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Dietary supplement

Serrapeptase Ingredients & Drug Interactions

by BioAnue

Serrapeptase label
See full label image
Capsule Category: Non-nutrient/non-botanical
Most serious interaction: Moderate
Clinical methodology reviewed by · Updated Sep 23, 2026 · Label data from the NIH DSLD
What is this page for?

First and foremost: checking Serrapeptase against your medications. The heart of this page is the interaction checker and the full interaction report — how this product’s ingredients may interact with prescription and over-the-counter medicines you may be taking.

Around that, we add a pharmacist’s high-level view of the product as a whole — what’s inside, the evidence for its stated use, how transparent the label is, and what safety data exists — so you can see the full picture in one place. It’s educational information from our licensed clinical databases and the clinical staff at HelloPharmacist — not medical advice — and we don’t sell or endorse products. Our editorial policy

The interaction bottom line Most serious interaction: Moderate

Serrapeptase is a dietary supplement by BioAnue with 1 active ingredient. Its ingredients are commonly taken for inflammation and swelling, sinus and respiratory congestion, pain after surgery or injury.Based on those ingredients, 122 medications have a known interaction with it, the most serious rated moderate. The ingredients most likely to interact are Serrapeptase. Use the checker below to test your specific medication, or read the full HelloPharmacist Interaction Report.

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Check Your Meds Against Serrapeptase by BioAnue

Ask about any prescription or over-the-counter medication and we check it for interactions with Serrapeptase by BioAnue — and tell you which ingredient is responsible.

Pharmacist-reviewed data Checks every ingredient Answer in seconds
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HelloPharmacist Scorecard of Serrapeptase by BioAnue

Our pharmacy team’s full take, with four database checks built into the cards below — a summary of what is known, not a grade of the product itself.

From our pharmacy team — supplement deep dive

Generated from HelloPharmacist’s pharmacist-curated databases and editorial rules · Last generated Sep 10, 2026

What’s inside

Full disclosure
Ingredient Transparency · database check
Full

Every active ingredient lists its own amount on the label.

Why this rating?
  • The label discloses an exact amount for 1 of its 1 active ingredient.
  • No proprietary blends here — you can verify the dose of every single component.

Serrapeptase is a single active ingredient—an enzyme extracted from silkworm pupae. It works by breaking down fibrin, a protein involved in blood clotting and inflammation.

The capsule itself is gelatin, an inactive ingredient that holds the enzyme.

Does it work?

Couldn't assess
Evidence for Intended Use · database check
By FDA rules, dietary supplements can’t claim to treat, cure, or prevent disease — so labels speak in careful marketing language. We discern each product’s intended use from its name, label claims, and label statements, then grade the clinical evidence for that use. How these ratings are computed
Not assessable

This is a single-ingredient Serrapeptase product and its label doesn't state a use — see Serrapeptase's own graded uses on its monograph.

Why this rating?
  • We looked at the product name, claims, and label statements and couldn't find a stated purpose to grade.

The evidence for serrapeptase isn't established in the data we hold. Effectiveness ratings for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis all show insufficient reliable evidence, meaning studies haven't yet made a solid case for or against it for these conditions.

If you're considering it for a specific health concern, talk that over with your doctor—they can tell you what the current research really supports.

The evidence, ingredient by ingredient Serrapeptase

How safe is it?

Well-documented data
Safety Information · database check
Well characterized

Adverse-effect, pregnancy, and general safety data are on file for most of these ingredients.

Why this rating?
  • We hold adverse-effect (side-effect) data for 1 of the 1 matched ingredient.
  • Pregnancy & breastfeeding safety ratings cover 1 of 1.
  • General safety write-ups exist for 1 of 1.
  • Remember: this measures how much safety information exists. Thin data is not the same as being safe.

Serrapeptase is generally well tolerated short-term, but long-term safety hasn't been well studied, so caution is warranted if you're thinking of using it long-term. The most common side effects from oral use are epigastric pain (upper belly discomfort), general gastrointestinal upset, and nausea; however, these appear to occur at the same rate as placebo in studies, meaning they may not be caused by the supplement itself.

Bullous pemphigoid (a rare serious skin condition) has been reported in rare cases. Safety data during pregnancy and breastfeeding is not adequate, so it's best avoided during both.

Side effects, ingredient by ingredient Serrapeptase

Meds to double-check

Moderate interaction found
Known Interaction Concern · database check
Moderate identified

The most serious documented interaction for these ingredients is Moderate. Check your medications for a personalized result.

Why this rating?
  • 1 of the 1 matched ingredient can interact with medications — Serrapeptase.
  • The most serious interaction on file is rated Moderate.
  • Some involve high-stakes drug classes: anticoagulant / antiplatelet drugs.
  • For scale: 122 individual medications appear in the full list. A big number alone doesn't make a product dangerous — what matters is whether YOUR medication is on it, so run yours through the interaction checker on this page.

Check any blood thinners (anticoagulants) or antiplatelet drugs you take—such as warfarin, dabigatran, apixaban, aspirin, clopidogrel, or ticagrelor—before starting serrapeptase, as the combination carries a Moderate risk of increased bleeding and bruising. No other drug interactions are documented for this ingredient in our data.

Check your own medication Run your meds through the checker above

The bottom line

Scorecard at a glanceFully disclosed formula with no assessable stated purpose. Moderate medication interactions have been identified, and safety information is well characterized.

Serrapeptase is an enzyme supplement generally well tolerated in the short term, but the main caution is its interaction with blood thinners and antiplatelet medications—a Moderate-severity risk. If you take any heart or clotting medications, check with your doctor or pharmacist before starting.

The evidence for its effectiveness on the conditions commonly marketed for it isn't solid yet, and long-term safety is unknown.

Educational only — not medical advice; always confirm with your pharmacist. Our editorial policy · How we use AI

Assessment coverage: 1 of 1 active ingredient matched to our full ingredient reviews (monographs). Based on the product label dated Nov 25, 2013.

This Scorecard evaluates available label information, ingredient evidence, and known medication-safety considerations. It does not independently verify product identity, purity, potency, contamination, or manufacturing quality. How these ratings are computed

At a glance

General information

Key facts about Serrapeptase, straight from the product label.

Brand BioAnue
Net contents 180 Capsule(s); 350 mg
Market status On market
Date entered into DSLD Nov 25, 2013
DSLD ID 27394
Product type Non-nutrient/non-botanical
Supplement form Capsule
Dietary claims / uses Structure/Function
Intended target group(s) Adult (18 - 50 Years)
From the label
Everything in this section is reproduced from the manufacturer’s own product label — it’s the label speaking, not HelloPharmacist. We show it so you can see exactly what the maker states; we don’t verify or endorse those statements.

Supplement Facts

The label details for Serrapeptase by BioAnue, sourced from the NIH Dietary Supplement Label Database.

Supplement Facts

Daily Value (DV) Target Group(s):
Adults and children 4 or more years of age
Minimum serving Sizes:
1 Capsule(s)
Maximum serving Sizes:
6 Capsule(s)
Servings per container
180
IngredientAmount% DV
Serrapeptase350 mg--

Other ingredients: Gelatin Capsule

Tap any ingredient to jump to its full detail below.

Label statements
These statements are the manufacturer’s wording, reproduced from the product label — the label is saying it, not HelloPharmacist. We don’t verify or endorse them.
FDA Disclaimer Statement

This statement has not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.

General Statements

Your Edge - Your New Beginning

Suggested/Recommended/Usage/Directions

Usage: As a dietary supplement consume 1 to 6 capsules per day, or as directed by a health care professional.

Is this label outdated? Report a formula or label change and our pharmacy team will review it.

See for yourself

Serrapeptase by BioAnue label

The label scan from the NIH Dietary Supplement Label Database. Tap to enlarge.

Serrapeptase label

Label images are published by the NIH Dietary Supplement Label Database for the version of this product on file. Always read your actual product label.

View the full label (PDF)
What’s inside

The Ingredients in Serrapeptase by BioAnue

This is the 1 active ingredient this product is made of. Select it to open its full monograph.

Serving size1 Capsule(s) Dosage formCapsule Servings per container180 Amounts shown are per serving.

Serrapeptase

Interacts with
122 drugs
350 mg per serving Form: Bombyx mori

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you...

Serrapeptase monograph & interactions

Other (inactive) ingredients: Gelatin Capsule. These complete the product’s ingredient list but are not active constituents.

Interaction report

Serrapeptase by BioAnue Drug Interactions

Want to check YOUR meds against Serrapeptase?

Ask about interactions with your drugs in plain English — “Can I take it with lisinopril?” — and we find you the answer in seconds, ingredient by ingredient.

 Go to the checker
122Drugs
122 Moderate

Ingredients driving the most interactions

Serrapeptase 122

Individual Drug Interactions

The ingredients in Serrapeptase interact with 122 drugs. Click any drug to see the details.

1 of the 1 ingredient in Serrapeptase interact with drugs. Each result below shows which ingredient is responsible. Serrapeptase

Each ingredient & the kinds of drugs it affects

For each ingredient in Serrapeptase with known interactions, here are the types of medications it can affect. Open any type for the detail — or search your exact drug in the checker above.

Serrapeptase1 drug type · 122 drugs

Anticoagulant/Antiplatelet Drugs

Theoretically, taking serrapeptase with drugs that have antiplatelet or anticoagulant effects might increase the risk of bruising and bleeding.
In vitro research shows that serrapeptase has fibrinolytic activity.

Likelihood Possible Evidence D
Serrapeptase full monograph & interactions
The maker

Brand information

Manufacturer and brand details for Serrapeptase, from the product label.

BioAnue

See all BioAnue products
Name
BioAnue Laboratories Inc.
Street Address
P.O. Box 1056, 123 Wood Tech Dr.
City
Rochelle
State
GA
ZipCode
31079
Phone Number
(229) 365-7222
Pharmacist Counseling Corner

Serrapeptase by BioAnue: Common Questions

Does Serrapeptase by BioAnue interact with any medications?
Yes. Based on its ingredients, Serrapeptase has a known interaction with 122 medications. Use the checker to see how it interacts with a specific drug.
How can one product interact with so many drugs?
Serrapeptase contains a single active ingredient, and that one ingredient can interact with many different medications on its own. We check it against each medication and show the mechanism responsible.
Where does this information come from?
The product label data comes from the NIH Dietary Supplement Label Database (DSLD); the interaction data is built on the Natural Medicines database and reviewed by HelloPharmacist pharmacists.
What is serrapeptase, and where does it come from?
Serrapeptase is an enzyme extracted from silkworm pupae. It works by breaking down fibrin, a protein involved in blood clotting and inflammation.
Does serrapeptase actually work for what it's marketed for?
The evidence isn't solid yet. Studies looking at serrapeptase for chronic bronchitis, asthma, atherosclerosis, back pain, and osteoporosis show insufficient reliable evidence, meaning we can't yet say whether it works for these conditions.
What are the common side effects?
The most common side effects are epigastric pain (upper belly discomfort), gastrointestinal upset, and nausea. However, these appear to occur at the same rate as placebo in studies, so they may not be caused by the supplement itself.
Is it safe to take serrapeptase long-term?
Serrapeptase is generally well tolerated in the short term, but long-term safety hasn't been well studied, so caution is warranted if you're thinking of using it for extended periods.
Can I take serrapeptase if I'm pregnant or breastfeeding?
Safety data during pregnancy and breastfeeding is not adequate, so it's best avoided during both. Talk with your doctor or pharmacist if you're considering it while pregnant or nursing.
Does serrapeptase interact with my blood thinner?
Yes—serrapeptase has fibrinolytic activity (it can thin blood), so taking it with anticoagulants or antiplatelet drugs carries a Moderate risk of increased bruising and bleeding. Check with your doctor or pharmacist before combining them.

Written and reviewed by the HelloPharmacist editorial staff. Our editorial policy

Not sure if Serrapeptase is safe with your meds?

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Label information is sourced from the NIH Dietary Supplement Label Database and reflects the product version on file; always read your actual product label. This page is for education only and is not a substitute for professional medical advice. Confirm with your pharmacist or doctor before combining supplements and medications.

Serrapeptase label
Go deeper

The Full Monographs Behind Serrapeptase’s Ingredients

Every ingredient we hold a full HelloPharmacist monograph for — uses, evidence, safety, and the complete interaction list.

Herb & supplement monograph

Serrapeptase

Interacts with 122 drugs

Serrapeptase is an enzyme marketed to reduce inflammation, swelling, pain, and mucus, but the human evidence is limited and mostly low quality. If you want to try it, choose an enteric-coate...

Read the full Serrapeptase monograph →
Sources

Sources & How We Checked

Serrapeptase's label data comes from the NIH Dietary Supplement Label Database; the ingredient interaction data is from the Natural Medicines database, reviewed by our pharmacists.

Content is written and reviewed by licensed HelloPharmacist pharmacists. See our data sources and editorial standards for how this information is built and checked.

The 2 references behind this product’s interaction data

Every citation that drives the interaction findings for this product’s ingredients, from the evidence-graded Natural Medicines (TRC Healthcare) database. Open an ingredient to browse its citations — links open the study on PubMed or the publisher’s site.

Serrapeptase 2 references
  1. Tachibana M, Mizukoshi O, Harada Y, et al. A multi-centre, double-blind study of serrapeptase versus placebo in post-antrotomy buccal swelling. Pharmatherapeutica 1984;3:526-30..
  2. Mazzone A, Catalani M, Costanzo M, et al. Evaluation of Serratia peptidase in acute or chronic inflammation of otorhinolaryngology pathology: a multicentre, double-blind, randomized trial versus placebo. J Int Med Res 1990;18:379-88.. PubMed

See these in context on the Serrapeptase monograph →

Parts of this content are provided by the Therapeutic Research Center, LLC.

DISCLAIMER: Currently this does not check for drug-drug interactions. This is not an all-inclusive comprehensive list of potential interactions and is for informational purposes only. Not all interactions are known or well-reported in the scientific literature, and new interactions are continually being reported. Input is needed from a qualified healthcare provider including a pharmacist before starting any therapy. Application of clinical judgment is necessary.

© 2021 Therapeutic Research Center, LLC

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