Interactions on record — worth a quick check against your medications. Based on 1 of 2 ingredients. Check your meds →
Dietary supplement

Seirogan Toi-A Ingredients & Drug Interactions

by Trumpet Brand

Seirogan Toi-A label
See full label image
Tablet Or Pill Category: Botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Seirogan Toi-A against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Seirogan Toi-A is a dietary supplement by Trumpet Brand with 2 active ingredients. Its ingredients are commonly taken for digestive complaints and diarrhea, inflammation and joint discomfort, stress and weight management (in combination products).Based on those ingredients, 1,160 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Phellodendron bark dried extract. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Seirogan Toi-A by Trumpet Brand

Ask about any prescription or over-the-counter medication and we check it for interactions with Seirogan Toi-A by Trumpet Brand — and tell you which ingredient is responsible.

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HelloPharmacist Scorecard of Seirogan Toi-A by Trumpet Brand

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 2 of its 2 active ingredients.
  • No proprietary blends here — you can verify the dose of every single component.

Seirogan Toi-A contains 2 active ingredients: powdered geranium and phellodendron bark dried extract. Phellodendron is a traditional Asian botanical that contains berberine, a compound with a long history in herbal medicine.

The product also contains several inactive ingredients — fillers, binders, and tablet coatings like talc, calcium carbonate, magnesium stearate, and cellulose derivatives.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Phellodendron product and its label doesn't state a use — see Phellodendron's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence we have for phellodendron's effectiveness is limited. Our data shows insufficient reliable evidence to rate it for acne, benign prostatic hyperplasia (enlarged prostate), diabetes, weight loss, osteoarthritis, or peptic ulcers.

If you're considering this product for one of these uses, talk with your doctor or pharmacist about whether the research supports it for your situation.

The evidence, ingredient by ingredient Phellodendron

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Phellodendron has been used short-term in traditional medicine, but human safety data are limited. In clinical trials of combination products containing phellodendron and magnolia together, a small number of participants reported sexual dysfunction, shaking hands, numbness around the lips, fatigue, headache, and heartburn — though it's unclear whether phellodendron was responsible.

The safety data advises against use in pregnancy because berberine (its active compound) may not be safe. Berberine can also pass into breast milk and may harm infants, so avoid this product while breastfeeding.

Side effects, ingredient by ingredient Phellodendron

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Phellodendron.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs; immunosuppressants / transplant drugs; diabetes medications.
  • For scale: 1,161 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Before taking this product, double-check with your pharmacist or doctor if you take medications processed through CYP3A4 (a very common liver pathway — many heart, cholesterol, and allergy drugs use it), CNS depressants (sedatives, sleep aids, anxiety medications), blood pressure medications, blood thinners or antiplatelet drugs, diabetes medications, or metformin specifically. Phellodendron may raise levels of the first group, increase drowsiness with the second, lower blood pressure with the third, raise bleeding risk with the fourth, increase low blood sugar (hypoglycemia) risk with the fifth, and boost both the effects and side effects of metformin.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Seirogan Toi-A is a traditional remedy with limited evidence for its claimed uses and a significant potential to interact with many common medications — especially those your liver processes. If you take any prescription or over-the-counter drugs, especially blood pressure medications, blood thinners, diabetes medications, or sedatives, check with your own doctor or pharmacist before starting this product.

It's not safe in pregnancy or while breastfeeding.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 2 active ingredients matched to our full ingredient reviews (monographs). Based on the product label dated Apr 22, 2016.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Seirogan Toi-A, straight from the product label.

Brand Trumpet Brand
Barcode (UPC) 039278960365
Net contents 36 Tablet(s)
Market status On market
Date entered into DSLD Apr 22, 2016
DSLD ID 58814
Product type Botanical
Supplement form Tablet Or Pill
Dietary claims / uses All Other, Structure/Function
Intended target group(s) Children 4 or More Years of Age, Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Seirogan Toi-A by Trumpet Brand, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
4 Tablet(s)
Maximum serving Sizes:
4 Tablet(s)
Servings per container
9
UPC/BARCODE
039278960365
IngredientAmount% DV
Total Carbohydrates0.5 Gram(s)1%
powdered Geranium100 mg--
Phellodendron bark dried extract100 mg--

Other ingredients: White Sugar, Talc, Magnesium Alumino-Metasilicate, Wood Creosote, Calcium Carbonate, Calcium Carboxymethylcellulose, low substituted Hydroxypropyl-Cellulose, synthetic Aluminum Silicate, Methylcellulose, Magnesium Stearate, powdered Acacia, Gelatin, Titanium Oxide, Macrogol 6000, Carmellose Sodium, Carnauba Wax, White Beeswax

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
General Statements

Sugar-coated tablet

Made in Japan

Serious side effects associated with use of the product may be reported on the toll free#.

6

FDA Statement of Identity

Herbal Dietary Supplement

Precautions

- Keep out of reach of children.

- For your protection, do not use if cap seal is broken or missing. Keep package insert for more details of warnings.

Not recommended for children under 5 years of age.

Warnings: - Pregnant or lactating women should not take this product without consulting their healthcare professionals.

Storage

Other Information: Store in a cool place away from direct sunlight.

FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

Suggested/Recommended/Usage/Directions

Uses: Seirogan Toi A Tablets is a herbal dietary supplement to help regulate digestive system to maintain normal bowel functions. Directions: Take 4 tablets after a meal with water up to 3 times a day as needed. For children 5-10 years of age, the recommended serving is 2 tablets. For age 11-14 years, the recommended serving is 3 tablets. Not recommended for children under 5 years of age.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Seirogan Toi-A by Trumpet Brand label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Seirogan Toi-A label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Seirogan Toi-A by Trumpet Brand

These are the 2 active ingredients this product is made of. Select any to open its full monograph.

Serving size4 Tablet(s) Dosage formTablet Or Pill Servings per container9 Amounts shown are per serving.

Most supplement products combine several ingredients, and a medication can interact with the product through any one of them. Each ingredient below shows whether it has known drug interactions.

Powdered Geranium

100 mg per serving

Phellodendron bark dried extract

Interacts with
1,160 drugs
100 mg per serving

Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and anti-inflamm...

Phellodendron bark dried extract monograph & interactions

Other (inactive) ingredients: White Sugar, Talc, Magnesium Alumino-Metasilicate, Wood Creosote, Calcium Carbonate, Calcium Carboxymethylcellulose, Low substituted Hydroxypropyl-Cellulose, Synthetic Aluminum Silicate, Methylcellulose, Magnesium Stearate, Powdered Acacia, Gelatin, Titanium Oxide, Macrogol 6000, Carmellose Sodium, Carnauba Wax, White Beeswax. These complete the product’s ingredient list but are not active constituents.

Interaction report

Seirogan Toi-A by Trumpet Brand Drug Interactions

Want to check YOUR meds against Seirogan Toi-A?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
1,160Drugs
1,160 Moderate

Ingredients driving the most interactions

Phellodendron bark dried extract 1,160

Individual Drug Interactions

The ingredients in Seirogan Toi-A interact with 1,160 drugs. Click any drug to see the details.

1 of the 2 ingredients in Seirogan Toi-A interact with drugs. Each result below shows which ingredient is responsible. Phellodendron bark dried extract

Each ingredient & the kinds of drugs it affects

For each ingredient in Seirogan Toi-A with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Phellodendron bark dried extract14 drug types · 1,160 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, phellodendron might increase the risk of bleeding when used with anticoagulant or antiplatelet drugs.
Phellodendron contains berberine. In vitro and in vivo research suggest that berberine can inhibit platelet aggregation. Theoretically, phellodendron might also inhibit platelet aggregation.

Likelihood Possible Evidence D
Antidiabetes Drugs

Theoretically, phellodendron may increase the risk of hypoglycemia when taken with antidiabetes drugs.
Phellodendron contains berberine. Clinical research shows that berberine may lower blood glucose levels. Theoretically, phellodendron might also lower blood glucose levels.

Likelihood Possible Evidence D
Antihypertensive Drugs

Theoretically, phellodendron might have additive effects with antihypertensive drugs.
Phellodendron contains berberine. Animal research suggests that berberine can have hypotensive effects. Also, a clinical study suggests that taking berberine in combination with amlodipine can lower systolic and diastolic blood pressure when compared with amlodipine alone. Theoretically, phellodendron might also reduce blood pressure.

Likelihood Possible Evidence D
Cns Depressants

Theoretically, phellodendron might increase the sedative effects of CNS depressants.
Phellodendron contains berberine. Animal research suggests that berberine may have sedative effects. Theoretically, phellodendron might also have CNS depressants effects.

Likelihood Possible Evidence D
Cyclosporine (Neoral, Sandimmune)

Theoretically, phellodendron might increase blood levels of cyclosporine.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can reduce metabolism of cyclosporine and increase serum levels, likely through inhibition of cytochrome P450 3A4 (CYP3A4), which metabolizes cyclosporine. Theoretically, phellodendron might also reduce the metabolism of cyclosporine.

Likelihood Possible Evidence D
Cytochrome P450 2C9 (Cyp2C9) Substrates

Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2C9.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit CYP2C9. Theoretically, phellodendron might also inhibit CYP2C9.

Likelihood Possible Evidence D
Cytochrome P450 2D6 (Cyp2D6) Substrates

Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP2D6.
Phellodendron contains berberine. In vitro research and preliminary clinical evidence show that berberine can inhibit CYP2D6. Theoretically, phellodendron might also inhibit CYP2D6.

Likelihood Possible Evidence D
Cytochrome P450 3A4 (Cyp3A4) Substrates

Theoretically, phellodendron might increase serum levels of drugs metabolized by CYP3A4.
Phellodendron contains berberine. In vitro research and preliminary clinical research show that berberine moderately inhibits CYP3A4. Theoretically, phellodendron might also inhibit CYP3A4.

Likelihood Possible Evidence D
Dextromethorphan (Robitussin Dm, Others)

Theoretically, phellodendron may increase serum levels of dextromethorphan.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 2D6 (CYP2D6) activity and reduce the metabolism of dextromethorphan. Theoretically, phellodendron may also inhibit the metabolism of dextromethorphan.

Likelihood Possible Evidence D
Losartan (Cozaar)

Theoretically, phellodendron might reduce the therapeutic effects of losartan by decreasing its conversion to its active form.
Phellodendron contains berberine. Preliminary clinical research suggests that berberine can inhibit cytochrome P450 2C9 (CYP2C9) activity and reduce metabolism of losartan. Theoretically, phellodendron might also inhibit the metabolism of losartan.

Likelihood Possible Evidence D
Metformin (Glucophage)

Theoretically, phellodendron might increase the therapeutic and adverse effects of metformin.
Phellodendron contains berberine. In vitro and animal studies show that berberine can increase the systemic exposure and half-life of metformin, potentially increasing metformin's effects and side effects. This interaction seems to be most apparent when berberine is administered 2 hours prior to metformin. Taking berberine and metformin at the same time does not appear to increase systemic exposure to metformin. It is unclear if phellodendron might have this same effect.

Likelihood Possible Evidence D
Midazolam (Versed)

Theoretically, phellodendron might reduce metabolism of midazolam, which might increase the risk of severe adverse effects.
Phellodendron contains berberine. Preliminary clinical research shows that berberine can inhibit cytochrome P450 3A4 (CYP3A4) activity and reduce metabolism of midazolam. Theoretically, phellodendron might also inhibit the metabolism of midazolam.

Likelihood Possible Evidence D
Pentobarbital (Nembutal)

Theoretically, phellodendron might increase the sedative effect of pentobarbital.
Phellodendron contains berberine. Animal research shows that berberine can prolong pentobarbital-induced sleeping time. Theoretically, phellodendron might increase the sedative effects of pentobarbital.

Likelihood Possible Evidence D
Tacrolimus (Prograf)

Theoretically, phellodendron might increase blood levels of tacrolimus.
Phellodendron contains berberine. In a 16-year-old patient with idiopathic nephrotic syndrome who was being treated with tacrolimus 6.5 mg twice daily, intake of berberine 200 mg three times daily increased the blood concentration of tacrolimus from 8 to 22 ng/mL. Following a reduction of the tacrolimus dose to 3 mg daily, blood levels of tacrolimus decreased to 12 ng/mL. It is unclear if phellodendron might have this same effect.

Likelihood Possible Evidence D
Phellodendron bark dried extract full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Seirogan Toi-A, from the product label.

Trumpet Brand

See all Trumpet Brand products
Name
Prince of Peace Enterprises, Inc.
Street Address
3536 Arden Road
City
Hayward
State
CA
ZipCode
94545-3908
Phone Number
1.800.732.2328
Pharmacist Counseling Corner

Seirogan Toi-A by Trumpet Brand: Common Questions

Does Seirogan Toi-A by Trumpet Brand interact with any medications?
Yes. Based on its ingredients, Seirogan Toi-A has a known interaction with 1,160 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Seirogan Toi-A contains 2 active ingredients, and an interaction can come from any of them. We check every ingredient, combine the results into one list per medication, and show which ingredient and mechanism is responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
Can I take Seirogan Toi-A if I'm pregnant or breastfeeding?
No — the safety data advises against it. Berberine, the active compound in phellodendron, may not be safe in pregnancy and can pass into breast milk where it may harm infants. Talk with your doctor before taking any supplement while pregnant or nursing.
What is phellodendron, and what is it supposed to do?
Phellodendron is a traditional Asian tree bark extract that contains berberine. This product uses it for several conditions — acne, enlarged prostate, diabetes, weight loss, osteoarthritis, and ulcers — but we don't have reliable evidence that it works for any of these. The evidence is classified as insufficient.
What side effects have been reported?
In clinical trials of combination products containing phellodendron plus magnolia, a small number of people reported sexual dysfunction, shaking hands, numbness around the lips, fatigue, headache, and heartburn. We can't be sure phellodendron alone caused these, since it was tested with another herb.
Is it safe to use if I'm not on any medications?
The product has been used short-term in traditional medicine, but human safety data are limited. Even without medications, talk with your pharmacist or doctor about whether it's right for you, especially since we don't have strong evidence it works for its claimed uses.
Why does this product interact with so many medications?
Phellodendron contains berberine, which can slow how your liver breaks down many drugs by blocking three major enzyme pathways (CYP3A4, CYP2D6, and CYP2C9). When your body processes medications more slowly, they can build up to higher levels and cause stronger effects or side effects. That's why the interaction count is large.
What is powdered geranium, and why can't you check it for interactions?
Powdered geranium is an herbal ingredient in this product, but we don't hold a monograph or safety data for it, so we can't check it for interactions. That doesn't mean it has none — just that we don't have the information.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Seirogan Toi-A label
Go deeper

The Full Monographs Behind Seirogan Toi-A’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Phellodendron

Interacts with 1,160 drugs

Phellodendron is a traditional Chinese medicine bark (Huang Bai) that contains berberine and other plant compounds with antimicrobial and anti-inflammatory activity in lab studies. Human evi...

Read the full Phellodendron monograph →
Sources

Sources & How We Checked

Seirogan Toi-A's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 22 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Phellodendron 22 references
  1. Chan E. Displacement of bilirubin from albumin by berberine. Biol Neonate 1993;63:201-8. PubMed
  2. Janbaz KH, Gilani AH. Studies on preventive and curative effects of berberine on chemical-induced hepatotoxicity in rodents. Fitoterapia 2000;71:25-33.. PubMed
  3. Wu X, Li Q, Xin H, Yu A, Zhong M. Effects of berberine on the blood concentration of cyclosporin A in renal transplanted recipients: clinical and pharmacokinetic study. Eur J Clin Pharmacol 2005;61:567-72. PubMed
  4. Garrison R, Chambliss WG. Effect of a proprietary Magnolia and Phellodendron extract on weight management: a pilot, double-blind, placebo-controlled clinical trial. Altern Ther Health Med 2006;12:50-4.
  5. Zhang Y, Li X, Zou D, et al. Treatment of type 2 diabetes and dyslipidemia with the natural plant alkaloid berberine. J Clin Endocrinol Metab 2008;93:2559-65. PubMed
  6. Budzinski JW, Foster BC, Vandenhoek S, Arnason JT. An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures. Phytomedicine 2000;7:273-82. PubMed
  7. Chatterjee P, Franklin MR. Human cytochrome p450 inhibition and metabolic-intermediate complex formation by goldenseal extract and its methylenedioxyphenyl components. Drug Metab Dispos 2003;31:1391-7. PubMed
  8. Shanbhag, S. M., Kulkarni, H. J., and Gaitonde, B. B. Pharmacological actions of berberine on the central nervous system. Jpn.J Pharmacol 1970;20(4):482-487. PubMed
  9. Wu, J. F. and Liu, T. P. [Effects of berberine on platelet aggregation and plasma levels of TXB2 and 6-keto-PGF1 alpha in rats with reversible middle cerebral artery occlusion]. Yao Xue.Xue.Bao. 1995;30(2):98-102.
  10. Peng, W. H., Hsieh, M. T., and Wu, C. R. Effect of long-term administration of berberine on scopolamine-induced amnesia in rats. Jpn J Pharmacol 1997;74(3):261-266. DOI
  11. Sabir M and Bhide NK. Study of some pharmacological actions of berberine. Ind J Physiol & Pharmac 1971;15(3):111-132.
  12. Tripathi YB and Shukla SD. Berberis artistata inhibits PAF induced aggregation of rabbit platelets. Phytotherapy Research 1996;10:628-630.
  13. Yin, J., Xing, H., and Ye, J. Efficacy of berberine in patients with type 2 diabetes mellitus. Metabolism 2008;57(5):712-717. PubMed
  14. Zhang, H., Wei, J., Xue, R., Wu, J. D., Zhao, W., Wang, Z. Z., Wang, S. K., Zhou, Z. X., Song, D. Q., Wang, Y. M., Pan, H. N., Kong, W. J., and Jiang, J. D. Berberine lowers blood glucose in type 2 diabetes mellitus patients through increasing insulin re
  15. Guo, Y., Chen, Y., Tan, Z. R., Klaassen, C. D., and Zhou, H. H. Repeated administration of berberine inhibits cytochromes P450 in humans. Eur J Clin Pharmacol 2012;68(2):213-217. PubMed
  16. Wei, W., Zhao, H., Wang, A., Sui, M., Liang, K., Deng, H., Ma, Y., Zhang, Y., Zhang, H., and Guan, Y. A clinical study on the short-term effect of berberine in comparison to metformin on the metabolic characteristics of women with polycystic ovary syndro
  17. Hermann, R. and von, Richter O. Clinical evidence of herbal drugs as perpetrators of pharmacokinetic drug interactions. Planta Med 2012;78(13):1458-1477. PubMed
  18. Chun YT, Yip TT, Lau KL, and et al. A biochemical study on the hypotensive effect of berberine in rats. Gen Pharmac 1979;10:177-182. PubMed
  19. Hou Q, Han W, Fu X. Pharmacokinetic interaction between tacrolimus and berberine in a child with idiopathic nephrotic syndrome. Eur J Clin Pharmacol 2013;69(10):1861-2. PubMed
  20. Lan J, Zhao Y, Dong F, et al. Meta-analysis of the effect and safety of berberine in the treatment of type 2 diabetes mellitus, hyperlipemia and hypertension. J Ethnopharmacol. 2015;161:69-81. PubMed
  21. Kalman DS, Feldman S, Feldman R, et al. Effect of a proprietary magnolia and phellodendron extract on stress levels in healthy women: a pilot, double-blind, placebo-controlled clinical trial. Nutr J 2008;7:11.
  22. Lyu Y, Zhang Y, Yang M, et al. Pharmacokinetic interactions between metformin and berberine in rats: Role of oral administration sequences and microbiota. Life Sci. 2019;235:116818. PubMed

See these in context on the Phellodendron monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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