Depressants Moderate
Interaction Summary
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole.
Read the full Sassafras Leaf Extract, Dry + Dehydrocholic Acid, Homatropine Methylbromide, Phenobarbital interactionDesipramineDesipramine, Norpramin, Pertofrane
How Desipramine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Desipramine interactionDeutetrabenazineAustedo
How Deutetrabenazine interacts with Sassafras Alcohol Free — through 1 ingredient. Tap an ingredient for the detail:
Sassafras Leaf Extract, DryCns Depressants Moderate
Interaction Summary
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Read the full Sassafras Leaf Extract, Dry + Deutetrabenazine interactionEach ingredient & the kinds of drugs it affects
For each ingredient in Sassafras Alcohol Free with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.
Sassafras Leaf Extract, Dry
Cns Depressants
Theoretically, concomitant use of sassafras with drugs with sedative properties may cause additive sedative effects.
Cytochrome P450 1A2 (Cyp1A2) Inducers
In vitro research suggests that cytochrome P450 1A2 (CYP1A2) inducers might increase the cytotoxicity of safrole. So far, this interaction has not been reported in humans. Also, it is not known if CYP1A2 inducers increase the toxicity of sassafras. Inducers of CYP1A2 include omeprazole (Prilosec).
Brand information
Manufacturer and brand details for Sassafras Alcohol Free, from the product label.
Herbal Terra
See all Herbal Terra products- Name
- Herbal Terra LLC
- Phone Number
- +18083857868
- Web Address
- herbalterra.com
Sassafras Alcohol Free by Herbal Terra: Common Questions
Does Sassafras Alcohol Free by Herbal Terra interact with any medications?
How can one product interact with so many drugs?
Where does this information come from?
Is Sassafras Alcohol Free safe during pregnancy?
Can this product cause side effects on the skin?
Is there evidence that this product works?
Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy
Not sure if Sassafras Alcohol Free is safe with your meds?
Our pharmacists answer your medication & supplement questions — free.
Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.
The Full Monographs Behind Sassafras Alcohol Free’s Ingredients
Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.
Sources & How We Checked
Sassafras Alcohol Free's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.
- NIH Dietary Supplement Label Database (DSLD) — The official product label on file for this supplement.
- Natural Medicines (Therapeutic Research Center) — Evidence-graded clinical reference behind the ingredient interaction data.
Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.
The 9 references behind this product’s interaction data
Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.
Sassafras 9 references
- Newall CA, Anderson LA, Philpson JD. Herbal Medicine: A Guide for Healthcare Professionals. London, UK: The Pharmaceutical Press, 1996.
- The Review of Natural Products by Facts and Comparisons. St. Louis, MO: Wolters Kluwer Co., 1999.
- Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs and Cosmetics. 2nd ed. New York, NY: John Wiley & Sons, 1996.
- McGuffin M, Hobbs C, Upton R, Goldberg A, eds. American Herbal Products Association's Botanical Safety Handbook. Boca Raton, FL: CRC Press, LLC 1997.
- Brinker F. Herb Contraindications and Drug Interactions. 2nd ed. Sandy, OR: Eclectic Medical Publications, 1998.
- Ueng, Y. F., Hsieh, C. H., Don, M. J., Chi, C. W., and Ho, L. K. Identification of the main human cytochrome P450 enzymes involved in safrole 1'-hydroxylation. Chem Res Toxicol 2004;17(8):1151-1156. PubMed
- Kapadia, G. J., Chung, E. B., Ghosh, B., Shukla, Y. N., Basak, S. P., Morton, J. F., and Pradhan, S. N. Carcinogenicity of some folk medicinal herbs in rats. J Natl.Cancer Inst. 1978;60(3):683-686.
- Segelman, A. B., Segelman, F. P., Karliner, J., and Sofia, R. D. Sassafras and herb tea. Potential health hazards. JAMA 8-2-1976;236(5):477. DOI
- Hu L, Wu F, He J, Zhong L, Song Y, Shao H. Cytotoxicity of safrole in HepaRG cells: studies on the role of CYP1A2-mediated ortho-quinone metabolic activation. Xenobiotica. 2019;49(12):1504-1515. PubMed
Parts of this content are provided by the Therapeutic Research Center, LLC.
DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.
© 2021 Therapeutic Research Center, LLC